Ambrx Biopharma (AMAM)

Cash burn rate (est.)	Burn method: Change in cash		Burn method: Operating income		Burn method: FCF (opex + capex)
	Last Q	Avg 4Q	Last Q	Avg 4Q	Last Q	Avg 4Q
Cash on hand (at last report)	228.93 mm	228.93 mm	228.93 mm	228.93 mm	228.93 mm	228.93 mm
Cash burn (monthly)	(no burn)	(no burn)	6.39 mm	2.93 mm	224.33 k	1.14 mm
Cash used (since last report)	n/a	n/a	113.85 mm	52.27 mm	4.00 mm	20.25 mm
Cash remaining	n/a	n/a	115.08 mm	176.66 mm	224.93 mm	208.68 mm
Runway (months of cash)	n/a	n/a	18.0	60.2	1002.7	183.6

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Financial data from company earnings reports.

Institutional ownership, Q2 2023

AMAM institutional ownership history Ownership history

13F holders	Current	Prev Q	Change
Total holders	51	37	+37.8%
Opened positions	19	21	-9.5%
Closed positions	5	6	-16.7%
Increased positions	12	9	+33.3%
Reduced positions	8	3	+166.7%

13F shares	Current	Prev Q	Change
Total value	754.91 bn	246.22 bn	+206.6%
Total shares	188.40 mm	177.54 mm	+6.1%
Total puts	243.90 k	218.60 k	+11.6%
Total calls	342.60 k	1.41 mm	-75.7%
Total put/call ratio	0.7	0.2	+360.0%

Largest owners	Shares	Value	Change
HOPU Reunion	38.95 mm	$351.74 mm	0.0%
WuXi PharmTech Healthcare Fund I	29.27 mm	$264.29 mm	0.0%
Venrock Healthcare Capital Partners III	26.74 mm	$74.34 mm	0.0%
D. E. Shaw & Co	22.05 mm	$276.51 mm	0.0%
Darwin Global Management	16.69 mm	$274.69 bn	+47.6%
Artal International S.C.A.	15.07 mm	$0.00	0.0%
Cormorant Asset Management	9.62 mm	$158.28 bn	+13.1%
HBM Healthcare Investments	8.40 mm	$0.00	0.0%
D. E. Shaw & Co.	4.02 mm	$66.10 bn	+2.1%
Commodore Capital	3.18 mm	$52.26 bn	-33.9%

Largest transactions	Shares	Bought/sold	Change
Darwin Global Management	16.69 mm	+5.38 mm	+47.6%
Farallon Capital Management	2.27 mm	+1.91 mm	+528.5%
Paradigm Biocapital Advisors	1.65 mm	+1.65 mm	NEW
Commodore Capital	3.18 mm	-1.63 mm	-33.9%
Cormorant Asset Management	9.62 mm	+1.12 mm	+13.1%
Holocene Advisors	913.75 k	+913.75 k	NEW
VR Adviser	2.48 mm	-813.62 k	-24.7%
T. Rowe Price	929.32 k	+718.69 k	+341.2%
ExodusPoint Capital Management	477.56 k	+458.06 k	+2349.4%
Point72 Asset Management	349.94 k	+349.94 k	NEW

Data from 13F filings, for the last complete 13F reporting period. For most recent data, click the ownership history button. Values as filed, not updated for current price. Long positions only.

Recent insider trades

AMAM insider ownership history Insider history

Date	Owner	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
18 Sep 23	Cormorant Asset Management	Ordinary Shares	Buy	Acquire P	Yes	No	9.2447	751,233	6.94 mm	69,465,823
15 Sep 23	Cormorant Asset Management	Ordinary Shares	Buy	Acquire P	Yes	No	9.0479	1,401,505	12.68 mm	68,714,590
1 Sep 23	Dalesandro Margaret	Ordinary Shares	Grant	Acquire A	No	No	0	70,833	0.00	70,833
1 Sep 23	Dalesandro Margaret	Ordinary Shares	Grant	Acquire A	No	No	0	125,000	0.00	125,000
27 Jun 23	Darwin Global Management	American Depository Shares ("ADSs") Ordinary Shares	Buy	Acquire P	Yes	No	13.93	5,384,063	75.00 mm	16,688,636

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.