In regards to our OPAL-0021 program portfolio, we own four patent families and
co-own
five patent families with Genentech. The first patent family we own includes a granted US and a granted EP patent (validated in six countries such as Germany, France, and United Kingdom), with claims directed to the composition of matter of derivatives of squaric acid, where the granted patents are expected to expire in between 2024 and 2027, excluding any patent term adjustment or patent term extension. The second patent family we own includes a granted US patent, a pending US patent application, foreign patents granted in Mexico and Russia, and foreign patent applications pending in India and Japan, with claims directed to the composition of matter of piperidine derivatives, where the granted patents and pending patent application, if granted, are expected to expire in 2031, excluding any patent term adjustment or patent term extension. The third patent family we own includes a granted US patent, foreign patents granted in Europe, Mexico, and Russia, and a pending patent application in Brazil, with claims directed to the composition of matter of guanidine compounds, where the granted patents and pending patent application, if granted, are expected to expire in 2031, excluding any patent term adjustment or patent term extension. The fourth patent family we own includes a granted US patent, a granted patent in Russia, and a pending application in Russia, with claims directed to the composition of matter of inhibitor compounds, where the granted patents and pending patent application, if granted, are expected to expire in 2031, excluding any patent term adjustment or patent term extension. We
co-own
two patent families which includes 5 granted US patents, two pending US patent applications, over 3 foreign patent granted in countries such as Mexico, Russia, and Europe, and over 5 foreign patent application pending in various countries as Brazil, Mexico and Venezuela, with claims directed to the composition of matter of inhibitor compounds, where the granted patents and pending patent application, if granted, are expected to expire in 2031, excluding any patent term adjustment or patent term extension. The third patent family we
co-own
includes a granted US patent and a European patent validated in Spain and Italy, with claims directed to the composition of matter of pyridinyl and pyrimidinyl sulfoxide and sulfone compounds, where the granted patents are expected to expire in 2033, excluding any patent term adjustment or patent term extension. The fourth patent family we
co-own
includes a granted US patent, a pending US patent application and a foreign patent application pending in Singapore, with claims directed to the composition of matter of
amido-benzyl
sulfoxide and sulfone compounds, where the granted patents and pending patent applications, if granted are expected to expire in 2033, excluding any patent term adjustment or patent term extension. The fifth patent family we
co-own
includes two granted US patents, a pending US patent application, and over 40 foreign patents granted in such jurisdictions as Austria, Australia, Belgium, Canada, Switzerland, China, Germany, United Kingdom, Italy Japan, and Singapore, with claims directed to the composition of matter of amido spirocyclic amide and sulfonamide compounds, where the granted patents and pending patent application, if granted, are expected to expire in 2033, excluding any patent term adjustment or patent term extension.