United States securities and exchange commission logo December 22, 2020 Giovanni Caforio, M.D. Chairman of the Board and Chief Executive Officer Bristol-Myers Squibb Company 430 E. 29th Street, 14FL New York, NY 10016 Re: Bristol-Myers Squibb Company Form 10-K for the Fiscal Year Ended December 31, 2019 Filed February 24, 2020 File No. 001-38533 Dear Mr. Caforio: We have reviewed your filing and have the following comment. In our comment, we may ask you to provide us with information so we may better understand your disclosure. Please respond to the comment within ten business days by providing the requested information or advise us as soon as possible when you will respond. If you do not believe our comment applies to your facts and circumstances, please tell us why in your response. After reviewing your response to the comment, we may have additional comments. Form 10-K for the Fiscal Year Ended December 31, 2019 General 1. We note that your forum selection provision in Article 58 of your bylaws identifies the Court of Chancery of the State of Delaware (or, if the Court of Chancery lacks jurisdiction, the federal district court for the District of Delaware) as the exclusive forum for certain litigation, including any derivative action. In future filings, please prominently describe the provision, including the relevant forum for litigation and any subject matter jurisdiction carve out, and whether this provision applies to actions arising under the Securities Act or Exchange Act. If so, please also state that there is uncertainty as to whether a court would enforce such provision and include risk factor disclosure of the risks to investors, such as the increased costs to bring a claim and that the provision may discourage claims or limit investors' ability to bring a claim in a judicial forum that they find favorable. Further, if the provision applies to Securities Act claims, please also state that investors cannot waive compliance with the federal securities laws and the rules and regulations thereunder. In that regard, we note that Section 22 of the Securities Act Giovanni Caforio, M.D. Bristol-Myers Squibb Company December 22, 2020 Page 2 creates concurrent jurisdiction for federal and state courts over all suits brought to enforce any duty or liability created by the Securities Act or the rules and regulations thereunder. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. You may contact Jeff Gabor at 202-551-2544 or Mary Beth Breslin at 202-551-3625 if you have questions regarding the comment. FirstName LastNameGiovanni Caforio, M.D. Sincerely, Comapany NameBristol-Myers Squibb Company Division of Corporation Finance December 22, 2020 Page 2 Office of Life Sciences FirstName LastName