Opaleye Management

Date	Owner	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
1 Nov 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	15.1963	8,002	121.60 k	12,002
1 Nov 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	15.1963	7,998	121.54 k	960,000
31 Oct 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	16.2912	4,000	65.16 k	4,000
31 Oct 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	16.2912	5,868	95.60 k	952,002
30 Oct 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	17.5	2,000	35.00 k	946,134
25 Oct 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	2.9088	25,000	72.72 k	8,545,000
23 Oct 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	7.9814	10,000	79.81 k	2,770,000
8 Oct 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	7.0292	3,970	27.91 k	82,070
8 Oct 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	7.0292	30,000	210.88 k	2,760,000
7 Oct 24	Opaleye Management	Common Stock, par value $0.001 per share	Buy	Acquire P	Yes	No	7.2235	1,248	9.01 k	78,100

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.