Acorda Therapeutics (ACORQ) 10-Q11 May 232023 Q1 Quarterly reportFinancial data

Company Profile

Document and Entity Information

Document and Entity Information - shares	3 Months Ended
Document and Entity Information - shares	Mar. 31, 2023	May 09, 2023
Cover [Abstract]
Entity Registrant Name	ACORDA THERAPEUTICS, INC.
Entity Central Index Key	0001008848
Document Type	10-Q
Document Period End Date	Mar. 31, 2023
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity Filer Category	Non-accelerated Filer
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Document Quarterly Report	true
Document Transition Report	false
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	Q1
Trading Symbol	ACOR
Title of each class	Common Stock $0.001 par value per share
Name of each exchange on which registered	NASDAQ
Entity Common Stock, Shares Outstanding		24,337,696
Entity File Number	001-31938
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	13-3831168
Entity Address, Address Line One	2 Blue Hill Plaza
Entity Address, Address Line Two	3rd Floor
Entity Address, City or Town	Pearl River
Entity Address, State or Province	NY
Entity Address, Postal Zip Code	10965
City Area Code	914
Local Phone Number	347-4300

Consolidated Balance Sheets

Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 30,255	$ 37,536
Restricted cash	6,989	6,884
Trade accounts receivable, net of allowances of $768 and $842, as of March 31, 2023 and December 31, 2022, respectively	9,190	13,866
Prepaid expenses	4,125	4,312
Inventory, net	13,465	12,752
Other current assets	4,070	6,765
Total current assets	68,094	82,115
Property and equipment, net of accumulated depreciation	2,383	2,603
Intangible assets, net of accumulated amortization	297,393	305,087
Right of use asset, net of accumulated amortization	5,029	5,287
Restricted cash	510	255
Other non-current assets	1,497	248
Total assets	374,906	395,595
Current liabilities:
Accounts payable	2,854	9,809
Accrued expenses and other current liabilities	27,017	23,680
Current portion of lease liabilities	1,556	1,545
Current portion of acquired contingent consideration	3,312	2,532
Deferred revenue		384
Total current liabilities	34,739	37,950
Convertible senior notes	171,496	167,031
Derivative liability	0	0
Non-current portion of acquired contingent consideration	36,488	38,668
Non-current portion of lease liabilities	4,055	4,341
Deferred tax liability	41,805	44,202
Other non-current liabilities	9,363	9,781
Commitments and contingencies
Stockholders’ equity:
Preferred stock, $0.001 par value per share. Authorized 1,000,000 shares at March 31, 2023 and December 31, 2022; no shares issued as of March 31, 2023 and December 31, 2022, respectively
Common stock, $0.001 par value per share. Authorized 61,666,666 shares at March 31, 2023 and December 31, 2022; issued 24,343,329 shares,including those held in treasury, as of March 31, 2023 and December 31, 2022, respectively	24	24
Treasury stock at cost (5,543 shares at March 31, 2023 and December 31, 2022)	(638)	(638)
Additional paid-in capital	1,029,952	1,029,881
Accumulated deficit	(953,097)	(936,273)
Accumulated other comprehensive loss	719	628
Total stockholders’ equity	76,960	93,622
Total liabilities and stockholders’ equity	$ 374,906	$ 395,595

Consolidated Balance Sheets (Pa

Consolidated Balance Sheets (Parenthetical) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Statement Of Financial Position [Abstract]
Trade accounts receivable, allowances (in dollars)	$ 768	$ 842
Preferred stock, par value (in dollars per share)	$ 0.001	$ 0.001
Preferred stock, Authorized shares	1,000,000	1,000,000
Preferred stock, issued shares	0	0
Common stock, par value (in dollars per share)	$ 0.001	$ 0.001
Common stock, Authorized shares	61,666,666	61,666,666
Common stock, issued shares	24,343,329	24,343,329
Treasury stock, shares	5,543	5,543

Consolidated Statements of Oper

Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Revenues:
Total net revenues	$ 22,258	$ 22,534
Costs and expenses:
Cost of sales	3,234	5,967
Research and development	1,386	1,694
Selling, general and administrative	22,514	26,938
Amortization of intangible assets	7,691	7,691
Change in fair value of derivative liability		(30)
Changes in fair value of acquired contingent consideration	(1,091)	(3,023)
Total operating expenses	33,734	39,237
Operating loss	(11,476)	(16,703)
Other income (expense), net:
Interest and amortization of debt discount expense	(7,571)	(7,562)
Interest income	93	1
Other income	92
Total other expense, net	(7,386)	(7,561)
Loss before taxes	(18,862)	(24,264)
(Provision for) benefit from income taxes	2,038	(258)
Net loss	$ (16,824)	$ (24,522)
Net loss per share—basic	$ (0.69)	$ (1.85)
Net loss per share—diluted	$ (0.69)	$ (1.85)
Weighted average common shares outstanding used in computing net loss per share—basic	24,338	13,251
Weighted average common shares outstanding used in computing net loss per share—diluted	24,338	13,251
Net Product Revenues
Revenues:
Total net revenues	$ 18,719	$ 18,575
Royalty Revenues
Revenues:
Total net revenues	3,528	$ 3,959
License revenues
Revenues:
Total net revenues	$ 11

Consolidated Statements of Comp

Consolidated Statements of Comprehensive Income (Loss) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Statement Of Income And Comprehensive Income [Abstract]
Net loss	$ (16,824)	$ (24,522)
Other comprehensive income (loss), net of tax:
Foreign currency translation adjustment	91	449
Other comprehensive income (loss), net of tax	91	449
Comprehensive income (loss)	$ (16,733)	$ (24,073)

Consolidated Statements of Chan

Consolidated Statements of Changes in Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands	Total	Common stock	Treasury stock	Additional paid-in capital	Accumulated deficit	Accumulated other comprehensive (loss) income
Balance at Dec. 31, 2021	$ 151,137	$ 13	$ (638)	$ 1,023,136	$ (870,357)	$ (1,017)
Balance (in shares) at Dec. 31, 2021		13,250
Compensation expense for issuance of stock options to employees	181			181
Compensation expense for issuance of restricted stock to employees	304			304
Compensation expense for issuance of restricted stock to employees (in shares)		35
Other comprehensive income, net of tax	449					449
Net loss	(24,522)				(24,522)
Balance at Mar. 31, 2022	127,549	$ 13	(638)	1,023,621	(894,879)	(568)
Balance (in shares) at Mar. 31, 2022		13,285
Balance at Dec. 31, 2022	93,622	$ 24	(638)	1,029,881	(936,273)	628
Balance (in shares) at Dec. 31, 2022		24,343
Compensation expense for issuance of stock options to employees	71			71
Other comprehensive income, net of tax	91					91
Net loss	(16,824)				(16,824)
Balance at Mar. 31, 2023	$ 76,960	$ 24	$ (638)	$ 1,029,952	$ (953,097)	$ 719
Balance (in shares) at Mar. 31, 2023		24,343

Consolidated Statements of Cash

Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Cash flows from operating activities:
Net loss	$ (16,824)	$ (24,522)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	71	485
Amortization of debt discount and debt issuance costs	4,465	4,040
Depreciation and amortization expense	7,913	8,534
Change in acquired contingent consideration obligation	(1,091)	(3,023)
Non-cash royalty revenue		(2,852)
Deferred tax (benefit) provision	(2,038)	258
Change in derivative liability		(30)
Changes in assets and liabilities:
Decrease in accounts receivable	4,688	5,012
Decrease in prepaid expenses and other current assets	2,871	66
Decrease (increase) in inventory	(713)	3,712
Increase in other assets	(1,251)	(858)
Decrease in accounts payable, accrued expenses, and other current liabilities	(4,676)	(4,209)
Decrease in other non-current liabilities	(433)	(250)
Net cash used in operating activities	(7,018)	(13,637)
Cash flows from investing activities:
Purchases of property and equipment		(39)
Net cash (used in) provided by investing activities		(39)
Cash flows from financing activities:
Effect of exchange rate changes on cash, cash equivalents and restricted cash	97	(92)
Net decrease in cash, cash equivalents and restricted cash	(6,921)	(13,768)
Cash, cash equivalents and restricted cash at beginning of period	44,675	65,223
Cash, cash equivalents and restricted cash at end of period	37,754	51,455
Supplemental disclosure:
Cash paid for taxes	$ 6	$ 5

Organization and Business Activ

Organization and Business Activities	3 Months Ended
Organization and Business Activities	Mar. 31, 2023
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Organization and Business Activities	(1) Organization and Business Activities Acorda Therapeutics, Inc. (“Acorda” or the “Company”) is a biopharmaceutical company focused on developing therapies that restore function and improve the lives of people with neurological disorders. The Company markets Inbrija (levodopa inhalation powder), which is approved in the U.S. for intermittent treatment of OFF episodes, also known as OFF periods, in people with Parkinson’s disease treated with carbidopa/levodopa. Inbrija is for as needed use and utilizes the Company’s ARCUS pulmonary delivery system, a technology platform designed to deliver medication through inhalation that the Company believes has potential to be used in the development of a variety of inhaled medicines. The Company has entered into agreements to commercialize Inbrija in Spain, Germany, Latin America, and China, and is in discussions with potential partners for commercialization of Inbrija in other jurisdictions outside of the U.S. The Company also markets branded Ampyra (dalfampridine) Extended Release Tablets, 10 mg to improve walking in adults with multiple sclerosis. Ampyra is marketed as Fampyra outside the U.S. by Biogen International GmbH, or Biogen, under a license and collaboration agreement that the Company entered into in June 2009. Fampyra has been approved in a number of countries across Europe, Asia, and the Americas.

Summary of Significant Accounti

Summary of Significant Accounting Policies	3 Months Ended
Summary of Significant Accounting Policies	Mar. 31, 2023
Accounting Policies [Abstract]
Summary of Significant Accounting Policies	(2) Summary of Significant Accounting Policies Basis of Presentation The accompanying unaudited consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the U.S. (“GAAP”) for interim financial information, Accounting Standards Codification (“ASC”) Topic 270-10, and with the instructions to Form 10-Q. Accordingly, these financial statements do not include all of the information and footnotes required by GAAP for complete financial statements. In management’s opinion, all adjustments considered necessary for a fair presentation have been included in the interim periods presented and all adjustments are of a normal recurring nature. The Company has evaluated subsequent events through the date of this filing. Operating results for the three-month period ended March 31, 2023 are not necessarily indicative of the results that may be expected for the year ending December 31, 2023. When used in these notes, the terms “Acorda” or “the Company” mean Acorda Therapeutics, Inc. The December 31, 2022 consolidated balance sheet data was derived from audited financial statements, but does not include all disclosures required by GAAP. You should read these unaudited interim condensed consolidated financial statements in conjunction with the consolidated financial statements and footnotes included in the Company’s Annual Report on Form 10-K, for the year ended December 31, 2022. The Company’s significant accounting policies are detailed in its Annual Report on Form 10-K for the year ended December 31, 2022. Effective January 1, 2022, the Company adopted ASU 2021-04, “Earnings Per Share (Topic 260), Debt—Modifications and Extinguishments (Subtopic 470-50), Compensation—Stock Compensation (Topic 718), and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40): Issuer’s Accounting for Certain Modifications or Exchanges of Freestanding Equity-Classified Written Call Options”. The Company’s significant accounting policies have not changed materially from December 31, 2022. Restricted Cash Restricted cash represents an escrow account with funds to maintain the interest payments for the remaining scheduled interest payments on the outstanding convertible senior secured notes due 2024 through the interest payment date of June 1, 2023 and an account with funds to cover the Company’s self-funded employee health insurance. At March 31, 2023, the Company also held $ 0.5 million of restricted cash related to cash collateralized standby letters of credit in connection with obligations under facility leases. See Note 10 to the Company’s Consolidated Financial Statements included in this report for a discussion of interest payments on the Company's outstanding 6.00 % convertible senior secured notes due December 2024 (“2024 Notes”). The following table provides a reconciliation of cash, cash equivalents, and restricted cash reported within the statement of financial position that sum to the total of the same amounts shown in the statement of cash flows: Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 (In thousands) Beginning of period End of period Beginning of period End of period Cash and cash equivalents $ 37,536 $ 30,255 $ 45,634 $ 31,873 Restricted cash 6,884 6,989 13,400 13,393 Restricted cash non-current 255 510 6,189 6,189 Total Cash, cash equivalents, and restricted cash per statement of cash flows $ 44,675 $ 37,754 $ 65,223 $ 51,455 Investments Short-term investments consist primarily of high-grade commercial paper and corporate bonds. The Company classifies marketable securities available to fund current operations as short-term investments in current assets on its consolidated balance sheets. Marketable securities are classified as long-term investments in long-term assets on the consolidated balance sheets if the Company has the ability and intent to hold them and such holding period is longer than one year. The Company classifies all its investments as available-for-sale. Available-for-sale securities are recorded at the fair value of the investments based on quoted market prices. Unrealized holding gains and losses on available-for-sale securities, which are determined to be temporary, are excluded from earnings and are reported as a separate component of accumulated other comprehensive loss. Premiums and discounts on investments are amortized over the life of the related available-for-sale security as an adjustment to yield using the effective‑interest method. Dividend and interest income are recognized when earned. Amortized premiums and discounts, dividend and interest income are included in interest income. Realized gains and losses are included in other income. There were no investments classified as short-term or long-term at March 31, 2023 or December 31, 2022. Inventory The following table provides the major classes of inventory: (In thousands) March 31, 2023 December 31, 2022 Raw materials $ 11,061 $ 6,212 Finished goods 2,404 6,540 Total $ 13,465 $ 12,752 The Company reviews inventory, including inventory purchase commitments, for slow moving or obsolete amounts based on expected product sales volume and provides reserves against the carrying amount of inventory as appropriate. Foreign Currency Translation The functional currency of operations outside the U.S. is deemed to be the currency of the local country, unless otherwise determined that the U.S. dollar would serve as a more appropriate functional currency given the economic operations of the entity. Accordingly, the assets and liabilities of the Company’s foreign subsidiary, Biotie, are translated into U.S. dollars using the period-end exchange rate; and income and expense items are translated using the average exchange rate during the period; and equity transactions are translated at historical rates. Cumulative translation adjustments are reflected as a separate component of equity. Foreign currency transaction gains and losses are charged to operations and reported in other income (expense) in consolidated statements of operations. Segment and Geographic Information The Company is managed and operated as one business which is focused on developing therapies that restore function and improve the lives of people with neurological disorders. The entire business is managed by a single management team that reports to the Chief Executive Officer. The Company does not operate separate lines of business with respect to any of its products or product candidates and the Company does not prepare discrete financial information to allocate resources to separate products or product candidates or by location. Accordingly, the Company views its business as one reportable operating segment. Net product revenues reported are substantially derived from the sales of Inbrija and Ampyra in the U.S. Impairment of Long-Lived Assets The Company continually evaluates whether events or circumstances have occurred that indicate that the estimated remaining useful lives of its long-lived assets, including identifiable intangible assets subject to amortization and property plant and equipment, may warrant revision or that the carrying value of the assets may be impaired. The Company evaluates the realizability of its long-lived assets based on profitability and cash flow expectations for the related assets. Factors the Company considers important that could trigger an impairment review include significant changes in the use of any assets, changes in historical trends in operating performance, changes in projected operating performance, stock price, loss of a major customer, and significant negative economic trends. The decline in the trading price of the Company’s common stock during the three-month period ended March 31, 2023, and related decrease in the Company’s market capitalization, was determined to be a triggering event in connection with the Company’s review of the recoverability of its long-lived assets for the three-month period ended March 31, 2023. The Company performed a recoverability test as of March 31, 2023 using the undiscounted cash flows, which are the sum of the future undiscounted cash flows expected to be derived from the direct use of the long-lived assets compared to the carrying value of the long-lived assets. Estimates of future cash flows were based on the Company’s own assumptions about its own use of the long-lived assets. The cash flow estimation period was based on the long-lived assets’ estimated remaining useful life to the Company. After performing the recoverability test, the Company determined that the undiscounted cash flows exceeded the carrying value and the long-lived assets were not impaired. Changes in these assumptions and resulting valuations could result in future long-lived asset impairment charges. During the three-month period ended March 31, 2023, no other impairment indicators were noted by the Company. Management will continue to monitor any changes in circumstances for indicators of impairment. Any write‑downs are treated as permanent reductions in the carrying amount of the assets. Liquidity The Company’s ability to meet its future operating requirements, repay its liabilities, meet its other obligations, and continue as a going concern are dependent upon a number of factors, including its ability to generate cash from product sales, reduce expenditures, and obtain additional financing. If the Company is unable to generate sufficient cash flow from the sale of its products, the Company will be required to adopt one or more alternatives, subject to the restrictions contained in the indenture governing the 2024 Notes, such as further reducing expenses, selling assets, restructuring debt, or obtaining additional equity capital on terms that may be onerous and which are likely to be highly dilutive. Also, the Company’s ability to raise additional capital and repay or restructure its indebtedness will depend on the capital markets and its financial condition at such time, among other factors. In addition, financing may not be available when needed, at all, on terms acceptable to the Company or in accordance with the restrictions described above. As a result of these factors, the Company may not be able to engage in any of the alternative activities, or engage in such activities on desirable terms, which could harm the Company’s business, financial condition and results of operations, as well as result in a default on the Company’s debt obligations. If the Company is unable to take these actions, it may be forced to significantly alter its business strategy, substantially curtail its current operations, or cease operations altogether. At March 3 1, 2023, the Company had $ 30.3 million of cash and cash equivalents, compared to $ 37.5 million at December 31, 2022. The Company’s March 31, 2023 cash and cash equivalents balance does not include $ 7.5 million of restricted cash, of which $ 6.2 million is currently held in escrow for payment of the June 1, 2023 interest payment on the 2024 Notes, $ 0.8 million is related to self-funded employee health insurance, and $ 0.5 million is related to collateralized standby letters of credit. The Company incurred a net loss of $ 16.8 million for the three-month period ended March 31, 2023. The Company assesses and determines its ability to continue as a going concern in accordance with the provisions of ASC Topic 205-40, “Presentation of Financials Statements—Going Concern” (“ASC Topic 205-40”), which requires the Company to evaluate whether there are conditions or events that raise substantial doubt about its ability to continue as a going concern within one year after the date that its annual and interim consolidated financial statements are issued. Certain additional financial statement disclosures are required if such conditions or events are identified. If and when an entity’s liquidation becomes imminent, financial statements should be prepared under the liquidation basis of accounting. Determining the extent, if any, to which conditions or events raise substantial doubt about the Company’s ability to continue as a going concern, or the extent to which mitigating plans sufficiently alleviate any such substantial doubt, as well as whether or not liquidation is imminent, requires significant judgment by management. The Company has evaluated whether there are conditions and events, considered in the aggregate, that raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date the consolidated financial statements contained in this report are issued. In June 2022, the Company received a deficiency letter from Nasdaq Stock Market, LLC (“Nasdaq”) notifying the Company that, for 30 consecutive business days, the bid price for the Company’s common stock had closed below $ 1.00 per share, which is the minimum closing price required to maintain continued listing on the Nasdaq Global Select Market (the “Minimum Bid Requirement”). The Company had 180 calendar days to regain compliance with the Minimum Bid Requirement. On November 11, 2022, the Company held a special meeting of stockholders in order to authorize the Board of Directors to approve the amendment and restatement of the Company’s Certificate of Incorporation to effect a reverse stock split at a ratio of any whole number in the range of 1-for-2 to 1-for-20 within one year following the conclusion of the special meeting, which proposal was approved by stockholders. After a hearing with the Nasdaq Hearings Panel in February 2023, the Company was granted an extension until June 20, 2023 to regain compliance with the Minimum Bid Requirement. In the event the Company does not achieve compliance with the Minimum Bid Requirement by June 20, 2023, the Company has committed to effecting the reverse stock split authorized by the Company’s stockholders in November 2022. The Company believes that its existing cash and cash equivalents will be sufficient to cover its cash flow requirements for at least the next twelve months from the issuance date of these financial statements. However, the Company’s future requirements may change and will depend on numerous factors, some of which may be beyond the Company’s control. Subsequent Events Subsequent events are defined as those events or transactions that occur after the balance sheet date, but before the financial statements are filed with the Securities and Exchange Commission. The Company completed an evaluation of the impact of any subsequent events through the date these financial statements were issued, and determined there were subsequent events that required disclosure in these financial statements. See Note 14 to the Company’s Consolidated Financial Statements included in this report for a discussion of subsequent events. Accounting Pronouncements Not Yet Adopted In August 2020, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) 2020-06, Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity. This update simplifies the accounting for convertible instruments by eliminating the cash conversion and beneficial conversion feature models which require separate accounting for embedded conversion features. This update also amends the guidance for the derivatives scope exception for contracts in an entity’s own equity to reduce form-over-substance-based accounting conclusions and requires the application of the if-converted method for calculating diluted earnings per share. ASU 2020-06 is effective for smaller reporting companies for fiscal periods beginning after December 15, 2023, including interim periods within those fiscal years. Early adoption is permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements.

Revenue

Revenue	3 Months Ended
Revenue	Mar. 31, 2023
Revenue From Contract With Customer [Abstract]
Revenue	(3) Revenue In accordance with ASC 606, the Company recognizes revenue when the customer obtains control of a promised good or service, in an amount that reflects the consideration to which the Company expects to be entitled in exchange for the good or service. ASC 606 requires entities to record a contract asset when a performance obligation has been satisfied or partially satisfied, but the amount of consideration has not yet been received because the receipt of the consideration is conditioned on something other than the passage of time. ASC 606 also requires an entity to present a revenue contract as a contract liability in instances when a customer pays consideration, or an entity has a right to an amount of consideration that is unconditional (e.g., receivable), before the entity transfers a good or service to the customer. As of March 31, 2023, the Company had contract liabilities of $ 5.7 million, as compared to $ 6.1 million as of December 31, 2022, which is the upfront payment received under the terms of the Company’s distribution agreement with Esteve Pharmaceuticals GmbH (“Esteve Germany”) entered into in 2021 related to the commercialization of Inbrija in Germany. As of March 31, 2023, approximately $ 0.4 million of the contract liability balance is expected to be recognized as revenue from the remaining performance obligations over the next 12 months for the Esteve Germany agreement as goods are shipped. The Company expects to recognize the remaining balance over the next 9 years. The Company will re-evaluate the transaction price in each reporting period and as certain events are resolved or other changes in circumstances occur. The following table disaggregates the Company’s revenue by major source. The Company’s Royalty Revenue set forth below relates to Fampyra royalties payable under the Company’s License and Collaboration Agreement with Biogen. (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Revenues: Net product revenues: Ampyra $ 12,606 $ 14,904 Inbrija 5,587 3,671 Inbrija ex-U.S. 526 — Total net product revenues 18,719 18,575 Royalty revenues 3,528 3,959 License Revenue 11 — Total net revenues $ 22,258 $ 22,534

Share-Based Compensation

Share-Based Compensation	3 Months Ended
Share-Based Compensation	Mar. 31, 2023
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Share-Based Compensation	(4) Share-Based Compensation During the three‑month periods ended March 31, 2023 and 2022, the Company recognized share-based compensation expense o f $ 0.1 m illion and $ 0.5 million, respectively. Activity in options and restricted stock during the three-month period ended March 31, 2023 and related balances outstanding as of that date are reflected below. The weighted average fair value p er share of options granted to employees for the three-month periods ended March 31, 2023 and 2022 were approximately $ 0.49 an d $ 1.60 , respectively. The following table summarizes share-based compensation expense included within the Company’s consolidated statements of operations: For the Three-month period ended March 31, (In thousands) 2023 2022 Research and development expense $ 1 $ 27 Selling, general and administrative expense 70 457 Cost of Sales — 1 Total $ 71 $ 485 A summary of share-based compensation activity for the three-month period ended March 31, 2023 is presented below: Stock Option Activity Number of thousands) Weighted Weighted Intrinsic thousands) Balance at January 1, 2023 1,026 $ 78.00 — — Granted 1,065 0.61 — — Cancelled ( 73 ) 182.59 — — Exercised — — — — Balance at March 31, 2023 2,018 $ 33.37 8.1 $ 10,176 Vested and expected to vest at 1,973 $ 34.10 8.0 $ 10,083 Vested and exercisable at 715 $ 92.13 5.1 $ 6,510 Restricted Stock and Performance Stock Unit Activity (In thousands) Restricted Stock and Performance Stock Units Number of Shares Nonvested at January 1, 2023 — Granted — Vested — Forfeited — Nonvested at March 31, 2023 — Unrec ognized compensation cost for unvested stock options, restricted stock awards, and restricted stock units as of March 31, 2023 totaled $ 1.0 million and is expected to be recognized over a weighted average period of approximately 1.9 years. During the three‑month period ended March 31, 2023, the Company did no t make any repurchases of shares.

Loss Per Share

Loss Per Share	3 Months Ended
Loss Per Share	Mar. 31, 2023
Earnings Per Share [Abstract]
Loss Per Share	(5) Loss Per Share The following table sets forth the computation of basic and diluted loss per share for the three-month periods ended March 31, 2023 and 2022: (In thousands, except per share data) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Basic and diluted Net loss—basic $ ( 16,824 ) $ ( 24,522 ) Weighted average common shares outstanding used in 24,338 13,251 Plus: net effect of dilutive stock options and restricted — — Weighted average common shares outstanding used in 24,338 13,251 Net loss per share—basic $ ( 0.69 ) $ ( 1.85 ) Net loss per share—diluted $ ( 0.69 ) $ ( 1.85 ) Securities that could potentially be dilutive are excluded from the computation of diluted loss per share when a loss from continuing operations exists or when the exercise price exceeds the average closing price of the Company’s common stock during the period, because their inclusion would result in an anti-dilutive effect on per share amounts. The following amounts were not included in the calculation of net loss per diluted share because their effects were anti-dilutive: (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Denominator Stock options and restricted common shares 1,087 1,299 Performance share units are excluded from the calculation of net loss per diluted share as the performance criteria has not been met for the three-month periods ended March 31, 2023 and 2022. Additionally, the impact of the 2024 Notes was determined to be anti-dilutive and excluded from the calculation of net loss per diluted share for the three-month periods ended March 31, 2023 and 2022.

Income Taxes

Income Taxes	3 Months Ended
Income Taxes	Mar. 31, 2023
Income Tax Disclosure [Abstract]
Income Taxes	(6) Income Taxes The Company’s effective income tax rate differs from the U.S. statutory rate primarily due to an increase in the valuation allowance and expense recorded on the equity forfeiture. For the three-month periods ended March 31, 2023 and 2022, the Company recorded a benefit of $ 2.0 million and a provision of ($ 0.3 ) million for income taxes, respectively. The effective income tax rates for the Company for the three-month periods ended March 31, 2023 and 2022 were 10.8 % and ( 1.1 %), respectively. The variances in the effective tax rates for the three-month period ended March 31, 2023, as compared to the three-month period ended March 31, 2022, was primarily due to an increase in the existing valuation allowance recorded on the Company’s deferred tax assets for which no tax benefit can be recognized, and the forfeitures of equity of which no tax deduction is recorded. The Company continues to evaluate the realizability of its deferred tax assets on a quarterly basis and will adjust such amounts in light of changing facts and circumstances including, but not limited to, future projections of taxable income, tax legislation, rulings by relevant tax authorities, the progress of ongoing tax audits, and the regulatory approval of products under development. Any changes to the valuation allowance or deferred tax assets and liabilities in the future would impact the Company’s income taxes. The Company has ongoing state examinations in Massachusetts which cover multiple years. There have been no proposed adjustments at this stage of the examination. The New Jersey examination was finalized during the first quarter of 2023 for tax years 2015 through 2018 with no adjustments.

Fair Value Measurements

Fair Value Measurements	3 Months Ended
Fair Value Measurements	Mar. 31, 2023
Fair Value Disclosures [Abstract]
Fair Value Measurements	(7) Fair Value Measurements The Company defines fair value as the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants in the market in which the reporting entity transacts. The Company bases fair value on the assumptions market participants would use when pricing the asset or liability. The following table presents information about the Company’s assets and liabilities measured at fair value on a recurring basis as of March 31, 2023 and December 31, 2022 and indicates the fair value hierarchy of the valuation techniques utilized to determine such fair value. In general, fair values determined by Level 1 inputs utilize quoted prices (unadjusted) in active markets for identical assets or liabilities. Fair values determined by Level 2 inputs utilize data points that are observable, such as quoted prices, interest rates, exchange rates and yield curves. Fair values determined by Level 3 inputs utilize unobservable data points for the asset or liability. The Company’s Level 1 assets consist of investments in a Treasury money market fund and U.S. government securities. The Company’s Level 3 liabilities represent acquired contingent consideration related to the acquisition of Civitas Therapeutics, Inc. (“Civitas”) which are valued using a probability weighted discounted cash flow valuation approach and derivative liabilities related to conversion options for the 2024 Notes which are valued using a binomial model. For assets and liabilities not accounted for at fair value, the carrying values of these accounts approximates their fair values at March 31, 2023, except for the fair value of the Company’s 2024 Notes, which was approximately $ 157.3 million as of March 31, 2023. The Company estimates the fair value of its notes utilizing market quotations for the debt (Level 2). (In thousands) Level 1 Level 2 Level 3 March 31, 2023 Assets Carried at Fair Value: Money market funds $ — $ — $ — Liabilities Carried at Fair Value: Acquired contingent consideration — — 39,800 Derivative liability - conversion option — — — December 31, 2022 Assets Carried at Fair Value: Money market funds $ 15,322 $ — $ — Liabilities Carried at Fair Value: Acquired contingent consideration — — 41,200 Derivative liability - conversion option — — — The following table presents additional information about liabilities measured at fair value on a recurring basis and for which the Company utilizes Level 3 inputs to determine fair value. Acquired contingent consideration (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Acquired contingent consideration: Balance, beginning of period $ 41,200 $ 49,600 Fair value change to contingent consideration ( 1,091 ) ( 3,023 ) Royalty payments ( 309 ) ( 177 ) Balance, end of period $ 39,800 $ 46,400 The Company estimates the fair value of its acquired contingent consideration using a probability weighted discounted cash flow valuation approach based on estimated future sales expected from Inbrija (levodopa inhalation powder), a U.S. Food and Drug Administration (“FDA”) approved drug for the treatment of OFF periods in Parkinson’s disease. Using this approach, expected future cash flows are calculated over the expected life of the agreement and discounted to estimate the current value of the liability at the period end date. Some of the more significant assumptions made in the valuation include (i) the estimated revenue forecast for Inbrija, and (ii) discount period and rate. The milestone payments ranged from $ 0 million to $ 15.5 million f or Inbrija. The discount rate used in the valuation was 22 % for the three-month period ended March 31, 2023, as compared to 21.5 % for the three-month period ended March 31, 2022. The valuation is performed quarterly and changes in the fair value of the contingent consideration are included in the statement of operations. For the three-month periods ended March 31, 2023 and 2022, changes in the fair value of the acquired contingent consideration were primarily due to change in projected revenue and the recalculation of cash flows for the passage of time. The acquired contingent consideration is classified as a Level 3 liability as its valuation requires substantial judgment and estimation of factors that are not currently observable in the market. If different assumptions were used for the various inputs to the valuation approach, including but not limited to, assumptions involving sales estimates for Inbrija and estimated discount rates, the estimated fair value could be significantly higher or lower than the fair value determined. Derivative Liability The following table represents a reconciliation of the derivative liability recorded in connection with the issuance of the 2024 Notes: (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Derivative Liability-Conversion Option: Balance, beginning of period $ — $ 37 Fair value adjustment — ( 30 ) Balance, end of period $ — $ 7 During 2019, a derivative liability was initially recorded as a result of the issuance of the 2024 Notes (See Note 10 to the Consolidated Financial Statements included in this report for more information on the 2024 Notes). The fair value measurement of the derivative liability is classified as Level 3 under the fair value hierarchy as it has been valued using certain unobservable inputs. These inputs include: (1) share price as of the valuation date, (2) assumed timing of conversion of the 2024 Notes, (3) historical volatility of the share price, and (4) the risk-adjusted discount rate used to present value the probability-weighted cash flows. Significant increases or decreases in any of those inputs in isolation could result in a significantly lower or higher fair value measurement. The fair value of the derivative liability was determined using a binomial model that calculates the fair value of the 2024 Notes with the conversion feature as compared to the fair value of the 2024 Notes without the conversion feature, with the difference representing the value of the conversion feature, or the derivative liability. There are several embedded features within the 2024 Notes which, upon issuance, did not meet the conditions for equity classification. As a result, these features were aggregated together and recorded as a derivative liability conversion option. The derivative liability conversion feature is measured at fair value on a quarterly basis and changes in the fair value will be recorded in the consolidated statement of operations. The Company received stockholder approval on August 28, 2020 to increase the number of authorized shares of the Company’s common stock from 13,333,333 shares to 61,666,666 shares. As a result of the share approval, the Company determined that multiple embedded conversion options met the conditions for equity classification. The Company performed a valuation of these conversion options as of September 17, 2020, which was the date the Company completed certain securities registration obligations. The resulting fair value of these conversion options was calculated to be $ 18.3 million which was reclassified to equity and presented in the statement of stockholder’s equity as of September 30, 2020 net of the $ 4.4 million tax impact. The equity component is not re-measured as long as it continues to meet the conditions for equity classification. The Company performed a valuation of the derivative liability related to certain embedded conversion features that are precluded from equity classification. The fair value of these conversion features was calculated to be negligible as of March 31, 2023. Key inputs used in the calculation of the fair value include stock price, volatility, risky (bond) rate, and the last observed bond price during the three-month period ended March 31, 2023.

Investments

Investments	3 Months Ended
Investments	Mar. 31, 2023
Investments Debt And Equity Securities [Abstract]
Investments	(8) Investments There were no available-for-sale investments at March 31, 2023 and December 31, 2022, respectively.

Liability Related to Sale of Fu

Liability Related to Sale of Future Royalties	3 Months Ended
Liability Related to Sale of Future Royalties	Mar. 31, 2023
Deferred Revenue Disclosure [Abstract]
Liability Related to Sale of Future Royalties	(9) Liability Related to Sale of Future Royalties In October 2017, the Company completed a royalty purchase agreement with HealthCare Royalty Partners, or HCRP (the “Royalty Agreement”). In exchange for the payment of $ 40 million to the Company, HCRP obtained the right to receive Fampyra royalties payable by Biogen under the collaboration and licensing agreement with the Company up to an agreed upon threshold of royalties. This threshold was met during the second quarter of 2022 and the Company’s obligations to HCRP expired upon Biogen’s payment of royalties for that quarter. The Royalty Agreement has been accounted for as a liability that will be amortized using the effective interest method over the life of the arrangement, in accordance with the relevant accounting guidance. The Company recorded the receipt of the $ 40 million payment from HCRP and established a corresponding liability in the amount of $ 40 million, net of transaction costs of approximately $ 2.2 million. The net liability is classified between the current and non-current portion of liability related to the sale of future royalties in the consolidated balance sheets based on the recognition of the interest and principal payments to be received by HCRP in the 12 months following the financial statement reporting date. The total net royalties to be paid, less the net proceeds received, is recorded to interest expense using the effective interest method over the life of the Royalty Agreement. The Company had a liability related to the sale of future royalties of $ 0 and $ 1.7 million for the periods ending March 31, 2023 and 2022, respectively. The following table shows the activity within the liability account for the three-month period ended March 31, 2023 and 2022, respectively: (In thousands) March 31, 2023 March 31, 2022 Liability related to sale of future royalties - beginning balance $ — $ 4,460 Deferred transaction costs amortized — 24 Non-cash royalty revenue payable to HCRP — ( 2,852 ) Non-cash interest expense recognized — 108 Liability related to sale of future royalties - ending balance $ — $ 1,740

Debt

Debt	3 Months Ended
Debt	Mar. 31, 2023
Debt Disclosure [Abstract]
Debt	(10) Debt Convertible Senior Secured Notes Due 2024 On December 24, 2019, the Company completed the private exchange of $ 276.0 million aggregate principal amount of its then outstanding 1.75 % Convertible Senior Notes due 2021 for the 2024 Notes and cash. The Company issued approximately $ 207.0 million aggregate principal amount of the 2024 Notes and paid approximate $ 55.2 million in cash to participating holders. The 2024 Notes were issued pursuant to an Indenture, dated as of December 23, 2019, among the Company, its wholly owned subsidiary, Civitas (along with any domestic subsidiaries acquired or formed after the date of issuance, the “Guarantors”), and Wilmington Trust, National Association, as trustee and collateral agent (the “2024 Indenture”). The 2024 Notes are senior obligations of the Company and the Guarantors, secured by a first priority security interest in substantially all of the assets of the Company and the Guarantors, subject to certain exceptions. The 2024 Notes will mature on December 1, 2024 unless earlier converted in accordance with their terms. Interest on the 2024 Notes is payable semi-annually in arrears at a rate of 6.00 % per annum on each June 1 and December 1. Under the 2024 Indenture, the Company may elect to pay interest in cash or shares of the Company’s common stock. In May 2023, the Company announced that it will make a cash interest payment of approximately $ 6.2 million in satisfaction of the interest payment due on June 1, 2023 which will be made out of restricted cash. Following the June 1, 2023 interest payment, the Company will no longer have the option to pay interest on the 2024 Notes in common stock. The 2024 Notes are convertible at the option of the holder into shares of common stock of the Company at any time prior to the close of business on the second scheduled trading day immediately preceding the maturity date. The adjusted conversion rate for the 2024 Notes is 47.6190 shares of the Company’s common stock per $ 1,000 principal amount of 2024 Notes, representing an adjusted conversion price of approximately $ 21.00 per share of common stock. The conversion rate was adjusted to reflect the 1-for-6 reverse stock split effected on December 31, 2020. The Company may elect to settle conversions of the 2024 Notes in cash, shares of the Company’s common stock or a combination of cash and shares of the Company’s common stock. Holders who convert their 2024 Notes prior to June 1, 2023 (other than in connection with a make-whole fundamental change) will also be entitled to an interest make-whole payment equal to the sum of all regularly scheduled stated interest payments, if any, due on such 2024 Notes on each interest payment date occurring after the conversion date for such conversion and on or before June 1, 2023. In addition, the Company will have the right to cause all 2024 Notes then outstanding to be converted automatically if the volume-weighted average price per share of the Company’s common stock equals or exceeds 130 % of the adjusted conversion price for a specified period of time and certain other conditions are satisfied. Holders of the 2024 Notes will have the right, at their option, to require the Company to purchase their 2024 Notes if a fundamental change (as defined in the 2024 Indenture) occurs, such as a delisting of the Company’s common stock from the Nasdaq Global Select Market, in each case, at a repurchase price equal to 100 % of the principal amount of the 2024 Notes to be repurchased, plus accrued and unpaid interest, if any, to, but excluding, the applicable repurchase date. If a make-whole fundamental change occurs, as described in the 2024 Indenture, and a holder elects to convert its 2024 Notes in connection with such make-whole fundamental change, such holder may be entitled to an increase in the adjusted conversion rate as described in the 2024 Indenture. Subject to a number of exceptions and qualifications, the 2024 Indenture restricts the ability of the Company and certain of its subsidiaries to, among other things, (i) pay dividends or make other payments or distributions on their capital stock, or purchase, redeem, defease or otherwise acquire or retire for value any capital stock, (ii) make certain investments, (iii) incur indebtedness or issue preferred stock, other than certain forms of permitted debt, (iv) create liens on their assets, (v) sell their assets, (vi) enter into certain transactions with affiliates or (vii) merge, consolidate, or sell all or substantially all of their assets. The 2024 Indenture also requires the Company to make an offer to repurchase the 2024 Notes upon the occurrence of certain asset sales. The 2024 Indenture provides that a number of events will constitute an event of default, including, among other things, (i) a failure to pay interest for 30 days, (ii) failure to pay the 2024 Notes when due at maturity, upon any required repurchase, upon declaration of acceleration or otherwise, (iii) failure to convert the 2024 Notes in accordance with the 2024 Indenture and the failure continues for five business days, (iv) not issuing certain notices required by the 2024 Indenture within a timely manner, (v) failure to comply with the other covenants or agreements in the 2024 Indenture for 60 days following the receipt of a notice of non-compliance, (vi) a default or other failure by the Company to make required payments under other indebtedness of the Company or certain subsidiaries having an outstanding principal amount of $ 30.0 million or more, (vii) failure by the Company or certain subsidiaries to pay final judgments aggregating in excess of $ 30.0 million, (viii) certain events of bankruptcy or insolvency and (ix) the commercial launch in the U.S. of a product determined by the FDA to be bioequivalent to Inbrija. In the case of an event of default arising from certain events of bankruptcy or insolvency with respect to the Company, all outstanding 2024 Notes will become due and payable immediately without further action or notice. If any other event of default occurs and is continuing, the trustee or the holders of at least 25 % in aggregate principal amount of the then outstanding 2024 Notes may declare all the notes to be due and payable immediately. The Company assessed all terms and features of the 2024 Notes in order to identify any potential embedded features that would require bifurcation. As part of this analysis, the Company assessed the economic characteristics and risks of the 2024 Notes, including the conversion, put and call features. The Company concluded the conversion features required bifurcation as a derivative. The fair value of the conversion features derivative was determined based on the difference between the fair value of the 2024 Notes with the conversion options and the fair value of the 2024 Notes without the conversion options using a binomial model. The Company determined that the fair value of the derivative upon issuance of the 2024 Notes was $ 59.4 million and recorded this amount as a derivative liability with an offsetting amount as a debt discount as a reduction to the carrying value of the 2024 Notes on the closing date, or December 24, 2019. There are several embedded features within the 2024 Notes which, upon issuance, did not meet the conditions for equity classification. As a result, these features were aggregated together and recorded as the derivative liability conversion option. The conversion feature is measured at fair value on a quarterly basis and the changes in the fair value of the conversion feature for the period will be recognized in the consolidated statements of operations. The Company received stockholder approval on August 28, 2020 to increase the number of authorized shares of the Company’s common stock from 13,333,333 shares to 61,666,666 shares. As a result of the share approval, the Company determined that multiple embedded conversion options met the conditions for equity classification. The Company performed a valuation of these conversion options as of September 17, 2020, which was the date the Company completed certain securities registration obligations for the shares underlying the 2024 Notes. The resulting fair value of these conversion options was $ 18.3 million, which was reclassified to equity and presented in the statement of stockholder’s equity as of September 30, 2020, net of the $ 4.4 million tax impact. The equity component is not re-measured as long as it continues to meet the conditions for equity classification. The Company performed a valuation of the derivative liability related to certain embedded conversion features that are precluded from equity classification. The fair value of these conversion features was calculated to be negligible as of March 31, 2023. The outstanding 2024 Notes balances as of March 31, 2023 and December 31, 2022 consisted of the following: (In thousands) March 31, 2023 December 31, 2022 Liability component: Principal 207,000 $ 207,000 Less: debt discount and debt issuance costs, net ( 35,504 ) ( 39,969 ) Net carrying amount $ 171,496 $ 167,031 Equity component $ 18,257 $ 18,257 Derivative liability-conversion option $ — $ — The Company determined that the expected life of the 2024 Notes was equal to the period through December 1, 2024 as this represents the point at which the 2024 Notes will mature unless earlier converted in accordance with their terms prior to such date. Accordingly, the total debt discount of $ 75.1 million, inclusive of the fair value of the embedded conversion feature derivative at issuance, is being amortized using the effective interest method through December 1, 2024. For the three-month period ended March 31, 2023, the Company recognized $ 7.6 million of interest expense related to the 2024 Notes at the effective interest rate of 18.13 %. The fair value of the Company’s 2024 Notes was approximately $ 157.3 mil lion as of March 31, 2023. In connection with the issuance of the 2024 Notes, the Company incurred approximately $ 5.7 million of debt issuance costs, which primarily consisted of underwriting, legal and other professional fees, and allocated these costs to the liability component and recorded as a reduction in the carrying amount of the debt liability on the balance sheet. The portion allocated to the 2024 Notes is amortized to interest expense over the expected life of the 2024 Notes using the effective interest method. The following table sets forth total interest expense recognized related to the 2024 Notes for the three-month periods ended March 31, 2023 and 2022: (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Contractual interest expense $ 3,105 $ 3,105 Amortization of debt issuance costs 317 266 Amortization of debt discount 4,148 3,474 Total interest expense $ 7,570 $ 6,845 Non-Convertible Capital Loans The Company’s Biotie Therapies Ltd. subsidiary received several non-convertible capital loans from Business Finland for research and development of specific drug candidates, with an aggregate adjusted acquisition-date fair value of $ 20.5 million. The loans were to be repaid only when the consolidated retained earnings of Biotie Therapies Ltd. from the development of specific product candidates was sufficient to fully repay the loans. The Company filed an application with Business Finland for waiver of the loans and accrued interest. In July 2022, Business Finland granted the waiver request, which became effective in December 2022. The Company recorded a gain on extinguishment of debt of $ 27.1 million for the carrying amount of the loans including accrued interest in December 2022.

Leases

Leases	3 Months Ended
Leases	Mar. 31, 2023
Leases [Abstract]
Leases	(11) Leases In February 2016, the FASB issued ASU 2016-02, “Leases” Topic 842, which amends the guidance in former ASC Topic 840, Leases . The new standard increases transparency and comparability most significantly by requiring the recognition by lessees of right-of-use (“ROU”) assets and lease liabilities on the balance sheet for all leases longer than 12 months. Under the standard, disclosures are required to meet the objective of enabling users of financial statements to assess the amount, timing, and uncertainty of cash flows arising from leases. For lessees, leases will be classified as finance or operating, with classification affecting the pattern and classification of expense recognition in the income statement. The Company adopted the new lease guidance effective January 1, 2019 using the modified retrospective transition approach, applying the new standard to all of its leases existing at the date of initial application which is the effective date of adoption. Consequently, financial information will not be updated and the disclosures required under the new standard will not be provided for dates and periods before January 1, 2019. The Company elected the package of practical expedients which permits the Company to not reassess (1) whether any expired or existing contracts are or contain leases, (2) the lease classification for any expired or existing leases, and (3) any initial direct costs for any existing leases as of the effective date. The Company did not elect the hindsight practical expedient which permits entities to use hindsight in determining the lease term and assessing impairment. The adoption of the lease standard did not change the Company’s previously reported consolidated statements of operations and did not result in a cumulative catch-up adjustment to opening equity. The interest rate implicit in lease contracts is typically not readily determinable. As such, the Company utilizes its incremental borrowing rate, which is the rate incurred to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment. In calculating the present value of the lease payments, the Company elected to utilize its incremental borrowing rate based on the remaining lease terms as of the January 1, 2019 adoption date. Operating lease ROU assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. The operating lease ROU asset also includes any lease payments made and excludes lease incentives and initial direct costs incurred, if any. The Company’s leases have remaining lease terms of 3.8 years to 5.3 years. Operating Leases The Company leases certain office space, manufacturing, and warehouse space under arrangements classified as leases under ASC 842. Leases with an initial term of 12 months or less are not recorded on the balance sheet; the Company recognizes lease expense for these leases on a straight-line basis over the lease term. Ardsley, New York The Company previously leased a facility in Ardsley, New York with approximately 160,000 square feet of space for its corporate headquarters. The Company exercised its early termination option under the lease, which was effective on June 22, 2022 . In connection with the lease termination, the Company paid an early termination fee of approximately $ 4.7 million. Concurrent with the Ardsley lease termination, in June 2022, the Company relocated its corporate headquarters to a substantially smaller subleased office in Pearl River, New York, described below. Pearl River, New York In June 2022, the Company entered into a 6 -year sublease for an aggregate of approximately 21,000 square feet of space in Pearl River, New York for its corporate headquarters. The Company has no opt ions to extend the term of the sublease. The Pearl River sublease provides for monthly payments of rent during the lease term. The base rent commencing on January 1, 2023 is $ 0.3 million per year, subject to an annual 2.0 % escalation factor in each subsequent year thereafter. Waltham, Massachusetts In October 2016, the Company entered into a 10 -year lease agreement with a term commencing January 1, 2017, for approximately 26,000 square feet of lab and office space in Waltham, Massachusetts. The lease provides for monthly rental payments over the lease term. The base rent under the lease is currently $ 1.2 million per year. The Company’s leases have remaining lease terms of 3.8 years to 5.3 years, which reflects the exercise of the early termination of the Company’s Ardsley, New York lease as described above. The weighted-average remaining lease term for the Company’s operating leases was 4.1 years at March 31, 2023. The weighted-average discount rate was 7.9 % at March 31, 2023. ROU assets and lease liabilities related to the Company’s operating leases are as follows: (In thousands) Balance Sheet Classification March 31, 2023 December 31, 2022 Right-of-use assets Right of use assets $ 5,029 $ 5,287 Current lease liabilities Current portion of lease liabilities 1,556 1,545 Non-current lease liabilities Non-current portion of lease liabilities 4,055 4,341 The Company has lease agreements that contain both lease and non-lease components. The Company accounts for lease components together with non-lease components (e.g., common-area maintenance). The components of lease costs were as follows: (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Operating lease cost $ 450 $ 1,478 Variable lease cost 100 860 Short-term lease cost — 1 Total lease cost $ 550 $ 2,339 Future minimum commitments under all non-cancelable operating leases are as follows: (In thousands) 2023 (excluding the three months ended March 31, 2023) $ 1,159 2024 1,588 2025 1,633 2026 1,678 2027 357 Later years 182 Total lease payments 6,597 Less: Imputed interest ( 986 ) Present value of lease liabilities $ 5,611 Supplemental cash flow information related to the Company’s operating leases are as follows: (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Operating cash flow information: Cash paid for amounts included in the measurement of lease liabilities $ 386 $ 1,562

Corporate Restructuring

Corporate Restructuring	3 Months Ended
Corporate Restructuring	Mar. 31, 2023
Restructuring And Related Activities [Abstract]
Corporate Restructuring	(12) Corporate Restructuring As part of the September 2021 restructuring, the Company further reduced its employee headcount by approximately 15 % through a reduction in workforce. A significant portion of the reductions in workforce took place in September 2021, and was materially completed as of March 31, 2022. During the three-month period ended March 31, 2023 , the Company incurred $ 0 of restructuring charges.

Commitments and Contingencies

Commitments and Contingencies	3 Months Ended
Commitments and Contingencies	Mar. 31, 2023
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies	(13) Commitments and Contingencies In February 2021, the Company sold its Chelsea manufacturing operations to Catalent Pharma Solutions (“Catalent”) . In connection with the sale, the Company entered into a long-term, global manufacturing services (supply) agreement (the “2021 MSA”) with Catalent for the manufacture of Inbrija. The 2021 MSA provided that the Company would purchase Inbrija exclusively from Catalent and was obligated to make minimum purchase commitments for Inbrija of $ 18 million annually through the expiration of the agreement on December 31, 2030. In December 2021, the Company and entered into an amendment of the 2021 MSA that adjusted the structure of the minimum payment terms for the period from July 1, 2021 through June 30, 2022 (the “Adjustment Period”). Under the amendment, the minimum payment obligation for the Adjustment Period was replaced with payments to Catalent for actual product delivered during the Adjustment Period subject to a cap for the Adjustment Period that corresponds to its original minimum purchase obligation for that period (i.e., $ 17 million), and with certain payments being made in the first half of 2022 instead of during the second half of 2021. As a result of the amendment, payments to Catalent for product delivered during the Adjustment Period were approximately $ 8.4 million less than the $ 17 million minimum inventory purchase obligation for that period. On December 31, 2022, the Company and Catalent entered into a termination letter, which was subsequently amended and restated in March 2023 (the “Termination Letter”), to terminate the 2021 MSA. In connection with the termination of the 2021 MSA, the Company is obligated to pay a $ 4 million termination fee to Catalent, payable in April 2024. The parties also entered into a Settlement and Release Agreement with respect to certain batches of Inbrija that were not delivered in 2022 as scheduled, and that were delivered in the first quarter of 2023. Effective January 1, 2023, the Company entered into a new manufacturing services agreement with Catalent, which was subsequently amended in March 2023 (as amended in March 2023, the “New MSA”). Under the New MSA, Catalent will continue to manufacture Inbrija through 2030, with reduced minimum annual commitments through 2024 and significantly lower pricing thereafter. The New MSA provides for the scale-up of new spray drying equipment (“PSD-7”), which will provide expanded capacity for the long-term world-wide manufacturing requirements of Inbrija. The Company will be subject to purchase commitments in 2023 and 2024 of 15 and 24 batches of Inbrija, respectively, at a total cost of $ 10.5 million and $ 15.5 million, respectively. Thereafter, in 2025, the Company will pay Catalent a fixed per capsule fee based on the amount of Inbrija that is delivered for sale in the U.S. and other markets. It is anticipated that by 2026, the PSD-7 equipment will be fully operational, which will significantly reduce the per capsule fees for all markets. The Company agreed to a minimum purchase requirement of at least three batches per year on the PSD-7 equipment, and will provide up to $ 1 million in each of 2023 and 2024 for capital expenditures to assist in the capacity expansion efforts. In addition, the Company will be obligated to pay Catalent $ 2 million in 2023 in connection with certain activities relating to the operational readiness of the PSD-7. The New MSA, unless earlier terminated, will continue until December 31, 2030, and will be automatically extended for successive two-year periods unless either party provides the other with at least 18-months’ prior written notice of non-renewal. Either party may terminate the New MSA by written notice under certain circumstances, including material breach (subject to specified cure periods) or insolvency. The Company may also terminate the New MSA upon certain specified regulatory events and for convenience upon 180 days’ prior written notice. During the quarter ended March 31, 2023, the Company incurred approximately $ 2.9 million of purchase commitments with Catalent which was previously reflected as other current assets as of December 31, 2022 and now recognized as inventory within its balance sheet. The Company did not recognize any purchase commitments in cost of sales within its consolidated statement of operations for the period.

Subsequent Events

Subsequent Events	3 Months Ended
Subsequent Events	Mar. 31, 2023
Subsequent Events [Abstract]
Subsequent Events	(14) Subsequent Events In May 2023, the Company entered into a distribution agreement and a commercial supply agreement with Hangzhou Chance Pharmaceuticals Co., Ltd. (“Chance”), for the exclusive distribution of Inbrija in China. Chance is obligated to use commercially reasonable efforts to market Inbrija in China. The agreements remain in effect until the earlier of (a) the last commercial sale of Inbrija on a jurisdiction-by-jurisdiction basis, and (b) 12 years from the effective date of the agreements, subject to customary termination for insolvency and certain other termination rights. The Company will receive a non-refundable upfront payment of $ 2.5 million, and a near term milestone payment of up to $ 6 million, depending on the clinical study requirements to be determined by the Chinese National Medical Products Administration (NMPA). The Company will also receive $ 3 million upon regulatory approval of Inbrija in China, up to $ 132.5 million in sales milestones based on specified sales volumes, and a fixed fee for each carton of Inbrija supplied to Chance.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	3 Months Ended
Summary of Significant Accounting Policies (Policies)	Mar. 31, 2023
Accounting Policies [Abstract]
Basis of Presentation	Basis of Presentation The accompanying unaudited consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the U.S. (“GAAP”) for interim financial information, Accounting Standards Codification (“ASC”) Topic 270-10, and with the instructions to Form 10-Q. Accordingly, these financial statements do not include all of the information and footnotes required by GAAP for complete financial statements. In management’s opinion, all adjustments considered necessary for a fair presentation have been included in the interim periods presented and all adjustments are of a normal recurring nature. The Company has evaluated subsequent events through the date of this filing. Operating results for the three-month period ended March 31, 2023 are not necessarily indicative of the results that may be expected for the year ending December 31, 2023. When used in these notes, the terms “Acorda” or “the Company” mean Acorda Therapeutics, Inc. The December 31, 2022 consolidated balance sheet data was derived from audited financial statements, but does not include all disclosures required by GAAP. You should read these unaudited interim condensed consolidated financial statements in conjunction with the consolidated financial statements and footnotes included in the Company’s Annual Report on Form 10-K, for the year ended December 31, 2022. The Company’s significant accounting policies are detailed in its Annual Report on Form 10-K for the year ended December 31, 2022. Effective January 1, 2022, the Company adopted ASU 2021-04, “Earnings Per Share (Topic 260), Debt—Modifications and Extinguishments (Subtopic 470-50), Compensation—Stock Compensation (Topic 718), and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40): Issuer’s Accounting for Certain Modifications or Exchanges of Freestanding Equity-Classified Written Call Options”. The Company’s significant accounting policies have not changed materially from December 31, 2022.
Restricted Cash	Restricted Cash Restricted cash represents an escrow account with funds to maintain the interest payments for the remaining scheduled interest payments on the outstanding convertible senior secured notes due 2024 through the interest payment date of June 1, 2023 and an account with funds to cover the Company’s self-funded employee health insurance. At March 31, 2023, the Company also held $ 0.5 million of restricted cash related to cash collateralized standby letters of credit in connection with obligations under facility leases. See Note 10 to the Company’s Consolidated Financial Statements included in this report for a discussion of interest payments on the Company's outstanding 6.00 % convertible senior secured notes due December 2024 (“2024 Notes”). The following table provides a reconciliation of cash, cash equivalents, and restricted cash reported within the statement of financial position that sum to the total of the same amounts shown in the statement of cash flows: Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 (In thousands) Beginning of period End of period Beginning of period End of period Cash and cash equivalents $ 37,536 $ 30,255 $ 45,634 $ 31,873 Restricted cash 6,884 6,989 13,400 13,393 Restricted cash non-current 255 510 6,189 6,189 Total Cash, cash equivalents, and restricted cash per statement of cash flows $ 44,675 $ 37,754 $ 65,223 $ 51,455
Investments	Investments Short-term investments consist primarily of high-grade commercial paper and corporate bonds. The Company classifies marketable securities available to fund current operations as short-term investments in current assets on its consolidated balance sheets. Marketable securities are classified as long-term investments in long-term assets on the consolidated balance sheets if the Company has the ability and intent to hold them and such holding period is longer than one year. The Company classifies all its investments as available-for-sale. Available-for-sale securities are recorded at the fair value of the investments based on quoted market prices. Unrealized holding gains and losses on available-for-sale securities, which are determined to be temporary, are excluded from earnings and are reported as a separate component of accumulated other comprehensive loss. Premiums and discounts on investments are amortized over the life of the related available-for-sale security as an adjustment to yield using the effective‑interest method. Dividend and interest income are recognized when earned. Amortized premiums and discounts, dividend and interest income are included in interest income. Realized gains and losses are included in other income. There were no investments classified as short-term or long-term at March 31, 2023 or December 31, 2022.
Inventory	Inventory The following table provides the major classes of inventory: (In thousands) March 31, 2023 December 31, 2022 Raw materials $ 11,061 $ 6,212 Finished goods 2,404 6,540 Total $ 13,465 $ 12,752 The Company reviews inventory, including inventory purchase commitments, for slow moving or obsolete amounts based on expected product sales volume and provides reserves against the carrying amount of inventory as appropriate.
Foreign Currency Translation	Foreign Currency Translation The functional currency of operations outside the U.S. is deemed to be the currency of the local country, unless otherwise determined that the U.S. dollar would serve as a more appropriate functional currency given the economic operations of the entity. Accordingly, the assets and liabilities of the Company’s foreign subsidiary, Biotie, are translated into U.S. dollars using the period-end exchange rate; and income and expense items are translated using the average exchange rate during the period; and equity transactions are translated at historical rates. Cumulative translation adjustments are reflected as a separate component of equity. Foreign currency transaction gains and losses are charged to operations and reported in other income (expense) in consolidated statements of operations.
Segment and Geographic Information	Segment and Geographic Information The Company is managed and operated as one business which is focused on developing therapies that restore function and improve the lives of people with neurological disorders. The entire business is managed by a single management team that reports to the Chief Executive Officer. The Company does not operate separate lines of business with respect to any of its products or product candidates and the Company does not prepare discrete financial information to allocate resources to separate products or product candidates or by location. Accordingly, the Company views its business as one reportable operating segment. Net product revenues reported are substantially derived from the sales of Inbrija and Ampyra in the U.S.
Impairment of Long-Lived Assets	Impairment of Long-Lived Assets The Company continually evaluates whether events or circumstances have occurred that indicate that the estimated remaining useful lives of its long-lived assets, including identifiable intangible assets subject to amortization and property plant and equipment, may warrant revision or that the carrying value of the assets may be impaired. The Company evaluates the realizability of its long-lived assets based on profitability and cash flow expectations for the related assets. Factors the Company considers important that could trigger an impairment review include significant changes in the use of any assets, changes in historical trends in operating performance, changes in projected operating performance, stock price, loss of a major customer, and significant negative economic trends. The decline in the trading price of the Company’s common stock during the three-month period ended March 31, 2023, and related decrease in the Company’s market capitalization, was determined to be a triggering event in connection with the Company’s review of the recoverability of its long-lived assets for the three-month period ended March 31, 2023. The Company performed a recoverability test as of March 31, 2023 using the undiscounted cash flows, which are the sum of the future undiscounted cash flows expected to be derived from the direct use of the long-lived assets compared to the carrying value of the long-lived assets. Estimates of future cash flows were based on the Company’s own assumptions about its own use of the long-lived assets. The cash flow estimation period was based on the long-lived assets’ estimated remaining useful life to the Company. After performing the recoverability test, the Company determined that the undiscounted cash flows exceeded the carrying value and the long-lived assets were not impaired. Changes in these assumptions and resulting valuations could result in future long-lived asset impairment charges. During the three-month period ended March 31, 2023, no other impairment indicators were noted by the Company. Management will continue to monitor any changes in circumstances for indicators of impairment. Any write‑downs are treated as permanent reductions in the carrying amount of the assets.
Liquidity	Liquidity The Company’s ability to meet its future operating requirements, repay its liabilities, meet its other obligations, and continue as a going concern are dependent upon a number of factors, including its ability to generate cash from product sales, reduce expenditures, and obtain additional financing. If the Company is unable to generate sufficient cash flow from the sale of its products, the Company will be required to adopt one or more alternatives, subject to the restrictions contained in the indenture governing the 2024 Notes, such as further reducing expenses, selling assets, restructuring debt, or obtaining additional equity capital on terms that may be onerous and which are likely to be highly dilutive. Also, the Company’s ability to raise additional capital and repay or restructure its indebtedness will depend on the capital markets and its financial condition at such time, among other factors. In addition, financing may not be available when needed, at all, on terms acceptable to the Company or in accordance with the restrictions described above. As a result of these factors, the Company may not be able to engage in any of the alternative activities, or engage in such activities on desirable terms, which could harm the Company’s business, financial condition and results of operations, as well as result in a default on the Company’s debt obligations. If the Company is unable to take these actions, it may be forced to significantly alter its business strategy, substantially curtail its current operations, or cease operations altogether. At March 3 1, 2023, the Company had $ 30.3 million of cash and cash equivalents, compared to $ 37.5 million at December 31, 2022. The Company’s March 31, 2023 cash and cash equivalents balance does not include $ 7.5 million of restricted cash, of which $ 6.2 million is currently held in escrow for payment of the June 1, 2023 interest payment on the 2024 Notes, $ 0.8 million is related to self-funded employee health insurance, and $ 0.5 million is related to collateralized standby letters of credit. The Company incurred a net loss of $ 16.8 million for the three-month period ended March 31, 2023. The Company assesses and determines its ability to continue as a going concern in accordance with the provisions of ASC Topic 205-40, “Presentation of Financials Statements—Going Concern” (“ASC Topic 205-40”), which requires the Company to evaluate whether there are conditions or events that raise substantial doubt about its ability to continue as a going concern within one year after the date that its annual and interim consolidated financial statements are issued. Certain additional financial statement disclosures are required if such conditions or events are identified. If and when an entity’s liquidation becomes imminent, financial statements should be prepared under the liquidation basis of accounting. Determining the extent, if any, to which conditions or events raise substantial doubt about the Company’s ability to continue as a going concern, or the extent to which mitigating plans sufficiently alleviate any such substantial doubt, as well as whether or not liquidation is imminent, requires significant judgment by management. The Company has evaluated whether there are conditions and events, considered in the aggregate, that raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date the consolidated financial statements contained in this report are issued. In June 2022, the Company received a deficiency letter from Nasdaq Stock Market, LLC (“Nasdaq”) notifying the Company that, for 30 consecutive business days, the bid price for the Company’s common stock had closed below $ 1.00 per share, which is the minimum closing price required to maintain continued listing on the Nasdaq Global Select Market (the “Minimum Bid Requirement”). The Company had 180 calendar days to regain compliance with the Minimum Bid Requirement. On November 11, 2022, the Company held a special meeting of stockholders in order to authorize the Board of Directors to approve the amendment and restatement of the Company’s Certificate of Incorporation to effect a reverse stock split at a ratio of any whole number in the range of 1-for-2 to 1-for-20 within one year following the conclusion of the special meeting, which proposal was approved by stockholders. After a hearing with the Nasdaq Hearings Panel in February 2023, the Company was granted an extension until June 20, 2023 to regain compliance with the Minimum Bid Requirement. In the event the Company does not achieve compliance with the Minimum Bid Requirement by June 20, 2023, the Company has committed to effecting the reverse stock split authorized by the Company’s stockholders in November 2022. The Company believes that its existing cash and cash equivalents will be sufficient to cover its cash flow requirements for at least the next twelve months from the issuance date of these financial statements. However, the Company’s future requirements may change and will depend on numerous factors, some of which may be beyond the Company’s control.
Subsequent Events	Subsequent Events Subsequent events are defined as those events or transactions that occur after the balance sheet date, but before the financial statements are filed with the Securities and Exchange Commission. The Company completed an evaluation of the impact of any subsequent events through the date these financial statements were issued, and determined there were subsequent events that required disclosure in these financial statements. See Note 14 to the Company’s Consolidated Financial Statements included in this report for a discussion of subsequent events.
Accounting Pronouncements Not Yet Adopted	Accounting Pronouncements Not Yet Adopted In August 2020, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) 2020-06, Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity. This update simplifies the accounting for convertible instruments by eliminating the cash conversion and beneficial conversion feature models which require separate accounting for embedded conversion features. This update also amends the guidance for the derivatives scope exception for contracts in an entity’s own equity to reduce form-over-substance-based accounting conclusions and requires the application of the if-converted method for calculating diluted earnings per share. ASU 2020-06 is effective for smaller reporting companies for fiscal periods beginning after December 15, 2023, including interim periods within those fiscal years. Early adoption is permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements.

Summary of Significant Accoun_3

Summary of Significant Accounting Policies (Tables)	3 Months Ended
Summary of Significant Accounting Policies (Tables)	Mar. 31, 2023
Accounting Policies [Abstract]
Reconciliation of Cash, Cash Equivalents and Restricted Cash	The following table provides a reconciliation of cash, cash equivalents, and restricted cash reported within the statement of financial position that sum to the total of the same amounts shown in the statement of cash flows: Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 (In thousands) Beginning of period End of period Beginning of period End of period Cash and cash equivalents $ 37,536 $ 30,255 $ 45,634 $ 31,873 Restricted cash 6,884 6,989 13,400 13,393 Restricted cash non-current 255 510 6,189 6,189 Total Cash, cash equivalents, and restricted cash per statement of cash flows $ 44,675 $ 37,754 $ 65,223 $ 51,455
Schedule of Major Classes of Inventory	The following table provides the major classes of inventory: (In thousands) March 31, 2023 December 31, 2022 Raw materials $ 11,061 $ 6,212 Finished goods 2,404 6,540 Total $ 13,465 $ 12,752

Revenue (Tables)

Revenue (Tables)	3 Months Ended
Revenue (Tables)	Mar. 31, 2023
Revenue From Contract With Customer [Abstract]
Disaggregation of Revenue	The following table disaggregates the Company’s revenue by major source. The Company’s Royalty Revenue set forth below relates to Fampyra royalties payable under the Company’s License and Collaboration Agreement with Biogen. (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Revenues: Net product revenues: Ampyra $ 12,606 $ 14,904 Inbrija 5,587 3,671 Inbrija ex-U.S. 526 — Total net product revenues 18,719 18,575 Royalty revenues 3,528 3,959 License Revenue 11 — Total net revenues $ 22,258 $ 22,534

Share-Based Compensation (Table

Share-Based Compensation (Tables)	3 Months Ended
Share-Based Compensation (Tables)	Mar. 31, 2023
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Schedule of Share-based Compensation Expense	The following table summarizes share-based compensation expense included within the Company’s consolidated statements of operations: For the Three-month period ended March 31, (In thousands) 2023 2022 Research and development expense $ 1 $ 27 Selling, general and administrative expense 70 457 Cost of Sales — 1 Total $ 71 $ 485
Schedule of Stock Option Activity	A summary of share-based compensation activity for the three-month period ended March 31, 2023 is presented below: Number of thousands) Weighted Weighted Intrinsic thousands) Balance at January 1, 2023 1,026 $ 78.00 — — Granted 1,065 0.61 — — Cancelled ( 73 ) 182.59 — — Exercised — — — — Balance at March 31, 2023 2,018 $ 33.37 8.1 $ 10,176 Vested and expected to vest at 1,973 $ 34.10 8.0 $ 10,083 Vested and exercisable at 715 $ 92.13 5.1 $ 6,510
Restricted Stock and Performance Stock Unit
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Schedule of Restricted Stock and Performance Stock Unit Activity	(In thousands) Restricted Stock and Performance Stock Units Number of Shares Nonvested at January 1, 2023 — Granted — Vested — Forfeited — Nonvested at March 31, 2023 —

Loss Per Share (Tables)

Loss Per Share (Tables)	3 Months Ended
Loss Per Share (Tables)	Mar. 31, 2023
Earnings Per Share [Abstract]
Schedule of Computation of Basic and Diluted Loss per Share	The following table sets forth the computation of basic and diluted loss per share for the three-month periods ended March 31, 2023 and 2022: (In thousands, except per share data) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Basic and diluted Net loss—basic $ ( 16,824 ) $ ( 24,522 ) Weighted average common shares outstanding used in 24,338 13,251 Plus: net effect of dilutive stock options and restricted — — Weighted average common shares outstanding used in 24,338 13,251 Net loss per share—basic $ ( 0.69 ) $ ( 1.85 ) Net loss per share—diluted $ ( 0.69 ) $ ( 1.85 )
Schedule of Anti-dilutive Securities Excluded from Calculation of Net Loss per Diluted Share	The following amounts were not included in the calculation of net loss per diluted share because their effects were anti-dilutive: (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Denominator Stock options and restricted common shares 1,087 1,299

Fair Value Measurements (Tables

Fair Value Measurements (Tables)	3 Months Ended
Fair Value Measurements (Tables)	Mar. 31, 2023
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Schedule of Assets and Liabilities Measured at Fair Value on a Recurring Basis	(In thousands) Level 1 Level 2 Level 3 March 31, 2023 Assets Carried at Fair Value: Money market funds $ — $ — $ — Liabilities Carried at Fair Value: Acquired contingent consideration — — 39,800 Derivative liability - conversion option — — — December 31, 2022 Assets Carried at Fair Value: Money market funds $ 15,322 $ — $ — Liabilities Carried at Fair Value: Acquired contingent consideration — — 41,200 Derivative liability - conversion option — — —
Contingent Consideration Liability
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Schedule of Contingent Liabilities	The following table presents additional information about liabilities measured at fair value on a recurring basis and for which the Company utilizes Level 3 inputs to determine fair value. (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Acquired contingent consideration: Balance, beginning of period $ 41,200 $ 49,600 Fair value change to contingent consideration ( 1,091 ) ( 3,023 ) Royalty payments ( 309 ) ( 177 ) Balance, end of period $ 39,800 $ 46,400
Derivative Liability-Conversion Option
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Schedule of Fair Value Reconciliation of Derivative Liabilities	The following table represents a reconciliation of the derivative liability recorded in connection with the issuance of the 2024 Notes: (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Derivative Liability-Conversion Option: Balance, beginning of period $ — $ 37 Fair value adjustment — ( 30 ) Balance, end of period $ — $ 7

Liability Related to Sale of _2

Liability Related to Sale of Future Royalties (Tables)	3 Months Ended
Liability Related to Sale of Future Royalties (Tables)	Mar. 31, 2023
Deferred Revenue Disclosure [Abstract]
Schedule of Activity Within Liability Related to Sale of Future Royalties	The following table shows the activity within the liability account for the three-month period ended March 31, 2023 and 2022, respectively: (In thousands) March 31, 2023 March 31, 2022 Liability related to sale of future royalties - beginning balance $ — $ 4,460 Deferred transaction costs amortized — 24 Non-cash royalty revenue payable to HCRP — ( 2,852 ) Non-cash interest expense recognized — 108 Liability related to sale of future royalties - ending balance $ — $ 1,740

Debt (Tables)

Debt (Tables) - Convertible Senior Secured Notes due 2024	3 Months Ended
Debt (Tables) - Convertible Senior Secured Notes due 2024	Mar. 31, 2023
Summary of Outstanding Note Balances	The outstanding 2024 Notes balances as of March 31, 2023 and December 31, 2022 consisted of the following: (In thousands) March 31, 2023 December 31, 2022 Liability component: Principal 207,000 $ 207,000 Less: debt discount and debt issuance costs, net ( 35,504 ) ( 39,969 ) Net carrying amount $ 171,496 $ 167,031 Equity component $ 18,257 $ 18,257 Derivative liability-conversion option $ — $ —
Schedule of Interest Expense Recognized Related to the Notes	The following table sets forth total interest expense recognized related to the 2024 Notes for the three-month periods ended March 31, 2023 and 2022: (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Contractual interest expense $ 3,105 $ 3,105 Amortization of debt issuance costs 317 266 Amortization of debt discount 4,148 3,474 Total interest expense $ 7,570 $ 6,845

Leases (Tables)

Leases (Tables)	3 Months Ended
Leases (Tables)	Mar. 31, 2023
Leases [Abstract]
Schedule of ROU Assets and Lease Liabilities Related to Operating Leases	ROU assets and lease liabilities related to the Company’s operating leases are as follows: (In thousands) Balance Sheet Classification March 31, 2023 December 31, 2022 Right-of-use assets Right of use assets $ 5,029 $ 5,287 Current lease liabilities Current portion of lease liabilities 1,556 1,545 Non-current lease liabilities Non-current portion of lease liabilities 4,055 4,341
Components of Lease Costs	The components of lease costs were as follows: (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Operating lease cost $ 450 $ 1,478 Variable lease cost 100 860 Short-term lease cost — 1 Total lease cost $ 550 $ 2,339
Schedule of Future Minimum Commitments under all Non-Cancelable Operating Leases	Future minimum commitments under all non-cancelable operating leases are as follows: (In thousands) 2023 (excluding the three months ended March 31, 2023) $ 1,159 2024 1,588 2025 1,633 2026 1,678 2027 357 Later years 182 Total lease payments 6,597 Less: Imputed interest ( 986 ) Present value of lease liabilities $ 5,611
Summary of Supplemental Cash Flow Information Related to Operating Leases	Supplemental cash flow information related to the Company’s operating leases are as follows: (In thousands) Three-month period ended March 31, 2023 Three-month period ended March 31, 2022 Operating cash flow information: Cash paid for amounts included in the measurement of lease liabilities $ 386 $ 1,562

Summary of Significant Accoun_4

Summary of Significant Accounting Policies - Additional Information (Details)			3 Months Ended
	Nov. 11, 2022	Jun. 30, 2022 $ / shares	Mar. 31, 2023 USD ($) Segment	Mar. 31, 2022 USD ($)	Dec. 31, 2022 USD ($)	Dec. 24, 2019
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]
Investments			$ 0		$ 0
Segment and Geographic Information
Number of operating segments \| Segment			1
Number of reportable operating segments \| Segment			1
Net loss			$ (16,824,000)	$ (24,522,000)
Convertible Senior Secured Notes due 2024
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]
Interest rate (as a percent)			6%			6%
Reverse stock split, description			1-for-6
VERSION A
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]
Reverse stock split, description	1-for-2 to 1-for-20
Segment and Geographic Information
Cash and cash equivalents			$ 30,300,000		$ 37,500,000
Restricted cash			7,500,000
Net loss			(16,800,000)
Closing bid price of common stock \| $ / shares		$ 1
Number of additional days for complying with minimum bid requirement		180 days
VERSION A \| Convertible Senior Secured Notes due 2024
Segment and Geographic Information
Periodic Interest payment from restricted escrow cash			6,200,000
Self-Funded Employee Health Insurance \| VERSION A
Segment and Geographic Information
Restricted cash			800,000
Letters of Credit
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]
Restricted Cash and Cash Equivalents			500,000
Letters of Credit \| VERSION A
Segment and Geographic Information
Restricted cash			$ 500,000

Summary of Significant Accoun_5

Summary of Significant Accounting Policies - Reconciliation of Cash, Cash Equivalents and Restricted Cash (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022	Mar. 31, 2022	Dec. 31, 2021
Accounting Policies [Abstract]
Cash and cash equivalents	$ 30,255	$ 37,536	$ 31,873	$ 45,634
Restricted cash	6,989	6,884	13,393	13,400
Restricted cash non-current	510	255	6,189	6,189
Total Cash, cash equivalents and restricted cash per statement of cash flows	$ 37,754	$ 44,675	$ 51,455	$ 65,223

Summary of Significant Accoun_6

Summary of Significant Accounting Policies - Schedule of Major Classes of Inventory (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Inventory Disclosure [Abstract]
Raw materials	$ 11,061	$ 6,212
Finished goods	2,404	6,540
Total	$ 13,465	$ 12,752

Revenue - Additional Informatio

Revenue - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Disaggregation Of Revenue [Line Items]
Contract Liabilities	$ 5,700		$ 6,100
Revenues	22,258	$ 22,534
Esteve Pharmaceuticals [Member]
Disaggregation Of Revenue [Line Items]
Revenue from remaining performance obligations	$ 400
Esteve Pharmaceuticals [Member] \| Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2023-04-01
Disaggregation Of Revenue [Line Items]
Revenue from the remaining performance obligations term	9 years

Revenue - Disaggregation of Rev

Revenue - Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Disaggregation Of Revenue [Line Items]
Total net revenues	$ 22,258	$ 22,534
Ampyra
Disaggregation Of Revenue [Line Items]
Total net revenues	12,606	14,904
Inbrija
Disaggregation Of Revenue [Line Items]
Total net revenues	5,587	3,671
Inbrija ex-U.S.
Disaggregation Of Revenue [Line Items]
Total net revenues	526
Net Product Revenues
Disaggregation Of Revenue [Line Items]
Total net revenues	18,719	18,575
Royalty Revenues
Disaggregation Of Revenue [Line Items]
Total net revenues	3,528	$ 3,959
License Revenue
Disaggregation Of Revenue [Line Items]
Total net revenues	$ 11

Share-Based Compensation - Addi

Share-Based Compensation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Share-based compensation expense recognized	$ 71	$ 485
Weighted average fair value of options granted (in dollars per share)	$ 0.49	$ 1.60
Unrecognized compensation costs for unvested stock options, restricted stock awards and restricted stock units	$ 1,000
Weighted average period	1 year 10 months 24 days
Purchase of Treasury Stock ,Shares	0

Share-Based Compensation - Sche

Share-Based Compensation - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation expense recognized	$ 71	$ 485
Research and development expense
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation expense recognized	1	27
Selling, general, and administrative expense
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation expense recognized	$ 70	457
Cost of sales
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation expense recognized		$ 1

Share-Based Compensation - Sc_2

Share-Based Compensation - Schedule of Stock Options Activity (Details) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2023 USD ($) $ / shares shares
Stock Option Activity
Beginning balance (in shares) \| shares	1,026
Granted (in shares) \| shares	1,065
Cancelled (in shares) \| shares	(73)
Ending balance (in shares) \| shares	2,018
Vested and expected to vest at the end of the period \| shares	1,973
Vested and exercisable at the end of the period \| shares	715
Weighted Average Exercise Price
Balance at the beginning of the period (in dollars per share) \| $ / shares	$ 78
Granted (in dollars per share) \| $ / shares	0.61
Cancelled (in dollars per share) \| $ / shares	182.59
Balance at the end of the period (in dollars per share) \| $ / shares	33.37
Vested and expected to vest at the end of the period (in dollars per share) \| $ / shares	34.10
Vested and exercisable at the end of the period (in dollars per share) \| $ / shares	$ 92.13
Weighted Average Remaining Contractual Term
Balance at the end of the period	8 years 1 month 6 days
Vested and expected to vest at the end of the period	8 years
Vested and exercisable at the end of the period	5 years 1 month 6 days
Intrinsic Value
Balance at the end of the period \| $	$ 10,176
Vested and expected to vest at the end of the period \| $	10,083
Vested and exercisable at the end of the period \| $	$ 6,510

Loss Per Share - Schedule of Co

Loss Per Share - Schedule of Computation of Basic and Diluted Loss Per Share (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Basic and diluted
Net loss—basic	$ (16,824)	$ (24,522)
Weighted average common shares outstanding used in computing net loss per share—basic	24,338	13,251
Weighted average common shares outstanding used in computing net loss per share—diluted	24,338	13,251
Net loss per share—basic	$ (0.69)	$ (1.85)
Net loss per share—diluted	$ (0.69)	$ (1.85)

Loss Per Share - Schedule of An

Loss Per Share - Schedule of Antidilutive Securities Excluded from Calculation of Net Loss Per Diluted Share (Details) - shares shares in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Stock options and restricted common shares
Antidilutive Securities
Anti-dilutive securities excluded from computation of loss per share (in shares)	1,087	1,299

Income Taxes - Additional Infor

Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Income Tax Disclosure [Abstract]
(Provision for) benefit from income taxes	$ 2,038	$ (258)
Effective income tax rate (as a percent)	10.80%	(1.10%)
Tax deduction	0%

Fair Value Measurements - Addit

Fair Value Measurements - Additional Information (Details) $ in Millions			9 Months Ended
	Sep. 17, 2020 USD ($) shares	Dec. 24, 2019	Sep. 30, 2020 USD ($)	Mar. 31, 2023 USD ($) shares	Dec. 31, 2022 shares	Mar. 31, 2022	Aug. 28, 2020 shares	Dec. 31, 2019 shares
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Common stock, Authorized shares \| shares	61,666,666			61,666,666	61,666,666		13,333,333	13,333,333
Derivative liability reclassified to equity	$ 18.3
Income tax effects on equity transactions			$ 4.4
Inbrija
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Milestone payment, minimum				$ 0
Milestone payment, maximum				$ 15.5
Convertible Senior Secured Notes due 2024
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Notes, interest rate		6%		6%
Notes, maturity date		Dec. 01, 2024
Fair Value, Inputs, Level 2 \| Convertible Senior Secured Notes due 2024
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Convertible senior notes				$ 157.3
Level 3 \| Weighted Discounted Cash Flow Valuation Approach \| Discount Rate
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Acquired contingent consideration, measurement input				22		21.5

Fair Value Measurements - Sched

Fair Value Measurements - Schedule of Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Liabilities Carried at Fair Value:
Derivative liability	$ 0	$ 0
Level 1 \| Recurring basis \| Money Market Funds
Assets Carried at Fair Value:
Assets, Fair Value		15,322
Level 3 \| Recurring basis
Liabilities Carried at Fair Value:
Acquired contingent consideration	$ 39,800	$ 41,200

Fair Value Measurements - Sch_2

Fair Value Measurements - Schedule of Contingent Liabilities (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Assets and liabilities measured at fair value on a recurring basis utilizing Level 3 inputs
Balance, beginning of period	$ 41,200	$ 49,600
Fair value change to contingent consideration included in the statement of operations	(1,091)	(3,023)
Royalty payments	(309)	(177)
Balance, end of period	$ 39,800	$ 46,400

Fair Value Measurements - Sch_3

Fair Value Measurements - Schedule of Fair Value Reconciliation of Derivative Liability (Details) - Convertible Senior Secured Notes due 2024 $ in Thousands	3 Months Ended
	Mar. 31, 2022 USD ($)
Fair Value Reconciliation Of Derivative Liability [Line Items]
Balance, beginning of period	$ 37
Fair value adjustment	(30)
Balance, end of period	$ 7

Investments - Additional Inform

Investments - Additional Information (Details) - USD ($)	Mar. 31, 2023	Dec. 31, 2022
Schedule Of Available For Sale Securities [Line Items]
Available-for-sale investments	$ 0	$ 0

Liability Related to Sale of _3

Liability Related to Sale of Future Royalties - Additional Information (Details) - Royalty Purchase Agreement - USD ($) $ in Thousands		3 Months Ended
	Oct. 01, 2017	Mar. 31, 2022	Mar. 31, 2023	Dec. 31, 2021
Liability Related To Sale Of Future Royalties [Line Items]
Payment from royalties	$ 40,000
Royalty liability	40,000
Net of transaction costs	$ 2,200	$ 24
Liability related to sale of future royalties - ending balance		$ 1,740	$ 0	$ 4,460

Liability Related to Sale of _4

Liability Related to Sale of Future Royalties - Schedule of Activity Within Liability Related to Sale of Future Royalties (Details) - USD ($) $ in Thousands		3 Months Ended
	Oct. 01, 2017	Mar. 31, 2022
Liability Related To Sale Of Future Royalties [Line Items]
Non-cash royalty revenue payable to HCRP		$ (2,852)
Royalty Purchase Agreement
Liability Related To Sale Of Future Royalties [Line Items]
Liability related to sale of future royalties - beginning balance		4,460
Deferred transaction costs amortized	$ 2,200	24
Non-cash royalty revenue payable to HCRP		(2,852)
Non-cash interest expense recognized		108
Liability related to sale of future royalties - ending balance		$ 1,740

Debt - Additional Information (

Debt - Additional Information (Details)				3 Months Ended		9 Months Ended
Debt - Additional Information (Details)	May 11, 2023 USD ($)	Sep. 17, 2020 USD ($) shares	Dec. 24, 2019 USD ($)	Mar. 31, 2023 USD ($) $ / shares shares	Mar. 31, 2022 USD ($)	Sep. 30, 2020 USD ($)	Dec. 31, 2022 USD ($) shares	Aug. 28, 2020 shares	Dec. 31, 2019 shares
Debt Instrument [Line Items]
Aggregate payment on debt exchange			$ 55,200,000
Gain on debt extinguishment				$ 27,100,000
Common stock, Authorized shares \| shares		61,666,666		61,666,666			61,666,666	13,333,333	13,333,333
Derivative liability reclassified to equity		$ 18,300,000
Income tax effects on equity transactions						$ 4,400,000
Interest expense				$ 7,571,000	$ 7,562,000
Subsequent Event
Debt Instrument [Line Items]
Cash interest payment	$ 6,200,000
Interest payment due date	June 1, 2023
Non Convertible Debt
Debt Instrument [Line Items]
Fair value of debt				$ 20,500,000
Convertible Senior Notes due 2021
Debt Instrument [Line Items]
Principal amount of debt exchanged			$ 276,000,000
Interest rate (as a percent)			1.75%
Convertible Senior Secured Notes due 2024
Debt Instrument [Line Items]
Interest rate (as a percent)			6%	6%
Principal			$ 207,000,000
Debt instrument, principal amount outstanding				$ 207,000,000			$ 207,000,000
Notes maturity date			Dec. 01, 2024
Notes frequency of periodic payment				semi-annually in arrears
Initial conversion rate of common stock				47.6190
Initial conversion price of convertible notes into common stock (in dollars per share) \| $ / shares				$ 21
Principal amount of Notes or an integral multiple thereof in which holder may repurchase the Notes				$ 1,000
Stockholders' equity, reverse stock split				1-for-6
Debt instrument conversion threshold stock price percentage			130%
Repurchase principal amount, Percentage			100%
Debt default, non payment of interest, period			30 days
Debt default, failure to convert notes, period			5 days
Debt default, non-compliance with covenants, period			60 days
Fair value of derivative liability			$ 59,400,000
Debt discount			$ 75,100,000
Interest expense				$ 7,600,000
Effective interest rate on liability component (as a percent)			18.13%
Debt fair value amount				157,300,000
Debt issuance costs				$ 5,700,000
Convertible Senior Secured Notes due 2024 \| Minimum
Debt Instrument [Line Items]
Debt default, non-payment of outstanding principal			$ 30,000,000
Debt default, failure to pay final judgements			$ 30,000,000
Debt default, percentage of principal outstanding required for immediate payment			25%

Debt - Summary of Outstanding N

Debt - Summary of Outstanding Note Balances (Details) - Convertible Senior Secured Notes due 2024 - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022	Dec. 24, 2019
Debt Instrument [Line Items]
Principal	$ 207,000	$ 207,000
Less: debt discount and debt issuance costs, net	(35,504)	(39,969)
Net carrying amount	171,496	167,031
Equity component	$ 18,257	$ 18,257
Derivative liability-conversion option			$ 59,400

Debt - Schedule of Interest Exp

Debt - Schedule of Interest Expense Recognized Related to the Notes (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Debt Instrument [Line Items]
Total interest expense	$ 7,571	$ 7,562
Convertible Senior Secured Notes due December 2024
Debt Instrument [Line Items]
Contractual interest expense	3,105	3,105
Amortization of debt issuance costs	317	266
Amortization of debt discount	4,148	3,474
Total interest expense	$ 7,570	$ 6,845

Leases - Additional Information

Leases - Additional Information (Details) $ in Millions	3 Months Ended
Leases - Additional Information (Details) $ in Millions	Mar. 31, 2023 USD ($) ft²	Jun. 30, 2022 ft²	Oct. 31, 2016 USD ($) ft²
Operating Lease Information
Operating lease description	Operating lease ROU assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. The operating lease ROU asset also includes any lease payments made and excludes lease incentives and initial direct costs incurred, if any. The Company’s leases have remaining lease terms of 3.8 years to 5.3 years.
Operating lease renewal option	true
Operating lease termination option	true
Operating lease weighted-average remaining lease term	4 years 1 month 6 days
Operating lease weighted-average discount rate	7.90%
Ardsley, New York
Operating Lease Information
Area of leased property \| ft²	160,000
Termination option effective date	Jun. 22, 2022
Termination Fee \| $	$ 4.7
Pearl River, New York
Operating Lease Information
Area of leased property \| ft²		21,000
Lease term		6 years
Operating sublease, existence of option to extend	false
Base rent payment commencing on January 1, 2023 \| $	$ 0.3
Base rent subject to annual escalation percentage	2%
Waltham, MA \| Office and Laboratory Space
Operating Lease Information
Area of leased property \| ft²			26,000
Lease term			10 years
Base rent \| $			$ 1.2
Minimum
Operating Lease Information
Operating lease remaining lease term	3 years 9 months 18 days
Maximum
Operating Lease Information
Operating lease remaining lease term	5 years 3 months 18 days

Leases - Schedule of ROU Assets

Leases - Schedule of ROU Assets and Lease Liabilities Related to Operating Leases (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Leases [Abstract]
Right-of-use assets	$ 5,029	$ 5,287
Current lease liabilities	1,556	1,545
Non-current lease liabilities	$ 4,055	$ 4,341

Leases - Components of Lease Co

Leases - Components of Lease Costs (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Leases [Abstract]
Operating lease cost	$ 450	$ 1,478
Variable lease cost	100	860
Short-term lease cost		1
Total lease cost	$ 550	$ 2,339

Leases - Schedule of Future Min

Leases - Schedule of Future Minimum Commitments under all Non-Cancelable Operating Leases (Details) $ in Thousands	Mar. 31, 2023 USD ($)
Leases [Abstract]
2023 (excluding the three months ended March 31, 2023)	$ 1,159
2024	1,588
2025	1,633
2026	1,678
2027	357
Later years	182
Total lease payments	6,597
Less: Imputed interest	(986)
Present value of lease liabilities	$ 5,611

Leases - Summary of Supplementa

Leases - Summary of Supplemental Cash Flow Information Related to Operating Leases (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Operating cash flow information:
Cash paid for amounts included in the measurement of lease liabilities	$ 386	$ 1,562

Corporate Restructuring - Addit

Corporate Restructuring - Additional Information (Details) - USD ($) $ in Millions		3 Months Ended
	Sep. 30, 2021	Mar. 31, 2023
Restructuring And Related Activities [Abstract]
Approximate percentage of headcount reduction	15%
Restructuring Charges For Severance And Other Employee Separation Related Cost		$ 0

Corporate Restructuring - Summa

Corporate Restructuring - Summary of Restructuring Charges (Details) $ in Millions	3 Months Ended
	Mar. 31, 2023 USD ($)
Restructuring And Related Activities [Abstract]
Restructuring Charges For Severance And Other Employee Separation Related Cost	$ 0

Commitments and Contingencies -

Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended		12 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2023	Jun. 30, 2022
Loss Contingencies [Line Items]
Cost of sales	$ 3,234	$ 5,967
Catalent
Loss Contingencies [Line Items]
Termination fee payment	4,000
Minimum purchase commitment	2,900
Catalent \| Forecast
Loss Contingencies [Line Items]
Contribution of fund agreed			$ 2,000
Catalent \| Inbrija
Loss Contingencies [Line Items]
Purchase Obligation	18,000
Purchase commitments in 2023	10,500
Purchase commitments in 2024	15,500
Cost of sales				$ 8,400
Maximum
Loss Contingencies [Line Items]
Capital expenditure provision in 2023	1,000
Capital expenditure provision in 2024	1,000
Minimum \| Catalent \| Inbrija
Loss Contingencies [Line Items]
Original Purchase Obligation	$ 17,000

Subsequent Events - Additional

Subsequent Events - Additional Information (Details) - Subsequent Event - Hangzhou Chance Pharmaceuticals Co Ltd	1 Months Ended
	May 31, 2023 USD ($)
Subsequent Event [Line Items]
Termination period	12 years
Non-refundable upfront payment	$ 2,500,000
Amount receivable upon regulatory approval	3,000,000
Sales milestones	132,500,000
Maximum
Subsequent Event [Line Items]
Near term milestone payment	$ 6,000,000