Acorda Therapeutics (ACORQ) 10-Q13 May 222022 Q1 Quarterly reportFinancial data

Company Profile

Document and Entity Information

Document and Entity Information - shares	3 Months Ended
Document and Entity Information - shares	Mar. 31, 2022	May 09, 2022
Cover [Abstract]
Entity Registrant Name	ACORDA THERAPEUTICS, INC.
Entity Central Index Key	0001008848
Document Type	10-Q
Document Period End Date	Mar. 31, 2022
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity Filer Category	Non-accelerated Filer
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Document Quarterly Report	true
Document Transition Report	false
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q1
Trading Symbol	ACOR
Title of each class	Common Stock $0.001 par value per share
Name of each exchange on which registered	NASDAQ
Entity Common Stock, Shares Outstanding		13,285,636
Entity File Number	001-31938
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	13-3831168
Entity Address, Address Line One	420 Saw Mill River Road
Entity Address, City or Town	Ardsley
Entity Address, State or Province	NY
Entity Address, Postal Zip Code	10502
City Area Code	914
Local Phone Number	347-4300

Consolidated Balance Sheets

Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 31,873	$ 45,634
Restricted cash	13,393	13,400
Trade accounts receivable, net of allowances of $746 and $1,012, as of March 31, 2022 and December 31, 2021, respectively	11,990	17,002
Prepaid expenses	6,507	6,574
Inventory, net	14,836	18,548
Other current assets	1,856	999
Total current assets	80,455	102,157
Property and equipment, net of accumulated depreciation	3,639	4,382
Intangible assets, net of accumulated amortization	328,228	335,980
Right of use asset, net of accumulated amortization	5,616	6,751
Restricted cash	6,189	6,189
Other assets	11	11
Total assets	424,138	455,470
Current liabilities:
Accounts payable	8,768	10,845
Accrued expenses and other current liabilities	26,228	28,605
Current portion of liability related to sale of future royalties	1,740	4,460
Current portion of lease liabilities	7,036	8,186
Current portion of acquired contingent consideration	2,228	1,929
Total current liabilities	46,000	54,025
Convertible senior notes	154,764	151,025
Derivative liability	7	37
Non-current portion of acquired contingent consideration	44,172	47,671
Non-current portion of lease liabilities	3,873	4,086
Non-current portion of loans payable	27,672	27,645
Deferred tax liability	14,187	13,930
Other non-current liabilities	5,914	5,914
Commitments and contingencies
Stockholders’ equity:
Preferred stock, $0.001 par value per share. Authorized 1,000,000 shares at March 31, 2022 and December 31, 2021; no shares issued as of March 31, 2022 and December 31, 2021, respectively
Common stock, $0.001 par value per share. Authorized 61,666,666 shares at March 31, 2022 and December 31, 2021; issued 13,285,211 and 13,249,802 shares, including those held in treasury, as of March 31, 2022 and December 31, 2021, respectively	13	13
Treasury stock at cost (5,543 shares at March 31, 2022 and December 31, 2021)	(638)	(638)
Additional paid-in capital	1,023,621	1,023,136
Accumulated deficit	(894,879)	(870,357)
Accumulated other comprehensive loss	(568)	(1,017)
Total stockholders’ equity	127,549	151,137
Total liabilities and stockholders’ equity	$ 424,138	$ 455,470

Consolidated Balance Sheets (Pa

Consolidated Balance Sheets (Parenthetical) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Statement Of Financial Position [Abstract]
Trade accounts receivable, allowances (in dollars)	$ 746	$ 1,012
Preferred stock, par value (in dollars per share)	$ 0.001	$ 0.001
Preferred stock, Authorized shares	1,000,000	1,000,000
Preferred stock, issued shares	0	0
Common stock, par value (in dollars per share)	$ 0.001	$ 0.001
Common stock, Authorized shares	61,666,666	61,666,666
Common stock, issued shares	13,285,211	13,249,802
Treasury stock, shares	5,543	5,543

Consolidated Statements of Oper

Consolidated Statements of Operations - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenues:
Total net revenues	$ 22,534	$ 28,862
Costs and expenses:
Cost of sales	5,967	11,961
Research and development	1,694	4,749
Selling, general and administrative	26,938	33,968
Amortization of intangible assets	7,691	7,691
Change in fair value of derivative liability	(30)	225
Changes in fair value of acquired contingent consideration	(3,023)	(951)
Total operating expenses	39,237	57,643
Operating loss	(16,703)	(28,781)
Other income (expense), net:
Interest and amortization of debt discount expense	(7,562)	(7,825)
Interest income	1	3
Other income (expense)		1
Realized loss on foreign currency transactions		(1)
Total other expense, net	(7,561)	(7,822)
Loss before taxes	(24,264)	(36,603)
(Provision for) benefit from income taxes	(258)	3,152
Net loss	$ (24,522)	$ (33,451)
Net loss per share—basic	$ (1.85)	$ (3.53)
Net loss per share—diluted	$ (1.85)	$ (3.53)
Weighted average common shares outstanding used in computing net loss per share—basic	13,251	9,470
Weighted average common shares outstanding used in computing net loss per share—diluted	13,251	9,470
Net Product Revenues
Revenues:
Total net revenues	$ 18,575	$ 25,247
Royalty Revenues
Revenues:
Total net revenues	$ 3,959	$ 3,615

Consolidated Statements of Comp

Consolidated Statements of Comprehensive Income (Loss) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Statement Of Income And Comprehensive Income [Abstract]
Net loss	$ (24,522)	$ (33,451)
Other comprehensive income (loss), net of tax:
Foreign currency translation adjustment	449	1,069
Other comprehensive income (loss), net of tax	449	1,069
Comprehensive income (loss)	$ (24,073)	$ (32,382)

Consolidated Statements of Chan

Consolidated Statements of Changes in Stockholders' Equity - USD ($) shares in Thousands, $ in Thousands	Total	Common stock	Treasury stock	Additional paid-in capital	Accumulated deficit	Accumulated other comprehensive (loss) income
Balance at Dec. 31, 2020	$ 237,955	$ 9	$ (638)	$ 1,007,790	$ (766,403)	$ (2,803)
Balance (in shares) at Dec. 31, 2020		9,476
Compensation expense for issuance of stock options to employees	483			483
Compensation expense for issuance of restricted stock to employees	224			224
Other comprehensive income, net of tax	1,069					1,069
Net loss	(33,451)				(33,451)
Balance at Mar. 31, 2021	206,281	$ 9	(638)	1,008,497	(799,854)	(1,734)
Balance (in shares) at Mar. 31, 2021		9,476
Balance at Dec. 31, 2021	151,137	$ 13	(638)	1,023,136	(870,357)	(1,017)
Balance (in shares) at Dec. 31, 2021		13,250
Compensation expense for issuance of stock options to employees	181			181
Compensation expense for issuance of restricted stock to employees	304			304
Compensation expense for issuance of restricted stock to employees (in shares)		35
Other comprehensive income, net of tax	449					449
Net loss	(24,522)				(24,522)
Balance at Mar. 31, 2022	$ 127,549	$ 13	$ (638)	$ 1,023,621	$ (894,879)	$ (568)
Balance (in shares) at Mar. 31, 2022		13,285

Consolidated Statements of Cash

Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Cash flows from operating activities:
Net loss	$ (24,522)	$ (33,451)
Adjustments to reconcile net loss to net cash (used in) provided by operating activities:
Share-based compensation expense	485	707
Amortization of debt discount and debt issuance costs	4,040	4,271
Depreciation and amortization expense	8,534	8,527
Change in acquired contingent consideration obligation	(3,023)	(951)
Non-cash royalty revenue	(2,852)	(3,000)
Deferred tax (benefit) provision	258	(3,152)
Change in derivative liability	(30)	225
Changes in assets and liabilities:
Decrease in accounts receivable	5,012	2,898
Decrease in prepaid expenses and other current assets	66	811
Decrease (increase) in inventory	3,712	(1,006)
Increase in other assets	(858)
Decrease in accounts payable, accrued expenses and other current liabilities	(4,209)	(2,567)
Decrease in other non-current liabilities	(250)	(200)
Net cash used in operating activities	(13,637)	(26,888)
Cash flows from investing activities:
Proceeds from sale of Chelsea facility, net		73,969
Purchases of property and equipment	(39)	(28)
Purchases of intangible assets		(26)
Net cash (used in) provided by investing activities	(39)	73,915
Cash flows from financing activities:
Repayment of loans payable		(655)
Net cash provided by (used in) financing activities		(655)
Effect of exchange rate changes on cash, cash equivalents and restricted cash	(92)	(831)
Net decrease in cash, cash equivalents and restricted cash	(13,768)	45,541
Cash, cash equivalents and restricted cash at beginning of period	65,223	102,895
Cash, cash equivalents and restricted cash at end of period	51,455	148,436
Supplemental disclosure:
Cash paid for interest		6
Cash paid for taxes	$ 5	$ 2

Organization and Business Activ

Organization and Business Activities	3 Months Ended
Organization and Business Activities	Mar. 31, 2022
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Organization and Business Activities	(1) Organization and Business Activities Acorda Therapeutics, Inc. (“Acorda” or the “Company”) is a biopharmaceutical company focused on developing therapies that restore function and improve the lives of people with neurological disorders. The accompanying unaudited consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States (GAAP) for interim financial information, Accounting Standards Codification (ASC) Topic 270-10 and with the instructions to Form 10-Q. Accordingly, these financial statements do not include all of the information and footnotes required by GAAP for complete financial statements. In management’s opinion, all adjustments considered necessary for a fair presentation have been included in the interim periods presented and all adjustments are of a normal recurring nature. The Company has evaluated subsequent events through the date of this filing. Operating results for the three-month period ended March 31, 2022 are not necessarily indicative of the results that may be expected for the year ending December 31, 2022. When used in these notes, the terms “Acorda” or “the Company” mean Acorda Therapeutics, Inc. The December 31, 2021 consolidated balance sheet data was derived from audited financial statements, but does not include all disclosures required by GAAP. You should read these unaudited interim condensed consolidated financial statements in conjunction with the consolidated financial statements and footnotes included in the Company's Annual Report on Form 10-K, for the year ended December 31, 2021.

Summary of Significant Accounti

Summary of Significant Accounting Policies	3 Months Ended
Summary of Significant Accounting Policies	Mar. 31, 2022
Accounting Policies [Abstract]
Summary of Significant Accounting	(2) Summary of Significant Accounting Policies The Company’s significant accounting policies are detailed in its Annual Report on Form 10-K for the year ended December 31, 2021. Effective January 1, 2021, the Company adopted ASU 2019-12, “Simplifying the Accounting for Income Taxes” (Topic 740). Effective January 1, 2022, the Company adopted ASU 2021-04, “Earnings Per Share (Topic 260), Debt—Modifications and Extinguishments (Subtopic 470-50), Compensation—Stock Compensation (Topic 718), and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40): Issuer’s Accounting for Certain Modifications or Exchanges of Freestanding Equity-Classified Written Call Options”. The Company’s significant accounting policies have not changed materially from December 31, 2021. Basis of Presentation The Company reclassified the net proceeds from the sale of the Chelsea facility of $74.0 million for the quarter ended March 31, 2021 from financing activities to investing activities in the accompanying Consolidated Statement of Cash Flows. Restricted Cash The following table provides a reconciliation of cash, cash equivalents, and restricted cash reported within the statement of financial position that sum to the total of the same amounts shown in the statement of cash flows: Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 (In thousands) Beginning of period End of period Beginning of period End of period Cash and cash equivalents $ 45,634 $ 31,873 $ 71,369 $ 116,773 Restricted cash 13,400 13,393 12,917 13,054 Restricted cash non-current 6,189 6,189 18,609 18,609 Total Cash, cash equivalents and restricted cash per statement of cash flows $ 65,223 $ 51,455 $ 102,894 $ 148,436 Restricted cash represents an escrow account with funds to maintain the interest payments for an amount equal to all remaining scheduled interest payments on the outstanding convertible senior secured notes due 2024 through the interest payment date of June 1, 2023; and a Inventory The following table provides the major classes of inventory: (In thousands) March 31, 2022 December 31, 2021 Raw materials $ 3,663 $ 3,338 Work-in-progress — — Finished goods 11,173 15,210 Total $ 14,836 $ 18,548 The Company reviews inventory, including inventory purchase commitments, for slow moving or obsolete amounts based on expected product sales volume and provides reserves against the carrying amount of inventory as appropriate. On February 10, 2021, the Company completed the sale of its Chelsea, Massachusetts manufacturing operations to Catalent Pharma Solutions. In connection with the sale of the manufacturing operations, the Company transferred approximately $2.3 million of raw materials to Catalent. See Note 12 to the Company’s Consolidated Financial Statements included in this report for a discussion of assets transferred upon the sale. Additionally, in reviewing the inventory for slow moving or obsolete amounts the Company recorded a charge of $1.3 million for the remaining work-in-progress inventory that was scrapped or discarded during the three-month period ended March 31, 2021. Foreign Currency Translation The functional currency of operations outside the United States of America is deemed to be the currency of the local country, unless otherwise determined that the United States dollar would serve as a more appropriate functional currency given the economic operations of the entity. Accordingly, the assets and liabilities of the Company’s foreign subsidiary, Biotie, are translated into United States dollars using the period-end exchange rate; and income and expense items are translated using the average exchange rate during the period; and equity transactions are translated at historical rates. Cumulative translation adjustments are reflected as a separate component of equity. Foreign currency transaction gains and losses are charged to operations and reported in other income (expense) in consolidated statements of operations. Segment and Geographic Information The Company is managed and operated as one business which is focused on developing therapies that restore function and improve the lives of people with neurological disorders. The entire business is managed by a single management team that reports to the Chief Executive Officer. The Company does not operate separate lines of business with respect to any of its products or product candidates and the Company does not prepare discrete financial information to allocate resources to separate products or product candidates or by location. Accordingly, the Company views its business as one reportable operating segment. Net product revenues reported are derived from the sales of Ampyra and Inbrija in the U.S. for the three-month periods ended March 31, 2022 and 2021. Impairment of Long-Lived Assets The Company continually evaluates whether events or circumstances have occurred that indicate that the estimated remaining useful lives of its long-lived assets, including identifiable intangible assets subject to amortization and property plant and equipment, may warrant revision or that the carrying value of the assets may be impaired. The Company evaluates the realizability of its long-lived assets based on profitability and cash flow expectations for the related assets. Factors the Company considers important that could trigger an impairment review include significant changes in the use of any assets, changes in historical trends in operating performance, changes in projected operating performance, stock price, loss of a major customer and significant negative economic trends. The decline in the trading price of the Company's common stock during the three-month period ended March 31, 2022, and related decrease in the Company's market capitalization, was determined to be a triggering event in connection with the Company's review of the recoverability of its long-lived assets for the three-month period ended March 31, 2022. The Company performed a recoverability test as of March 31, 2022 using the undiscounted cash flows, which are the sum of the future undiscounted cash flows expected to be derived from the direct use of the long-lived assets to the carrying value of the long-lived assets. Estimates of future cash flows were based on the Company’s own assumptions about its own use of the long-lived assets. The cash flow estimation period was based on the long-lived assets’ estimated remaining useful life to the Company. After performing the recoverability test, the Company determined that the undiscounted cash flows exceeded the carrying value and the long-lived assets were not impaired. Changes in these assumptions and resulting valuations could result in future long-lived asset impairment charges. During the three-month period ended March 31, 2022, no other impairment indicators were noted by the Company. Management will continue to monitor any changes in circumstances for indicators of impairment. Any write‑downs are treated as permanent reductions in the carrying amount of the assets. Liquidity The Company’s ability to meet its future operating requirements, repay its liabilities, and meet its other obligations are dependent upon a number of factors, including its ability to generate cash from product sales, reduce planned expenditures, and obtain additional financing. If the Company is unable to generate sufficient cash flow from the sale of its products, the Company will be required to adopt one or more alternatives, subject to the restrictions contained in the indenture governing its convertible senior secured notes due 2024, such as further reducing expenses, selling assets, restructuring debt, or obtaining additional equity capital on terms that may be onerous and which are likely to be highly dilutive. Also, the Company’s ability to raise additional capital and repay or restructure its indebtedness will depend on the capital markets and its financial condition at such time, among other factors. In addition, financing may not be available when needed, at all, on terms acceptable to the Company or in accordance with the restrictions described above. As a result of these factors, the Company may not be able to engage in any of the alternative activities, or engage in such activities on desirable terms, which could harm the Company’s business, financial condition and results of operations, as well as result in a default on the Company’s debt obligations. If the Company is unable to take these actions, it may be forced to significantly alter its business strategy, substantially curtail its current operations, or cease operations altogether. At March 31, 2022, the Company had $31.9 million of cash and cash equivalents, compared to $45.6 million at December 31, 2021. The Company’s March 31, 2022 cash and cash equivalents balance does not include $18.6 million of restricted cash that is currently held in escrow under the terms of its convertible senior secured notes due 2024, which may potentially be released from escrow if the Company pays interest on those notes using shares of its common stock (the amount released would correspond to the amount of interest paid using shares). The Company incurred a net loss of $24.5 million for the three-month period ended March 31, 2022. Based on the Company’s cash and cash equivalents at March 31, 2022, Subsequent Events Subsequent events are defined as those events or transactions that occur after the balance sheet date, but before the financial statements are filed with the Securities and Exchange Commission. The Company completed an evaluation of the impact of any subsequent events through the date these financial statements were issued, and determined there were no subsequent events that required disclosure or adjustment in these financial statements. Accounting Pronouncements Adopted In December 2019, the FASB issued ASU 2019-12, Simplifying the Accounting for Income Taxes. The ASU enhances and simplifies various aspects of the income tax accounting guidance in ASC 740 and removes certain exceptions for recognizing deferred taxes for investments, performing intraperiod allocation and calculating income taxes in interim periods. The ASU also adds guidance to reduce complexity in certain areas, including recognizing deferred taxes for tax goodwill and allocating taxes to members of a consolidated group. This ASU is effective for fiscal years beginning after December 15, 2020, and interim periods within those fiscal years with early adoption permitted. The Company adopted this guidance effective January 1, 2021. The adoption of this guidance did not have a significant impact on the consolidated financial statements. In May 2021, the FASB issued ASU 2021-04, Earnings Per Share (Topic 260), Debt – Modifications and Extinguishments (Subtopic 470-50), Compensation – Stock Compensation (Topic 718), and Derivatives and Hedging – Contracts in Entity’s Own Equity (Subtopic 815-40): Issuer’s Accounting for Certain Modifications or Exchanges of Freestanding Equity-Classified Written Call Options. The FASB is issuing this update to clarify and reduce diversity in an issuer’s accounting for modifications or exchanges of freestanding equity-classified written call options (for example, warrants) that remain equity classified after modification or exchange. The amendments in this update are effective for all entities for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. The Company adopted this guidance effective January 1, 2022. The adoption of this guidance did not have a significant impact on the consolidated financial statements. Accounting Pronouncements Not Yet Adopted In March 2020, the FASB issued ASU 2020-03, “Codification Improvements to Financial Instruments”: The amendments in this update are to clarify, correct errors in, or make minor improvements to a variety of ASC topics. The changes in ASU 2020-03 are not expected to have a significant effect on current accounting practices. The ASU improves various financial instrument topics in the Codification to increase stakeholder awareness of the amendments and to expedite the improvement process by making the Codification easier to understand and easier to apply by eliminating inconsistencies and providing clarifications. The ASU is effective for smaller reporting companies for fiscal years beginning after December 15, 2022 with early application permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements. In August 2020, the FASB issued ASU 2020-06, Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity. This update simplifies the accounting for convertible instruments by eliminating the cash conversion and beneficial conversion feature models which require separate accounting for embedded conversion features. This update also amends the guidance for the derivatives scope exception for contracts in an entity’s own equity to reduce form-over-substance-based accounting conclusions and requires the application of the if-converted method for calculating diluted earnings per share. ASU 2020-06 is effective for smaller reporting companies for fiscal periods beginning after December 15, 2023, including interim periods within those fiscal years. Early adoption is permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements. In March, 2022, the FASB issued ASU 2022-02, Financial Instruments – Credit Losses: Troubled Debt Restructurings and Vintage Disclosures. The amendments in this Update eliminate the accounting guidance for Troubled Debt Restructurings by creditors in Subtopic 310-40, Receivables—Troubled Debt Restructurings by Creditors, while enhancing disclosure requirements for certain loan refinancings and restructurings by creditors when a borrower is experiencing financial difficulty. This update also includes amendments which require that an entity disclose current-period gross writeoffs by year of origination for financing receivables and net investments in leases within the scope of Subtopic 326-20, Financial Instruments—Credit Losses—Measured at Amortized Cost. The ASU is effective for entities that have adopted the amendments in Update 2016-13 for fiscal years beginning after December 15, 2022, including interim periods within those fiscal years. Early adoption is permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements.

Revenue

Revenue	3 Months Ended
Revenue	Mar. 31, 2022
Revenue From Contract With Customer [Abstract]
Revenue	(3) Revenue In accordance with ASC 606, the Company recognizes revenue when the customer obtains control of a promised good or service, in an amount that reflects the consideration to which the Company expects to be entitled in exchange for the good or service. ASC 606 requires entities to record a contract asset when a performance obligation has been satisfied or partially satisfied, but the amount of consideration has not yet been received because the receipt of the consideration is conditioned on something other than the passage of time. ASC 606 also requires an entity to present a revenue contract as a contract liability in instances when a customer pays consideration, or an entity has a right to an amount of consideration that is unconditional (e.g. receivable), before the entity transfers a good or service to the customer. As of March 31, 2022, the Company had contract liabilities of $5.9 million, which is the upfront payment received as part of the Esteve Germany distribution agreement entered into in 2021. The Company did not have any contract liabilities as of March 31, 2021. The Company did not have any contract assets as of March 31, 2022 or 2021. The Company did not recognize any revenues during the period ended March 31, 2022 from its distribution agreement with Esteve. Esteve expects to launch Inbrija in Germany in June 2022. The following table disaggregates the Company’s revenue by major source. The Company’s Royalty Revenue set forth below relates to Fampyra royalties payable under the Company’s License and Collaboration Agreement with Biogen. See Note 9 for additional information on the Company’s related payment obligation to HealthCare Royalty Partners, or HCRP, in connection with a 2017 royalty purchase agreement with HCRP. (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Revenues: Net product revenues: Ampyra $ 14,904 $ 20,250 Inbrija 3,671 4,996 Other — 1 Total net product revenues 18,575 25,247 Royalty revenues 3,959 3,615 Total net revenues $ 22,534 $ 28,862

Share-based Compensation

Share-based Compensation	3 Months Ended
Share-based Compensation	Mar. 31, 2022
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Share-based Compensation	(4) Share-based Compensation During the three‑month periods ended March 31, 2022 and 2021, the Company recognized share-based compensation expense of $0.5 million and $0.7 million, respectively. Activity in options and restricted stock during the three-month period ended March 31, 2022 and related balances outstanding as of that date are reflected below. The weighted average fair value per share of options granted to employees for the three-month periods ended March 31, 2022 and 2021 were approximately $1.60 and $3.81, respectively. The following table summarizes share-based compensation expense included within the Company’s consolidated statements of operations: For the Three-month period ended March 31, (In thousands) 2022 2021 Research and development expense $ 27 $ 166 Selling, general and administrative expense 457 534 Cost of Sales 1 7 Total $ 485 $ 707 A summary of share-based compensation activity for the three-month period ended March 31, 2022 is presented below: Stock Option Activity Number of Shares (In Weighted Average Exercise Price Weighted Average Remaining Contractual Term Intrinsic Value (In Balance at January 1, 2022 1,186 $ 94.38 Granted 25 2.30 Cancelled (129 ) 127.08 Exercised — — Balance at March 31, 2022 1,082 $ 88.31 6.0 $ — Vested and expected to vest at March 31, 2022 1,070 $ 89.26 5.9 $ — Vested and exercisable at March 31, 2022 764 $ 122.60 4.5 $ — Restricted Stock and Performance Stock Unit Activity (In thousands) Restricted Stock and Performance Stock Units Number of Shares Nonvested at January 1, 2022 116 Granted — Vested (35 ) Forfeited (4 ) Nonvested at March 31, 2022 77 Unrecognized compensation cost for unvested stock options, restricted stock awards, and restricted stock units as of March 31, 2022 totaled $1.6 million and is expected to be recognized over a weighted average period of approximately 2.6 years. During the three‑month period ended March 31, 2022, the Company did not make any repurchases of shares.

Loss Per Share

Loss Per Share	3 Months Ended
Loss Per Share	Mar. 31, 2022
Earnings Per Share [Abstract]
Loss Per Share	(5) Loss Per Share The following table sets forth the computation of basic and diluted loss per share for the three-month periods ended March 31, 2022 and 2021: (In thousands, except per share data) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Basic and diluted Net loss—basic $ (24,522 ) $ (33,451 ) Weighted average common shares outstanding used in computing net loss per share—basic 13,251 9,470 Plus: net effect of dilutive stock options and restricted common shares — — Weighted average common shares outstanding used in computing net loss per share—diluted 13,251 9,470 Net loss per share—basic $ (1.85 ) $ (3.53 ) Net loss per share—diluted $ (1.85 ) $ (3.53 ) Securities that could potentially be dilutive are excluded from the computation of diluted loss per share when a loss from continuing operations exists or when the exercise price exceeds the average closing price of the Company’s common stock during the period, because their inclusion would result in an anti-dilutive effect on per share amounts. The following amounts were not included in the calculation of net loss per diluted share because their effects were anti-dilutive: (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Denominator Stock options and restricted common shares 1,299 1,391 Performance share units are excluded from the calculation of net loss per diluted share as the performance criteria has not been met for the three-month periods ended March 31, 2022 and 2021. Additionally, the impact of the convertible senior notes was determined to be anti-dilutive and excluded from the calculation of net loss per diluted share for the three-month periods ended March 31, 2022 and 2021.

Income Taxes

Income Taxes	3 Months Ended
Income Taxes	Mar. 31, 2022
Income Tax Disclosure [Abstract]
Income Taxes	(6) Income Taxes The Company’s effective income tax rate differs from the U.S. statutory rate primarily due to an increase in the valuation allowance and expense recorded on the equity forfeiture. For the three-month periods ended March 31, 2022 and 2021, the Company recorded a provision of $(0.3) million and a benefit of $3.2 million for income taxes, respectively. The effective income tax rates for the Company for the three-month periods ended March 31, 2022 and 2021 were (1.1%) and 8.6%, respectively. The variances in the effective tax rates for the three-month period ended March 31, 2022, as compared to the three-month period ended March 31, 2021, was due primarily to the forfeitures of equity of which no tax deduction is recorded and The Company continues to evaluate the realizability of its deferred tax assets on a quarterly basis and will adjust such amounts in light of changing facts and circumstances including, but not limited to, future projections of taxable income, tax legislation, rulings by relevant tax authorities, the progress of ongoing tax audits and the regulatory approval of products currently under development. Any changes to the valuation allowance or deferred tax assets and liabilities in the future would impact the Company's income taxes. The Company has ongoing state examinations in Massachusetts, Minnesota, and New Jersey which cover multiple years. There have been no proposed adjustments at this stage of the examination.

Fair Value Measurements

Fair Value Measurements	3 Months Ended
Fair Value Measurements	Mar. 31, 2022
Fair Value Disclosures [Abstract]
Fair Value Measurements	(7) Fair Value Measurements The following table presents information about the Company’s assets and liabilities measured at fair value on a recurring basis as of March 31 , 2022 (In thousands) Level 1 Level 2 Level 3 March 31, 2022 Assets Carried at Fair Value: Money market funds $ 12,193 $ — $ — Liabilities Carried at Fair Value: Acquired contingent consideration — — 46,400 Derivative liability - conversion option — — 7 December 31, 2021 Assets Carried at Fair Value: Money market funds $ 12,192 $ — $ — Liabilities Carried at Fair Value: Acquired contingent consideration — — 49,600 Derivative liability - conversion option — — 37 The following table presents additional information about liabilities measured at fair value on a recurring basis and for which the Company utilizes Level 3 inputs to determine fair value. Acquired contingent consideration (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Acquired contingent consideration: Balance, beginning of period $ 49,600 $ 48,200 Fair value change to contingent consideration included in the statement of operations (3,023 ) (951 ) Royalty payments (177 ) (249 ) Balance, end of period $ 46,400 $ 47,000 The Company estimates the fair value of its acquired contingent consideration using a probability weighted discounted cash flow valuation approach based on estimated future sales expected from Inbrija (levodopa inhalation powder) an FDA approved drug OFF periods in Parkinson’s disease. the estimated revenue forecast for Inbrija Inbrija. changes in the fair value of the contingent consideration primarily due to The acquired contingent consideration is classified as a Level 3 liability as its valuation requires substantial judgment and estimation of factors that are not currently observable in the market. If different assumptions were used for the various inputs to the valuation approach, including but not limited to, assumptions involving sales estimates for Inbrija Derivative Liability-Conversion Option The following table represents a reconciliation of the derivative liability recorded in connection with the issuance of the convertible senior secured notes due 2024: (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Derivative Liability-Conversion Option Balance, beginning of period $ 37 $ 1,193 Fair value adjustment (30 ) 225 Balance, end of period $ 7 $ 1,418 During 2019, a derivative liability was initially recorded as a result of the issuance of the 6.00% Convertible Senior Secured Notes due 2024 (See Note 10 to the Consolidated Financial Statements included in this report for more information on the Convertible Senior Notes due 2024). The fair value measurement of the derivative liability is classified as Level 3 under the fair value hierarchy as it has been valued using certain unobservable inputs. These inputs include: (1) share price as of the valuation date, (2) assumed timing of conversion of the Notes, (3) historical volatility of the share price, and (4) the risk-adjusted discount rate used to present value the probability-weighted cash flows. Significant increases or decreases in any of those inputs in isolation could result in a significantly lower or higher fair value measurement. The fair value of the derivative liability was determined using a binomial model that calculates the fair value of the Notes with the conversion feature as compared to the fair value of the Notes without the conversion feature, with the difference representing the value of the conversion feature, or the derivative liability. There are several embedded features within the Notes which, upon issuance, did not meet the conditions for equity classification. As a result, these features were aggregated together and recorded as a derivative liability conversion option.

Investments

Investments	3 Months Ended
Investments	Mar. 31, 2022
Investments Debt And Equity Securities [Abstract]
Investments	(8) Investments There were no available-for-sale investments at March 31, 2022 and December 31, 2021, respectively. Short-term investments with maturities of three months or less from date of purchase have been classified as cash equivalents, and amounted to approximately $12.2 million as of March 31, 2022 and December 31, 2021, respectively. There were no short-term investments will original maturities of greater than 3 months but less than 1 year as of March 31, 2022 and December 31, 2021, respectively. Additionally, there were no short-term investments in an unrealized loss position as of March 31, 2022 and December 31, 2021, respectively. Long-term investments have original maturities of greater than 1 year. There were no investments classified as long-term at March 31, 2022 or December 31, 2021. The Company has determined that there were no other-than-temporary declines in the fair values of its investments as of March 31, 2022 as the Company does not have any short or long-term investments as of March 31, 2022.

Liability Related to Sale of Fu

Liability Related to Sale of Future Royalties	3 Months Ended
Liability Related to Sale of Future Royalties	Mar. 31, 2022
Deferred Revenue Disclosure [Abstract]
Liability Related to Sale of Future Royalties	(9) Liability Related to Sale of Future Royalties As of October 1, 2017, the Company completed a royalty purchase agreement with HealthCare Royalty Partners Since the Company maintained rights under the Biogen Collaboration Agreement, therefore, the Royalty Agreement has been accounted for as a liability that will be amortized using the effective interest method over the life of the arrangement, in accordance with the relevant accounting guidance. The Company recorded the receipt of the $40 million payment from HCRP and established a corresponding liability in the amount of $40 million, net of transaction costs of approximately $2.2 million. The net liability is classified between the current and non-current portion of liability related to the sale of future royalties in the consolidated balance sheets based on the recognition of the interest and principal payments to be received by HCRP in the next 12 months from the financial statement reporting date. The total net royalties to be paid, less the net proceeds received will be recorded to interest expense using the effective interest method over the life of the Royalty Agreement. The Company will estimate the payments to be made to HCRP over the term of the Royalty Agreement based on forecasted royalties and will calculate the interest rate required to discount such payments back to the liability balance. Over the course of the Royalty Agreement, the actual interest rate will be affected by the amount and timing of net royalty revenue recognized and changes in forecasted revenue. On a quarterly basis, the Company will reassess the effective interest rate and adjust the rate prospectively as necessary. The following table shows the activity within the liability account for March 31 (In thousands) March 31, 2022 March 31, 2021 Liability related to sale of future royalties - beginning balance $ 4,460 $ 15,257 Deferred transaction costs amortized 24 70 Non-cash royalty revenue payable to HCRP (2,852 ) (3,000 ) Non-cash interest expense recognized 108 330 Liability related to sale of future royalties - ending balance $ 1,740 $ 12,657

Debt

Debt	3 Months Ended
Debt	Mar. 31, 2022
Debt Disclosure [Abstract]
Debt	(10) Debt Convertible Senior Secured Notes Due 2024 On December 24, 2019, the Company completed the private exchange of $276.0 million aggregate principal amount of its outstanding 1.75% Convertible Senior Notes due 2021 (the “2021 Notes”) for a combination of newly issued 6.00% Convertible Senior Secured Notes due 2024 (the “2024 Notes”) and cash. For each $1,000 principal amount of exchanged 2021 Notes, the Company issued $750 principal amount of the 2024 Notes and made a cash payment of $200 (the “Exchange”). In the aggregate, the Company issued approximately $207.0 million aggregate principal amount of the 2024 Notes and paid approximate $55.2 million in cash to participating holders. The Exchange was conducted with a limited number of institutional holders of the 2021 Notes pursuant to Exchange Agreements dated as of December 20, 2019. The 2021 Notes received by the Company in the Exchange were cancelled in accordance with their terms. Accordingly, upon completion of the Exchange, $ 69.0 million of the 2021 Notes remained outstanding. On June 15, 2021, the Company repaid the outstanding balance of the 2021 Notes at their maturity date using cash on hand. The 2024 Notes were issued pursuant to an Indenture, dated as of December 23, 2019, among the Company, its wholly owned subsidiary, Civitas Therapeutics, Inc. (along with any domestic subsidiaries acquired or formed after the date of issuance, the “Guarantors”), and Wilmington Trust, National Association, as trustee and collateral agent (the “2024 Indenture”). The 2024 Notes are senior obligations of the Company and the Guarantors, secured by a first priority security interest in substantially all of the assets of the Company and the Guarantors, subject to certain exceptions described in the Security Agreement, dated as of December 23, 2019, between the grantors party thereto and Wilmington Trust, National Association, as collateral agent. The 2024 Notes will mature on December 1, 2024 unless earlier converted in accordance with their terms prior to such date. Interest on the 2024 Notes is payable semi-annually in arrears at a rate of 6.00% per annum on each June 1 and December 1, beginning on June 1, 2020. The Company may elect to pay interest in cash or shares of the Company’s common stock, subject to the satisfaction of certain conditions. If the Company elects to pay interest in shares of common stock, such common stock will have a per share value equal to 95% of the daily volume-weighted average price for the 10 trading days ending on and including the trading day immediately preceding the relevant interest payment date. The 2024 Notes are convertible at the option of the holder into shares of common stock of the Company at any time prior to the close of business on the second scheduled trading day immediately preceding the maturity date. The adjusted conversion rate for the 2024 Notes is 47.6190 shares of the Company’s common stock per $1,000 principal amount of 2024 Notes, representing an adjusted conversion price of approximately $21.00 per share of common stock. The conversion rate was adjusted to reflect the 1-for-6 reverse stock split effected on December 31, 2020 and is subject to additional adjustments in certain circumstances as described in the 2024 Indenture. The Company may elect to settle conversions of the 2024 Notes in cash, shares of the Company’s common stock or a combination of cash and shares of the Company’s common stock. Holders who convert their 2024 Notes prior to June 1, 2023 (other than in connection with a make-whole fundamental change) will also be entitled to an interest make-whole payment equal to the sum of all regularly scheduled stated interest payments, if any, due on such 2024 Notes on each interest payment date occurring after the conversion date for such conversion and on or before June 1, 2023. In addition, the Company will have the right to cause all 2024 Notes then outstanding to be converted automatically if the volume-weighted average price per share of the Company’s common stock equals or exceeds 130% of the adjusted conversion price for a specified period of time and certain other conditions are satisfied. Holders of the 2024 Notes will have the right, at their option, to require the Company to purchase their 2024 Notes if a fundamental change (as defined in the 2024 Indenture) occurs, in each case, at a repurchase price equal to 100% of the principal amount of the 2024 Notes to be repurchased, plus accrued and unpaid interest, if any, to, but excluding, the applicable repurchase date. If a make-whole fundamental change occurs, as described in the 2024 Indenture, and a holder elects to convert its 2024 Notes in connection with such make-whole fundamental change, such holder may be entitled to an increase in the adjusted conversion rate as described in the 2024 Indenture. Subject to a number of exceptions and qualifications, the 2024 Indenture restricts the ability of the Company and certain of its subsidiaries to, among other things, (i) pay dividends or make other payments or distributions on their capital stock, or purchase, redeem, defease or otherwise acquire or retire for value any capital stock, (ii) make certain investments, (iii) incur indebtedness or issue preferred stock, other than certain forms of permitted debt, which includes, among other items, indebtedness incurred to refinance the 2021 Notes, (iv) create liens on their assets, (v) sell their assets, (vi) enter into certain transactions with affiliates or (vii) merge, consolidate or sell of all or substantially all of their assets. The 2024 Indenture also requires the Company to make an offer to repurchase the 2024 Notes upon the occurrence of certain asset sales. The 2024 Indenture provides that a number of events will constitute an event of default, including, among other things, (i) a failure to pay interest for 30 days, (ii) failure to pay the 2024 Notes when due at maturity, upon any required repurchase, upon declaration of acceleration or otherwise, (iii) failure to convert the 2024 Notes in accordance with the 2024 Indenture and the failure continues for five business days, (iv) not issuing certain notices required by the 2024 Indenture within a timely manner, (v) failure to comply with the other covenants or agreements in the 2024 Indenture for 60 days following the receipt of a notice of non-compliance, (vi) a default or other failure by the Company to make required payments under other indebtedness of the Company or certain subsidiaries having an outstanding principal amount of $ 30.0 million or more, (vii) failure by the Company or certain subsidiaries to pay final judgments aggregating in excess of $ 30.0 million, (viii) certain events of bankruptcy or insolvency and (ix) the commercial launch in the United States of a product determined by the U.S. FDA to be bioequivalent to Inbrija . In the case of an event of default arising from certain events of bankruptcy or insolvency with respect to the Company, all outstanding 2024 Notes will become due and payable immediately without further action or notice. If any other event of default occurs and is continuing, the trustee or the holders of at least 25 % in aggregate principal amount of the then outstanding 2024 Notes may declare all the notes to be due and payable immediately. The Company determined that the exchange of the 2021 Notes for 2024 Notes qualified for a debt extinguishment and recognized a gain on extinguishment of $55.1 million for the year ended December 31, 2019, representing the difference between the fair value of the liability component immediately before the exchange and the carrying value of the debt. The Company recorded an adjustment of $38.4 million to additional paid-in capital to adjust the equity component of 2021 Notes in connection with the extinguishment. The Company assessed all terms and features of the 2024 Notes in order to identify any potential embedded features that would require bifurcation. As part of this analysis, the Company assessed the economic characteristics and risks of the 2024 Notes, including the conversion, put and call features. The Company concluded the conversion features required bifurcation as a derivative. The fair value of the conversion features derivative was determined based on the difference between the fair value of the 2024 Notes with the conversion options and the fair value of the 2024 Notes without the conversion options using a binomial model. The Company determined that the fair value of the derivative upon issuance of the 2024 Notes was $59.4 There are several embedded features within the 2024 Notes which, upon issuance, did not meet the conditions for equity classification. As a result, these features were aggregated together and recorded as the derivative liability conversion option. The Company received stockholder approval on August 28, 2020 to increase the number of authorized shares of the Company’s common stock from 13,333,333 shares to 61,666,666 shares. As a result of the share approval, the Company determined that multiple embedded conversion options met the conditions for equity classification. performed a valuation of these conversion options as of September 17, 2020, which was the date the Company completed certain securities registration obligations for the shares underlying the 2024 Notes. The resulting fair value of these conversion options was $18.3 million, which was reclassified to equity and presented in the statement of stockholder’s equity as of September 30, 2020, net of the $4.4 million tax impact. The equity component is not re-measured as long as it continues to meet the conditions for equity classification. The Company performed a valuation of the derivative liability related to certain embedded conversion features that are precluded from equity classification. The fair value of these conversion features was calculated to be negligible as of March 31, 2022. The outstanding 2024 Note balances as of March 31 (In thousands) March 31, 2022 December 31, 2021 Liability component: Principal 207,000 $ 207,000 Less: debt discount and debt issuance costs, net (52,236 ) (55,975 ) Net carrying amount $ 154,764 $ 151,025 Equity component $ 18,257 $ 18,257 Derivative liability-conversion option $ 7 $ 37 The Company determined that the expected life of the 2024 Notes was equal to the period through December 1, 2024 as this represents the point at which the 2024 Notes will mature unless earlier converted in accordance with their terms prior to such date. March 31 March 31 In connection with the issuance of the 2024 Notes, the Company incurred approximately $5.7 million of debt issuance costs, which primarily consisted of underwriting, legal and other professional fees, and allocated these costs to the liability component and recorded as a reduction in the carrying amount of the debt liability on the balance sheet. The portion allocated to the 2024 Notes is amortized to interest expense over the expected life of the 2024 Notes using the effective interest method. The following table sets forth total interest expense recognized related to the 2024 Notes for the three-month periods ended March 31 (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Contractual interest expense $ 3,105 $ 3,105 Amortization of debt issuance costs 266 222 Amortization of debt discount 3,474 2,910 Total interest expense $ 6,845 $ 6,237 Convertible Senior Notes Due 2021 On June 17, 2014, the Company issued $345 million aggregate principal amount of 1.75% Convertible Senior Notes due 2021 (the “2021 Notes”). On December 24, 2019, the Company completed the private exchange of $276.0 million aggregate principal amount of its then-outstanding 2021 Notes for a combination of newly issued 6.00% Convertible Senior Secured Notes due 2024 (the “2024 Notes”) and cash. The 2021 Notes received by the Company in the exchange were cancelled in accordance with their terms. Accordingly, upon completion of the exchange, $69.0 million of the 2021 Notes remained outstanding. On June 15, 2021, the Company repaid the outstanding balance of the 2021 Notes at their maturity date using cash on hand. In accounting for the issuance of the 2021 Notes, the Company separated the 2021 Notes into liability and equity components. The carrying amount of the liability component was calculated by measuring the fair value of a similar liability that does not have an associated convertible feature. The carrying amount of the equity component representing the conversion option was determined by deducting the fair value of the liability component from the par value of the 2021 Notes as a whole. The equity component is not re-measured as long as it continues to meet the conditions for equity classification. In connection with the issuance of the 2021 Notes, the Company incurred approximately $7.5 million of debt issuance costs, which primarily consisted of underwriting, legal and other professional fees, and allocated these costs to the liability and equity components based on the allocation of the proceeds. Of the total $7.5 million of debt issuance costs, $1.3 million were allocated to the equity component and recorded as a reduction to additional paid-in capital and $6.2 million were allocated to the liability component and recorded as a reduction in the carrying amount of the debt liability on the balance sheet. The portion allocated to the liability component is amortized to interest expense over the expected life of the 2021 Notes using the effective interest method. The Company wrote off $1.2 million of issuance cost associated with the exchange of the 2021 Notes. The following table sets forth total interest expense recognized related to the 2021 Notes for the three-month periods ended March 31 (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Contractual interest expense $ — $ 302 Amortization of debt issuance costs — 52 Amortization of debt discount — 507 Total interest expense $ — $ 861

Leases

Leases	3 Months Ended
Leases	Mar. 31, 2022
Leases [Abstract]
Leases	(11) Leases In February 2016, the FASB issued ASU 2016-02, “Leases” Topic 842, which amends the guidance in former ASC Topic 840, Leases The interest rate implicit in lease contracts is typically not readily determinable. As such, the Company utilizes its incremental borrowing rate, which is the rate incurred to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment. Operating lease ROU assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. The operating lease ROU asset also includes any lease payments made and excludes lease incentives and initial direct costs incurred, if any. The Company’s leases have remaining lease terms of 0.25 years to 4.75 years. The Company has exercised the option to terminate the Ardsley lease with a termination date of June 22, 2022. Operating Leases The Company leases certain office space, manufacturing and warehouse space under arrangements classified as leases under ASC 842. Leases with an initial term of 12 months or less are not recorded on the balance sheet; the Company recognizes lease expense for these leases on a straight-line basis over the lease term. Ardsley, New York In June 2011, the Company entered into a 15-year lease for an aggregate of approximately 138,000 square feet of office and laboratory space in Ardsley, New York. In 2014, the Company exercised its option to expand into an additional 25,405 square feet of office space, which the Company occupied in January 2015. The Company’s base rent through the June 22, 2022 termination date is $2.4 million. In September 2021, the Company sent the landlord notice of exercise of the Company’s early termination option (the “Early Termination Option”) under the lease. Pursuant to the Early Termination Option, the lease will terminate on June 22, 2022 (the “Early Termination Date”), subject to the conditions that (a) on the last business day before the Early Termination Date, the Company pays an early termination fee of approximately $4.7 million, (b) on the day immediately prior to the Early Termination Date, the Company is not in “Default” under the Lease beyond applicable cure periods, and (c) as of the Early Termination Date, the Company has complied with its end-of-term obligations. The Company is currently evaluating facility alternatives for its corporate operations after its departure from the Ardsley headquarters. Chelsea, Massachusetts The Company’s Civitas subsidiary leased a manufacturing facility in Chelsea, Massachusetts which it used to manufacture On February 10, 2021, the Company completed the sale of its Chelsea manufacturing operations to Catalent Pharma Solutions and assigned the lease of the Chelsea facility to a Catalent affiliate. In 2018, the Company initiated a renovation and expansion of a building within the Chelsea manufacturing facility that increased the size of the facility to approximately 95,000 square feet. The project added a new size 7 spray dryer manufacturing production line for Inbrija and other ARCUS products that has greater capacity than the existing size 4 spray dryer manufacturing production line, and created additional warehousing space for manufactured product. Additional Facilities In October 2016, the Company entered into a 10-year lease agreement with a term commencing January 1, 2017, for approximately 26,000 square feet of lab and office space in Waltham, MA. The lease provides for monthly rental payments over the lease term. The Company’s leases have remaining lease terms of 0.25 years to 4.75 years, which reflects the exercise of the early termination of the Company’s Ardsley, NY lease as described above. The weighted-average remaining lease term for the Company’s operating leases was 2.3 years at March 31, 2022. The weighted-average discount rate was 7.13 % at March 31, 2022. ROU assets and lease liabilities related to the Company’s operating leases are as follows: (In thousands) Balance Sheet Classification March 31, 2022 December 31, 2021 Right-of-use assets Right of use assets $ 5,616 $ 6,751 Current lease liabilities Current portion of lease liabilities 7,036 8,186 Non-current lease liabilities Non-current portion of lease liabilities 3,873 4,086 The Company has lease agreements that contain both lease and non-lease components. The Company accounts for lease components together with non-lease components (e.g., common-area maintenance). The components of lease costs were as follows: (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Operating lease cost $ 1,478 $ 1,586 Variable lease cost 860 1,356 Short-term lease cost 1 305 Total lease cost $ 2,339 $ 3,247 Future minimum commitments under all non-cancelable operating leases are as follows: (In thousands) 2022 (excluding the three months ended March 31, 2022) $ 6,792 2023 1,216 2024 1,252 2025 1,290 2026 1,328 Later years — Total lease payments 11,877 Less: Imputed interest (968 ) Present value of lease liabilities $ 10,909 Supplemental cash flow information related to the Company’s operating leases are as follows: (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Operating cash flow information: Cash paid for amounts included in the measurement of lease liabilities $ 1,562 $ 1,522

Disposal of Assets

Disposal of Assets	3 Months Ended
Disposal of Assets	Mar. 31, 2022
Property Plant And Equipment [Abstract]
Disposal of Assets	(12) Disposal of Assets On January 12, 2021 the Company and Catalent entered into an asset purchase agreement, pursuant to which the Company agreed to sell to Catalent certain assets related to the Company’s manufacturing activities located at the facilities situated in Chelsea, Massachusetts (the “Chelsea Facility”) and Waltham, Massachusetts (the “Waltham Facility”), for a purchase price of $80 million, plus an additional $2.3 million for raw materials transferred, and the assumption by Catalent of certain liabilities relating to such manufacturing activities. The Company closed the transaction on February 10, 2021. The Company determined that the criterion to classify the Chelsea manufacturing operations as assets held for sale within the Company’s consolidated balance sheet effective December 31, 2020 were met. Accordingly, the assets were classified as current assets held for sale at December 31, 2020 as the Company, at that time, expected to divest the Chelsea manufacturing operations within the next twelve months. The classification to assets held for sale impacted the net book value of the assets expected to be transferred upon sale. The estimated fair value of the Chelsea manufacturing operations was determined using the purchase price in the purchase agreement along with estimated broker, accounting, legal, and other selling expenses, which resulted in a fair value less costs to sell of approximately $ 71.8 million. The carrying value of the assets classified as held for sale was approximately $ 129.7 million, which included property and equipment of $ 129.6 million and prepaid expenses of $ 0.1 million. As a result, the Company recorded a loss on assets held for sale of $ 57.9 million against the Chelsea manufacturing operations. Upon completion of the divestiture, final net proceeds were $ 74.0 million. Additionally, the expected divestiture of the Chelsea manufacturing operations was not deemed to represent a fundamental strategic shift that would have a major effect on the Company’s operations, and accordingly, the operating results of the Chelsea manufacturing operations were not reported as discontinued operations in the Company’s consolidated statement of income as of December 31, 2020. In connection with the sale of the Chelsea manufacturing operations, the Company assigned the lease of the Chelsea manufacturing facility to a Catalent affiliate, which had a net carrying value of $(0.5) million as of the close date. During the three-month period ended March 31, 2021, the Company recorded a gain on disposal of approximately $0.5 million based on the net assets transferred and final net proceeds received at the close.

Corporate Restructuring

Corporate Restructuring	3 Months Ended
Corporate Restructuring	Mar. 31, 2022
Restructuring And Related Activities [Abstract]
Corporate Restructuring	(13) Corporate Restructuring In January 2021 and September 2021, the Company announced corporate restructurings to reduce costs, more closely align operating expenses with expected revenue, and focus its resources on Inbrija. As part of the January 2021 restructuring, the Company reduced headcount by approximately 16% through a reduction in force (excluding the employees that transferred to Catalent at the closing of the sale of the Company’s Chelsea manufacturing operations). All of the reduction in personnel in connection with the January 2021 restructuring took place during the three-month period ended March 31, 2021. As part of the September 2021 restructuring, the Company reduced headcount by approximately 15% through a reduction in force. Most of this reduction in force took place in September 2021, and was materially completed as of March 31, 2022, with negligible expenses to be incurred in the second quarter of 2022. During the three-month period ended March 31, 2022, the Company incurred $0.2 million of restructuring charges, substantially all of which were cash expenditures for severance and other employee separation-related costs. Of the restructuring charges, $0.2 million were recorded in selling, general and administrative expenses for the three-month period ended March 31, 2022. A summary of the restructuring charges for the three-month period ended March 31, 2022 is as follows: (In thousands) Restructuring Costs Restructuring Liability as of December 31, 2021 $ 1,851 Q1 Restructuring Costs 226 Q1 Restructuring Payments (1,700 ) Restructuring Liability as of March 31, 2022 $ 377

Commitments and Contingencies

Commitments and Contingencies	3 Months Ended
Commitments and Contingencies	Mar. 31, 2022
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies	(14) Commitments and Contingencies On November 9, 2020, Drug Royalty III, L.P., and LSRC III S.ar.l. (collectively, “DRI”) filed an arbitration claim against the Company with the American Arbitration Association under a September 26, 2003 License Agreement that it originally entered into with Rush-Presbyterian St. Luke’s Medical Center (“Rush”). DRI previously purchased license royalty rights under the license agreement from Rush. DRI alleges a dispute over the last-to-expire patent covering sales of the drug Ampyra under the license agreement, and is claiming damages based on unpaid license royalties of $6 million plus interest. The Company believes that it has valid defenses against this claim and intends to defend itself vigorously. While the Company is unable to determine the ultimate outcome of the dispute, the Company determined that it is probable that the Company may incur a liability related to the dispute which the Company estimated could be up to $2 million, inclusive of its legal costs. The Company recorded a liability of $2 million for the year ended December 31, 2020 in accrued expense and other current liabilities related to the dispute. However, the Company notes that depending upon the ultimate outcome of the dispute, the potential liability could be more or less than the amount recorded. In addition to the arbitration described above, from time to time the Company is involved in litigation or other legal proceedings relating to claims arising out of operations in the normal course of business. The Company has assessed all litigation and legal proceedings and does not believe that it is probable that a liability has been incurred or that the amount of any potential liability or range of losses can be reasonably estimated. As a result, the Company did not record any loss contingencies for these other matters. Litigation expenses are expensed as incurred. On February 10, 2021, the Company sold its Chelsea manufacturing operations to Catalent Pharma Solutions. In connection with the sale, the Company entered into a long-term, global manufacturing services (supply) agreement with a Catalent affiliate pursuant to which they have agreed to manufacture Inbrija for the Company at the Chelsea facility. The manufacturing services agreement provides that Catalent will manufacture Inbrija , to the Company’s specifications, and the Company will purchase Inbrija exclusively from Catalent during the term of the manufacturing services agreement; provided that such exclusivity requirement will not apply to Inbrija intended for sale in China. Under the Company’s agreement with Catalent , it is obligated to make minimum purchase commitments for Inbrija through the expiration of the agreement on December 31, 2030. Under the manufacturing services agreement, the Company agreed to purchase from Catalent at least $16 million of Inbrija in 2021 (pro-rated for a partial year) and $18 million of Inbrija each year from 2022 through 2030, subject to reduction in certain cases. In December 2021, the Company and Catalent amended the manufacturing services agreement to adjust the structure of the minimum payment terms the is replaced with payments to minimum , and with certain payments being made in the first half of 2022 instead of during the second half of 2021 The Company has submitted a binding forecast for Inbrija batches for the Adjustment Period, the total cost of which Additionally, pursuant to the amendment, the Company agreed that it would reimburse a portion of Catalent’s costs in completing the installation and qualification of a larger size 7 spray dryer at the Chelsea manufacturing facility, which the Company believes will be beneficial to its future production needs, in the amount of $1.5 million. This amount will be paid quarterly over a one-year period commencing no sooner than January 1, 2024. The manufacturing services agreement contains customary representations, warranties and covenants, including with respect to the ownership of any intellectual property created pursuant to the manufacturing services agreement, as well as provisions relating to ordering, payment and shipping terms, regulatory matters, reporting obligations, indemnity, confidentiality and other matters. During the quarter ended March 31, 2022, the Company incurred approximately $1.4 million of purchase commitments with Catalent, of which $1.1 million are recognized as inventory within the Company’s balance sheet and $0.3 million are recognized as cost of sales within the Company’s consolidated statement of operations for the period. As of March 31, 2022, the minimum remaining purchase commitment to Catalent was $9 million through December 31, 2022, plus any additional payments to Catalent for actual product delivered during the remainder of the Adjustment Period subject to a cap for the Adjustment Period, and $18.0 million annually each year thereafter.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	3 Months Ended
Summary of Significant Accounting Policies (Policies)	Mar. 31, 2022
Accounting Policies [Abstract]
Basis of Presentation	Basis of Presentation The Company reclassified the net proceeds from the sale of the Chelsea facility of $74.0 million for the quarter ended March 31, 2021 from financing activities to investing activities in the accompanying Consolidated Statement of Cash Flows.
Restricted Cash	Restricted Cash The following table provides a reconciliation of cash, cash equivalents, and restricted cash reported within the statement of financial position that sum to the total of the same amounts shown in the statement of cash flows: Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 (In thousands) Beginning of period End of period Beginning of period End of period Cash and cash equivalents $ 45,634 $ 31,873 $ 71,369 $ 116,773 Restricted cash 13,400 13,393 12,917 13,054 Restricted cash non-current 6,189 6,189 18,609 18,609 Total Cash, cash equivalents and restricted cash per statement of cash flows $ 65,223 $ 51,455 $ 102,894 $ 148,436 Restricted cash represents an escrow account with funds to maintain the interest payments for an amount equal to all remaining scheduled interest payments on the outstanding convertible senior secured notes due 2024 through the interest payment date of June 1, 2023; and a
Inventory	Inventory The following table provides the major classes of inventory: (In thousands) March 31, 2022 December 31, 2021 Raw materials $ 3,663 $ 3,338 Work-in-progress — — Finished goods 11,173 15,210 Total $ 14,836 $ 18,548 The Company reviews inventory, including inventory purchase commitments, for slow moving or obsolete amounts based on expected product sales volume and provides reserves against the carrying amount of inventory as appropriate. On February 10, 2021, the Company completed the sale of its Chelsea, Massachusetts manufacturing operations to Catalent Pharma Solutions. In connection with the sale of the manufacturing operations, the Company transferred approximately $2.3 million of raw materials to Catalent. See Note 12 to the Company’s Consolidated Financial Statements included in this report for a discussion of assets transferred upon the sale. Additionally, in reviewing the inventory for slow moving or obsolete amounts the Company recorded a charge of $1.3 million for the remaining work-in-progress inventory that was scrapped or discarded during the three-month period ended March 31, 2021.
Foreign Currency Translation	Foreign Currency Translation The functional currency of operations outside the United States of America is deemed to be the currency of the local country, unless otherwise determined that the United States dollar would serve as a more appropriate functional currency given the economic operations of the entity. Accordingly, the assets and liabilities of the Company’s foreign subsidiary, Biotie, are translated into United States dollars using the period-end exchange rate; and income and expense items are translated using the average exchange rate during the period; and equity transactions are translated at historical rates. Cumulative translation adjustments are reflected as a separate component of equity. Foreign currency transaction gains and losses are charged to operations and reported in other income (expense) in consolidated statements of operations.
Segment and Geographic Information	Segment and Geographic Information The Company is managed and operated as one business which is focused on developing therapies that restore function and improve the lives of people with neurological disorders. The entire business is managed by a single management team that reports to the Chief Executive Officer. The Company does not operate separate lines of business with respect to any of its products or product candidates and the Company does not prepare discrete financial information to allocate resources to separate products or product candidates or by location. Accordingly, the Company views its business as one reportable operating segment. Net product revenues reported are derived from the sales of Ampyra and Inbrija in the U.S. for the three-month periods ended March 31, 2022 and 2021.
Impairment Or Disposal Of Long Lived Assets	Impairment of Long-Lived Assets The Company continually evaluates whether events or circumstances have occurred that indicate that the estimated remaining useful lives of its long-lived assets, including identifiable intangible assets subject to amortization and property plant and equipment, may warrant revision or that the carrying value of the assets may be impaired. The Company evaluates the realizability of its long-lived assets based on profitability and cash flow expectations for the related assets. Factors the Company considers important that could trigger an impairment review include significant changes in the use of any assets, changes in historical trends in operating performance, changes in projected operating performance, stock price, loss of a major customer and significant negative economic trends. The decline in the trading price of the Company's common stock during the three-month period ended March 31, 2022, and related decrease in the Company's market capitalization, was determined to be a triggering event in connection with the Company's review of the recoverability of its long-lived assets for the three-month period ended March 31, 2022. The Company performed a recoverability test as of March 31, 2022 using the undiscounted cash flows, which are the sum of the future undiscounted cash flows expected to be derived from the direct use of the long-lived assets to the carrying value of the long-lived assets. Estimates of future cash flows were based on the Company’s own assumptions about its own use of the long-lived assets. The cash flow estimation period was based on the long-lived assets’ estimated remaining useful life to the Company. After performing the recoverability test, the Company determined that the undiscounted cash flows exceeded the carrying value and the long-lived assets were not impaired. Changes in these assumptions and resulting valuations could result in future long-lived asset impairment charges. During the three-month period ended March 31, 2022, no other impairment indicators were noted by the Company. Management will continue to monitor any changes in circumstances for indicators of impairment. Any write‑downs are treated as permanent reductions in the carrying amount of the assets.
Liquidity	Liquidity The Company’s ability to meet its future operating requirements, repay its liabilities, and meet its other obligations are dependent upon a number of factors, including its ability to generate cash from product sales, reduce planned expenditures, and obtain additional financing. If the Company is unable to generate sufficient cash flow from the sale of its products, the Company will be required to adopt one or more alternatives, subject to the restrictions contained in the indenture governing its convertible senior secured notes due 2024, such as further reducing expenses, selling assets, restructuring debt, or obtaining additional equity capital on terms that may be onerous and which are likely to be highly dilutive. Also, the Company’s ability to raise additional capital and repay or restructure its indebtedness will depend on the capital markets and its financial condition at such time, among other factors. In addition, financing may not be available when needed, at all, on terms acceptable to the Company or in accordance with the restrictions described above. As a result of these factors, the Company may not be able to engage in any of the alternative activities, or engage in such activities on desirable terms, which could harm the Company’s business, financial condition and results of operations, as well as result in a default on the Company’s debt obligations. If the Company is unable to take these actions, it may be forced to significantly alter its business strategy, substantially curtail its current operations, or cease operations altogether. At March 31, 2022, the Company had $31.9 million of cash and cash equivalents, compared to $45.6 million at December 31, 2021. The Company’s March 31, 2022 cash and cash equivalents balance does not include $18.6 million of restricted cash that is currently held in escrow under the terms of its convertible senior secured notes due 2024, which may potentially be released from escrow if the Company pays interest on those notes using shares of its common stock (the amount released would correspond to the amount of interest paid using shares). The Company incurred a net loss of $24.5 million for the three-month period ended March 31, 2022. Based on the Company’s cash and cash equivalents at March 31, 2022,
Subsequent Events	Subsequent Events Subsequent events are defined as those events or transactions that occur after the balance sheet date, but before the financial statements are filed with the Securities and Exchange Commission. The Company completed an evaluation of the impact of any subsequent events through the date these financial statements were issued, and determined there were no subsequent events that required disclosure or adjustment in these financial statements.
Accounting Pronouncements Adopted	Accounting Pronouncements Adopted In December 2019, the FASB issued ASU 2019-12, Simplifying the Accounting for Income Taxes. The ASU enhances and simplifies various aspects of the income tax accounting guidance in ASC 740 and removes certain exceptions for recognizing deferred taxes for investments, performing intraperiod allocation and calculating income taxes in interim periods. The ASU also adds guidance to reduce complexity in certain areas, including recognizing deferred taxes for tax goodwill and allocating taxes to members of a consolidated group. This ASU is effective for fiscal years beginning after December 15, 2020, and interim periods within those fiscal years with early adoption permitted. The Company adopted this guidance effective January 1, 2021. The adoption of this guidance did not have a significant impact on the consolidated financial statements. In May 2021, the FASB issued ASU 2021-04, Earnings Per Share (Topic 260), Debt – Modifications and Extinguishments (Subtopic 470-50), Compensation – Stock Compensation (Topic 718), and Derivatives and Hedging – Contracts in Entity’s Own Equity (Subtopic 815-40): Issuer’s Accounting for Certain Modifications or Exchanges of Freestanding Equity-Classified Written Call Options. The FASB is issuing this update to clarify and reduce diversity in an issuer’s accounting for modifications or exchanges of freestanding equity-classified written call options (for example, warrants) that remain equity classified after modification or exchange. The amendments in this update are effective for all entities for fiscal years beginning after December 15, 2021, including interim periods within those fiscal years. The Company adopted this guidance effective January 1, 2022. The adoption of this guidance did not have a significant impact on the consolidated financial statements.
Accounting Pronouncements Not Yet Adopted	Accounting Pronouncements Not Yet Adopted In March 2020, the FASB issued ASU 2020-03, “Codification Improvements to Financial Instruments”: The amendments in this update are to clarify, correct errors in, or make minor improvements to a variety of ASC topics. The changes in ASU 2020-03 are not expected to have a significant effect on current accounting practices. The ASU improves various financial instrument topics in the Codification to increase stakeholder awareness of the amendments and to expedite the improvement process by making the Codification easier to understand and easier to apply by eliminating inconsistencies and providing clarifications. The ASU is effective for smaller reporting companies for fiscal years beginning after December 15, 2022 with early application permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements. In August 2020, the FASB issued ASU 2020-06, Accounting for Convertible Instruments and Contracts in an Entity’s Own Equity. This update simplifies the accounting for convertible instruments by eliminating the cash conversion and beneficial conversion feature models which require separate accounting for embedded conversion features. This update also amends the guidance for the derivatives scope exception for contracts in an entity’s own equity to reduce form-over-substance-based accounting conclusions and requires the application of the if-converted method for calculating diluted earnings per share. ASU 2020-06 is effective for smaller reporting companies for fiscal periods beginning after December 15, 2023, including interim periods within those fiscal years. Early adoption is permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements. In March, 2022, the FASB issued ASU 2022-02, Financial Instruments – Credit Losses: Troubled Debt Restructurings and Vintage Disclosures. The amendments in this Update eliminate the accounting guidance for Troubled Debt Restructurings by creditors in Subtopic 310-40, Receivables—Troubled Debt Restructurings by Creditors, while enhancing disclosure requirements for certain loan refinancings and restructurings by creditors when a borrower is experiencing financial difficulty. This update also includes amendments which require that an entity disclose current-period gross writeoffs by year of origination for financing receivables and net investments in leases within the scope of Subtopic 326-20, Financial Instruments—Credit Losses—Measured at Amortized Cost. The ASU is effective for entities that have adopted the amendments in Update 2016-13 for fiscal years beginning after December 15, 2022, including interim periods within those fiscal years. Early adoption is permitted. The Company is currently evaluating the impact the adoption of this guidance may have on its consolidated financial statements.

Summary of Significant Accoun_3

Summary of Significant Accounting Policies (Tables)	3 Months Ended
Summary of Significant Accounting Policies (Tables)	Mar. 31, 2022
Accounting Policies [Abstract]
Reconciliation of Cash, Cash Equivalents and Restricted Cash	The following table provides a reconciliation of cash, cash equivalents, and restricted cash reported within the statement of financial position that sum to the total of the same amounts shown in the statement of cash flows: Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 (In thousands) Beginning of period End of period Beginning of period End of period Cash and cash equivalents $ 45,634 $ 31,873 $ 71,369 $ 116,773 Restricted cash 13,400 13,393 12,917 13,054 Restricted cash non-current 6,189 6,189 18,609 18,609 Total Cash, cash equivalents and restricted cash per statement of cash flows $ 65,223 $ 51,455 $ 102,894 $ 148,436
Schedule of Major Classes of Inventory	The following table provides the major classes of inventory: (In thousands) March 31, 2022 December 31, 2021 Raw materials $ 3,663 $ 3,338 Work-in-progress — — Finished goods 11,173 15,210 Total $ 14,836 $ 18,548

Revenue (Tables)

Revenue (Tables)	3 Months Ended
Revenue (Tables)	Mar. 31, 2022
Revenue From Contract With Customer [Abstract]
Disaggregation of Revenue	The following table disaggregates the Company’s revenue by major source. The Company’s Royalty Revenue set forth below relates to Fampyra royalties payable under the Company’s License and Collaboration Agreement with Biogen. See Note 9 for additional information on the Company’s related payment obligation to HealthCare Royalty Partners, or HCRP, in connection with a 2017 royalty purchase agreement with HCRP. (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Revenues: Net product revenues: Ampyra $ 14,904 $ 20,250 Inbrija 3,671 4,996 Other — 1 Total net product revenues 18,575 25,247 Royalty revenues 3,959 3,615 Total net revenues $ 22,534 $ 28,862

Share-based Compensation (Table

Share-based Compensation (Tables)	3 Months Ended
Share-based Compensation (Tables)	Mar. 31, 2022
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Schedule of Share-based Compensation Expense	The following table summarizes share-based compensation expense included within the Company’s consolidated statements of operations: For the Three-month period ended March 31, (In thousands) 2022 2021 Research and development expense $ 27 $ 166 Selling, general and administrative expense 457 534 Cost of Sales 1 7 Total $ 485 $ 707
Schedule of Stock Option Activity	A summary of share-based compensation activity for the three-month period ended March 31, 2022 is presented below: Number of Shares (In Weighted Average Exercise Price Weighted Average Remaining Contractual Term Intrinsic Value (In Balance at January 1, 2022 1,186 $ 94.38 Granted 25 2.30 Cancelled (129 ) 127.08 Exercised — — Balance at March 31, 2022 1,082 $ 88.31 6.0 $ — Vested and expected to vest at March 31, 2022 1,070 $ 89.26 5.9 $ — Vested and exercisable at March 31, 2022 764 $ 122.60 4.5 $ —
Restricted Stock and Performance Stock Unit
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Schedule of Restricted Stock and Performance Stock Unit Activity	(In thousands) Restricted Stock and Performance Stock Units Number of Shares Nonvested at January 1, 2022 116 Granted — Vested (35 ) Forfeited (4 ) Nonvested at March 31, 2022 77

Loss Per Share (Tables)

Loss Per Share (Tables)	3 Months Ended
Loss Per Share (Tables)	Mar. 31, 2022
Earnings Per Share [Abstract]
Schedule of Computation of Basic and Diluted Loss per Share	The following table sets forth the computation of basic and diluted loss per share for the three-month periods ended March 31, 2022 and 2021: (In thousands, except per share data) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Basic and diluted Net loss—basic $ (24,522 ) $ (33,451 ) Weighted average common shares outstanding used in computing net loss per share—basic 13,251 9,470 Plus: net effect of dilutive stock options and restricted common shares — — Weighted average common shares outstanding used in computing net loss per share—diluted 13,251 9,470 Net loss per share—basic $ (1.85 ) $ (3.53 ) Net loss per share—diluted $ (1.85 ) $ (3.53 )
Schedule of Anti-dilutive Securities Excluded from Calculation of Net Loss per Diluted Share	The following amounts were not included in the calculation of net loss per diluted share because their effects were anti-dilutive: (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Denominator Stock options and restricted common shares 1,299 1,391

Fair Value Measurements (Tables

Fair Value Measurements (Tables)	3 Months Ended
Fair Value Measurements (Tables)	Mar. 31, 2022
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Schedule of Assets and Liabilities Measured at Fair Value on a Recurring Basis	(In thousands) Level 1 Level 2 Level 3 March 31, 2022 Assets Carried at Fair Value: Money market funds $ 12,193 $ — $ — Liabilities Carried at Fair Value: Acquired contingent consideration — — 46,400 Derivative liability - conversion option — — 7 December 31, 2021 Assets Carried at Fair Value: Money market funds $ 12,192 $ — $ — Liabilities Carried at Fair Value: Acquired contingent consideration — — 49,600 Derivative liability - conversion option — — 37
Contingent Consideration Liability
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Schedule of Contingent Liabilities	The following table presents additional information about liabilities measured at fair value on a recurring basis and for which the Company utilizes Level 3 inputs to determine fair value. (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Acquired contingent consideration: Balance, beginning of period $ 49,600 $ 48,200 Fair value change to contingent consideration included in the statement of operations (3,023 ) (951 ) Royalty payments (177 ) (249 ) Balance, end of period $ 46,400 $ 47,000
Derivative Liability-Conversion Option
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Schedule of Fair Value Reconciliation of Derivative Liabilities	The following table represents a reconciliation of the derivative liability recorded in connection with the issuance of the convertible senior secured notes due 2024: (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Derivative Liability-Conversion Option Balance, beginning of period $ 37 $ 1,193 Fair value adjustment (30 ) 225 Balance, end of period $ 7 $ 1,418

Liability Related to Sale of _2

Liability Related to Sale of Future Royalties (Tables)	3 Months Ended
Liability Related to Sale of Future Royalties (Tables)	Mar. 31, 2022
Deferred Revenue Disclosure [Abstract]
Schedule of Activity Within Liability Related to Sale of Future Royalties	The following table shows the activity within the liability account for March 31 (In thousands) March 31, 2022 March 31, 2021 Liability related to sale of future royalties - beginning balance $ 4,460 $ 15,257 Deferred transaction costs amortized 24 70 Non-cash royalty revenue payable to HCRP (2,852 ) (3,000 ) Non-cash interest expense recognized 108 330 Liability related to sale of future royalties - ending balance $ 1,740 $ 12,657

Debt (Tables)

Debt (Tables)	3 Months Ended
Debt (Tables)	Mar. 31, 2022
Convertible Senior Secured Notes due 2024
Summary of Outstanding Note Balances	The outstanding 2024 Note balances as of March 31 (In thousands) March 31, 2022 December 31, 2021 Liability component: Principal 207,000 $ 207,000 Less: debt discount and debt issuance costs, net (52,236 ) (55,975 ) Net carrying amount $ 154,764 $ 151,025 Equity component $ 18,257 $ 18,257 Derivative liability-conversion option $ 7 $ 37
Schedule of Interest Expense Recognized Related to the Notes	The following table sets forth total interest expense recognized related to the 2024 Notes for the three-month periods ended March 31 (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Contractual interest expense $ 3,105 $ 3,105 Amortization of debt issuance costs 266 222 Amortization of debt discount 3,474 2,910 Total interest expense $ 6,845 $ 6,237
Convertible Senior Notes due 2021
Schedule of Interest Expense Recognized Related to the Notes	The following table sets forth total interest expense recognized related to the 2021 Notes for the three-month periods ended March 31 (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Contractual interest expense $ — $ 302 Amortization of debt issuance costs — 52 Amortization of debt discount — 507 Total interest expense $ — $ 861

Leases (Tables)

Leases (Tables)	3 Months Ended
Leases (Tables)	Mar. 31, 2022
Leases [Abstract]
Schedule of ROU Assets and Lease Liabilities Related to Operating Leases	ROU assets and lease liabilities related to the Company’s operating leases are as follows: (In thousands) Balance Sheet Classification March 31, 2022 December 31, 2021 Right-of-use assets Right of use assets $ 5,616 $ 6,751 Current lease liabilities Current portion of lease liabilities 7,036 8,186 Non-current lease liabilities Non-current portion of lease liabilities 3,873 4,086
Components of Lease Costs	The components of lease costs were as follows: (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Operating lease cost $ 1,478 $ 1,586 Variable lease cost 860 1,356 Short-term lease cost 1 305 Total lease cost $ 2,339 $ 3,247
Schedule of Future Minimum Commitments under all Non-Cancelable Operating Leases	Future minimum commitments under all non-cancelable operating leases are as follows: (In thousands) 2022 (excluding the three months ended March 31, 2022) $ 6,792 2023 1,216 2024 1,252 2025 1,290 2026 1,328 Later years — Total lease payments 11,877 Less: Imputed interest (968 ) Present value of lease liabilities $ 10,909
Summary of Supplemental Cash Flow Information Related to Operating Leases	Supplemental cash flow information related to the Company’s operating leases are as follows: (In thousands) Three-month period ended March 31, 2022 Three-month period ended March 31, 2021 Operating cash flow information: Cash paid for amounts included in the measurement of lease liabilities $ 1,562 $ 1,522

Corporate Restructuring (Tables

Corporate Restructuring (Tables)	3 Months Ended
Corporate Restructuring (Tables)	Mar. 31, 2022
Restructuring And Related Activities [Abstract]
Summary of Restructuring Charges	A summary of the restructuring charges for the three-month period ended March 31, 2022 is as follows: (In thousands) Restructuring Costs Restructuring Liability as of December 31, 2021 $ 1,851 Q1 Restructuring Costs 226 Q1 Restructuring Payments (1,700 ) Restructuring Liability as of March 31, 2022 $ 377

Summary of Significant Accoun_4

Summary of Significant Accounting Policies - Additional Information (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2022USD ($)Segment	Mar. 31, 2021USD ($)Segment	Dec. 31, 2021USD ($)
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]
Proceeds from sale of facility	$ 74,000
Transfer of raw material	2,300
Charge for excess and obsolete inventory	$ 1,300
Segment and Geographic Information
Number of operating segments \| Segment	1
Number of reportable operating segments \| Segment	1	1
Cash and cash equivalents	$ 31,900		$ 45,600
Restricted cash	18,600
Net loss	(24,522)	$ (33,451)
Letters of Credit
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]
Restricted Cash and Cash Equivalents	300
Restricted Cash - Non Current
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]
Escrow account for interest payments	5,900
Chelsea Facility
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]
Proceeds from sale of facility	$ 74,000

Summary of Significant Accoun_5

Summary of Significant Accounting Policies - Reconciliation of Cash, Cash Equivalents and Restricted Cash (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021	Mar. 31, 2021	Dec. 31, 2020
Accounting Policies [Abstract]
Cash and cash equivalents	$ 31,873	$ 45,634	$ 116,773	$ 71,369
Restricted cash	13,393	13,400	13,054	12,917
Restricted cash non-current	6,189	6,189	18,609	18,609
Total Cash, cash equivalents and restricted cash per statement of cash flows	$ 51,455	$ 65,223	$ 148,436	$ 102,894

Summary of Significant Accoun_6

Summary of Significant Accounting Policies - Schedule of Major Classes of Inventory (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Inventory Disclosure [Abstract]
Raw materials	$ 3,663	$ 3,338
Finished goods	11,173	15,210
Total	$ 14,836	$ 18,548

Revenue - Additional Informatio

Revenue - Additional Information (Details) - USD ($)	Mar. 31, 2022	Mar. 31, 2021
Revenue From Contract With Customer [Abstract]
Contract Liabilities	$ 5,900,000	$ 0
Contract assets	$ 0	$ 0

Revenue - Disaggregation of Rev

Revenue - Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Disaggregation Of Revenue [Line Items]
Total net revenues	$ 22,534	$ 28,862
Ampyra
Disaggregation Of Revenue [Line Items]
Total net revenues	14,904	20,250
Inbrija
Disaggregation Of Revenue [Line Items]
Total net revenues	3,671	4,996
Other
Disaggregation Of Revenue [Line Items]
Total net revenues		1
Net Product Revenues
Disaggregation Of Revenue [Line Items]
Total net revenues	18,575	25,247
Royalty Revenues
Disaggregation Of Revenue [Line Items]
Total net revenues	$ 3,959	$ 3,615

Share-based Compensation - Addi

Share-based Compensation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Share-based compensation expense recognized	$ 485	$ 707
Weighted average fair value of options granted (in dollars per share)	$ 1.60	$ 3.81
Unrecognized compensation costs for unvested stock options, restricted stock awards and restricted stock units	$ 1,600
Weighted average period	2 years 7 months 6 days
Purchase of Treasury Stock ,Shares	0

Share-based Compensation - Sche

Share-based Compensation - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation expense recognized	$ 485	$ 707
Research and development expense
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation expense recognized	27	166
Selling, general, and administrative expense
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation expense recognized	457	534
Cost of sales
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Share-based compensation expense recognized	$ 1	$ 7

Share-based Compensation - Sc_2

Share-based Compensation - Schedule of Stock Options Activity (Details) shares in Thousands	3 Months Ended
	Mar. 31, 2022$ / sharesshares
Stock Option Activity
Beginning balance (in shares) \| shares	1,186
Granted (in shares) \| shares	25
Cancelled (in shares) \| shares	(129)
Ending balance (in shares) \| shares	1,082
Vested and expected to vest at the end of the period \| shares	1,070
Vested and exercisable at the end of the period \| shares	764
Weighted Average Exercise Price
Balance at the beginning of the period (in dollars per share) \| $ / shares	$ 94.38
Granted (in dollars per share) \| $ / shares	2.30
Cancelled (in dollars per share) \| $ / shares	127.08
Balance at the end of the period (in dollars per share) \| $ / shares	88.31
Vested and expected to vest at the end of the period (in dollars per share) \| $ / shares	89.26
Vested and exercisable at the end of the period (in dollars per share) \| $ / shares	$ 122.60
Weighted Average Remaining Contractual Term
Balance at the end of the period	6 years
Vested and expected to vest at the end of the period	5 years 10 months 24 days
Vested and exercisable at the end of the period	4 years 6 months

Share-based Compensation - Sc_3

Share-based Compensation - Schedule of Restricted Stock and Performance Stock Unit Activity (Details) - Restricted Stock and Performance Stock Unit shares in Thousands	3 Months Ended
	Mar. 31, 2022shares
Restricted Stock and Performance Stock Units
Nonvested at the beginning of the period (in shares)	116
Granted (in shares)	0
Vested (in shares)	(35)
Forfeited (in shares)	(4)
Nonvested at the end of the period (in shares)	77

Loss Per Share - Schedule of Co

Loss Per Share - Schedule of Computation of Basic and Diluted Loss Per Share (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Basic and diluted
Net loss—basic	$ (24,522)	$ (33,451)
Weighted average common shares outstanding used in computing net loss per share—basic	13,251	9,470
Weighted average common shares outstanding used in computing net loss per share—diluted	13,251	9,470
Net loss per share—basic	$ (1.85)	$ (3.53)
Net loss per share—diluted	$ (1.85)	$ (3.53)

Loss Per Share - Schedule of An

Loss Per Share - Schedule of Antidilutive Securities Excluded from Calculation of Net Loss Per Diluted Share (Details) - shares shares in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Stock options and restricted common shares
Antidilutive Securities
Anti-dilutive securities excluded from computation of loss per share (in shares)	1,299	1,391

Income Taxes - Additional Infor

Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Income Tax Disclosure [Abstract]
(Provision for) benefit from income taxes	$ (258)	$ 3,152
Effective income tax rate (as a percent)	(1.10%)	8.60%
Tax Deduction	0.00%

Fair Value Measurements - Addit

Fair Value Measurements - Additional Information (Details)	Sep. 17, 2020USD ($)shares	Dec. 24, 2019	Mar. 31, 2022USD ($)shares	Mar. 31, 2021	Sep. 30, 2020USD ($)	Dec. 31, 2021shares	Aug. 28, 2020shares	Dec. 31, 2019shares
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Notes, interest rate		6.00%
Common stock, Authorized shares \| shares	61,666,666		61,666,666			61,666,666	13,333,333	13,333,333
Derivative liability reclassified to equity	$ 18,300,000
Income tax effects on equity transactions					$ 4,400,000
Inbrija
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Milestone payment, minimum			$ 0
Milestone payment, maximum			$ 23,000,000
Convertible Senior Secured Notes due 2024
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Debt instrument maturity date			2024-12
Notes, interest rate		6.00%		6.00%
Notes, maturity date		Dec. 1, 2024		Dec. 1, 2024
Fair Value, Inputs, Level 2 \| Convertible Senior Secured Notes due 2024
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Convertible senior notes			$ 156,800,000
Level 3 \| Weighted Discounted Cash Flow Valuation Approach \| Discount Rate
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Acquired contingent consideration, measurement input			21.5

Fair Value Measurements - Sched

Fair Value Measurements - Schedule of Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Liabilities Carried at Fair Value:
Derivative liability	$ 7	$ 37
Level 1 \| Recurring basis \| Money Market Funds
Assets Carried at Fair Value:
Assets, Fair Value	12,193	12,192
Level 3 \| Recurring basis
Liabilities Carried at Fair Value:
Acquired contingent consideration	46,400	49,600
Derivative liability	$ 7	$ 37

Fair Value Measurements - Sch_2

Fair Value Measurements - Schedule of Contingent Liabilities (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Assets and liabilities measured at fair value on a recurring basis utilizing Level 3 inputs
Balance, beginning of period	$ 49,600	$ 48,200
Fair value change to contingent consideration included in the statement of operations	(3,023)	(951)
Royalty payments	(177)	(249)
Balance, end of period	$ 46,400	$ 47,000

Fair Value Measurements - Sch_3

Fair Value Measurements - Schedule of Fair Value Reconciliation of Derivative Liability (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Fair Value Reconciliation Of Derivative Liability [Line Items]
Balance, beginning of period	$ 37
Balance, end of period	7
Convertible Senior Secured Notes due 2024
Fair Value Reconciliation Of Derivative Liability [Line Items]
Balance, beginning of period	37	$ 1,193
Fair value adjustment	(30)	225
Balance, end of period	$ 7	$ 1,418

Investments - Additional Inform

Investments - Additional Information (Details) - USD ($)	Mar. 31, 2022	Dec. 31, 2021
Schedule Of Available For Sale Securities [Line Items]
Available-for-sale investments	$ 0	$ 0
Long-term investments	0	0
Short-term investments	0	0
Cash and cash equivalents	31,900,000	45,600,000
Short Term Investments
Schedule Of Available For Sale Securities [Line Items]
Cash and cash equivalents	$ 12,200,000	$ 12,200,000

Liability Related to Sale of _3

Liability Related to Sale of Future Royalties - Additional Information (Details) - Royalty Purchase Agreement - USD ($) $ in Thousands	Oct. 01, 2017	Mar. 31, 2022	Mar. 31, 2021
Liability Related To Sale Of Future Royalties [Line Items]
Payment from royalties	$ 40,000
Royalty liability	40,000
Net of transaction costs	$ 2,200	$ 24	$ 70

Liability Related to Sale of _4

Liability Related to Sale of Future Royalties - Schedule of Activity Within Liability Related to Sale of Future Royalties (Details) - USD ($) $ in Thousands	Oct. 01, 2017	Mar. 31, 2022	Mar. 31, 2021
Liability Related To Sale Of Future Royalties [Line Items]
Non-cash royalty revenue payable to HCRP		$ (2,852)	$ (3,000)
Royalty Purchase Agreement
Liability Related To Sale Of Future Royalties [Line Items]
Liability related to sale of future royalties - beginning balance		4,460	15,257
Deferred transaction costs amortized	$ 2,200	24	70
Non-cash royalty revenue payable to HCRP		(2,852)	(3,000)
Non-cash interest expense recognized		108	330
Liability related to sale of future royalties - ending balance		$ 1,740	$ 12,657

Debt - Additional Information (

Debt - Additional Information (Details)	Sep. 17, 2020USD ($)shares	Dec. 24, 2019USD ($)TradingDay	Mar. 31, 2022USD ($)$ / sharesshares	Mar. 31, 2021USD ($)	Sep. 30, 2020USD ($)	Dec. 31, 2019USD ($)shares	Dec. 31, 2021USD ($)shares	Aug. 28, 2020shares	Jun. 17, 2014USD ($)
Debt Instrument [Line Items]
Interest rate (as a percent)		6.00%
Cash payment made for exchange of notes		$ 200
Aggregate payment on debt exchange		55,200,000
Gain on debt extinguishment						$ 55,100,000
Adjusted equity component of convertible notes exchange						$ 38,400,000
Common stock, Authorized shares \| shares	61,666,666		61,666,666			13,333,333	61,666,666	13,333,333
Derivative liability reclassified to equity	$ 18,300,000
Income tax effects on equity transactions					$ 4,400,000
Interest expense			$ 7,562,000	$ 7,825,000
Convertible Senior Notes due 2021
Debt Instrument [Line Items]
Principal amount of debt exchanged		$ 276,000,000
Interest rate (as a percent)		1.75%							1.75%
Principal amount denomination for debt conversion		$ 1,000
Principal									$ 345,000,000
Debt instrument, principal amount outstanding		$ 69,000,000	69,000,000
Debt issuance costs			7,500,000
Reclassification of derivative liability to equity, net of tax			1,300,000
Debt issuance costs allocated to liability component			6,200,000
Debt issuance cost associated with exchange, written off			1,200,000
Convertible Senior Secured Notes due 2024
Debt Instrument [Line Items]
Interest rate (as a percent)		6.00%		6.00%
Principal amount of debt issued for exchange		$ 750
Principal		$ 207,000,000
Debt instrument, principal amount outstanding			$ 207,000,000				$ 207,000,000
Notes maturity date		Dec. 1, 2024		Dec. 1, 2024
Interest payment in shares, percentage of daily volume-weighted average price		95.00%
Notes frequency of periodic payment			semi-annually in arrears
Interest in shares of common stock, threshold trading days \| TradingDay		10
Initial conversion rate of common stock			47.6190
Initial conversion price of convertible notes into common stock (in dollars per share) \| $ / shares			$ 21
Principal amount of Notes or an integral multiple thereof in which holder may repurchase the Notes			$ 1,000
Reverse stock split, description			1-for-6
Debt instrument conversion threshold stock price percentage		130.00%
Debt repurchase price percentage on principal amount		100.00%
Debt default, non payment of interest, period		30 days
Debt default, failure to convert notes, period		5 days
Debt default, non-compliance with covenants, period		60 days
Fair value of derivative liability		$ 59,400,000	$ 7,000				$ 37,000
Debt discount		$ 75,100,000
Interest expense			6,800,000
Effective interest rate on liability component (as a percent)		18.13%
Debt fair value amount			156,800,000
Debt issuance costs			$ 5,700,000
Convertible Senior Secured Notes due 2024 \| Minimum
Debt Instrument [Line Items]
Debt default, non-payment of outstanding principal		$ 30,000,000
Debt default, failure to pay final judgements		$ 30,000,000
Debt default, percentage of principal outstanding required for immediate payment		25.00%

Debt - Summary of Outstanding N

Debt - Summary of Outstanding Note Balances (Details) - Convertible Senior Secured Notes due 2024 - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021	Dec. 24, 2019
Debt Instrument [Line Items]
Principal	$ 207,000	$ 207,000
Less: debt discount and debt issuance costs, net	(52,236)	(55,975)
Net carrying amount	154,764	151,025
Equity component	18,257	18,257
Derivative liability-conversion option	$ 7	$ 37	$ 59,400

Debt - Schedule of Interest Exp

Debt - Schedule of Interest Expense Recognized Related to the Notes (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Debt Instrument [Line Items]
Total interest expense	$ 7,562	$ 7,825
Convertible Senior Secured Notes due December 2024
Debt Instrument [Line Items]
Contractual interest expense	3,105	3,105
Amortization of debt issuance costs	266	222
Amortization of debt discount	3,474	2,910
Total interest expense	$ 6,845	6,237
Convertible Senior Notes due September 2021
Debt Instrument [Line Items]
Contractual interest expense		302
Amortization of debt issuance costs		52
Amortization of debt discount		507
Total interest expense		$ 861

Leases - Additional Information

Leases - Additional Information (Details) $ in Millions	3 Months Ended	12 Months Ended
Leases - Additional Information (Details) $ in Millions	Mar. 31, 2022USD ($)	Dec. 31, 2021USD ($)	Dec. 31, 2018ft²	Oct. 31, 2016USD ($)ft²	Dec. 31, 2014ft²	Jun. 30, 2011ft²
Operating Lease Information
Operating lease description	Operating lease ROU assets and operating lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. The operating lease ROU asset also includes any lease payments made and excludes lease incentives and initial direct costs incurred, if any. The Company’s leases have remaining lease terms of 0.25 years to 4.75 years. The Company has exercised the option to terminate the Ardsley lease with a termination date of June 22, 2022.
Operating lease renewal option	true
Operating lease termination option	true
Operating lease termination date	Jun. 22, 2022
Operating lease weighted-average remaining lease term	2 years 3 months 18 days
Operating lease weighted-average discount rate	7.13%
Ardsley, New York \| Office and Laboratory Space
Operating Lease Information
Lease term						15 years
Area of leased property \| ft²						138,000
Additional Lease Option Rights Exercised (In Square Feet) \| ft²					25,405
Base rent \| $	$ 2.4
Termination Option Term	--06-22
Termination Fee \| $	$ 4.7
Chelsea, Massachusetts \| Manufacturing Facility
Operating Lease Information
Area of leased property \| ft²			95,000
Contribution Of Fund Agreed \| $		$ 1.5
Waltham, MA \| Office and Laboratory Space
Operating Lease Information
Lease term				10 years
Area of leased property \| ft²				26,000
Base rent \| $				$ 1.2
Minimum
Operating Lease Information
Operating lease remaining lease term	3 months
Maximum [Member]
Operating Lease Information
Operating lease remaining lease term	4 years 9 months

Leases - Schedule of ROU Assets

Leases - Schedule of ROU Assets and Lease Liabilities Related to Operating Leases (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Leases [Abstract]
Right-of-use assets	$ 5,616	$ 6,751
Current lease liabilities	7,036	8,186
Non-current lease liabilities	$ 3,873	$ 4,086

Leases - Components of Lease Co

Leases - Components of Lease Costs (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Leases [Abstract]
Operating lease cost	$ 1,478	$ 1,586
Variable lease cost	860	1,356
Short-term lease cost	1	305
Total lease cost	$ 2,339	$ 3,247

Leases - Schedule of Future Min

Leases - Schedule of Future Minimum Commitments under all Non-Cancelable Operating Leases (Details) $ in Thousands	Mar. 31, 2022USD ($)
Leases [Abstract]
2022 (excluding the three months ended March 31, 2022)	$ 6,792
2023	1,216
2024	1,252
2025	1,290
2026	1,328
Total lease payments	11,877
Less: Imputed interest	(968)
Present value of lease liabilities	$ 10,909

Leases - Summary of Supplementa

Leases - Summary of Supplemental Cash Flow Information Related to Operating Leases (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Operating cash flow information:
Cash paid for amounts included in the measurement of lease liabilities	$ 1,562	$ 1,522

Disposal of Assets - Additional

Disposal of Assets - Additional Information (Details) - USD ($) $ in Millions	1 Months Ended	3 Months Ended
	Jan. 12, 2021	Mar. 31, 2022	Mar. 31, 2021
Long Lived Assets Held For Sale [Line Items]
Estimated fair value of assets held for sale		$ 71.8
Carrying value of the assets held for sale		129.7
Proceeds from completion of divestiture		74
Prepaid Expenses
Long Lived Assets Held For Sale [Line Items]
Carrying value of the assets held for sale		0.1
Property and Equipment
Long Lived Assets Held For Sale [Line Items]
Carrying value of the assets held for sale		129.6
Manufacturing Facility
Long Lived Assets Held For Sale [Line Items]
Loss on assets held for sale		57.9
Catalent \| Chelsea, Massachusetts
Long Lived Assets Held For Sale [Line Items]
Purchase price of assets related to manufacturing activities	$ 80
Additional raw materials purchase price	$ 2.3
Catalent \| Leases
Long Lived Assets Held For Sale [Line Items]
Carrying value of the assets held for sale		$ (0.5)
Loss on assets held for sale			$ 0.5

Corporate Restructuring - Addit

Corporate Restructuring - Additional Information (Details) - USD ($) $ in Thousands	Jan. 31, 2021	Mar. 31, 2022	Sep. 30, 2021
Restructuring Cost And Reserve [Line Items]
Approximate percentage of headcount reduction	16.00%		15.00%
Restructuring Charges For Severance And Other Employee Separation Related Cost		$ 226
Selling, general, and administrative expense
Restructuring Cost And Reserve [Line Items]
Restructuring Charges For Severance And Other Employee Separation Related Cost		$ 200

Corporate Restructuring - Summa

Corporate Restructuring - Summary of Restructuring Charges (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2022USD ($)
Restructuring And Related Activities [Abstract]
Restructuring Liability	$ 1,851
Restructuring Charges For Severance And Other Employee Separation Related Cost	226
Restructuring Payments	(1,700)
Restructuring Liability	$ 377

Commitments and Contingencies -

Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021	Dec. 31, 2020
Loss Contingencies [Line Items]
Commitments and contingencies
Cost of sales	5,967	$ 11,961
Inventory, net	14,836		18,548
Catalent
Loss Contingencies [Line Items]
Cost of sales	300
Inventory, net	1,100
Minimum purchase commitment	1,400
Purchase Commitment, Remaining Minimum Amount Committed	9,000
Purchase Commitment Remaining Minimum Amount Committed There After	18,000
Catalent \| Inbrija
Loss Contingencies [Line Items]
Purchase Obligation			16,000
Purchase Obligation from 2022 through 2030			18,000
Cash			5,300
Reimburse cost	1,500
Minimum \| Catalent \| Inbrija
Loss Contingencies [Line Items]
Original Purchase Obligation			$ 17,000
Licensing Agreements
Loss Contingencies [Line Items]
Commitments and contingencies				$ 2,000
Unpaid license royalties	6,000
Licensing Agreements \| Maximum [Member]
Loss Contingencies [Line Items]
Commitment legal cost	$ 2,000