Rockwell Medical (RMTI) 10-Q15 May 232023 Q1 Quarterly reportFinancial data

Company Profile

Cover

Cover - shares	3 Months Ended
Cover - shares	Mar. 31, 2023	May 12, 2023
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Mar. 31, 2023
Document Transition Report	false
Entity File Number	000-23661
Entity Registrant Name	ROCKWELL MEDICAL, INC.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	38-3317208
Entity Address, Address Line One	30142 S. Wixom Road
Entity Address, City or Town	Wixom
Entity Address, State or Province	MI
Entity Address, Postal Zip Code	48393
City Area Code	248
Local Phone Number	960-9009
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Title of 12(b) Security	Common Stock, par value $0.0001
Trading Symbol	RMTI
Security Exchange Name	NASDAQ
Entity Common Stock, Shares Outstanding (in shares)		13,743,673
Entity Central Index Key	0001041024
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	Q1

CONDENSED CONSOLIDATED BALANCE

CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
ASSETS
Cash and Cash Equivalents	$ 10,894	$ 10,102
Investments Available-for-Sale	5,940	11,390
Accounts Receivable, net	6,021	6,259
Inventory	5,595	5,814
Prepaid and Other Current Assets	1,240	1,745
Total Current Assets	29,690	35,310
Property and Equipment, net	2,179	2,194
Inventory, Non-Current	1,276	1,276
Right of Use Assets-Operating, net	3,558	3,943
Right of Use Assets-Financing, net	2,326	2,468
Goodwill	921	921
Other Non-Current Assets	522	523
Total Assets	40,472	46,635
LIABILITIES AND STOCKHOLDERS’ EQUITY
Accounts Payable	5,202	4,053
Accrued Liabilities	4,359	7,702
Lease Liability-Operating - Current	1,473	1,483
Lease Liability-Financing - Current	532	522
Deferred License Revenue - Current	259	1,731
Term Loan - Net of Issuance Costs	3,131	1,631
Insurance Financing Note Payable	0	503
Customer Deposits	114	66
Total Current Liabilities	15,070	17,691
Lease Liability-Operating - Long-Term	2,214	2,581
Lease Liability-Financing - Long-Term	1,950	2,088
Term Loan, Net of Issuance Costs	6,147	7,555
Deferred License Revenue - Long-Term	2,535	2,600
Long Term Liability - Other	14	14
Total Liabilities	27,930	32,529
Stockholders’ Equity:
Preferred Stock, $0.0001 par value, 2,000,000 shares authorized; 15,000 shares issued and outstanding at March 31, 2023 and December 31, 2022, respectively	0	0
Common Stock, $0.0001 par value; 170,000,000 shares authorized; 12,552,673 and 12,163,673 shares issued and outstanding at March 31, 2023 and December 31, 2022, respectively	1	1
Additional Paid-in Capital	402,894	402,701
Accumulated Deficit	(390,509)	(388,759)
Accumulated Other Comprehensive Income	156	163
Total Stockholders’ Equity	12,542	14,106
Total Liabilities and Stockholders’ Equity	$ 40,472	$ 46,635
Preferred shares, shares issued (in shares)	15,000	15,000
Preferred shares, shares outstanding (in shares)	15,000	15,000

CONDENSED CONSOLIDATED BALANC_2

CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares	Mar. 31, 2023	Dec. 31, 2022	Mar. 31, 2022
Statement of Financial Position [Abstract]
Preferred shares, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred shares, shares authorized (in shares)	2,000,000	2,000,000
Preferred shares, shares issued (in shares)	15,000	15,000
Preferred shares, shares outstanding (in shares)	15,000	15,000
Common shares, par value (in dollars per share)	$ 0.0001	$ 0.0001
Common shares, shares authorized (in shares)	170,000,000	170,000,000
Common shares, shares issued (in shares)	12,552,673	12,163,673
Common shares, shares outstanding (in shares)	12,552,673	12,163,673	8,544,225

UNAUDITED CONDENSED CONSOLIDATE

UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Income Statement [Abstract]
Net Sales	$ 19,668	$ 16,124
Cost of Sales	17,069	16,910
Gross Profit (Loss)	2,599	(786)
Research and Product Development	278	1,567
Selling and Marketing	498	455
General and Administrative	3,250	3,818
Operating Loss	(1,427)	(6,626)
Other (Expense) Income
Realized Gain on Investments	0	4
Interest Expense	(387)	(540)
Interest Income	64	0
Total Other Expense	(323)	(536)
Net Loss	$ (1,750)	$ (7,162)
Basic Net Loss per Share (in dollars per share)	$ (0.10)	$ (0.84)
Diluted Net Loss per Share (in dollars per share)	$ (0.10)	$ (0.84)
Basic Weighted Average Shares Outstanding (in shares)	18,359,940	8,544,225
Diluted Weighted Average Shares Outstanding (in shares)	18,359,940	8,544,225

UNAUDITED CONDENSED CONSOLIDA_2

UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Statement of Comprehensive Income [Abstract]
Net Income (Loss) Attributable to Parent	$ (1,750)	$ (7,162)
Unrealized Loss on Available-for-Sale Debt Instrument Investments	(3)	0
Foreign Currency Translation Adjustments	(4)	(1)
Comprehensive Loss	$ (1,757)	$ (7,163)

UNAUDITED CONDENSED CONSOLIDA_3

UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	PREFERRED STOCK	COMMON STOCK	ADDITIONAL PAID-IN CAPITAL	ACCUMULATED DEFICIT	ACCUMULATED OTHER COMPREHENSIVE INCOME
Beginning balance (in shares) at Dec. 31, 2021			8,544,225
Beginning balance at Dec. 31, 2021	$ 2,535		$ 1	$ 372,562	$ (370,080)	$ 52
Increase (Decrease) in Shareholders' Equity
Net Income (Loss) Attributable to Parent	(7,162)				(7,162)
Unrealized Loss on Available-for-Sale Debt Instrument Investments	0
Foreign Currency Translation Adjustments	(1)					(1)
Stock-based Compensation and modification expense	$ (179)			(179)
Ending balance (in shares) at Mar. 31, 2022	8,544,225		8,544,225
Ending balance at Mar. 31, 2022	$ (4,807)		$ 1	372,383	(377,242)	51
Beginning balance (in shares) at Dec. 31, 2022	15,000	15,000
Beginning balance (in shares) at Dec. 31, 2022	12,163,673		12,163,673
Beginning balance at Dec. 31, 2022	$ 14,106		$ 1	402,701	(388,759)	163
Increase (Decrease) in Shareholders' Equity
Net Income (Loss) Attributable to Parent	(1,750)				(1,750)	0
Unrealized Loss on Available-for-Sale Debt Instrument Investments	(3)					(3)
Foreign Currency Translation Adjustments	(4)					(4)
Issuance of common stock upon exercise of prefunded warrants (in shares)			389,000
Stock-based Compensation and modification expense	$ 193			193
Ending balance (in shares) at Mar. 31, 2023	15,000	15,000
Ending balance (in shares) at Mar. 31, 2023	12,552,673		12,552,673
Ending balance at Mar. 31, 2023	$ 12,542		$ 1	$ 402,894	$ (390,509)	$ 156

UNAUDITED CONDENSED CONSOLIDA_4

UNAUDITED CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Cash Flows From Operating Activities:
Net Income (Loss) Attributable to Parent	$ (1,750)	$ (7,162)
Adjustments To Reconcile Net Loss To Net Cash Used In Operating Activities:
Depreciation and Amortization	160	138
Stock-based Compensation	193	(179)
Non-cash lease expense from Right of Use Asset	485	520
Amortization of Debt Financing Costs and Accretion of Debt Discount	92	92
Loss on Disposal of Assets	1	0
Realized Gain on Sale of Investments Available-for-Sale	0	(4)
Changes in operating Assets and Liabilities:
Accounts Receivable, net	238	(1,208)
Inventory	219	(1,455)
Prepaid and Other Assets	505	630
Accounts Payable	1,149	485
Lease Liability	(336)	(490)
Other Liabilities	(3,295)	(640)
Deferred License Revenue	(1,537)	(538)
Changes in operating Assets and Liabilities	(3,057)	(3,216)
Cash Used In Operating Activities	(3,876)	(9,811)
Cash Flows From Investing Activities:
Purchase of Investments Available-for-Sale	(2,053)	(2,810)
Sale of Investments Available-for-Sale	7,500	11,972
Purchase of Equipment	(145)	(29)
Cash Provided by Investing Activities	5,302	9,133
Cash Flows From Financing Activities:
Payments on Debt	0	(2,250)
Payments on Insurance Financing Note Payable	(503)	(437)
Payment on Financing Lease Liabilities	(128)	0
Cash Used In Financing Activities	(631)	(2,687)
Effect of exchange rate changes on cash	(3)	(1)
Increase (Decrease) in Cash and Cash Equivalents	792	(3,366)
Cash and Cash Equivalents at Beginning of Period	10,102	13,280
Cash and Cash Equivalents at End of Period	10,894	9,914
Supplemental Disclosure of Cash Flow Information:
Cash Paid for Interest	295	461
Supplemental Disclosure of Noncash Investing and Financing Activities:
Change in Unrealized Loss on Marketable Securities Available-for-Sale	$ (3)	$ 0

Description of Business

Description of Business	3 Months Ended
Description of Business	Mar. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Description of Business	Description of Business Rockwell Medical, Inc. (the "Company", "Rockwell", "we", or "us") is a healthcare company that develops, manufactures, commercializes, and distributes a portfolio of hemodialysis products for dialysis providers worldwide. Rockwell is a revenue-generating business and the second largest supplier of acid and bicarbonate concentrates for dialysis patients in the United States. Hemodialysis is the most common form of end-stage kidney disease treatment and is usually performed at freestanding outpatient dialysis centers, at hospital-based outpatient centers, at skilled nursing facilities, or in a patient’s home. Rockwell provides the hemodialysis community with products controlled by a Quality Management System regulated by the U.S. Food and Drug Administration ("FDA"). Rockwell is ISO 13485 Certified and adheres to current Good Manufacturing Practices ("cGMP") and Association for Advancement of Medical Instrumentation ("AAMI") standards. Rockwell manufactures hemodialysis concentrates at its three facilities in Michigan, Texas, and South Carolina totaling approximately 175,000 square feet, and manufactures its dry acid concentrate mixers at its facility in Iowa. Rockwell delivers the majority of its hemodialysis concentrates products and mixers to dialysis clinics throughout the United States and internationally utilizing its own delivery trucks and third-party carriers. In addition to its primary focus on hemodialysis concentrates, Rockwell also has a proprietary parenteral iron product, Triferic ® (ferric pyrophosphate citrate ("FPC")), which is indicated to maintain hemoglobin in adult patients with hemodialysis-dependent chronic kidney disease. While Rockwell has discontinued commercialization of Triferic in the United States, the Company has established several international partnerships with companies seeking to develop and commercialize Triferic outside the United States and is working closely with these international partners to develop and commercialize Triferic in their respective regions. Additionally, Rockwell continues to evaluate the viability of its FPC platform and FPC's potential to treat iron deficiency, iron deficiency anemia, and acute heart failure. Rockwell was incorporated in the state of Michigan in 1996 and re-domiciled to the state of Delaware in 2019. Rockwell's headquarters is located at 30142 Wixom Road, Wixom, Michigan 48393.

Liquidity and Capital Resources

Liquidity and Capital Resources	3 Months Ended
Liquidity and Capital Resources	Mar. 31, 2023
Liquidity and Going Concern Considerations [Abstract]
Liquidity and Capital Resources	Liquidity and Capital Resources As of March 31, 2023, Rockwell had approximately $16.8 million of cash, cash equivalents and investments available-for-sale, and working capital of $14.6 million. Net cash used in operating activities for the three months ended March 31, 2023 was approximately $3.9 million. Based on the currently available working capital, management believes the Company currently has sufficient funds to meet its operating requirements for at least the next twelve months from the date of the filing of this report. The Company continues to review its operational plans, execute on the acquisition of new customers and cost containment activities. The Company may require additional capital to sustain its operations and make the investments it needs to execute its strategic plan. Additionally, the Company's operational plans include raising capital, if needed, by using its at-the-market ("ATM") facility or other methods or forms of financings, subject to existing limitations. If the Company attempts to obtain additional debt or equity financing, the Company cannot assume such financing will be available on favorable terms, if at all. Currently, because the Company's public float is less than $75 million, it is subject to the baby shelf limitations under Form S-3, which limit the amount the Company may offer pursuant to its registration statement on Form S-3. In addition, the Company is subject to certain covenants and cure provisions under its Loan Agreement with Innovatus. As of the date of this report, the Company is in compliance with all covenants (See Note 14 for further detail). In addition, the global macroeconomic environment is uncertain, and could be negatively affected by, among other things, increased U.S. trade tariffs and trade disputes with other countries, instability in the global capital and credit markets, recent bank failures in the United States, supply chain weaknesses, and instability in the geopolitical environment, including as a result of the Russian invasion of Ukraine and other political tensions, and lingering effects of the COVID-19 pandemic. Such challenges have caused, and may continue to cause, recession fears, rising interest rates, foreign exchange volatility and inflationary pressures. At this time, the Company is unable to quantify the potential effects of this economic instability on our future operations. Rockwell has utilized a range of financing methods to fund its operations in the past; however, current conditions in the financial and credit markets may limit the availability of funding, refinancing or increase the cost of funding. Due to the rapidly evolving nature of the global situation, it is not possible to predict the extent to which these conditions could adversely affect the Company's liquidity and capital resources in the future.

Basis of Presentation, Summary

Basis of Presentation, Summary of Significant Accounting Policies and Recent Accounting Pronouncements	3 Months Ended
	Mar. 31, 2023
Accounting Policies [Abstract]
Basis of Presentation, Summary of Significant Accounting Policies and Recent Accounting Pronouncements	Basis of Presentation, Summary of Significant Accounting Policies and Recent Accounting Pronouncements The accompanying condensed consolidated financial statements have been prepared in accordance with the accounting principles generally accepted in the United States of America (“U.S. GAAP”) for interim financial information and pursuant to the instructions to Form 10-Q and Rule 10-01 of Regulation S-X of the U. S. Securities and Exchange Commission (“SEC”) and on the same basis as the Company prepares its annual audited consolidated financial statements. The condensed consolidated balance sheet at March 31, 2023, and the condensed consolidated statements of operations, comprehensive loss, changes in stockholders' equity, and cash flows for the three months ended March 31, 2023 and 2022 are unaudited, but include all adjustments, consisting of normal recurring adjustments the Company considers necessary for a fair presentation of the financial position, operating results and cash flows for the periods presented. The results for the three months ended March 31, 2023 are not necessarily indicative of results to be expected for the year ending December 31, 2023 or for any future interim period. The condensed consolidated balance sheet at December 31, 2022 has been derived from audited financial statements, however, it does not include all of the information and notes required by U.S. GAAP for complete financial statements. The accompanying condensed consolidated financial statements should be read in conjunction with the audited financial statements for the year ended December 31, 2022 and notes thereto included in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2022 as filed with the SEC on March 30, 2023. The Company’s consolidated subsidiaries consist of its wholly-owned subsidiaries, Rockwell Transportation, Inc. and Rockwell Medical India Private Limited. The accompanying condensed consolidated interim financial statements include the accounts of the Company and its subsidiaries. All material intercompany balances and transactions have been eliminated in consolidation. Reverse Stock Split On May 9, 2022, the stockholders of the Company authorized the Board of Directors to effect a reverse stock split of all outstanding shares of common stock. The Board of Directors subsequently approved the implementation of a reverse stock split as a ratio of one-for-eleven shares, which became effective on May 13, 2022. The Company’s outstanding stock options were also adjusted to reflect the one-for-eleven reverse stock split of the Company’s common stock. Outstanding stock options were proportionately reduced and the respective exercise prices, if applicable, were proportionately increased. The reverse stock split resulted in an adjustment to the Series X convertible preferred stock conversion prices to reflect a proportional decrease in the number of shares of common stock to be issued upon conversion. All share and per share data in these condensed consolidated financial statements and related notes hereto have been retroactively adjusted to account for the effect of the reverse stock split. Use of Estimates The preparation of the condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that may affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and reported amounts of expenses during the reporting period. Actual results could differ from those estimates. Leases The Company accounts for its leases under Accounting Standards Codification (“ASC”) 842, Leases . Under this guidance, arrangements meeting the definition of a lease are classified as operating or financing leases and are recorded on the consolidated balance sheet as both a right-of-use asset and lease liability, calculated by discounting fixed lease payments over the lease term at the rate implicit in the lease or the Company’s incremental borrowing rate. Lease liabilities are increased by interest and reduced by payments each period, and the right-of-use asset is amortized over the lease term. For operating leases, interest on the lease liability and the amortization of the right-of-use asset result in straight-line rent expense over the lease term. Variable lease expenses, if any, are recorded when incurred. In calculating the right-of-use asset and lease liability, the Company elects to combine lease and non-lease components. The Company excludes short-term leases having initial terms of 12 months or less as an accounting policy election and recognizes rent expense on a straight-line basis over the lease term. Loss Per Share Basic and diluted net loss per share for the three months ended March 31, 2023 and 2022 was calculated as follows: As of March 31, (In Thousands, Except Shares and Per Share Amounts) 2023 2022 Numerator: Net loss $ (1,750) $ (7,162) Net loss attributable to common stockholders for basic and diluted loss per share $ (1,750) $ (7,162) Denominator: Weighted average number of shares of common stock outstanding - basic and diluted 18,359,940 8,544,225 Net loss per share attributable to common stockholders - basic and diluted $ (0.10) $ (0.84) Included within the weighted average shares of common stock outstanding for the three months ended March 31, 2023 and 2022, are 5,911,000 and nil, respectively, of shares of common stock issuable upon the exercise of the pre-funded warrants (see Note 10), as the warrants are exercisable at any time for nominal consideration, and as such, the shares are considered outstanding for the purpose of calculating basic and diluted net loss per share attributable to common stockholders. The Company’s potentially dilutive securities include stock options, restricted stock awards and units, convertible preferred stock and warrants. These securities were excluded from the computations of diluted net loss per share for the three months ended March 31, 2023 and 2022, as the effect would be to reduce the net loss per share. The following table includes the potential shares of common stock, presented based on amounts outstanding at each period end, that were excluded from the computation of diluted net loss per share attributable to common stockholders for the periods indicated because including them would have had an anti-dilutive effect: As of March 31, 2023 2022 Options to purchase common stock 1,194,202 511,117 Unvested restricted stock awards 891 891 Unvested restricted stock units 125,000 28,066 Convertible Preferred Stock 1,363,636 — Warrants to purchase common stock 10,196,268 2,402,442 Total 12,879,997 2,942,516 Adoption of Recent Accounting Pronouncements The Company continually assesses new accounting pronouncements to determine their applicability. When it is determined a new accounting pronouncement affects the Company’s financial reporting, the Company undertakes a review to determine the consequences of the change to its consolidated financial statements and assures there are sufficient controls in place to ascertain the Company’s consolidated financial statements properly reflect the change. In June 2016, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update ("ASU") 2016-13, "Financial Instruments - Credit Losses (Topic 326)," which introduced an impairment model that is based on expected credit losses, rather than incurred losses, to estimate credit losses on certain types of financial instruments (e.g., loan commitments). The expected credit losses should consider historical information, current information, and reasonable and supportable forecasts, including estimates of prepayments, over the contractual term. Financial instruments with similar risk characteristics may be grouped together when estimating expected credit losses. The Company adopted the new guidance, as of January 1, 2023, and it did not have a material impact on the Condensed Consolidated Financial Statements.

Revenue Recognition

Revenue Recognition	3 Months Ended
Revenue Recognition	Mar. 31, 2023
Revenue from Contract with Customer [Abstract]
Revenue Recognition	Revenue Recognition The Company recognizes revenue under ASC 606, Revenue from Contracts with Customers. The core principle of the new revenue standard is that a company should recognize revenue to depict the transfer of promised goods or services to customers in an amount that reflects the consideration to which the company expects to be entitled in exchange for those goods or services. The following five steps are applied to achieve that core principle: • Step 1: Identify the contract with the customer • Step 2: Identify the performance obligations in the contract • Step 3: Determine the transaction price • Step 4: Allocate the transaction price to the performance obligations in the contract • Step 5: Recognize revenue when the company satisfies a performance obligation Taxes assessed by a governmental authority that are both imposed on and concurrent with a specific revenue-producing transaction, that are collected by us from a customer, are excluded from revenue. Shipping and handling costs associated with outbound freight related to contracts with customers are accounted for as a fulfillment cost and are included in cost of sales when control of the goods transfers to the customer. Nature of goods and services The following is a description of principal activities from which the Company generates its revenue. We currently operate in one market segment, the hemodialysis market, which involves the manufacture, sale and distribution of hemodialysis products to hemodialysis clinics, including pharmaceutical, dialysis concentrates, dialysis kits and other ancillary products used in the dialysis process. Our customer mix is diverse with most customer sales concentrations under 10% and one customer, DaVita, Inc., at approximately 48%. Our accounts receivable from this customer were approximately 34% of the outstanding balance at March 31, 2023. Product sales – The Company accounts for individual products and services separately if they are distinct (i.e., if a product or service is separately identifiable from other items and if a customer can benefit from it on its own or with other resources that are readily available to the customer). The consideration, including any discounts, is allocated between separate products and services based on their stand-alone selling prices. The stand-alone selling prices are determined based on the cost plus margin approach. Drug and dialysis concentrates products are sold directly to dialysis clinics and to wholesale distributors in both domestic and international markets. Distribution and license agreements for which upfront fees are received are evaluated upon execution or modification of the agreement to determine if the agreement creates a separate performance obligation from the underlying product sales. For all existing distribution and license agreements, the distribution and license agreement is not a distinct performance obligation from the product sales. In instances where regulatory approval of the product has not been established and the Company does not have sufficient experience with the foreign regulatory body to conclude regulatory approval is probable, the revenue for the performance obligation is recognized over the term of the license agreement (over time recognition). Conversely, when regulatory approval already exists or is probable, revenue is recognized at the point in time control of the product transfers to the customer. The Company received upfront fees under five distribution and license agreements that have been deferred as a contract liability. The amounts received from Wanbang Biopharmaceuticals Co., Ltd. (“Wanbang”), Sun Pharmaceutical Industries Ltd. ("Sun Pharma"), Jeil Pharmaceutical Co., Ltd. ("Jeil Pharma") and Drogsan Pharmaceuticals ("Drogsan Pharma") are recognized as revenue over the estimated term of the applicable distribution and license agreement as regulatory approval was not received and the Company did not have sufficient experience in China, India, South Korea and Turkey, respectively, to determine regulatory approval was probable as of the execution of the agreement. The amounts received from Baxter Healthcare Corporation (“Baxter”) were recognized as revenue at the point in time the estimated product sales under the agreement occurred. On November 9, 2022, Rockwell reacquired its distribution rights to its hemodialysis concentrates products from Baxter and terminated the Distribution Agreement. Under the Distribution Agreement, effective December 31, 2022, Baxter distributed and commercialized Rockwell’s hemodialysis concentrates products and provided customer service and order delivery to nearly all United States customers. Following the reacquisition of these rights, Rockwell is now unrestricted in its ability to sell its hemodialysis concentrates products to dialysis clinics throughout the United States and around the world. Rockwell agreed to pay Baxter a fee for the reacquisition of its distribution rights. This fee was payable in two equal installments on January 1, 2023 and April 1, 2023. As of March 31, 2023, the April 1, 2023 installment has been recorded as a component of accrued liabilities and other current liabilities on the accompanying condensed consolidated balance sheet. To ensure that customer needs continue to be met after January 1, 2023, Baxter and Rockwell worked closely together to transition customers’ purchases of Rockwell’s hemodialysis concentrates from Baxter to Rockwell. For the majority of the Company’s U.S. and international customers, the Company recognizes revenue at the shipping point, which is generally the Company’s plant or warehouse. For other business, the Company recognizes revenue based on when the customer takes control of the product. The amount of revenue recognized is based on the purchase order less returns and adjusted for any rebates, discounts, chargebacks or other amounts paid to customers. There were no such adjustments for the periods reported. Customers typically pay for the product based on customary business practices with payment terms averaging 30 days, while a small subset of customers have payment terms averaging 60 days. Disaggregation of revenue Revenue is disaggregated by primary geographical market, major product line, and timing of revenue recognition. In thousands of U.S. dollars ($) Three Months Ended March 31, 2023 Products By Geographic Area Total U.S. Rest of World Drug Revenues Product Sales – Point-in-time $ — $ — $ — License Fee – Over time 65 — 65 Total Drug Products 65 — 65 Concentrates Products Product Sales – Point-in-time 18,131 16,459 1,672 License Fee – Over time 1,472 1,472 — Total Concentrate Products 19,603 17,931 1,672 Net Revenue $ 19,668 $ 17,931 $ 1,737 In thousands of U.S. dollars ($) Three Months Ended March 31, 2022 Products By Geographic Area Total U.S. Rest of World Drug Revenues Product Sales – Point-in-time $ 159 $ 159 $ — License Fee – Over time 62 — 62 Total Drug Products 221 159 62 Concentrates Products Product Sales – Point-in-time 15,427 13,810 1,617 License Fee – Over time 476 476 — Total Concentrate Products 15,903 14,286 1,617 Net Revenue $ 16,124 $ 14,445 $ 1,679 Contract balances The following table provides information about receivables, contract assets, and contract liabilities from contracts with customers. In thousands of U.S. dollars ($) March 31, 2023 December 31, 2022 Accounts Receivable, net $ 6,021 $ 6,259 Contract liabilities, which are included in Deferred revenue $ 2,794 $ 4,331 There were no bad debt expenses recognized related to any receivables arising from the Company’s contracts with customers for the three months ended March 31, 2023 and 2022. For the three months ended March 31, 2023 and March 31, 2022, the Company did not recognize any material bad-debt expense. There were no material contract assets recorded on the condensed consolidated balance sheet as of March 31, 2023 and December 31, 2022. The Company does not generally accept returns of its concentrates products and no material reserve for returns of concentrates products was established as of March 31, 2023 or December 31, 2022. The contract liabilities primarily relate to upfront payments and consideration received from customers in advance of the customer assuming control of the related products. Transaction price allocated to remaining performance obligations For the three months ended March 31, 2023, revenue recognized from performance obligations related to prior periods was not material.

Investments - Available-for-Sal

Investments - Available-for-Sale	3 Months Ended
Investments - Available-for-Sale	Mar. 31, 2023
Investments, Debt and Equity Securities [Abstract]
Investments - Available-for-Sale	Investments - Available-for-Sale Investments available-for-sale consisted of the following as of March 31, 2023 and December 31, 2022 (table in thousands): March 31, 2023 Amortized Cost Unrealized Gain Unrealized Loss Accrued Interest Fair Value Available-for-Sale Securities Debt securities $ 5,868 $ 72 $ — $ — $ 5,940 December 31, 2022 Amortized Cost Unrealized Gain Unrealized Loss Accrued Interest Fair Value Available-for-Sale Securities Debt securities $ 11,315 $ 75 $ — $ — $ 11,390 The fair value of investments available-for-sale are determined using quoted market prices from daily exchange-traded markets based on the closing price as of the balance sheet date and are classified as a Level 1 measurement under ASC 820 Fair Value Measurements. As of March 31, 2023 and December 31, 2022, the amortized cost and estimated fair value of our available-for-sale securities were all due within one year.

Inventory

Inventory	3 Months Ended
Inventory	Mar. 31, 2023
Inventory Disclosure [Abstract]
Inventory	Inventory Components of inventory, net of reserves, as of March 31, 2023 and December 31, 2022 are as follows (table in thousands): March 31, December 31, Inventory - Current Portion Raw Materials $ 2,806 $ 3,351 Work in Process 504 351 Finished Goods 2,285 2,112 Total Current Inventory 5,595 5,814 Inventory - Long Term 1,276 1,276 Total Inventory $ 6,871 $ 7,090 As of both March 31, 2023 and December 31, 2022, the Company classified $1.3 million of inventory as non-current, all of which was related to Triferic raw materials. This Triferic inventory will be utilized for the Company's international partnerships. The Company has discontinued its New Drug Applications ("NDAs") for Triferic (dialysate) and Triferic AVNU in the United States. As of both March 31, 2023 and December 31, 2022, the total Triferic inventory net of reserve was $1.3 million. As of March 31, 2023 and December 31, 2022, Rockwell had total Concentrate inventory aggregating $5.6 million and $5.8 million, respectively, against which Rockwell had reserved $25,000 for both periods.

Property and Equipment, net

Property and Equipment, net	3 Months Ended
Property and Equipment, net	Mar. 31, 2023
Property, Plant and Equipment [Abstract]
Property and Equipment, net	Property and Equipment, net As of March 31, 2023 and December 31, 2022, the Company’s property and equipment consisted of the following (table in thousands): March 31, December 31, Leasehold Improvements $ 1,322 $ 1,256 Machinery and Equipment 6,001 5,922 Information Technology & Office Equipment 1,845 1,845 Laboratory Equipment 807 807 Total Property and Equipment 9,975 9,830 Accumulated Depreciation (7,796) (7,636) Property and Equipment, net $ 2,179 $ 2,194 Depreciation expense for the three months ended March 31, 2023 and 2022 was $0.2 million and $0.1 million respectively.

Accrued Liabilities

Accrued Liabilities	3 Months Ended
Accrued Liabilities	Mar. 31, 2023
Payables and Accruals [Abstract]
Accrued Liabilities	Accrued Liabilities Accrued liabilities as of March 31, 2023 and December 31, 2022 consisted of the following (table in thousands): March 31, December 31, Accrued Research & Development Expense $ — $ 43 Accrued Compensation and Benefits 1,804 2,568 Accrued Unvouchered Receipts 358 585 Accrued Workers Compensation 303 306 Other Accrued Liabilities 1,894 4,200 Total Accrued Liabilities $ 4,359 $ 7,702

Deferred Revenue

Deferred Revenue	3 Months Ended
Deferred Revenue	Mar. 31, 2023
Revenue from Contract with Customer [Abstract]
Deferred Revenue	Deferred Revenue In October 2014, the Company entered into the Baxter Agreement, which had a term of 10 years and received an upfront fee of $20 million. The upfront fee was recorded as deferred revenue and was being recognized based on the proportion of product shipments to Baxter in each period, compared with total expected sales volume over the term of the Distribution Agreement. On November 9, 2022, Rockwell reacquired its distribution rights to its hemodialysis concentrates products from Baxter and terminated the Distribution Agreement. Exclusivity and other provisions associated with the distribution agreement terminated November 9, 2022 and the remaining operational elements of the agreement terminated December 31, 2022. Rockwell agreed to provide certain services to a group of Baxter's customers until March 31, 2023. Under the Distribution Agreement, Baxter distributed and commercialized Rockwell’s hemodialysis concentrates products and provided customer service and order delivery to nearly all United States customers. Following the reacquisition of these rights, Rockwell is now unrestricted in its ability to sell its hemodialysis concentrates products to dialysis clinics throughout the United States and around the world. The Company recognized the remaining revenue of $1.5 million during the three months ended March 31, 2023. In 2016, the Company entered into a distribution agreement with Wanbang (the "Wanbang Agreement") and received an upfront fee of $4.0 million. The upfront fee was recorded as deferred revenue and is being recognized as revenue based on the agreement term. The Company recognized revenue of approximately $0.1 million for both the three months ended March 31, 2023 and 2022. Deferred revenue related to the Wanbang Agreement totaled $2.3 million as of March 31, 2023 and $2.5 million as of December 31, 2022. In January 2020, the Company entered into license and supply agreements with Sun Pharma (the "Sun Pharma Agreements"), for the rights to commercialize Triferic (dialysate) in India. In consideration for the license, the Company received an upfront fee of $0.1 million. The upfront fee was recorded as deferred revenue and is being recognized as revenue based on the agreement term. The Company recognized revenue of approximately $2,500 for both the three months ended March 31, 2023 and 2022. Deferred revenue related to the Sun Pharma Agreement totaled $67,500 and $70,000 as of March 31, 2023 and December 31, 2022, respectively. In September 2020, the Company entered into a license and supply agreements with Jeil Pharmaceutical (the "Jeil Agreements"), for the rights to commercialize Triferic (dialysate) in South Korea. In consideration for the license, the Company received an upfront fee of $0.2 million. In May 2022, Jeil Pharmaceutical obtained regulatory approval in South Korea and paid the Company $0.2 million in consideration of reaching the milestone. The upfront fee and milestone payments were recorded as deferred revenue and are being recognized as revenue based on the agreement term. The Company recognized revenue of $5,200 and $2,500 for the three months ended March 31, 2023 and 2022, respectively. Deferred revenue related to the Jeil Agreement totaled approximately $0.4 million and $0.2 million as of March 31, 2023 and December 31, 2022 respectively. In June 2021, the Company entered into license and supply agreements with Drogsan Pharmaceuticals (the "Drogsan Agreements"), for the rights to commercialize Triferic (dialysate) and Triferic AVNU in Turkey. In consideration for the license, the Company received an upfront fee of $0.15 million. The upfront fee was recorded as deferred revenue and will be recognized as revenue based on the agreement term. The Company recognized revenue of $3,750 for both the three months ended March 31, 2023 and 2022. Deferred revenue related to the Drogsan Agreements totaled approximately $123,750 and $127,500 as of March 31, 2023 and December 31, 2022, respectively.

Stockholders_ Equity

Stockholders’ Equity	3 Months Ended
Stockholders’ Equity	Mar. 31, 2023
Equity [Abstract]
Stockholders' Equity	Stockholders’ Equity Preferred Stock On April 6, 2022, the Company and DaVita entered into the Securities Purchase Agreement (the "SPA"), which provided for the issuance by the Company of up to $15 million of preferred stock to DaVita. On April 6, 2022, the Company issued 7,500 shares of Series X Preferred Stock for gross proceeds of $7.5 million. On June 16, 2022 the Company issued an additional 7,500 shares of the Series X Preferred Stock to DaVita for gross proceeds of $7.5 million. The Series X Preferred Stock was issued for a price of $1,000 per share (the "Face Amount"), subject to accretion at a rate of 1% per annum, compounded annually. If the Company’s common stock trades above $22.00 for a period of 30 calendar days, the accretion will thereafter cease. The Series X Convertible Preferred Stock is convertible to common stock at rate equal to the Face Amount, divided by a conversion price of $11.00 per share (subject to adjustment for future stock splits, reverse stock splits and similar recapitalization events). As a result, each share of Series X Preferred Stock will initially convert into approximately 91 shares of common stock. DaVita’s right to convert to common stock is subject to a beneficial ownership limitation, which is initially set at 9.9% of the outstanding common stock, which limitation may be reset (not to exceed 19.9%) at DaVita’s option and upon providing prior written notice to the Company. In addition, any debt financing is limited by the terms of our Securities Purchase Agreement with DaVita. Specifically, until DaVita owns less than 50% of its investment, the Company may only incur additional debt in the form of a purchase money loan, a working capital line of up to $5 million or to refinance existing debt, unless DaVita consents. Additionally, the Series X Preferred Stock has a deemed liquidation event and redemption clause which could be triggered if the sale of all or substantially all of the Company's assets relating to the Company's dialysis concentrates business line. Since the Series X Preferred Stock may be redeemed if certain assets are sold at the option of the holder, but is not mandatorily redeemable, the preferred stock has been classified as permanent equity and initially recognized at fair value of $15 million (the proceeds on the date of issuance) less issuance costs of $0.1 million, resulting in an initial value of $14.9 million. The Company will assess at each reporting period whether conditions have changed to now meet the mandatorily redemptive definition which could trigger liability classification. As of both March 31, 2023 and December 31, 2022, there were 2,000,000 shares of preferred stock, $0.0001 par value per share, authorized and 15,000 shares of preferred stock issued and outstanding. Common Stock As of March 31, 2023 and December 31, 2022, there were 170,000,000 shares of common stock, $0.0001 par value per share, authorized and 12,552,673 and 12,163,673 shares issued and outstanding, respectively. As of March 31, 2023 and 2022, the Company has reserved for issuance the following shares of common stock related to the potential exercise of employee stock options, unvested restricted stock, convertible preferred stock, pre-funded warrants and all other warrants (collectively, "common stock equivalents"): As of March 31, Common stock and common stock equivalents: 2023 2022 Common stock 12,552,673 8,544,225 Common stock issuable upon exercise of pre-funded warrants 5,911,000 — Common stock and pre-funded stock warrants 18,463,673 8,544,225 Options to purchase common stock 1,194,202 511,117 Unvested restricted stock awards 891 891 Unvested restricted stock units 125,000 28,066 Convertible Preferred Stock 1,363,636 — Warrants to purchase common stock 10,196,268 2,402,442 Total 31,343,670 11,486,741 During the three months ended March 31, 2023 and 2022, 389,000 and nil pre-funded warrants were exercised, respectively. During the three months ended March 31, 2023 and 2022, no vested employee stock options were exercised. On April 20, 2023, 1,191,000 Pre-Funded Warrants to purchase common stock were exercised. Controlled Equity Offering On April 8, 2022, the Company entered into the Sales Agreement with Cantor Fitzgerald & Co. as Agent, pursuant to which the Company may offer and sell from time to time up to $12,200,000 of shares of Company’s common stock through the Agent. The offering and sale of such shares has been registered under the Securities Act of 1933, as amended, pursuant to the Company’s Registration Statement on Form S-3 (File No. 333-259923) (the “Registration Statement”), which was originally filed with the SEC on September 30, 2021 and declared effective by the SEC on October 8, 2021, the base prospectus contained within the Registration Statement, and a prospectus supplement that was filed with the SEC on April 8, 2022. During the quarter ended March 31, 2023, no sales were made pursuant to the Sales Agreement. Approximately $12.2 million remains available for sale under the ATM facility (subject to restrictions under General Instruction I.B.6 to Form S-3). Registered Direct Offering On May 30, 2022, the Company entered into the RD Purchase Agreement with the Purchaser named therein, pursuant to which the Company agreed to issue and sell, in a registered direct offering (the “Offering”), 844,613 shares of its common stock at price of $1.39 per share, and pre-funded warrants to purchase up to an aggregate of 7,788,480 shares of common stock (the “Pre-Funded Warrants” and the shares of common stock underlying the Pre-Funded Warrants, the “Warrant Shares”). The purchase price of each Pre-Funded Warrant is equal to the price at which a share of common stock was sold to the public in the Offering, minus $0.0001, and the exercise price of each Pre-Funded Warrant is $0.0001 per share. A holder (together with its affiliates) may not exercise any portion of the Pre-Funded Warrants to the extent the holder would own more than 9.99% of the Company’s outstanding common stock immediately after exercise, as such percentage ownership is determined in accordance with the terms of the Pre-Funded Warrant. The RD Purchase Agreement contains customary representations and warranties and agreements of the Company and the Purchaser and customary indemnification rights and obligations of the parties. A total of 5,911,000 Pre-Funded Warrants remained outstanding as of March 31, 2023. On April 20, 2023, 1,191,000 Pre-Funded Warrants to purchase common stock were exercised. Private Placement Also on May 30, 2022, concurrently with the Offering, the Company entered into the PIPE Purchase Agreement relating to the offering and sale (the “Private Placement”) of warrants to purchase up to a total of 9,900,990 shares of common stock and pre-funded warrants to purchase up to a total of 1,267,897 shares of common stock (the “PIPE Warrants”). Each warrant was sold at a price of $0.125 per underlying warrant share and is exercisable at an exercise price of $1.39 per share. The purchase price of each Pre-Funded Warrant was equal to the price at which a share of common stock was sold to the public in the Offering, minus $0.0001, and the exercise price of each prefunded warrant is $0.0001 per share. As of March 31, 2023, 9,900,990 common stock warrants and no PIPE Warrants remained outstanding.

Stock-Based Compensation

Stock-Based Compensation	3 Months Ended
Stock-Based Compensation	Mar. 31, 2023
Share-Based Payment Arrangement [Abstract]
Stock-Based Compensation	Stock-Based Compensation The Company recognized total stock-based compensation expense during the three months ended March 31, 2023 and 2022 as follows (table in thousands): Three Months Ended 2023 2022 Service-based awards: Restricted stock units $ 45 $ 12 Stock option awards 148 200 Total Service Based Awards 193 212 Performance-based awards: Restricted stock awards — (391) Total Performance Based Awards — (391) Total $ 193 $ (179) Performance Based Restricted Stock A summary of the Company’s restricted stock awards during the three months ended March 31, 2023 is as follows: Number of Shares Weighted Average Unvested at January 1, 2023 891 $ 62.70 Unvested at March 31, 2023 891 $ 62.70 A summary of the Company’s restricted stock awards during the three months ended March 31, 2022 is as follows: Number of Shares Weighted Average Unvested at January 1, 2022 7,118 $ 62.70 Forfeited (6,227) $ 62.70 Unvested at March 31, 2022 891 $ 62.70 The fair value of restricted stock awards are measured based on their fair value on the date of grant and amortized over the vesting period of 20 months. As of both March 31, 2023 and 2022, unvested restricted stock awards of 891 were related to performance-based awards. The forfeited performance-based restricted stock awards of 6,227 was due to the resignation of the Company's Chief Development Officer on March 25, 2022. These forfeited awards reduced stock-based compensation expense by $0.4 million in 2022. Service-Based Restricted Stock Units A summary of the Company’s service-based restricted stock units during the three months ended March 31, 2023 is as follows: Number of Shares Weighted Average Unvested at January 1, 2023 125,000 $ 1.47 Unvested at March 31, 2023 125,000 $ 1.47 A summary of the Company’s service-based restricted stock units during the three months ended March 31, 2022 is as follows: Number of Shares Weighted Average Unvested at January 1, 2022 29,289 $ 12.87 Forfeited (1,223) 52.91 Unvested at March 31, 2022 28,066 $ 11.11 The fair value of service based restricted stock units are measured based on their fair value on the date of grant and amortized over the vesting period. The vesting periods range from 1 to 3 years. Stock-based compensation expense of $45,184 and $12,000 was recognized for the three months ended March 31, 2023 and 2022, respectively. As of March 31, 2023, the unrecognized stock-based compensation expense was $34,139, which is expected to be recognized over an estimated weighted average remaining term of less than 1 year. Service-Based Stock Options During the three months ended March 31, 2023 there were no service based stock options issued. A summary of the Company’s service-based stock option activity for the three months ended March 31, 2023 is as follows: Shares Weighted Weighted Outstanding at January 1, 2023 1,206,905 $ 8.32 8.9 Forfeited (8,083) 3.54 — Expired (4,620) 18.44 — Outstanding at March 31, 2023 1,194,202 $ 8.32 8.6 Exercisable at March 31, 2023 239,075 $ 28.45 6.7 A summary of the Company’s service-based stock option activity for the three months ended March 31, 2022 is as follows: Shares Weighted Weighted Outstanding at January 1, 2022 528,591 $ 32.01 7.5 Granted 909 4.07 9.9 Forfeited (14,839) 17.49 — Expired (3,545) 85.36 — Outstanding at March 31, 2022 511,116 $ 32.01 7.0 Exercisable at March 31, 2022 230,858 $ 54.56 5.0 The aggregate intrinsic value is calculated as the difference between the closing price of the Company's common stock and the exercise price of the stock options that had strike prices below the closing price. The intrinsic value of the outstanding options were not significant for all periods presented. During the three months ended March 31, 2023, the Company granted no stock options to purchase shares of common stock. During the three months ended March 31, 2023, 8,083 shares were forfeited and 4,620 shares expired. Forfeitures are recorded in the period of occurrence and compensation expense is adjusted accordingly. Stock-based compensation expense recognized for service-based stock options was $0.1 million and $0.2 million for the three months ended March 31, 2023, and 2022 respectively. As of March 31, 2023, total stock-based compensation expense related to unvested options not yet recognized totaled approximately $0.7 million, which is expected to be recognized over an estimated weighted average remaining term of 8.64 years.

Licensing Agreements

Licensing Agreements	3 Months Ended
Licensing Agreements	Mar. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Licensing Agreements	Licensing Agreements Product License Agreements The Company is a party to a Licensing Agreement between the Company and Charak, LLC ("Charak") dated January 7, 2002 (the "2002 Agreement") that grants the Company exclusive worldwide rights to certain patents and information related to our Triferic product. On October 7, 2018, the Company entered into a Master Services and IP Agreement (the “Charak MSA”) with Charak and Dr. Ajay Gupta, a former Officer of the Company. Pursuant to the MSA, the parties entered into three additional agreements described below related to the license of certain soluble ferric pyrophosphate (“SFP”) intellectual property owned by Charak. As of March 31, 2023, the Company has accrued $85,400 relating to certain IP reimbursement expenses and certain sublicense royalty fees, which is included within accrued liabilities on the condensed consolidated balance sheet. Pursuant to the Charak MSA, the aforementioned parties entered into an Amendment, dated as of October 7, 2018 (the “Charak Amendment”), to the 2002 Agreement, under which Charak granted the Company an exclusive, worldwide, non-transferable license to commercialize SFP for the treatment of patients with renal failure. The Charak Amendment amends the royalty payments due to Charak under the 2002 Agreement such that the Company is liable to pay Charak royalties on net sales by the Company of products developed under the license, which includes the Company’s Triferic product, at a specified rate until December 31, 2021 and thereafter at a reduced rate from January 1, 2022 until February 1, 2034. Additionally, the Company shall pay Charak a percentage of any sublicense income during the term of the agreement, which amount shall not be less than a minimum specified percentage of net sales of the licensed products by the sublicensee in jurisdictions where there exists a valid claim, on a country-by-country basis, and be no less than a lower rate of the net sales of the licensed products by the sublicensee in jurisdictions where there exists no valid claim, on a country-by-country basis. Also pursuant to the Charak MSA, the Company and Charak entered into a Commercialization and Technology License Agreement I.V. Triferic dated as of October 7, 2018 (the “IV Agreement”), under which Charak granted the Company an exclusive, sublicensable, royalty-bearing license to SFP for the purpose of commercializing certain intravenous-delivered products incorporating SFP for the treatment of iron disorders worldwide for a term that expires on the later of February 1, 2034 or upon the expiration or termination of a valid claim of a licensed patent. The Company was liable to pay Charak royalties on net sales by the Company of products developed under the license at a specified rate until December 31, 2021. From January 1, 2022 until February 1, 2034, the Company is liable to pay Charak a base royalty at a reduced rate on net sales and an additional royalty on net sales while there exists a valid claim of a licensed patent, on a country-by-country basis. The Company shall also pay to Charak a percentage of any sublicense income received during the term of the IV Agreement, which amount shall not be less than a minimum specified percentage of net sales of the licensed products by the sublicensee in jurisdictions where there exists a valid claim, on a country-by-country basis, and not be less than a lower rate of the net sales of the licensed products by the sublicensee in jurisdictions where there exists no valid claim, on a country-by-country basis. Also pursuant to the Charak MSA, the Company and Charak entered into a Technology License Agreement TPN Triferic dated as of October 7, 2018 (the “TPN Agreement”), pursuant to which Charak granted the Company an exclusive, sublicensable, royalty-bearing license to SFP for the purpose of commercializing worldwide certain TPN products incorporating SFP. The license grant under the TPN Agreement continues for a term that expires on the later of February 1, 2034 or upon the expiration or termination of a valid claim of a licensed patent. During the term of the TPN Agreement, the Company is liable to pay Charak a base royalty on net sales and an additional royalty on net sales while there exists a valid claim of a licensed patent, on a country-by-country basis. The Company shall also pay to Charak a percentage of any sublicense income received during the term of the TPN Agreement, which amount shall not be less than a minimum royalty on net sales of the licensed products by the sublicensee in jurisdictions where there exists a valid claim, on a country-by-country basis, and not be less than a lower rate of the net sales of the licensed products by the sublicensee in jurisdictions where there exists no valid claim, on a country-by-country basis. The potential sub-license milestone payments are not yet considered probable, and no milestone payments have been accrued at March 31, 2023.

Leases

Leases	3 Months Ended
Leases	Mar. 31, 2023
Leases [Abstract]
Leases	Leases Rockwell leases its production facilities and administrative offices as well as certain equipment used in its operations including leases on transportation equipment used in the delivery of its products. The lease terms range from monthly to six years. Rockwell occupies a 51,000 square foot facility and a 17,500 square foot facility in Wixom, Michigan under a lease expiring in August 2024. Rockwell also occupies two other manufacturing facilities, a 51,000 square foot facility in Grapevine, Texas under a lease expiring in December 2025, and a 57,000 square foot facility in Greer, South Carolina under a lease expiring February 2026. In addition, Rockwell occupied 4,100 square feet of office space in Hackensack, New Jersey under a lease expiring on October 31, 2024. This lease was subleased on December 15, 2021 with an expiration date of October 31, 2024. At March 31, 2023, the Company had operating and finance lease liabilities of $6.2 million and right-of-use assets of $5.9 million, which are included in the condensed consolidated balance sheet. At December 31, 2022, the Company had operating and finance lease liabilities of $6.7 million and right-of-use assets of $6.4 million, which are included in the condensed consolidated balance sheet. The following summarizes quantitative information about the Company’s operating leases (table in thousands): Three Months Ended March 31, 2023 Three Months Ended March 31, 2022 Operating leases Operating lease cost $ 344 $ 449 Interest on lease obligations 60 — Variable lease cost 115 95 Operating lease expense 519 544 Finance leases Non-cash lease expense from right-of-use assets 141 141 Interest on lease obligations 39 47 Finance lease expense 180 188 Short-term lease rent expense 4 4 Total lease expense $ 703 $ 736 Other information Operating cash flows from operating leases $ 424 $ 464 Operating cash flows from finance leases $ 39 $ 47 Financing cash flows from finance leases $ 128 $ 118 Weighted-average remaining lease term – operating leases 2.8 3.4 Weighted-average remaining lease term – finance leases 4.2 5.2 Weighted-average discount rate – operating leases 6.4 % 6.3 % Weighted-average discount rate – finance leases 6.4 % 6.4 % Future minimum rental payments under operating lease agreements are as follows (in thousands): Operating Finance Year ending December 31, 2023 (remaining) $ 1,249 $ 502 Year ending December 31, 2024 1,405 672 Year ending December 31, 2025 937 676 Year ending December 31, 2026 310 666 Year ending December 31, 2027 121 311 Total $ 4,022 $ 2,827 Less present value discount (335) (345) Operating and finance lease liabilities $ 3,687 $ 2,482
Leases	Leases Rockwell leases its production facilities and administrative offices as well as certain equipment used in its operations including leases on transportation equipment used in the delivery of its products. The lease terms range from monthly to six years. Rockwell occupies a 51,000 square foot facility and a 17,500 square foot facility in Wixom, Michigan under a lease expiring in August 2024. Rockwell also occupies two other manufacturing facilities, a 51,000 square foot facility in Grapevine, Texas under a lease expiring in December 2025, and a 57,000 square foot facility in Greer, South Carolina under a lease expiring February 2026. In addition, Rockwell occupied 4,100 square feet of office space in Hackensack, New Jersey under a lease expiring on October 31, 2024. This lease was subleased on December 15, 2021 with an expiration date of October 31, 2024. At March 31, 2023, the Company had operating and finance lease liabilities of $6.2 million and right-of-use assets of $5.9 million, which are included in the condensed consolidated balance sheet. At December 31, 2022, the Company had operating and finance lease liabilities of $6.7 million and right-of-use assets of $6.4 million, which are included in the condensed consolidated balance sheet. The following summarizes quantitative information about the Company’s operating leases (table in thousands): Three Months Ended March 31, 2023 Three Months Ended March 31, 2022 Operating leases Operating lease cost $ 344 $ 449 Interest on lease obligations 60 — Variable lease cost 115 95 Operating lease expense 519 544 Finance leases Non-cash lease expense from right-of-use assets 141 141 Interest on lease obligations 39 47 Finance lease expense 180 188 Short-term lease rent expense 4 4 Total lease expense $ 703 $ 736 Other information Operating cash flows from operating leases $ 424 $ 464 Operating cash flows from finance leases $ 39 $ 47 Financing cash flows from finance leases $ 128 $ 118 Weighted-average remaining lease term – operating leases 2.8 3.4 Weighted-average remaining lease term – finance leases 4.2 5.2 Weighted-average discount rate – operating leases 6.4 % 6.3 % Weighted-average discount rate – finance leases 6.4 % 6.4 % Future minimum rental payments under operating lease agreements are as follows (in thousands): Operating Finance Year ending December 31, 2023 (remaining) $ 1,249 $ 502 Year ending December 31, 2024 1,405 672 Year ending December 31, 2025 937 676 Year ending December 31, 2026 310 666 Year ending December 31, 2027 121 311 Total $ 4,022 $ 2,827 Less present value discount (335) (345) Operating and finance lease liabilities $ 3,687 $ 2,482

Loans and Security Agreement

Loans and Security Agreement	3 Months Ended
Loans and Security Agreement	Mar. 31, 2023
Debt Disclosure [Abstract]
Loans and Security Agreement	Loan and Security Agreement On March 16, 2020, the Company and Rockwell Transportation, Inc., as Borrowers, entered into a Loan and Security Agreement (the "Loan Agreement") with Innovatus Life Sciences Lending Fund I, LP ("Innovatus"), as collateral agent and the lenders party thereto, pursuant to which Innovatus, as a lender, agreed to make certain term loans to the Company in the aggregate principal amount of up to $35.0 million (the "Term Loans"). Funding of the first $22.5 million tranche was completed on March 16, 2020. The Company is no longer eligible to draw on a second tranche of $5.0 million or a third tranche of $7.5 million, which were tied to the achievement of certain milestones by a specific date. Net draw down proceeds were $21.2 million with closing costs of $1.3 million. In connection with each funding of the Term Loans, the Company is required to issue to Innovatus a warrant (the “Warrants”) to purchase a number of shares of the Company’s common stock equal to 3.5% of the principal amount of the relevant Term Loan funded divided by the exercise price, which will be based on the lower of (i) the volume weighted average closing price of the Company’s stock for the 5-trading day period ending on the last trading day immediately preceding the execution of the Loan Agreement or (ii) the closing price on the last trading day immediately preceding the execution of the Loan Agreement (or for the second and third tranches only at the lower of (i) $18.15 per share or (ii) the volume weighted average closing price of the Company’s stock for the 5-trading day period ending on the last trading day immediately preceding the relevant Term Loan funding). The Warrants may be exercised on a cashless basis and are immediately exercisable through the seventh anniversary of the applicable funding date. The number of shares of common stock for which each Warrant is exercisable and the associated exercise price are subject to certain proportional adjustments as set forth in such Warrant. In connection with the first tranche of the Term Loans, the Company issued a Warrant to Innovatus, exercisable for an aggregate of 43,388 shares of the Company’s common stock at an exercise price of $18.15 per share. The Company evaluated the warrant under ASC 470, Debt, and recognized an additional debt discount of approximately $0.5 million based on the relative fair value of the base instruments and warrants. The Company calculated the fair value of the warrant using the Black-Scholes model. The Company is entitled to make interest-only payments for thirty months, or up to thirty-six months if certain conditions are met. The Term Loans will mature on March 16, 2025, and will bear interest at the greater of (i) Prime Rate (as defined in the Loan Agreement) and (ii) 4.75%, plus 4.00% with an initial interest rate of 8.75% per annum and an effective interest rate of 10.9%. The Company has the option, under certain circumstances, to add 1.00% of such interest rate amount to the then outstanding principal balance in lieu of paying such amount in cash. For both the three months ended March 31, 2023 and 2022, interest expense amounted to $0.4 million. The Loan Agreement is secured by all assets of the Company and Rockwell Transportation, Inc. Proceeds are used for working capital purposes. The Loan Agreement contained customary representations and warranties and covenants, subject to customary carve outs, and included financial covenants related to liquidity and trailing twelve months sales of Triferic, with the latter beginning with the period ending December 31, 2020. In September 2021, the Company entered into an amendment to the Loan Agreement in which the Company, in exchange for Innovatus lowering the sales covenants, agreed to (i) prepay an aggregate principal amount of $7.5 million in ten installments commencing on December 1, 2021; (ii) pay an additional prepayment premium of 5% on prepaid amounts if the Company elects to prepay all outstanding Term Loans on or before September 24, 2023 and (iii) maintain minimum liquidity of no less than $5.0 million if the aggregate principal amount of Term Loans is greater than $15 million pursuant to the liquidity covenant in the Loan Agreement. On November 10, 2022, the Company entered into a Second Amendment to the Loan and Security Agreement (the “Second Amendment”) dated as of November 14, 2022 with Innovatus, which amended the Loan Agreement. Pursuant to the Second Amendment, the Company (i) prepaid an aggregate principal amount of $5.0 million in Term Loans in one installment on November 14, 2022; (ii) shall pay interest only payments until September 2023 at which time will resume scheduled debt payments. Additionally, the financial covenants related to the trailing twelve months sales of Triferic was replaced with a trailing 6 months revenue of our concentrates products beginning with the period ending September 30, 2022. The Company cannot assure that it can maintain compliance with the covenants under our Loan Agreement, which may result in an event of default. The Company's ability to comply with these covenants may be adversely affected by events beyond its control. If the Company is unable to comply with the covenants under the Loan Agreement, it would pursue all available cure options in order to regain compliance. However, the Company may not be able to mutually agree with Innovatus on appropriate remedies to cure a future breach of a covenant, which could give rise to an event of default. If the Company is unable to avoid an event of default, any required repayments could have an adverse effect on its liquidity. As of March 31, 2023, the Company was in compliance with all covenants under the Loan Agreement. As of March 31, 2023, the outstanding balance of the Term Loan was $9.3 million, net of unamortized issuance costs and discount of $0.7 million. The following table reflects the schedule of principal payments on the Term Loan as of March 31, 2023 (in thousands): Principal Payments 2023 (remaining) 2,000 2024 6,000 2025 2,000 $ 10,000

Insurance Financing Note Payabl

Insurance Financing Note Payable	3 Months Ended
Insurance Financing Note Payable	Mar. 31, 2023
Debt Disclosure [Abstract]
Insurance Financing Note Payable	Insurance Financing Note PayableOn June 2, 2022, the Company entered into a short-term note payable for $1.5 million, bearing interest at 5.40% per annum to finance various insurance policies. Principal and interest payments related to this note began on July 3, 2022 and were paid on a straight-line amortization over 9 months with the final payment due on March 3, 2023. As of March 31, 2023, the Company's insurance note payable was paid in full.

Subsequent Events

Subsequent Events	3 Months Ended
Subsequent Events	Mar. 31, 2023
Subsequent Events [Abstract]
Subsequent Events	Subsequent EventsOn April 20, 2023, Pre-Funded Warrants to purchase 1,191,000 shares of common stock issued on May 30, 2022 were exercised. The exercise price of each Pre-Funded Warrant is $0.0001 per share and resulted in gross proceeds to the Company of $119.10 (See Note 10 for more detail on the Pre-Funded Warrants).

Basis of Presentation, Summar_2

Basis of Presentation, Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Policies)	3 Months Ended
	Mar. 31, 2023
Accounting Policies [Abstract]
Basis of Presentation	The accompanying condensed consolidated interim financial statements include the accounts of the Company and its subsidiaries. All material intercompany balances and transactions have been eliminated in consolidation.
Reverse Stock Split	Reverse Stock Split On May 9, 2022, the stockholders of the Company authorized the Board of Directors to effect a reverse stock split of all outstanding shares of common stock. The Board of Directors subsequently approved the implementation of a reverse stock split as a ratio of one-for-eleven shares, which became effective on May 13, 2022. The Company’s outstanding stock options were also adjusted to reflect the one-for-eleven reverse stock split of the Company’s common stock. Outstanding stock options were proportionately reduced and the respective exercise prices, if applicable, were proportionately increased. The reverse stock split resulted in an adjustment to the Series X convertible preferred stock conversion prices to reflect a proportional decrease in the number of shares of common stock to be issued upon conversion. All share and per share data in these condensed consolidated financial statements and related notes hereto have been retroactively adjusted to account for the effect of the reverse stock split.
Use of Estimates	Use of Estimates The preparation of the condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that may affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and reported amounts of expenses during the reporting period. Actual results could differ from those estimates.
Leases	Leases The Company accounts for its leases under Accounting Standards Codification (“ASC”) 842, Leases . Under this guidance, arrangements meeting the definition of a lease are classified as operating or financing leases and are recorded on the consolidated balance sheet as both a right-of-use asset and lease liability, calculated by discounting fixed lease payments over the lease term at the rate implicit in the lease or the Company’s incremental borrowing rate. Lease liabilities are increased by interest and reduced by payments each period, and the right-of-use asset is amortized over the lease term. For operating leases, interest on the lease liability and the amortization of the right-of-use asset result in straight-line rent expense over the lease term. Variable lease expenses, if any, are recorded when incurred. In calculating the right-of-use asset and lease liability, the Company elects to combine lease and non-lease components. The Company excludes short-term leases having initial terms of 12 months or less as an accounting policy election and recognizes rent expense on a straight-line basis over the lease term.
Loss Per Share	Included within the weighted average shares of common stock outstanding for the three months ended March 31, 2023 and 2022, are 5,911,000 and nil, respectively, of shares of common stock issuable upon the exercise of the pre-funded warrants (see Note 10), as the warrants are exercisable at any time for nominal consideration, and as such, the shares are considered outstanding for the purpose of calculating basic and diluted net loss per share attributable to common stockholders.The Company’s potentially dilutive securities include stock options, restricted stock awards and units, convertible preferred stock and warrants. These securities were excluded from the computations of diluted net loss per share for the three months ended March 31, 2023 and 2022, as the effect would be to reduce the net loss per share.
Adoption of Recent Accounting Pronouncements	Adoption of Recent Accounting Pronouncements The Company continually assesses new accounting pronouncements to determine their applicability. When it is determined a new accounting pronouncement affects the Company’s financial reporting, the Company undertakes a review to determine the consequences of the change to its consolidated financial statements and assures there are sufficient controls in place to ascertain the Company’s consolidated financial statements properly reflect the change. In June 2016, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update ("ASU") 2016-13, "Financial Instruments - Credit Losses (Topic 326)," which introduced an impairment model that is based on expected credit losses, rather than incurred losses, to estimate credit losses on certain types of financial instruments (e.g., loan commitments). The expected credit losses should consider historical information, current information, and reasonable and supportable forecasts, including estimates of prepayments, over the contractual term. Financial instruments with similar risk characteristics may be grouped together when estimating expected credit losses. The Company adopted the new guidance, as of January 1, 2023, and it did not have a material impact on the Condensed Consolidated Financial Statements.
Revenue recognition	The Company recognizes revenue under ASC 606, Revenue from Contracts with Customers. The core principle of the new revenue standard is that a company should recognize revenue to depict the transfer of promised goods or services to customers in an amount that reflects the consideration to which the company expects to be entitled in exchange for those goods or services. The following five steps are applied to achieve that core principle: • Step 1: Identify the contract with the customer • Step 2: Identify the performance obligations in the contract • Step 3: Determine the transaction price • Step 4: Allocate the transaction price to the performance obligations in the contract • Step 5: Recognize revenue when the company satisfies a performance obligation Taxes assessed by a governmental authority that are both imposed on and concurrent with a specific revenue-producing transaction, that are collected by us from a customer, are excluded from revenue. Shipping and handling costs associated with outbound freight related to contracts with customers are accounted for as a fulfillment cost and are included in cost of sales when control of the goods transfers to the customer.

Basis of Presentation, Summar_3

Basis of Presentation, Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Tables)	3 Months Ended
	Mar. 31, 2023
Accounting Policies [Abstract]
Summary of Potentially Dilutive Securities	The following table includes the potential shares of common stock, presented based on amounts outstanding at each period end, that were excluded from the computation of diluted net loss per share attributable to common stockholders for the periods indicated because including them would have had an anti-dilutive effect: As of March 31, 2023 2022 Options to purchase common stock 1,194,202 511,117 Unvested restricted stock awards 891 891 Unvested restricted stock units 125,000 28,066 Convertible Preferred Stock 1,363,636 — Warrants to purchase common stock 10,196,268 2,402,442 Total 12,879,997 2,942,516
Schedule of Basic and Diluted Net Loss Per Share	Basic and diluted net loss per share for the three months ended March 31, 2023 and 2022 was calculated as follows: As of March 31, (In Thousands, Except Shares and Per Share Amounts) 2023 2022 Numerator: Net loss $ (1,750) $ (7,162) Net loss attributable to common stockholders for basic and diluted loss per share $ (1,750) $ (7,162) Denominator: Weighted average number of shares of common stock outstanding - basic and diluted 18,359,940 8,544,225 Net loss per share attributable to common stockholders - basic and diluted $ (0.10) $ (0.84)

Revenue Recognition (Tables)

Revenue Recognition (Tables)	3 Months Ended
Revenue Recognition (Tables)	Mar. 31, 2023
Revenue from Contract with Customer [Abstract]
Disaggregation of Revenue	Revenue is disaggregated by primary geographical market, major product line, and timing of revenue recognition. In thousands of U.S. dollars ($) Three Months Ended March 31, 2023 Products By Geographic Area Total U.S. Rest of World Drug Revenues Product Sales – Point-in-time $ — $ — $ — License Fee – Over time 65 — 65 Total Drug Products 65 — 65 Concentrates Products Product Sales – Point-in-time 18,131 16,459 1,672 License Fee – Over time 1,472 1,472 — Total Concentrate Products 19,603 17,931 1,672 Net Revenue $ 19,668 $ 17,931 $ 1,737 In thousands of U.S. dollars ($) Three Months Ended March 31, 2022 Products By Geographic Area Total U.S. Rest of World Drug Revenues Product Sales – Point-in-time $ 159 $ 159 $ — License Fee – Over time 62 — 62 Total Drug Products 221 159 62 Concentrates Products Product Sales – Point-in-time 15,427 13,810 1,617 License Fee – Over time 476 476 — Total Concentrate Products 15,903 14,286 1,617 Net Revenue $ 16,124 $ 14,445 $ 1,679
Contract Balances	The following table provides information about receivables, contract assets, and contract liabilities from contracts with customers. In thousands of U.S. dollars ($) March 31, 2023 December 31, 2022 Accounts Receivable, net $ 6,021 $ 6,259 Contract liabilities, which are included in Deferred revenue $ 2,794 $ 4,331

Investments - Available-for-S_2

Investments - Available-for-Sale (Tables)	3 Months Ended
Investments - Available-for-Sale (Tables)	Mar. 31, 2023
Investments, Debt and Equity Securities [Abstract]
Investments Available-for-Sale	Investments available-for-sale consisted of the following as of March 31, 2023 and December 31, 2022 (table in thousands): March 31, 2023 Amortized Cost Unrealized Gain Unrealized Loss Accrued Interest Fair Value Available-for-Sale Securities Debt securities $ 5,868 $ 72 $ — $ — $ 5,940 December 31, 2022 Amortized Cost Unrealized Gain Unrealized Loss Accrued Interest Fair Value Available-for-Sale Securities Debt securities $ 11,315 $ 75 $ — $ — $ 11,390

Inventory (Tables)

Inventory (Tables)	3 Months Ended
Inventory (Tables)	Mar. 31, 2023
Inventory Disclosure [Abstract]
Schedule Components of Inventory	Components of inventory, net of reserves, as of March 31, 2023 and December 31, 2022 are as follows (table in thousands): March 31, December 31, Inventory - Current Portion Raw Materials $ 2,806 $ 3,351 Work in Process 504 351 Finished Goods 2,285 2,112 Total Current Inventory 5,595 5,814 Inventory - Long Term 1,276 1,276 Total Inventory $ 6,871 $ 7,090

Property and Equipment, net (Ta

Property and Equipment, net (Tables)	3 Months Ended
Property and Equipment, net (Tables)	Mar. 31, 2023
Property, Plant and Equipment [Abstract]
Schedule of Major Classes of Property and Equipment	As of March 31, 2023 and December 31, 2022, the Company’s property and equipment consisted of the following (table in thousands): March 31, December 31, Leasehold Improvements $ 1,322 $ 1,256 Machinery and Equipment 6,001 5,922 Information Technology & Office Equipment 1,845 1,845 Laboratory Equipment 807 807 Total Property and Equipment 9,975 9,830 Accumulated Depreciation (7,796) (7,636) Property and Equipment, net $ 2,179 $ 2,194

Accrued Liabilities (Tables)

Accrued Liabilities (Tables)	3 Months Ended
Accrued Liabilities (Tables)	Mar. 31, 2023
Payables and Accruals [Abstract]
Schedule of Accrued Liabilities	Accrued liabilities as of March 31, 2023 and December 31, 2022 consisted of the following (table in thousands): March 31, December 31, Accrued Research & Development Expense $ — $ 43 Accrued Compensation and Benefits 1,804 2,568 Accrued Unvouchered Receipts 358 585 Accrued Workers Compensation 303 306 Other Accrued Liabilities 1,894 4,200 Total Accrued Liabilities $ 4,359 $ 7,702

Stockholder's Equity (Tables)

Stockholder's Equity (Tables)	3 Months Ended
Stockholder's Equity (Tables)	Mar. 31, 2023
Equity [Abstract]
Summary of Common Stock Reserved for Issuance	As of March 31, 2023 and 2022, the Company has reserved for issuance the following shares of common stock related to the potential exercise of employee stock options, unvested restricted stock, convertible preferred stock, pre-funded warrants and all other warrants (collectively, "common stock equivalents"): As of March 31, Common stock and common stock equivalents: 2023 2022 Common stock 12,552,673 8,544,225 Common stock issuable upon exercise of pre-funded warrants 5,911,000 — Common stock and pre-funded stock warrants 18,463,673 8,544,225 Options to purchase common stock 1,194,202 511,117 Unvested restricted stock awards 891 891 Unvested restricted stock units 125,000 28,066 Convertible Preferred Stock 1,363,636 — Warrants to purchase common stock 10,196,268 2,402,442 Total 31,343,670 11,486,741

Stock-Based Compensation (Table

Stock-Based Compensation (Tables)	3 Months Ended
Stock-Based Compensation (Tables)	Mar. 31, 2023
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Schedule of Total Stock-Based Compensation Expense	The Company recognized total stock-based compensation expense during the three months ended March 31, 2023 and 2022 as follows (table in thousands): Three Months Ended 2023 2022 Service-based awards: Restricted stock units $ 45 $ 12 Stock option awards 148 200 Total Service Based Awards 193 212 Performance-based awards: Restricted stock awards — (391) Total Performance Based Awards — (391) Total $ 193 $ (179)
Restricted stock awards
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Schedule of Restricted Stock Awards	A summary of the Company’s restricted stock awards during the three months ended March 31, 2023 is as follows: Number of Shares Weighted Average Unvested at January 1, 2023 891 $ 62.70 Unvested at March 31, 2023 891 $ 62.70 A summary of the Company’s restricted stock awards during the three months ended March 31, 2022 is as follows: Number of Shares Weighted Average Unvested at January 1, 2022 7,118 $ 62.70 Forfeited (6,227) $ 62.70 Unvested at March 31, 2022 891 $ 62.70
Restricted stock units - service based awards
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Schedule of Restricted Stock Awards	A summary of the Company’s service-based restricted stock units during the three months ended March 31, 2023 is as follows: Number of Shares Weighted Average Unvested at January 1, 2023 125,000 $ 1.47 Unvested at March 31, 2023 125,000 $ 1.47 A summary of the Company’s service-based restricted stock units during the three months ended March 31, 2022 is as follows: Number of Shares Weighted Average Unvested at January 1, 2022 29,289 $ 12.87 Forfeited (1,223) 52.91 Unvested at March 31, 2022 28,066 $ 11.11
Stock option awards - service based awards
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Schedule of Stock Options Activity	A summary of the Company’s service-based stock option activity for the three months ended March 31, 2023 is as follows: Shares Weighted Weighted Outstanding at January 1, 2023 1,206,905 $ 8.32 8.9 Forfeited (8,083) 3.54 — Expired (4,620) 18.44 — Outstanding at March 31, 2023 1,194,202 $ 8.32 8.6 Exercisable at March 31, 2023 239,075 $ 28.45 6.7 A summary of the Company’s service-based stock option activity for the three months ended March 31, 2022 is as follows: Shares Weighted Weighted Outstanding at January 1, 2022 528,591 $ 32.01 7.5 Granted 909 4.07 9.9 Forfeited (14,839) 17.49 — Expired (3,545) 85.36 — Outstanding at March 31, 2022 511,116 $ 32.01 7.0 Exercisable at March 31, 2022 230,858 $ 54.56 5.0

Leases (Tables)

Leases (Tables)	3 Months Ended
Leases (Tables)	Mar. 31, 2023
Leases [Abstract]
Summary of Lease Costs	The following summarizes quantitative information about the Company’s operating leases (table in thousands): Three Months Ended March 31, 2023 Three Months Ended March 31, 2022 Operating leases Operating lease cost $ 344 $ 449 Interest on lease obligations 60 — Variable lease cost 115 95 Operating lease expense 519 544 Finance leases Non-cash lease expense from right-of-use assets 141 141 Interest on lease obligations 39 47 Finance lease expense 180 188 Short-term lease rent expense 4 4 Total lease expense $ 703 $ 736 Other information Operating cash flows from operating leases $ 424 $ 464 Operating cash flows from finance leases $ 39 $ 47 Financing cash flows from finance leases $ 128 $ 118 Weighted-average remaining lease term – operating leases 2.8 3.4 Weighted-average remaining lease term – finance leases 4.2 5.2 Weighted-average discount rate – operating leases 6.4 % 6.3 % Weighted-average discount rate – finance leases 6.4 % 6.4 %
Operating Lease Maturities	Future minimum rental payments under operating lease agreements are as follows (in thousands): Operating Finance Year ending December 31, 2023 (remaining) $ 1,249 $ 502 Year ending December 31, 2024 1,405 672 Year ending December 31, 2025 937 676 Year ending December 31, 2026 310 666 Year ending December 31, 2027 121 311 Total $ 4,022 $ 2,827 Less present value discount (335) (345) Operating and finance lease liabilities $ 3,687 $ 2,482
Finance Lease Maturities	Future minimum rental payments under operating lease agreements are as follows (in thousands): Operating Finance Year ending December 31, 2023 (remaining) $ 1,249 $ 502 Year ending December 31, 2024 1,405 672 Year ending December 31, 2025 937 676 Year ending December 31, 2026 310 666 Year ending December 31, 2027 121 311 Total $ 4,022 $ 2,827 Less present value discount (335) (345) Operating and finance lease liabilities $ 3,687 $ 2,482

Loans and Security Agreement (T

Loans and Security Agreement (Tables)	3 Months Ended
Loans and Security Agreement (Tables)	Mar. 31, 2023
Debt Disclosure [Abstract]
Schedule of Principal Payments on Term Loan	The following table reflects the schedule of principal payments on the Term Loan as of March 31, 2023 (in thousands): Principal Payments 2023 (remaining) 2,000 2024 6,000 2025 2,000 $ 10,000

Description of Business (Detail

Description of Business (Details)	3 Months Ended
Description of Business (Details)	Mar. 31, 2023 ft² facility
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Number of facilities \| facility	3
Operating space \| ft²	175,000

Liquidity and Capital Resourc_2

Liquidity and Capital Resources (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Liquidity and Going Concern Considerations [Abstract]
Cash, cash equivalents and investments available-for-sale	$ 16,800
Working capital	14,600
Net cash used in operating activities	$ (3,876)	$ (9,811)

Basis of Presentation, Summar_4

Basis of Presentation, Summary of Significant Accounting Policies and Recent Accounting Pronouncements - Schedule of Basic and Diluted Net Loss Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Numerator:
Net loss	$ (1,750)	$ (7,162)
Net loss attributable to common stockholders for basic loss per share	(1,750)	(7,162)
Net loss attributable to common stockholders for diluted loss per share	$ (1,750)	$ (7,162)
Denominator:
Weighted average number of common shares outstanding - basic (in shares)	18,359,940	8,544,225
Weighted average number of common shares outstanding - diluted (in shares)	18,359,940	8,544,225
Net loss per share attributable to common stockholders - diluted (in dollars per share)	$ (0.10)	$ (0.84)
Net loss per share attributable to common stockholders - basic (in dollars per share)	$ (0.10)	$ (0.84)

Basis of Presentation, Summar_5

Basis of Presentation, Summary of Significant Accounting Policies and Recent Accounting Pronouncements (Details)		3 Months Ended
	May 09, 2022	Mar. 31, 2023 shares	Mar. 31, 2022 shares
Accounting Policies [Abstract]
Reverse stock split	0.09
Net Earnings per Share
Antidilutive securities (in shares)		12,879,997	2,942,516
Registered Direct Offering Warrants
Net Earnings per Share
Warrants outstanding (in shares)		5,911,000	0
Options to purchase common stock
Net Earnings per Share
Antidilutive securities (in shares)		1,194,202	511,117
Unvested restricted stock awards
Net Earnings per Share
Antidilutive securities (in shares)		891	891
Unvested restricted stock units
Net Earnings per Share
Antidilutive securities (in shares)		125,000	28,066
Convertible Preferred Stock
Net Earnings per Share
Antidilutive securities (in shares)		1,363,636	0
Warrants to purchase common stock
Net Earnings per Share
Antidilutive securities (in shares)		10,196,268	2,402,442

Revenue Recognition - Nature of

Revenue Recognition - Nature of Goods and Services (Details)	3 Months Ended
	Mar. 31, 2023 Segment agreement
Revenue Recognition [Line Items]
Number of operating market segments \| Segment	1
Number of distribution and license agreements \| agreement	5
Customers average payment term	30 days
Distributors average payment term	60 days

Revenue Recognition - Disaggreg

Revenue Recognition - Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Disaggregation of Revenue [Line Items]
Net Revenue	$ 19,668	$ 16,124
Drug products
Disaggregation of Revenue [Line Items]
Net Revenue	65	221
Concentrates Products
Disaggregation of Revenue [Line Items]
Net Revenue	19,603	15,903
U.S.
Disaggregation of Revenue [Line Items]
Net Revenue	17,931	14,445
U.S. \| Drug products
Disaggregation of Revenue [Line Items]
Net Revenue	0	159
U.S. \| Concentrates Products
Disaggregation of Revenue [Line Items]
Net Revenue	17,931	14,286
Rest of World
Disaggregation of Revenue [Line Items]
Net Revenue	1,737	1,679
Rest of World \| Drug products
Disaggregation of Revenue [Line Items]
Net Revenue	65	62
Rest of World \| Concentrates Products
Disaggregation of Revenue [Line Items]
Net Revenue	1,672	1,617
Product Sales – Point-in-time \| Drug product sales
Disaggregation of Revenue [Line Items]
Net Revenue	0	159
Product Sales – Point-in-time \| Concentrates product sales
Disaggregation of Revenue [Line Items]
Net Revenue	18,131	15,427
Product Sales – Point-in-time \| U.S. \| Drug product sales
Disaggregation of Revenue [Line Items]
Net Revenue	0	159
Product Sales – Point-in-time \| U.S. \| Concentrates product sales
Disaggregation of Revenue [Line Items]
Net Revenue	16,459	13,810
Product Sales – Point-in-time \| Rest of World \| Drug product sales
Disaggregation of Revenue [Line Items]
Net Revenue	0	0
Product Sales – Point-in-time \| Rest of World \| Concentrates product sales
Disaggregation of Revenue [Line Items]
Net Revenue	1,672	1,617
License Fee – Over time \| Drug license fee
Disaggregation of Revenue [Line Items]
Net Revenue	65	62
License Fee – Over time \| Concentrates product license fee
Disaggregation of Revenue [Line Items]
Net Revenue	1,472	476
License Fee – Over time \| U.S. \| Drug license fee
Disaggregation of Revenue [Line Items]
Net Revenue	0	0
License Fee – Over time \| U.S. \| Concentrates product license fee
Disaggregation of Revenue [Line Items]
Net Revenue	1,472	476
License Fee – Over time \| Rest of World \| Drug license fee
Disaggregation of Revenue [Line Items]
Net Revenue	65	62
License Fee – Over time \| Rest of World \| Concentrates product license fee
Disaggregation of Revenue [Line Items]
Net Revenue	$ 0	$ 0

Revenue Recognition - Contract

Revenue Recognition - Contract Balances (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Revenue from Contract with Customer [Abstract]
Accounts Receivable, net	$ 6,021	$ 6,259
Contract liabilities, which are included in Deferred revenue	$ 2,794	$ 4,331

Revenue Recognition - Narrative

Revenue Recognition - Narrative (Details) - USD ($)	3 Months Ended
Revenue Recognition - Narrative (Details) - USD ($)	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Revenue Recognition [Line Items]
Impairment losses	$ 0	$ 0
Contract assets	0		$ 0
Revenue performance obligation	$ 2,800,000
Da Vita Healthcare Partners Inc \| Revenue Benchmark \| Customer Concentration Risk
Revenue Recognition [Line Items]
Customer concentration, percentage	48%
Da Vita Healthcare Partners Inc \| Accounts Receivable \| Customer Concentration Risk
Revenue Recognition [Line Items]
Customer concentration, percentage	34%
Concentrates Products
Revenue Recognition [Line Items]
Reserve for returns	$ 0		$ 0

Investments - Available-for-S_3

Investments - Available-for-Sale (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Investments, Debt and Equity Securities [Abstract]
Amortized Cost	$ 5,868	$ 11,315
Unrealized Gain	72	75
Unrealized Loss	0	0
Accrued Interest	0	0
Fair Value	$ 5,940	$ 11,390

Inventory (Details)

Inventory (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Inventory - Current Portion
Raw Materials	$ 2,806	$ 3,351
Work in Process	504	351
Finished Goods	2,285	2,112
Total Current Inventory	5,595	5,814
Inventory - Long Term	1,276	1,276
Total Inventory	6,871	7,090
Triferic Inventory
Inventory - Current Portion
Total Current Inventory	1,300	1,300
Inventory - Long Term	1,300	1,300
Inventory, gross	5,600	5,800
Inventory, reserve	$ 25	$ 25

Property and Equipment, net (De

Property and Equipment, net (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Property and equipment
Gross property and equipment	$ 9,975		$ 9,830
Accumulated Depreciation	(7,796)		(7,636)
Property and Equipment, net	2,179		2,194
Depreciation expense	200	$ 100
Leasehold Improvements
Property and equipment
Gross property and equipment	1,322		1,256
Machinery and Equipment
Property and equipment
Gross property and equipment	6,001		5,922
Information Technology & Office Equipment
Property and equipment
Gross property and equipment	1,845		1,845
Laboratory Equipment
Property and equipment
Gross property and equipment	$ 807		$ 807

Accrued Liabilities (Details)

Accrued Liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Payables and Accruals [Abstract]
Accrued Research & Development Expense	$ 0	$ 43
Accrued Compensation and Benefits	1,804	2,568
Accrued Unvouchered Receipts	358	585
Accrued Workers Compensation	303	306
Other Accrued Liabilities	1,894	4,200
Total Accrued Liabilities	$ 4,359	$ 7,702

Deferred Revenue (Details)

Deferred Revenue (Details) - USD ($)	1 Months Ended					3 Months Ended		12 Months Ended
Deferred Revenue (Details) - USD ($)	May 31, 2022	Jun. 30, 2021	Sep. 30, 2020	Jan. 31, 2020	Oct. 31, 2014	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2016	Dec. 31, 2022
Deferred Revenue Arrangement [Line Items]
Deferred revenue						$ 2,794,000			$ 4,331,000
Baxter Healthcare Organization
Deferred Revenue Arrangement [Line Items]
Term of agreement					10 years
Upfront payment					$ 20,000,000
Recognized deferred revenue						1,500,000
Wanbang Biopharmaceutical
Deferred Revenue Arrangement [Line Items]
Upfront payment								$ 4,000,000
Recognized deferred revenue						100,000
Deferred revenue						2,300,000			2,500,000
Sun Pharma Agreements
Deferred Revenue Arrangement [Line Items]
Upfront payment				$ 100,000
Recognized deferred revenue						2,500	$ 2,500
Deferred revenue						67,500			70,000
Jeil Pharma Agreements
Deferred Revenue Arrangement [Line Items]
Upfront payment			$ 200,000
Recognized deferred revenue						5,200	2,500
Deferred revenue						400,000			200,000
Milestone consideration	$ 200,000
Drogsan Agreements
Deferred Revenue Arrangement [Line Items]
Upfront payment		$ 150,000
Recognized deferred revenue						3,750	$ 3,750
Deferred revenue						$ 123,750			$ 127,500

Stockholders_ Equity (Details)

Stockholders’ Equity (Details)				3 Months Ended
Stockholders’ Equity (Details)	Jun. 16, 2022 USD ($) shares	May 30, 2022 $ / shares shares	Apr. 06, 2022 USD ($) $ / shares shares	Mar. 31, 2023 $ / shares shares	Mar. 31, 2022 shares	Dec. 31, 2022 $ / shares shares	Apr. 08, 2022 USD ($)
Class of Stock [Line Items]
Preferred shares, shares authorized (in shares)				2,000,000		2,000,000
Preferred shares, par value (in dollars per share) \| $ / shares				$ 0.0001		$ 0.0001
Preferred shares, shares issued (in shares)				15,000		15,000
Preferred shares, shares outstanding (in shares)				15,000		15,000
Common shares, shares authorized (in shares)				170,000,000		170,000,000
Common shares, par value (in dollars per share) \| $ / shares				$ 0.0001		$ 0.0001
Common shares, shares outstanding (in shares)				12,552,673	8,544,225	12,163,673
Common shares, shares issued (in shares)				12,552,673		12,163,673
Exercise of Employee Stock Options, Net of Tax (in shares)				0	0
PIPE Purchase Agreement Pre-Funded Warrant
Class of Stock [Line Items]
Warrants exercised (in shares)				389,000	0
Number of shares of common stock for which warrant is exercisable (in shares)		1,267,897
Discount from stock price (dollars per share) \| $ / shares		$ 0.0001
Exercise price of warrant (in dollars per share) \| $ / shares		$ 0.0001
Warrants outstanding (in shares)				0
Registered Direct Offering Warrants
Class of Stock [Line Items]
Number of shares of common stock for which warrant is exercisable (in shares)		7,788,480
Discount from stock price (dollars per share) \| $ / shares		$ 0.0001
Exercise price of warrant (in dollars per share) \| $ / shares		$ 0.0001
Ownership threshold		9.99%
Warrants outstanding (in shares)				5,911,000	0
PIPE Purchase Agreement Warrant
Class of Stock [Line Items]
Number of shares of common stock for which warrant is exercisable (in shares)		9,900,990
Exercise price of warrant (in dollars per share) \| $ / shares		$ 1.39
Warrants outstanding (in shares)				9,900,990
Warrant price (dollars per share) \| $ / shares		$ 0.125
Registered Direct Offering
Class of Stock [Line Items]
Number of shares issued		844,613
Common stock trading price (in dollars per share) \| $ / shares		$ 1.39
Series X Convertible Preferred Stock
Class of Stock [Line Items]
Interest rate percentage			1%
Common stock trading price (per share) \| $ / shares			$ 22
Common stock trading period			30 days
Conversion price (per share) \| $ / shares			$ 11
Convertible preferred stock (in shares)			91
Outstanding common stock, percentage			9.90%
Outstanding common stock, not to exceed, percentage			19.90%
Percentage of investment owned			50%
Maximum working capital line \| $			$ 5,000,000
Consideration received \| $			15,000,000
Stock issuance costs \| $			100,000
Proceeds from sale of equity, net \| $			14,900,000
Da Vita Healthcare Partners Inc \| Share Issuance, Tranche One
Class of Stock [Line Items]
Proceeds from issuance of convertible preferred stock \| $	$ 7,500,000		7,500,000
Da Vita Healthcare Partners Inc \| Series X Convertible Preferred Stock \| Private Placement
Class of Stock [Line Items]
Sale of stock, aggregate consideration authorized \| $			$ 15,000,000
Common stock trading price (in dollars per share) \| $ / shares			$ 1,000
Da Vita Healthcare Partners Inc \| Series X Convertible Preferred Stock \| Private Placement \| Share Issuance, Tranche One
Class of Stock [Line Items]
Number of shares issued	7,500		7,500
Cantor Fitzgerald & Co \| Controlled Equity Offering
Class of Stock [Line Items]
Sale of stock, aggregate consideration authorized \| $							$ 12,200,000

Stockholder's Equity - Summary

Stockholder's Equity - Summary of Common Stock Reserved for Issuance (Details) - shares	Mar. 31, 2023	Dec. 31, 2022	Mar. 31, 2022	Dec. 31, 2021
Common stock and common stock equivalents:
Common shares, shares outstanding (in shares)	12,552,673	12,163,673	8,544,225
Common stock and pre-funded stock warrants (in shares)	18,463,673		8,544,225
Options to purchase common stock (in shares)	1,194,202		511,117
Convertible preferred stock (in shares)	1,363,636		0
Total	31,343,670		11,486,741
Registered Direct Offering Warrants
Common stock and common stock equivalents:
Warrants outstanding (in shares)	5,911,000		0
Private Placement Warrants
Common stock and common stock equivalents:
Warrants outstanding (in shares)	10,196,268		2,402,442
Unvested restricted stock awards
Common stock and common stock equivalents:
Unvested restricted stock awards/units (in shares)	891		891
Unvested restricted stock units
Common stock and common stock equivalents:
Unvested restricted stock awards/units (in shares)	125,000	125,000	28,066	29,289

Stock-Based Compensation - Shar

Stock-Based Compensation - Share-Based Compensation Expense (Details) - USD ($)	3 Months Ended		12 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total share based compensation expense	$ 193,000	$ (179,000)
Service based awards
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total share based compensation expense	193,000	212,000
Unvested restricted stock units
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total share based compensation expense	45,184	12,000
Stock option awards - service based awards
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total share based compensation expense	148,000	200,000
Performance based awards
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total share based compensation expense	0	(391,000)
Restricted stock awards - performance based awards
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total share based compensation expense	$ 0	$ (391,000)	$ (400,000)

Stock-Based Compensation - Rest

Stock-Based Compensation - Restricted Stock Awards (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		12 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Number of Shares
Forfeited (in shares)			(6,227)
Weighted Average Grant-Date Fair Value
Forfeited (in shares)			(6,227)
Stock based compensation expenses	$ 193	$ (179)
Restricted stock awards
Number of Shares
Unvested at end of period (in shares)	891	891
Weighted Average Grant-Date Fair Value
Vesting period	20 months
Unvested, number of shares (in shares)	891	891
Restricted stock awards - performance based awards
Number of Shares
Unvested at beginning of period (in shares)	891	7,118	7,118
Forfeited (in shares)		(6,227)
Unvested at end of period (in shares)	891	891	891
Weighted Average Grant-Date Fair Value
Unvested at beginning of period (in dollars per share)	$ 62.70	$ 62.70	$ 62.70
Forfeited (in dollars per share)		62.70
Unvested at end of period (in dollars per share)	$ 62.70	$ 62.70	$ 62.70
Unvested, number of shares (in shares)	891	891	891
Forfeited (in shares)		(6,227)
Stock based compensation expenses	$ 0	$ (391)	$ (400)

Stock-Based Compensation - Serv

Stock-Based Compensation - Service Based Restricted Stock Units (Details) - USD ($)	3 Months Ended		12 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Number of Shares
Forfeited (in shares)			(6,227)
Weighted Average Grant-Date Fair Value
Stock based compensation expenses	$ 193,000	$ (179,000)
Restricted stock units - service based awards
Number of Shares
Unvested at beginning of period (in shares)	125,000	29,289	29,289
Forfeited (in shares)		(1,223)
Unvested at end of period (in shares)	125,000	28,066	125,000
Weighted Average Grant-Date Fair Value
Unvested at beginning of period (in dollars per share)	$ 1.47	$ 12.87	$ 12.87
Forfeited (in dollars per share)		(52.91)
Unvested at end of period (in dollars per share)	$ 1.47	$ 11.11	$ 1.47
Stock based compensation expenses	$ 45,184	$ 12,000
Unrecognized stock-based compensation expense	$ 34,139
Unrecognized stock-based compensation expense, weighted average remaining term (in years) (less than)	1 year
Restricted stock units - service based awards \| Minimum
Weighted Average Grant-Date Fair Value
Vesting period	1 year
Restricted stock units - service based awards \| Maximum
Weighted Average Grant-Date Fair Value
Vesting period	3 years

Stock-Based Compensation - Se_2

Stock-Based Compensation - Service Based Stock Options (Details) - $ / shares	3 Months Ended		12 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022	Dec. 31, 2021
Shares Underlying Options
Outstanding at the end of the period (in shares)	1,194,202	511,117
Stock option awards - service based awards
Shares Underlying Options
Outstanding at the beginning of the period (in shares)	1,206,905	528,591	528,591
Granted (in shares)	0	909
Forfeited (in shares)	(8,083)	(14,839)
Expired (in shares)	(4,620)	(3,545)
Outstanding at the end of the period (in shares)	1,194,202	511,116	1,206,905	528,591
Exercisable at end of period (in shares)	239,075	230,858
Weighted Average Exercise Price
Outstanding at the beginning of the period (in dollars per share)	$ 8.32	$ 32.01	$ 32.01
Granted (in dollars per share)		4.07
Forfeited (in dollars per share)	3.54	17.49
Expired (in dollar per share)	18.44	85.36
Outstanding at the end of the period (in dollars per share)	8.32	32.01	$ 8.32	$ 32.01
Exercisable at end of the period (in dollars per share)	$ 28.45	$ 54.56
Weighted Average Remaining Contractual Term
Outstanding	8 years 7 months 6 days	7 years	8 years 10 months 24 days	7 years 6 months
Granted		9 years 10 months 24 days
Exercisable at end of the period	6 years 8 months 12 days	5 years

Stock-Based Compensation - Se_3

Stock-Based Compensation - Service Based Stock Options - Others (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock based compensation expenses	$ 193	$ (179)
Stock option awards - service based awards
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Forfeited (in shares)	8,083	14,839
Expirations (in shares)	4,620	3,545
Stock based compensation expenses	$ 148	$ 200
Unrecognized stock-based compensation expenses	$ 700
Unrecognized stock-based compensation expense, weighted average remaining term (in years)	8 years 7 months 20 days

Licensing Agreements (Details)

Licensing Agreements (Details)	Oct. 07, 2018 agreement	Mar. 31, 2023 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Number of additional agreements \| agreement	3
Master Services And Ip Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative arrangement, accrued reimbursement of IP expenses and sublicense royalty fees		$ 85,400
Milestone payments		$ 0

Leases - Narrative (Details)

Leases - Narrative (Details) $ in Millions	Mar. 31, 2023 USD ($) ft²	Dec. 31, 2022 USD ($)
Lessee, Lease, Description [Line Items]
Operating lease and finance lease liabilities \| $	$ 6.2	$ 6.7
Operating lease and finance lease, right of use assets, net \| $	$ 5.9	$ 6.4
Wixom, Michigan \| Wixom, Michigan Property One
Lessee, Lease, Description [Line Items]
Facility sqft.	51,000
Wixom, Michigan \| Wixom, Michigan Property Two
Lessee, Lease, Description [Line Items]
Facility sqft.	17,500
Grapevine, Texas
Lessee, Lease, Description [Line Items]
Facility sqft.	51,000
Greer, South Carolina
Lessee, Lease, Description [Line Items]
Facility sqft.	57,000
Hackensack, New Jersey
Lessee, Lease, Description [Line Items]
Facility sqft.	4,100
Maximum
Lessee, Lease, Description [Line Items]
Lease term	6 years

Leases - Summary of Lease Costs

Leases - Summary of Lease Costs (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Operating leases
Operating lease cost	$ 344	$ 449
Interest on lease obligations	60	0
Variable lease cost	115	95
Operating lease expense	519	544
Finance leases
Non-cash lease expense from right-of-use assets	141	141
Interest on lease obligations	39	47
Finance lease expense	180	188
Short-term lease rent expense	4	4
Total lease expense	703	736
Other information
Operating cash flows from operating leases	424	464
Operating cash flows from finance leases	39	47
Financing cash flows from finance leases	$ 128	$ 118
Weighted-average remaining lease term – operating leases	2 years 9 months 18 days	3 years 4 months 24 days
Weighted-average remaining lease term – finance leases	4 years 2 months 12 days	5 years 2 months 12 days
Weighted-average discount rate – operating leases	6.40%	6.30%
Weighted-average discount rate – finance leases	6.40%	6.40%

Leases - Finance Lease and Oper

Leases - Finance Lease and Operating Lease Maturities (Details) $ in Thousands	Mar. 31, 2023 USD ($)
Operating
Year ending December 31, 2023 (remaining)	$ 1,249
Year ending December 31, 2024	1,405
Year ending December 31, 2025	937
Year ending December 31, 2026	310
Year ending December 31, 2027	121
Total	4,022
Less present value discount	(335)
Operating lease liabilities	3,687
Finance
Year ending December 31, 2023 (remaining)	502
Year ending December 31, 2024	672
Year ending December 31, 2025	676
Year ending December 31, 2026	666
Year ending December 31, 2027	311
Total	2,827
Less present value discount	(345)
Finance lease liabilities	$ 2,482

Loans and Security Agreement -

Loans and Security Agreement - Narrative (Details) - Term loan		1 Months Ended	3 Months Ended
	Mar. 16, 2020 USD ($) $ / shares shares	Sep. 30, 2021 USD ($) installment	Mar. 31, 2023 USD ($)	Mar. 31, 2022 USD ($)	Nov. 10, 2022 USD ($)
Term loan
Debt Instrument [Line Items]
Aggregate principal amount	$ 35,000,000	$ 7,500,000			$ 5,000,000
Calculation for number of shares of common stock able to be purchased by warrant, percentage of principal amount of relevant term loan funded funded	3.50%
Warrant exercise price calculation, period immediately preceding execution of loan agreement, number of trading days	5 days
Interest rate, base percentage	4.75%
Interest rate, additional percentage added to base percentage	4%
Initial interest rate percentage	8.75%
Effective interest rate	10.90%
Option to add interest rate amount to outstanding principal balance in lieu of paying such amount in cash, percentage	1%
Interest expense			$ 400,000	$ 400,000
Number of monthly installments \| installment		10
Prepayment premium percentage		5%
Minimum liquidity floor		$ 5,000,000
Minimum principal amount pursuant to liquidity covenant		$ 15,000,000
Outstanding balance, net of unamortized issuance costs and unaccreted discount			9,300,000
Unamortized issuance costs and unaccreted discount			$ 700,000
Term loan \| Minimum
Debt Instrument [Line Items]
Period for which company is entitled to make interest-only payments	30 months
Term loan \| Maximum
Debt Instrument [Line Items]
Period for which company is entitled to make interest-only payments	36 months
Term loan, first tranche
Debt Instrument [Line Items]
Aggregate principal amount	$ 22,500,000
Net draw down proceeds	21,200,000
Closing costs	$ 1,300,000
Exercise price of warrant (in dollars per share) \| $ / shares	$ 18.15
Number of shares of common stock for which warrant is exercisable (in shares) \| shares	43,388
Additional debt discount recognized	$ 500,000
Term loan, second and third tranches
Debt Instrument [Line Items]
Warrant exercise price calculation, period immediately preceding relevant funding, number of trading days	5 days
Term loan, second and third tranches \| Maximum
Debt Instrument [Line Items]
Exercise price of warrant (in dollars per share) \| $ / shares	$ 18.15
Term loan, second tranche
Debt Instrument [Line Items]
Aggregate principal amount	$ 5,000,000
Term loan, third tranche
Debt Instrument [Line Items]
Aggregate principal amount	$ 7,500,000

Loans and Security Agreement _2

Loans and Security Agreement - Schedule of Principal Payments on Term Loan (Details) - Term loan - Term loan $ in Thousands	Mar. 31, 2023 USD ($)
Debt Instrument [Line Items]
2023 (remaining)	$ 2,000
2024	6,000
2025	2,000
Principal Payments	$ 10,000

Insurance Financing Note Paya_2

Insurance Financing Note Payable (Details) - 5.40% Note Payable - Notes Payable to Banks $ in Millions	Jun. 02, 2022 USD ($)
Short-term Debt [Line Items]
Short-term note payable	$ 1.5
Interest rate, base percentage	5.40%
Amortization period (in months)	9 months

Subsequent Events (Details)

Subsequent Events (Details) - PIPE Purchase Agreement Pre-Funded Warrant - USD ($)	Apr. 20, 2023	Mar. 31, 2023	May 30, 2022	Mar. 31, 2022
Subsequent Event [Line Items]
Warrants exercised (in shares)		389,000		0
Exercise price of warrant (in dollars per share)			$ 0.0001
Subsequent event
Subsequent Event [Line Items]
Warrants exercised (in shares)	1,191,000
Exercise price of warrant (in dollars per share)	$ 0.0001
Gross proceeds	$ 119.10