Artal 13FHR Quarterly holdings report by institutional manager | SEC 14 Aug 24

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ACELYRIN Inc	COM	00445A100	8,912,116	2,020,888	SH		DFND	1,2,3,4,5	2,020,888	0	0
Achilles Therapeutics PLC	SPONSORED ADS	00449L102	615,631	755,375	SH		DFND	1,2,3,4,5	755,375	0	0
ADC Therapeutics SA	SHS	H0036K147	3,218,337	1,018,461	SH		DFND	1,2,3,4,5	1,018,461	0	0
Adobe Inc	COM	00724F101	499,986	900	SH		DFND	1,2,3,4,5	900	0	0
Aerovate Therapeutics Inc	COM	008064107	1,343,936	809,600	SH		DFND	1,2,3,4,5	809,600	0	0
Agenus Inc	COM NEW	00847G804	12,981,250	775,000	SH		DFND	1,2,3,4,5	775,000	0	0
Allovir Inc	COM	019818103	4,771,731	6,597,167	SH		DFND	1,2,3,4,5	6,597,167	0	0
Alphabet Inc	CAP STK CL A	02079K305	1,275,050	7,000	SH		DFND	1,2,3,4,5	7,000	0	0
Alto Neuroscience Inc	COM SHS	02157Q109	3,741,500	350,000	SH		DFND	1,2,3,4,5	350,000	0	0
Amazon Com Inc	COM	023135106	3,720,063	19,250	SH		DFND	1,2,3,4,5	19,250	0	0
Apellis Pharmaceuticals Inc	COM	03753U106	56,277,189	1,467,080	SH		DFND	1,2,3,4,5	1,467,080	0	0
Applied Therapeutics Inc	COM	03828A101	4,714,365	1,009,500	SH		DFND	1,2,3,4,5	1,009,500	0	0
Arrowhead Pharmaceuticals Inc	COM	04280A100	25,990,000	1,000,000	SH	Call	DFND	1,2,3,4,5	1,000,000	0	0
Arrowhead Pharmaceuticals Inc	COM	04280A100	82,892,220	3,189,389	SH		DFND	1,2,3,4,5	3,189,389	0	0
Ascendis Pharma A/S	SPONSORED ADR	04351P101	13,788,018	101,100	SH		DFND	1,2,3,4,5	101,100	0	0
Avidity Biosciences Inc	COM	05370A108	26,779,422	655,555	SH		DFND	1,2,3,4,5	655,555	0	0
Beigene Ltd	SPONSORED ADR	07725L102	43,281,655	303,369	SH		DFND	1,2,3,4,5	303,369	0	0
Biohaven Ltd	COM	G1110E107	10,645,661	306,703	SH		DFND	1,2,3,4,5	306,703	0	0
Black Diamond Therapeutics Inc	COM	09203E105	4,876,769	1,046,517	SH		DFND	1,2,3,4,5	1,046,517	0	0
Caribou Biosciences Inc	COM	142038108	172,769	105,347	SH		DFND	1,2,3,4,5	105,347	0	0
Cartesian Therapeutics Inc	COM NEW	816212302	8,226,004	304,554	SH		DFND	1,2,3,4,5	304,554	0	0
Cava Group Inc	COM	148929102	2,180,366,073	23,507,990	SH		DFND	1,2,3,4	23,507,990	0	0
CCC Intelligent Solutions Holdings Inc	COM	12510Q100	555,500	50,000	SH		DFND	1,2,3,4,5	50,000	0	0
Centessa Pharmaceuticals PLC	SPONSORED ADS	152309100	19,075,875	2,112,500	SH		DFND	1,2,3,4,5	2,112,500	0	0
Confluent Inc	CLASS A COM	20717M103	561,070	19,000	SH		DFND	1,2,3,4,5	19,000	0	0
Crinetics Pharmaceuticals Inc	COM	22663K107	47,749,007	1,066,064	SH		DFND	1,2,3,4,5	1,066,064	0	0
Cullinan Therapeutics Inc	COM	230031106	18,450,631	1,057,949	SH		DFND	1,2,3,4,5	1,057,949	0	0
Cyclerion Therapeutics Inc	COM	23255M204	269,309	117,091	SH		DFND	1,2,3,4,5	117,091	0	0
Cyclerion Therapeutics Inc	COM	23255M204	1,270	552	SH		DFND	1,2,3,4	552	0	0
Cytokinetics Inc	COM NEW	23282W605	26,787,730	494,421	SH		DFND	1,2,3,4,5	494,421	0	0
Datadog Inc	CL A COM	23804L103	3,751,283	28,925	SH		DFND	1,2,3,4,5	28,925	0	0
Dell Technologies Inc	CL C	24703L202	137,910	1,000	SH		DFND	1,2,3,4,5	1,000	0	0
Denali Therapeutics Inc	COM	24823R105	11,677,315	502,899	SH		DFND	1,2,3,4,5	502,899	0	0
Dlocal Ltd	CLASS A COM	G29018101	84,799	10,482	SH		DFND	1,2,3,4,5	10,482	0	0
Dynatrace Inc	COM NEW	268150109	4,876,660	109,000	SH		DFND	1,2,3,4,5	109,000	0	0
Dyne Therapeutics Inc	COM	26818M108	53,533,518	1,516,960	SH		DFND	1,2,3,4,5	1,516,960	0	0
Edgewise Therapeutics Inc	COM	28036F105	14,619,041	811,718	SH		DFND	1,2,3,4,5	811,718	0	0
Elevation Oncology Inc	COM	28623U101	2,735,141	1,013,015	SH		DFND	1,2,3,4,5	1,013,015	0	0
Erasca Inc	COM	29479A108	22,728,712	9,630,810	SH		DFND	1,2,3,4,5	9,630,810	0	0
Fate Therapeutics Inc	COM	31189P102	3,386,600	1,032,500	SH		DFND	1,2,3,4,5	1,032,500	0	0
Foghorn Therapeutics Inc.	COM	344174107	4,144,140	720,720	SH		DFND	1,2,3,4,5	720,720	0	0
Generation Bio Co	COM	37148K100	7,982,267	2,830,591	SH		DFND	1,2,3,4,5	2,830,591	0	0
GlycoMimetics Inc	COM	38000Q102	2,418,680	8,589,064	SH		DFND	1,2,3,4,5	8,589,064	0	0
Gossamer Bio Inc	COM	38341P102	186,486	207,000	SH	Call	DFND	1,2,3,4,5	207,000	0	0
Gossamer Bio Inc	COM	38341P102	11,990,049	13,308,968	SH		DFND	1,2,3,4,5	13,308,968	0	0
Gritstone Bio Inc	COM	39868T105	1,872,825	3,030,952	SH		DFND	1,2,3,4,5	3,030,952	0	0
HOOKIPA Pharma Inc	COM	43906K100	3,353,381	5,666,410	SH		DFND	1,2,3,4,5	5,666,410	0	0
IGM Biosciences Inc	COM	449585108	22,879,999	3,330,422	SH		DFND	1,2,3,4,5	3,330,422	0	0
Intapp Inc	COM	45827U109	476,710	13,000	SH		DFND	1,2,3,4,5	13,000	0	0
Intel Corp	COM	458140100	774,250	25,000	SH		DFND	1,2,3,4,5	25,000	0	0
Iovance Biotherapeutics Inc	COM	462260100	8,112,230	1,011,500	SH		DFND	1,2,3,4,5	1,011,500	0	0
Ironwood Pharmaceuticals Inc	COM CL A	46333X108	720,669	110,532	SH		DFND	1,2,3,4	110,532	0	0
Janux Therapeutics Inc	COM	47103J105	8,503,670	203,000	SH		DFND	1,2,3,4,5	203,000	0	0
Jfrog Ltd	ORD SHS	M6191J100	938,750	25,000	SH		DFND	1,2,3,4,5	25,000	0	0
Kanzhun Ltd	SPONSORED ADS	48553T106	940,500	50,000	SH		DFND	1,2,3,4,5	50,000	0	0
Ke Holdings Inc	SPONSORED ADS	482497104	3,183,750	225,000	SH		DFND	1,2,3,4,5	225,000	0	0
Kenvue Inc	COM	49177J102	2,490,660	137,000	SH		DFND	1,2,3,4,5	137,000	0	0
Korro Bio Inc	COM	500946108	13,990,749	413,072	SH		DFND	1,2,3,4,5	413,072	0	0
Kronos Bio Inc	COM	50107A104	1,045,263	842,954	SH		DFND	1,2,3,4,5	842,954	0	0
Kura Oncology Inc	COM	50127T109	37,471,412	1,819,884	SH		DFND	1,2,3,4,5	1,819,884	0	0
Kymera Therapeutics Inc	COM	501575104	89,717,459	3,005,610	SH		DFND	1,2,3,4,5	3,005,610	0	0
Kyverna Therapeutics Inc	COM	501976104	1,500,000	200,000	SH		DFND	1,2,3,4,5	200,000	0	0
Lexeo Therapeutics Inc	COM	52886X107	9,679,097	603,435	SH		DFND	1,2,3,4,5	603,435	0	0
Lexicon Pharmaceuticals Inc	COM NEW	528872302	5,907,240	3,516,214	SH		DFND	1,2,3,4,5	3,516,214	0	0
Lexicon Pharmaceuticals Inc	COM NEW	528872302	288,259,726	171,583,170	SH		DFND	1,2,3,4	171,583,170	0	0
Merus NV	COM	N5749R100	44,990,205	760,355	SH		DFND	1,2,3,4,5	760,355	0	0
Meta Platforms Inc	CL A	30303M102	554,642	1,100	SH		DFND	1,2,3,4,5	1,100	0	0
Metagenomi Inc	COM	59102M104	1,224,000	300,000	SH		DFND	1,2,3,4,5	300,000	0	0
Microsoft Corp	COM	594918104	5,050,535	11,300	SH		DFND	1,2,3,4,5	11,300	0	0
Mind Medicine MindMed Inc	COM NEW	60255C885	7,266,779	1,007,875	SH		DFND	1,2,3,4,5	1,007,875	0	0
MongoDB Inc	CL A	60937P106	1,005,089	4,021	SH		DFND	1,2,3,4,5	4,021	0	0
Morphic Holding Inc	COM	61775R105	86,060,752	2,525,998	SH		DFND	1,2,3,4,5	2,525,998	0	0
Neumora Therapeutics Inc	COM	640979100	27,760,431	2,824,052	SH		DFND	1,2,3,4,5	2,824,052	0	0
New Oriental Education & Technology Group Inc	SPONSORED ADR	647581206	971,625	12,500	SH		DFND	1,2,3,4,5	12,500	0	0
NewAmsterdam Pharma Company NV	ORDINARY SHARES	N62509109	15,368,000	800,000	SH		DFND	1,2,3,4,5	800,000	0	0
NVIDIA Corp	COM	67066G104	5,312,220	43,000	SH		DFND	1,2,3,4,5	43,000	0	0
Omega Therapeutics Inc	COMMON STOCK	68217N105	2,739,707	1,323,530	SH		DFND	1,2,3,4,5	1,323,530	0	0
Ovid Therapeutics Inc	COM	690469101	1,923,000	2,500,000	SH		DFND	1,2,3,4,5	2,500,000	0	0
Palo Alto Networks Inc	COM	697435105	1,525,545	4,500	SH		DFND	1,2,3,4,5	4,500	0	0
PayPal Holdings Inc	COM	70450Y103	1,508,780	26,000	SH	Call	DFND	1,2,3,4,5	26,000	0	0
PayPal Holdings Inc	COM	70450Y103	870,450	15,000	SH		DFND	1,2,3,4,5	15,000	0	0
PDD Holdings Inc	SPONSORED ADS	722304102	6,049,225	45,500	SH		DFND	1,2,3,4,5	45,500	0	0
Pegasystems Inc	COM	705573103	696,095	11,500	SH		DFND	1,2,3,4,5	11,500	0	0
PepGen Inc	COM	713317105	1,808,539	113,317	SH		DFND	1,2,3,4,5	113,317	0	0
Perception Capital Corp III	W EXP 99/99/999	G7185D114	3,547	126,666	SH		DFND	1,2,3,4,5	126,666	0	0
Procore Technologies Inc	COM	74275K108	2,141,813	32,300	SH		DFND	1,2,3,4,5	32,300	0	0
Prothena Corporation PLC	SHS	G72800108	20,668,070	1,001,360	SH		DFND	1,2,3,4,5	1,001,360	0	0
Qualcomm Inc	COM	747525103	1,493,850	7,500	SH		DFND	1,2,3,4,5	7,500	0	0
Rapport Therapeutics Inc	COM	75383L102	8,141,000	350,000	SH		DFND	1,2,3,4,5	350,000	0	0
Regenxbio Inc	COM	75901B107	2,925,000	250,000	SH		DFND	1,2,3,4,5	250,000	0	0
Remitly Global Inc	COM	75960P104	303,000	25,000	SH		DFND	1,2,3,4,5	25,000	0	0
Revolution Medicines Inc	COM	76155X100	39,422,267	1,015,776	SH		DFND	1,2,3,4,5	1,015,776	0	0
Rubrik Inc	CL A	781154109	1,073,100	35,000	SH		DFND	1,2,3,4,5	35,000	0	0
Sagimet Biosciences Inc	COM SER A	786700104	2,478,717	724,771	SH		DFND	1,2,3,4,5	724,771	0	0
Scholar Rock Holding Corp	COM	80706P103	93,791,119	11,259,438	SH		DFND	1,2,3,4,5	11,259,438	0	0
Sea Ltd	SPONSORED ADS	81141R100	6,963,450	97,500	SH		DFND	1,2,3,4,5	97,500	0	0
Seer Inc	COM CL A	81578P106	7,980,000	4,750,000	SH		DFND	1,2,3,4,5	4,750,000	0	0
ServiceNow Inc	COM	81762P102	1,966,675	2,500	SH		DFND	1,2,3,4,5	2,500	0	0
Silence Therapeutics PLC	ADS	82686Q101	52,812,761	2,779,619	SH		DFND	1,2,3,4,5	2,779,619	0	0
Snowflake Inc	CL A	833445109	682,340	5,051	SH		DFND	1,2,3,4,5	5,051	0	0
Solid Biosciences Inc	COM NEW	83422E204	14,175,000	2,500,000	SH		DFND	1,2,3,4,5	2,500,000	0	0
SpringWorks Therapeutics Inc	COM	85205L107	49,461,689	1,313,026	SH		DFND	1,2,3,4,5	1,313,026	0	0
Syros Pharmaceuticals Inc	COM NEW	87184Q206	12,925,867	2,505,013	SH		DFND	1,2,3,4,5	2,505,013	0	0
Taiwan Semiconductor Manufacturing Co Ltd	SPONSORED ADS	874039100	4,519,060	26,000	SH		DFND	1,2,3,4,5	26,000	0	0
Tango Therapeutics Inc	COM	87583X109	21,620,236	2,519,841	SH		DFND	1,2,3,4,5	2,519,841	0	0
Taysha Gene Therapies Inc	COM SHS	877619106	9,753,439	4,354,214	SH		DFND	1,2,3,4,5	4,354,214	0	0
Tesla Inc	COM	88160R101	395,760	2,000	SH		DFND	1,2,3,4,5	2,000	0	0
Tourmaline Bio Inc	COM	89157D105	1,175,738	91,426	SH		DFND	1,2,3,4,5	91,426	0	0
Ultragenyx Pharmaceutical Inc	COM	90400D108	11,302,500	275,000	SH		DFND	1,2,3,4,5	275,000	0	0
Vera Therapeutics Inc	CL A	92337R101	33,139,939	915,974	SH		DFND	1,2,3,4,5	915,974	0	0
Vigil Neuroscience Inc	COM	92673K108	7,314,764	1,828,691	SH		DFND	1,2,3,4,5	1,828,691	0	0
Visa Inc	COM CL A	92826C839	4,986,930	19,000	SH		DFND	1,2,3,4,5	19,000	0	0
WAVE Life Sciences Ltd	SHS	Y95308105	22,785,592	4,566,251	SH		DFND	1,2,3,4,5	4,566,251	0	0
Xenon Pharmaceuticals Inc	COM	98420N105	14,876,790	381,554	SH		DFND	1,2,3,4,5	381,554	0	0

Artal 13F-HRQuarterly holdings report by institutional manager