ICON Public Limited 6K 2024 Q2 Current report | ICLR Filing

EXHIBIT 22.1

SUBSIDIARY GUARANTORS AND ISSUER OF GUARANTEED SECURITIES AND AFFILIATES WHOSE SECURITIES COLLATERALIZE SECURITIES OF

ICON INVESTMENTS SIX DESIGNATED ACTIVITY COMPANY

The following subsidiaries of ICON plc, (the “Company”) are guarantors of ICON Investments Six Designated Activity Company’s (the “Issuer”) 5.809% Senior Secured Notes due 2027, 5.849% Senior Secured Notes due 2029 and 6.000% Senior Secured Notes due 2034:


NAME OF SUBSIDIARY						STATE OR OTHER JURISDICTION OF INCORPORATION OR ORGANIZATION
ICON Global Treasury Unlimited Company						Ireland
ICON Clinical Research Limited						Ireland
ICON Holdings Unlimited Company						Ireland
DOCS Resourcing Limited						Ireland
ICON Clinical International Unlimited Company						Ireland
ICON Clinical Research Property Development (Ireland) Limited						Ireland
Accellacare Limited						Ireland
ICON Operational Holdings Unlimited Company						Ireland
ICON Operational Financing Unlimited Company						Ireland
ICON Investments Four Unlimited Company						Ireland
ICON Clinical Global Holdings Unlimited Company						Ireland
ICON Luxembourg S.à r.l.						Luxembourg
ICON Early Phase Services, LLC						Texas
Beacon Bioscience, Inc.						Delaware
ICON Clinical Research LLC						Delaware
ICON Laboratory Services, Inc.						Delaware
MolecularMD Corp.						Delaware
ICON US Holdings Inc.						Delaware
PriceSpective LLC						Delaware
DOCS Global, Inc.						New Jersey
Accellacare US Inc.						North Carolina
Clinical Resource Network, LLC						Illinois
ICON Clinical Investments LLC						Delaware
PRA Health Sciences, Inc.						Delaware
ReSearch Pharmaceutical Services, Inc.						Delaware
Source Healthcare Analytics, LLC						Delaware
Symphony Health Solutions Corporation						Delaware
Pharmaceutical Research Associates, Inc.						Virginia
PRA Holdings, Inc.						Delaware
PRA International, LLC						Delaware
RPS Global Holdings, LLC						Delaware
RPS Parent Holding LLC						Delaware
Roy RPS Holdings LLC						Delaware
CRN Holdings, LLC						Delaware

All issued and outstanding equity securities of the following subsidiaries of the Company, subject to the limitations set forth below, collateralize the Issuer’s 5.809% Senior Secured Notes due 2027, 5.849% Senior Secured Notes due 2029 and 6.000% Senior Secured Notes due 2034:

NAME (STATE OR OTHER JURISDICTION OF INCORPORATION OR ORGANIZATION)

OWNER

PERCENT PLEDGED

ICON Investments Six Designated Activity Company (Ireland)

ICON plc

100%

ICON Clinical Research Limited (Ireland)

ICON Operational Holdings Unlimited Company

100%

ICON Holdings Unlimited Company (Ireland)

ICON Operational Financing Unlimited Company

100%

ICON Investments Four Unlimited Company (Ireland)

ICON Clinical Global Holdings Unlimited Company

100%

ICON Operational Holdings Unlimited Company (Ireland)

ICON Operational Financing Unlimited Company

100%

ICON Operational Financing Unlimited Company (Ireland)

ICON Clinical Global Holdings Unlimited Company

100%

ICON Clinical Global Holdings Unlimited Company (Ireland)

ICON plc

100%

ICON Investments Five Unlimited Company (Ireland)

ICON plc

100%

DOCS Resourcing Limited (Ireland)

ICON Clinical International Unlimited Company

100%

ICON Clinical International Unlimited Company (Ireland)

ICON Holdings Unlimited Company

100%

ICON Clinical International Unlimited Company (Ireland)

ICON plc

100%

ICON Clinical Research Property Holdings (Ireland) Limited (Ireland)

ICON plc

100%

ICON (LR) Limited (United Kingdom)

ICON Clinical Research Limited

100%

ICON Holdings Clinical Research International Limited (Ireland)

ICON Holdings Unlimited Company

100%

Accellacare Limited (Ireland)

ICON Holdings Unlimited Company

100%

ICON Global Treasury Unlimited Company (Ireland)

ICON Clinical Research Limited

100%

ICON Global Treasury Unlimited Company (Ireland)

ICON plc

100%

ICON Luxembourg S.à r.l.(Luxembourg)

ICON Holdings Unlimited Company

100%

ICON Luxembourg S.à r.l. (Luxembourg)

ICON Clinical Research Limited

100%

ICON Luxembourg S.à r.l. (Luxembourg)

ICON plc

100%

ICON Early Phase Services, LLC (f/k/a Healthcare Discoveries, LLC) (Texas)

ICON Clinical Research LLC

100%

Beacon Bioscience, Inc. (Delaware)

ICON Clinical Research LLC

100%

ICON Clinical Research LLC (Delaware)

ICON US Holdings Inc.

100%

ICON Laboratory Services, Inc. (f/k/a ICON Central Laboratories, Inc.) (Delaware)

ICON US Holdings Inc.

100%

MolecularMD Corp. (Delaware)

ICON Laboratory Services, Inc. (f/k/a ICON Central Laboratories, Inc.)

100%

ICON US Holdings Inc. (Delaware)

ICON Operational Financing Unlimited Company

100%

PriceSpective LLC (Delaware)

ICON Clinical Research LLC

100%

CRN Holdings, LLC (Delaware)

ICON Clinical Research LLC

100%

ICON Clinical Investments, LLC (Delaware)

ICON Luxembourg S.à r.l

100%

Clinical Resource Network, LLC (d/b/a Symphony Clinical Research) (Illinois)

CRN Holdings, LLC

100%

DOCS Global, Inc. (New Jersey)

ICON Clinical Research LLC

100%

Accellacare US Inc. (North Carolina)

ICON Clinical Research LLC

100%

RPS Bermuda, Ltd. (Bermuda)

ReSearch Pharmaceutical Services, Inc.

65%

Services de Recherche Pharmaceutique Srl (Canada)

ReSearch Pharmaceutical Services, Inc.

65%

PRA Health Sciences Colombia Ltda. (Colombia)

Pharmaceutical Research Associates, Inc.

65%

Pharmaceutical Research Associates Hungary Research and Development Ltd. (Hungary)

Pharmaceutical Research Associates, Inc.

65%

Pharmaceutical Research Associates Italy S.r.l. (Italy)

Pharmaceutical Research Associates, Inc.

65%

Pharmaceutical Research Associates Mexico S. de R.L. de C. V. (Mexico)

Pharmaceutical Research Associates, Inc.

65%

Pharmaceutical Research Associates Mexico S. de R.L. de C. V. (Mexico)

PRA International, LLC

65%

ReSearch Pharmaceutical Services Netherlands B.V. (Netherlands)

ReSearch Pharmaceutical Services, Inc.

65%

RPS Perú S.A.C. (Peru)

Pharmaceutical Research Associates, Inc.

65%

Research Pharmaceutical Services Puerto Rico, Inc. (Puerto Rico)

ReSearch Pharmaceutical Services, Inc.

65%

Pharmaceutical Research Associates Romania S.R.L. (Romania)

Pharmaceutical Research Associates, Inc.

65%

Pharmaceutical Research Associates España, S.A.U. (Spain)

Pharmaceutical Research Associates, Inc.

65%

PRA International Sweden AB (Sweden)

Pharmaceutical Research Associates, Inc.

65%

RPS Research (Thailand) Co., Ltd. (Thailand)

ReSearch Pharmaceutical Services, Inc.

65%

Sterling Synergy Systems Limited (United Kingdom)

Pharmaceutical Research Associates, Inc.

65%

ClinStar LLC (California)

Pharmaceutical Research Associates, Inc.

100%

Nextrials, Inc. (California)

Pharmaceutical Research Associates, Inc.

100%

Care Innovations, Inc. (Delaware)

Pharmaceutical Research Associates, Inc.

100%

CRI NewCo, Inc. (Delaware)

Pharmaceutical Research Associates, Inc.

100%

International Medical Technical Consultants, LLC (Delaware)

Pharmaceutical Research Associates, Inc.

100%

Parallel 6, Inc. (Delaware)

Pharmaceutical Research Associates, Inc.

100%

PRA Early Development Research, Inc. (f/k/a Pharma Bio-Research USA, Inc.) (Delaware)

Pharmaceutical Research Associates, Inc.

100%

PRA Health Sciences, Inc. (Delaware)

ICON US Holdings Inc.

100%

PRA Holdings, Inc. (Delaware)

PRA Health Sciences, Inc.

100%

PRA Receivables, LLC (Delaware)

Pharmaceutical Research Associates, Inc.

100%

ReSearch Pharmaceutical Services, Inc. (Delaware)

Roy RPS Holdings, LLC

100%

ReSearch Pharmaceutical Services, LLC (Delaware)

ReSearch Pharmaceutical Services, Inc.

100%

Source Healthcare Analytics, LLC (Delaware)

Symphony Health Solutions Corporation

100%

Sunset Hills, LLC (Delaware)

Pharmaceutical Research Associates, Inc.

100%

Symphony Health Solutions Corporation (Delaware)

Pharmaceutical Research Associates, Inc.

100%

Pharmaceutical Research Associates, Inc. (Virginia)

PRA International, LLC

100%

PRA International, LLC (Delaware)

PRA Holdings, Inc.

100%

Roy RPS Holdings LLC (Delaware)

RPS Parent Holding LLC

100%

RPS Global Holdings, LLC (Delaware)

PRA Holdings, Inc.

100%

RPS Parent Holding LLC (Delaware)

RPS Global Holdings, LLC

100%

ICON Government and Public Health Solutions, Inc. (Virginia)

ICON US Holdings Inc.

100%

Accellacare of Bristol, LLC (Tennessee)

Accellacare US Inc.

100%

Accellacare of Charleston, LLC (South Carolina)

Accellacare US Inc.

100%

Accellacare of Charlotte, LLC (North Carolina)

Accellacare US Inc.

100%

Accellacare of Christie Clinic, LLC (Illinois)

Accellacare US Inc.

100%

Accellacare of Hickory, LLC (North Carolina)

Accellacare US Inc.

100%

Accellacare of Raleigh, LLC (North Carolina)

Accellacare US Inc.

100%

Accellacare of Rocky Mount, LLC (North Carolina)

Accellacare US Inc.

100%

Accellacare of Salisbury, LLC (North Carolina)

Accellacare US Inc.

100%

Accellacare of Wilmington, LLC (North Carolina)

Accellacare US Inc.

100%

Accellacare of Winston-Salem, LLC (North Carolina)

Accellacare US Inc.

100%

Averion Europe GmbH (Germany)

ICON Clinical Research LLC

65%

CHC Group, LLC (Delaware)

ICON Clinical Research LLC

100%

PubsHub LLC (Delaware)

ICON Clinical Research LLC

100%

Global Pharmaceutical Strategies Group, LLC (Delaware)

ICON Clinical Research LLC

100%

MMMM Group, LLC (Delaware)

ICON Clinical Research LLC

100%

ICON Tennessee, LLC (Delaware)

ICON Clinical Research LLC

100%

ADDPLAN, Inc. (Delaware)

ICON Clinical Research LLC

100%

ICON Clinical Research LP (Delaware)

ICON Clinical Research LLC

100%

ICON Clinical Research LP (Delaware)

ICON Tennessee, LLC

100%

CRN North America, LLC (d/b/a Symphony Clinical Staffing) (Delaware)

CRN Holdings, LLC

100%

Symphony Clinical Research Sp. Z O O. (Poland)

CRN Holdings, LLC

65%

ICON Clinical Research Holdings (U.K.) Limited (United Kingdom)

Pharmaceutical Research Associates, Inc.

65%

Oncacare Limited (Ireland)

ICON Clinical Research Limited

100%

Biotel Research LLC (Delaware)

ICON Clinical Research LLC

100%

HumanFirst LLC (Delaware)

ICON Clinical Research LLC

100%

ICON Clinical Research Holdings (Ireland) Unlimited Company (Ireland)

ICON Holdings Unlimited Company

100%

ICON Public Limited (ICLR) 6-K2024 Q2 Current report (foreign)