Balance Sheet Components | 5. Balance Sheet Components Cash and Cash Equivalents The Company considers all highly-liquid investments purchased with an original maturity of three months or less at the date of purchase to be cash equivalents. Cash and cash equivalents include money market funds in the amount of $ 34.2 million and $ 92.3 million as of March 31, 2023 and December 31, 2022, respectively. As of March 31, 2023 and December 31, 2022, the Company’s cash equivalents were held at institutions in the United States and include deposits in a money market fund which was unrestricted as to withdrawal or use. The Company also held cash in foreign banks of approximately $ 8.0 million at March 31, 2023 and $ 18.6 million at December 31, 2022 that was not insured. The Company has not experienced any losses on its deposits of cash and cash equivalents. Investments The Company measures its cash equivalents and short-term investments at fair value, with unrealized gains and losses recorded in accumulated other comprehensive income within stockholders’ equity. The Company regularly reviews its investments and evaluates the current expected credit loss by considering factors such as historical experience, market data, and the near-term prospects of the investee. The following is a summary of the gross unrealized gains and unrealized losses on the Company’s investment securities, excluding investments in money market funds (in thousands): March 31, 2023 Amortized Gross Gross Aggregate Investment Securities Agency bonds $ 221,163 $ 3 $ ( 720 ) $ 220,446 Commercial paper 40,994 2 ( 21 ) 40,975 Treasury bonds 31,038 12 ( 117 ) 30,933 Total securities $ 293,195 $ 17 $ ( 858 ) $ 292,354 December 31, 2022 Amortized Gross Gross Aggregate Investment Securities Agency bonds $ 184,666 $ 2 $ ( 990 ) $ 183,678 Commercial paper 24,767 5 ( 30 ) 24,742 Treasury bonds 46,008 — ( 416 ) 45,592 Total securities $ 255,441 $ 7 $ ( 1,436 ) $ 254,012 Realized gains or losses and other-than-temporary impairments, if any, on available-for-sale securities are reported in other income (expense), net as incurred. The cost of securities sold is determined based on the specific identification method. The amount of realized gains and realized losses on investments recorded for the periods presented has not been material. The contractual maturities of the Company’s investment securities as of March 31, 2023 were as follows (in thousands): Amortized Cost Fair Value Amounts maturing within one year $ 283,671 $ 282,818 Amounts maturing after one year through five years 9,524 9,536 Total investment securities $ 293,195 $ 292,354 Inventories (in thousands) March 31, December 31, 2023 2022 Raw materials $ 57,477 $ 53,384 Work in process 2,551 1,195 Finished goods 53,265 45,059 Total inventories $ 113,293 $ 99,638 Inventories are stated at the lower of cost or net realizable value. Cost is determined using the standard cost method which approximates the first-in, first-out basis. Net realizable value is determined as the prices in the ordinary course of business, less reasonably predictable costs of completion, disposal and transportation. The Company regularly reviews inventory quantities compared to forecasted sales to record a provision for excess and obsolete inventory when appropriate. Inventory write-downs are recorded for excess and obsolete inventory. The Company estimates forecasted sales by considering product acceptance in the marketplace, customer demand, historical sales, product obsolescence and technological innovations. The Company periodically evaluates the carrying value of inventory on hand for potential excess amount over demand using the same lower of cost or net realizable value approach as that has been used to value the inventory. The Company also periodically evaluates inventory quantities in consideration of actual loss experience. As a result of these evaluations, the Company recognized total write-downs of $ 1.3 million and $ 1.1 million, respectively, for its inventories for the three months ended March 31, 2023 and 2022 . Property and Equipment, Net (in thousands) March 31, December 31, 2023 2022 Laboratory and manufacturing equipment $ 11,940 $ 11,482 Computer equipment and software 21,530 18,626 Furniture and fixtures 4,485 4,421 Leasehold improvements 10,589 10,589 Construction in process 4,739 5,984 Total 53,283 51,102 Less: Accumulated depreciation and amortization ( 30,372 ) ( 28,831 ) Property and equipment, net $ 22,911 $ 22,271 The Company recognized depreciation and amortization expense on property and equipment as follows (in thousands): Three Months Ended March 31, 2023 2022 Depreciation and amortization expense $ 1,541 $ 1,495 Accrued Liabilities (in thousands) March 31, December 31, 2023 2022 Accrued payroll and related expenses $ 26,490 $ 35,341 Accrued professional fees 2,877 1,425 Accrued taxes 2,974 1,910 Accrued clinical and research expenses 235 282 Accrued interest 2,609 1,305 Accrued warranty 1,147 866 Accrued other 4,035 6,039 Total accrued liabilities $ 40,367 $ 47,168 |