Sphera Funds Management 13FHR Quarterly holdings report by institutional manager | SEC 14 Feb 24

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
89BIO INC	COM	282559103	4,564,889	408,674	SH		DFND	1,2	408,674	0	0
ABBVIE INC	COM	00287Y109	7,128,620	46,000	SH		DFND	1,2	46,000	0	0
ADVANCED MICRO DEVICES INC	COM	007903107	7,427,548	50,387	SH		DFND		50,387	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	6,934,784	36,230	SH		DFND	1,2	36,230	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	3,828,200	20,000	SH	Call	DFND	1,2	0	0	0
ALPINE IMMUNE SCIENCES INC	COM	02083G100	4,476,069	234,841	SH		DFND	1,2	234,841	0	0
AMAZON COM INC	COM	023135106	8,459,411	55,676	SH		DFND		55,676	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	2,703,328	183,650	SH		DFND	1,2	183,650	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	1,472,000	100,000	SH	Call	DFND	1,2	0	0	0
APOGEE THERAPEUTICS INC	COM	03770N101	838,200	30,000	SH		DFND	1,2	30,000	0	0
ARBE ROBOTICS LTD	ORDINARY SHARES	M1R95N100	94,100	43,165	SH		DFND		43,165	0	0
ARROWHEAD PHARMACEUTICALS IN	COM	04280A100	4,433,909	144,899	SH		DFND	1,2	144,899	0	0
ASTRAZENECA PLC	SPONSORED ADR	046353108	12,127,041	180,060	SH		DFND	1,2	180,060	0	0
ASTRIA THERAPEUTICS INC	COM	04635X102	8,840,794	1,151,145	SH		DFND	1,2	1,151,145	0	0
BIOGEN INC	COM	09062X103	11,992,954	46,346	SH		DFND	1,2	46,346	0	0
BRIDGEBIO PHARMA INC	COM	10806X102	11,390,234	282,146	SH		DFND	1,2	282,146	0	0
BROADCOM INC	COM	11135F101	2,009,250	1,800	SH		DFND		1,800	0	0
CARGO THERAPEUTICS INC	COM	14179K101	1,736,250	75,000	SH		DFND	1,2	75,000	0	0
CARTESIAN THERAPEUTICS INC	COM	816212104	518,523	752,137	SH		DFND	1,2	752,137	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	12,518,441	315,644	SH		DFND	1,2	315,644	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	4,588,662	115,700	SH	Call	DFND	1,2	0	0	0
COGENT BIOSCIENCES INC	COM	19240Q201	1,524,102	259,201	SH		DFND	1,2	259,201	0	0
COMPUGEN LTD	ORD	M25722105	1,523,093	769,239	SH		DFND	1,2	769,239	0	0
CYTOKINETICS INC	COM NEW	23282W605	18,686,732	223,820	SH		DFND	1,2	223,820	0	0
CYTOKINETICS INC	COM NEW	23282W605	2,988,942	35,800	SH	Call	DFND	1,2	0	0	0
DAY ONE BIOPHARMACEUTICALS I	COM	23954D109	7,489,800	513,000	SH		DFND	1,2	513,000	0	0
ELEVATION ONCOLOGY INC	COM	28623U101	483,300	900,000	SH		DFND	1,2	900,000	0	0
ELI LILLY & CO	COM	532457108	8,271,635	14,190	SH		DFND	1,2	14,190	0	0
ENLIGHT RENEWABLE ENERGY LTD	SHS	M4056D110	3,240,019	169,280	SH		DFND		169,280	0	0
ENPHASE ENERGY INC	COM	29355A107	4,598,472	34,800	SH		DFND		34,800	0	0
ENPHASE ENERGY INC	COM	29355A107	4,241,694	32,100	SH	Call	DFND		0	0	0
FIVE9 INC	COM	338307101	1,180,350	15,000	SH		DFND		15,000	0	0
FREELINE THERAPEUTICS HLDGS	SPONSORED ADS	35655L206	104,755	16,445	SH		DFND	1,2	16,445	0	0
FUSION PHARMACEUTICALS INC	COM	36118A100	10,432,991	1,085,639	SH		DFND	1,2	1,085,639	0	0
GILEAD SCIENCES INC	COM	375558103	1,620,200	20,000	SH		DFND	1,2	20,000	0	0
GLOBAL E ONLINE LTD	SHS	M5216V106	10,691,936	269,794	SH		DFND		269,794	0	0
GOSSAMER BIO INC	COM	38341P102	1,221,007	1,338,090	SH		DFND	1,2	1,338,090	0	0
GRACELL BIOTECHNOLOGIES INC	SPONSORED ADS	38406L103	5,049,477	502,936	SH		DFND	1,2	502,936	0	0
GSK PLC	SPONSORED ADR	37733W204	3,706,000	100,000	SH		DFND	1,2	100,000	0	0
ICL GROUP LTD	SHS	M53213100	2,104,200	420,000	SH		DFND		420,000	0	0
IMMATICS N.V	*W EXP 07/01/202	N44445117	292,000	100,000	SH		DFND	1,2	0	0	0
IMMATICS N.V	SHS	N44445109	6,540,299	621,111	SH		DFND	1,2	621,111	0	0
INCYTE CORP	COM	45337C102	5,623,221	89,556	SH		DFND	1,2	89,556	0	0
INHIBRX INC	COM	45720L107	8,608,938	226,551	SH		DFND	1,2	226,551	0	0
INOZYME PHARMA INC	COM	45790W108	6,657,984	1,562,907	SH		DFND	1,2	1,562,907	0	0
JASPER THERAPEUTICS INC	COM	471871103	5,626,063	713,063	SH		DFND	1,2	713,063	0	0
JFROG LTD	ORD SHS	M6191J100	3,803,812	109,905	SH		DFND		109,905	0	0
JOHNSON & JOHNSON	COM	478160104	12,512,711	79,831	SH		DFND	1,2	79,831	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	1,943,758	2,051,676	SH		DFND	1,2	2,051,676	0	0
KURA ONCOLOGY INC	COM	50127T109	10,113,267	703,287	SH		DFND	1,2	703,287	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	6,424,728	27,767	SH		DFND	1,2	27,767	0	0
MEDIWOUND LTD	SHS NEW	M68830112	498,124	48,980	SH		DFND	1,2	48,980	0	0
MERCK & CO INC	COM	58933Y105	13,474,872	123,600	SH		DFND	1,2	123,600	0	0
MERUS N V	COM	N5749R100	6,334,158	230,333	SH		DFND	1,2	230,333	0	0
META PLATFORMS INC	CL A	30303M102	12,141,890	34,303	SH		DFND		34,303	0	0
MICROSOFT CORP	COM	594918104	8,967,802	23,848	SH		DFND		23,848	0	0
MINERALYS THERAPEUTICS INC	COM	603170101	6,394,883	743,591	SH		DFND	1,2	743,591	0	0
MONTE ROSA THERAPEUTICS INC	COM	61225M102	274,087	48,511	SH		DFND	1,2	48,511	0	0
MORPHIC HLDG INC	COM	61775R105	431,814	14,952	SH		DFND	1,2	14,952	0	0
NICE LTD	SPONSORED ADR	653656108	13,510,418	67,718	SH		DFND		67,718	0	0
NOVA LTD	COM	M7516K103	18,135,480	132,000	SH		DFND		132,000	0	0
NOVARTIS AG	SPONSORED ADR	66987V109	6,058,070	60,000	SH		DFND	1,2	60,000	0	0
NOVO-NORDISK A S	ADR	670100205	9,629,126	93,080	SH		DFND	1,2	93,080	0	0
ORIC PHARMACEUTICALS INC	COM	68622P109	1,166,560	126,800	SH		DFND	1,2	126,800	0	0
PALO ALTO NETWORKS INC	COM	697435105	4,890,585	16,585	SH		DFND		16,585	0	0
PERSPECTIVE THERAPEUTICS INC	COM	46489V104	10,320	25,671	SH		DFND	1,2	25,671	0	0
PFIZER INC	COM	717081103	2,591,100	90,000	SH		DFND	1,2	90,000	0	0
PHARVARIS N V	COM	N69605108	6,872,250	245,000	SH		DFND	1,2	245,000	0	0
PLIANT THERAPEUTICS INC	COM	729139105	3,505,263	193,554	SH		DFND	1,2	193,554	0	0
PRAXIS PRECISION MEDICINES I	COM NEW	74006W108	7,329,808	328,986	SH		DFND	1,2	328,986	0	0
PRIME MEDICINE INC	COM	74168J101	655,463	73,980	SH		DFND	1,2	73,980	0	0
PROMIS NEUROSCIENCES INC	COM NEW	74346M406	2,109,148	1,834,042	SH		DFND	1,2	1,834,042	0	0
PROTHENA CORP PLC	SHS	G72800108	2,478,388	68,200	SH	Call	DFND	1,2	0	0	0
PTC THERAPEUTICS INC	COM	69366J200	3,762,629	136,525	SH		DFND	1,2	136,525	0	0
REPLIMUNE GROUP INC	COM	76029N106	135,689	16,096	SH		DFND	1,2	16,096	0	0
REZOLUTE INC	COM NEW	76200L309	989,235	996,710	SH		DFND	1,2	996,710	0	0
RIGEL PHARMACEUTICALS INC	COM NEW	766559603	1,780,783	1,228,126	SH		DFND	1,2	1,228,126	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	5,717,767	190,783	SH		DFND	1,2	190,783	0	0
SANOFI	SPONSORED ADR	80105N105	24,840,881	499,515	SH		DFND	1,2	499,515	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	1,205,375	12,500	SH		DFND	1,2	12,500	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	2,545,752	26,400	SH	Call	DFND	1,2	0	0	0
SENTINELONE INC	CL A	81730H109	5,856,190	213,418	SH		DFND		213,418	0	0
SHL TELEMEDICINE LTD	SPONSORED ADS	78423T200	5,043,837	632,456	SH		DFND		632,456	0	0
SOLAREDGE TECHNOLOGIES INC	COM	83417M104	4,492,800	48,000	SH		DFND		48,000	0	0
SOLAREDGE TECHNOLOGIES INC	COM	83417M104	2,508,480	26,800	SH	Call	DFND		0	0	0
SPDR SER TR	S&P BIOTECH	78464A870	44,645,000	500,000	SH	Put	DFND	1,2	500,000	0	0
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	6,214,855	170,270	SH		DFND	1,2	170,270	0	0
SYNDAX PHARMACEUTICALS INC	COM	87164F105	16,703,752	772,964	SH		DFND	1,2	772,964	0	0
TABOOLA.COM LTD	ORD SHS	M8744T106	7,469,025	1,724,948	SH		DFND		1,724,948	0	0
TEVA PHARMACEUTICAL INDS LTD	SPONSORED ADS	881624209	20,557,404	1,969,100	SH		DFND		1,969,100	0	0
TEVA PHARMACEUTICAL INDS LTD	SPONSORED ADS	881624209	5,220,000	500,000	SH		DFND	1,2	500,000	0	0
TEVA PHARMACEUTICAL INDS LTD	SPONSORED ADS	881624209	13,404,959	1,284,000	SH	Call	DFND		0	0	0
TOWER SEMICONDUCTOR LTD	SHS NEW	M87915274	16,123,716	528,300	SH		DFND		528,300	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	9,613,924	201,044	SH		DFND	1,2	201,044	0	0
UPWORK INC	COM	91688F104	3,758,898	252,784	SH		DFND		252,784	0	0
VENTYX BIOSCIENCES INC	COM	92332V107	444,600	180,000	SH		DFND	1,2	180,000	0	0
VIGIL NEUROSCIENCE INC	COM	92673K108	1,808,706	535,120	SH		DFND	1,2	535,120	0	0
VISTAGEN THERAPEUTICS INC	COM	92840H400	4,155,947	808,550	SH		DFND	1,2	808,550	0	0
WEREWOLF THERAPEUTICS INC	COM	95075A107	2,419,487	626,810	SH		DFND	1,2	626,810	0	0
WIX COM LTD	SHS	M98068105	7,070,821	57,477	SH		DFND		57,477	0	0

Sphera Funds Management 13F-HRQuarterly holdings report by institutional manager