Sphera Funds Management 13FHR Quarterly holdings report by institutional manager | SEC 15 May 24

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
4D MOLECULAR THERAPEUTICS IN	COM	35104E100	5,166,449	162,161	SH		DFND	1,2	162,161	0	0
89BIO INC	COM	282559103	6,004,866	515,882	SH		DFND	1,2	515,882	0	0
ABBVIE INC	COM	00287Y109	6,919,800	38,000	SH		DFND	1,2	38,000	0	0
ACADIA PHARMACEUTICALS INC	COM	004225108	2,311,250	125,000	SH		DFND	1,2	125,000	0	0
ACADIA PHARMACEUTICALS INC	COM	004225108	1,849,000	100,000	SH	Call	DFND	1,2	0	0	0
ADVANCED MICRO DEVICES INC	COM	007903107	1,985,390	11,000	SH		DFND		11,000	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	4,052,841	160,445	SH		DFND	1,2	160,445	0	0
ALECTOR INC	COM	014442107	3,371,200	560,000	SH		DFND	1,2	560,000	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	2,989,000	20,000	SH	Call	DFND	1,2	0	0	0
ALPINE IMMUNE SCIENCES INC	COM	02083G100	1,777,497	44,841	SH		DFND	1,2	44,841	0	0
ALTO NEUROSCIENCE INC	COM SHS	02157Q109	468,175	30,500	SH		DFND	1,2	30,500	0	0
AMAZON COM INC	COM	023135106	9,818,444	54,432	SH		DFND		54,432	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	758,990	267,250	SH		DFND	1,2	267,250	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	681,600	240,000	SH	Call	DFND	1,2	0	0	0
ANNEXON INC	COM	03589W102	81,738	11,400	SH	Put	DFND	1,2	11,400	0	0
APPLE INC	COM	037833100	3,000,900	17,500	SH		DFND		17,500	0	0
APPLIED MATLS INC	COM	038222105	6,599,360	32,000	SH		DFND		32,000	0	0
APPLIED THERAPEUTICS INC	COM	03828A101	4,209,397	619,029	SH		DFND	1,2	619,029	0	0
APREA THERAPEUTICS INC	COM NEW	03836J201	1,806,300	270,000	SH		DFND	1,2	270,000	0	0
ARBE ROBOTICS LTD	ORDINARY SHARES	M1R95N100	90,215	43,165	SH		DFND		43,165	0	0
ASTRAZENECA PLC	SPONSORED ADR	046353108	12,876,565	190,060	SH		DFND	1,2	190,060	0	0
ASTRIA THERAPEUTICS INC	COM	04635X102	1,588,251	112,842	SH		DFND	1,2	112,842	0	0
BIOGEN INC	COM	09062X103	15,233,397	70,646	SH		DFND	1,2	70,646	0	0
BRIDGEBIO PHARMA INC	COM	10806X102	18,117,760	585,956	SH		DFND	1,2	585,956	0	0
BRIDGEBIO PHARMA INC	COM	10806X102	1,546,000	50,000	SH	Call	DFND	1,2	0	0	0
BROADCOM INC	COM	11135F101	1,326,735	1,001	SH		DFND		1,001	0	0
CAMTEK LTD	ORD	M20791105	6,275,127	74,909	SH		DFND		74,909	0	0
CARGO THERAPEUTICS INC	COM	14179K101	1,674,000	75,000	SH		DFND	1,2	75,000	0	0
CARTESIAN THERAPEUTICS INC	COM	816212104	488,889	25,071	SH		DFND	1,2	25,071	0	0
CATALYST PHARMACEUTICALS INC	COM	14888U101	4,590,720	288,000	SH		DFND	1,2	288,000	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	11,625,522	276,996	SH		DFND	1,2	276,996	0	0
COMPUGEN LTD	ORD	M25722105	1,984,637	769,239	SH		DFND	1,2	769,239	0	0
CORBUS PHARMACEUTICALS HLDGS	COM NEW	21833P301	1,373,400	35,000	SH		DFND	1,2	35,000	0	0
CYBIN INC	COM	23256X100	10,577,907	25,581,395	SH		DFND	1,2	25,581,395	0	0
CYTOKINETICS INC	COM NEW	23282W605	19,747,954	281,671	SH		DFND	1,2	281,671	0	0
DAY ONE BIOPHARMACEUTICALS I	COM	23954D109	8,138,198	492,627	SH		DFND	1,2	492,627	0	0
DISC MEDICINE INC	COM	254604101	3,043,642	48,886	SH		DFND	1,2	48,886	0	0
DISC MEDICINE INC	COM	254604101	1,556,500	25,000	SH	Call	DFND	1,2	0	0	0
ELASTIC N V	ORD SHS	N14506104	2,004,800	20,000	SH		DFND		20,000	0	0
ELEVATION ONCOLOGY INC	COM	28623U101	2,205,900	430,000	SH		DFND	1,2	430,000	0	0
ELI LILLY & CO	COM	532457108	11,039,252	14,190	SH		DFND	1,2	14,190	0	0
ENLIGHT RENEWABLE ENERGY LTD	SHS	M4056D110	2,864,218	169,280	SH		DFND		169,280	0	0
ENPHASE ENERGY INC	COM	29355A107	5,708,199	47,183	SH		DFND		47,183	0	0
FIVE9 INC	COM	338307101	1,708,025	27,500	SH		DFND		27,500	0	0
FUSION PHARMACEUTICALS INC	COM	36118A100	9,573,554	449,041	SH		DFND	1,2	449,041	0	0
GERON CORP	COM	374163103	1,268,375	384,356	SH		DFND	1,2	384,356	0	0
GLOBAL E ONLINE LTD	SHS	M5216V106	7,589,298	208,784	SH		DFND		208,784	0	0
GOSSAMER BIO INC	COM	38341P102	1,212,018	1,027,134	SH		DFND	1,2	1,027,134	0	0
GSK PLC	SPONSORED ADR	37733W204	4,287,000	100,000	SH		DFND	1,2	100,000	0	0
ICL GROUP LTD	SHS	M53213100	701,956	130,475	SH		DFND		130,475	0	0
IMMATICS N.V	SHS	N44445109	7,000,827	666,111	SH		DFND	1,2	666,111	0	0
IMMATICS N.V	*W EXP 07/01/202	N44445117	270,000	100,000	SH		DFND	1,2	100,000	0	0
INCYTE CORP	COM	45337C102	5,102,005	89,556	SH		DFND	1,2	89,556	0	0
INOZYME PHARMA INC	COM	45790W108	10,516,468	1,372,907	SH		DFND	1,2	1,372,907	0	0
INSMED INC	COM PAR $.01	457669307	762,353	28,100	SH	Call	DFND	1,2	0	0	0
JASPER THERAPEUTICS INC	COM NEW	471871202	14,833,905	505,242	SH		DFND	1,2	505,242	0	0
JFROG LTD	ORD SHS	M6191J100	9,922,128	224,381	SH		DFND		224,381	0	0
JOHNSON & JOHNSON	COM	478160104	12,628,466	79,831	SH		DFND	1,2	79,831	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	1,849,791	2,051,676	SH		DFND	1,2	2,051,676	0	0
KURA ONCOLOGY INC	COM	50127T109	13,028,919	610,826	SH		DFND	1,2	610,826	0	0
LAVA THERAPEUTICS NV	SHS	N51517105	1,224,048	367,582	SH		DFND	1,2	367,582	0	0
MERCK & CO INC	COM	58933Y105	13,670,020	103,600	SH		DFND	1,2	103,600	0	0
MERUS N V	COM	N5749R100	6,724,465	149,333	SH		DFND	1,2	149,333	0	0
META PLATFORMS INC	CL A	30303M102	12,352,670	25,439	SH		DFND		25,439	0	0
MICROSOFT CORP	COM	594918104	11,589,995	27,548	SH		DFND		27,548	0	0
MINERALYS THERAPEUTICS INC	COM	603170101	8,505,147	658,803	SH		DFND	1,2	658,803	0	0
NICE LTD	SPONSORED ADR	653656108	22,382,306	85,881	SH		DFND		85,881	0	0
NOVA LTD	COM	M7516K103	6,227,102	35,106	SH		DFND		35,106	0	0
NOVARTIS AG	SPONSORED ADR	66987V109	4,836,500	50,000	SH		DFND	1,2	50,000	0	0
NOVO-NORDISK A S	ADR	670100205	10,667,472	83,080	SH		DFND	1,2	83,080	0	0
NUTRIEN LTD	COM	67077M108	1,940,496	35,730	SH		DFND		35,730	0	0
OUTLOOK THERAPEUTICS INC	COM	69012T305	6,822,857	571,429	SH		DFND	1,2	571,429	0	0
PERSPECTIVE THERAPEUTICS INC	COM	46489V104	14,807,909	12,443,621	SH		DFND	1,2	12,443,621	0	0
PFIZER INC	COM	717081103	2,497,500	90,000	SH		DFND	1,2	90,000	0	0
PHARVARIS N V	COM	N69605108	9,079,387	392,877	SH		DFND	1,2	392,877	0	0
PLIANT THERAPEUTICS INC	COM	729139105	3,852,455	258,554	SH		DFND	1,2	258,554	0	0
PRAXIS PRECISION MEDICINES I	COM NEW	74006W207	10,809,022	177,139	SH		DFND	1,2	177,139	0	0
PRIME MEDICINE INC	COM	74168J101	1,436,694	205,242	SH		DFND	1,2	205,242	0	0
PROMIS NEUROSCIENCES INC	COM NEW	74346M406	3,503,030	1,834,047	SH		DFND	1,2	1,834,047	0	0
QUALCOMM INC	COM	747525103	2,539,500	15,000	SH		DFND		15,000	0	0
REZOLUTE INC	COM NEW	76200L309	2,541,611	996,710	SH		DFND	1,2	996,710	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	4,949,471	183,722	SH		DFND	1,2	183,722	0	0
SANOFI	SPONSORED ADR	80105N105	24,276,429	499,515	SH		DFND	1,2	499,515	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	7,199,788	55,614	SH		DFND	1,2	55,614	0	0
SENTINELONE INC	CL A	81730H109	12,839,568	550,818	SH		DFND		550,818	0	0
SHL TELEMEDICINE LTD	SPONSORED ADS	78423T200	3,857,982	632,456	SH		DFND		632,456	0	0
SOLAREDGE TECHNOLOGIES INC	COM	83417M104	2,851,622	40,175	SH		DFND		40,175	0	0
SOLAREDGE TECHNOLOGIES INC	COM	83417M104	1,902,264	26,800	SH	Call	DFND		0	0	0
SPDR SER TR	S&P BIOTECH	78464A870	36,058,200	380,000	SH	Put	DFND	1,2	380,000	0	0
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	3,458,640	70,269	SH		DFND	1,2	70,269	0	0
SYNDAX PHARMACEUTICALS INC	COM	87164F105	19,348,543	812,964	SH		DFND	1,2	812,964	0	0
TABOOLA.COM LTD	ORD SHS	M8744T106	5,288,351	1,191,070	SH		DFND		1,191,070	0	0
TEVA PHARMACEUTICAL INDS LTD	SPONSORED ADS	881624209	5,996,750	425,000	SH		DFND	1,2	425,000	0	0
TEVA PHARMACEUTICAL INDS LTD	SPONSORED ADS	881624209	20,666,917	1,464,700	SH		DFND		1,464,700	0	0
TEVA PHARMACEUTICAL INDS LTD	SPONSORED ADS	881624209	44,202,396	3,132,700	SH	Call	DFND		0	0	0
TOWER SEMICONDUCTOR LTD	SHS NEW	M87915274	6,007,620	179,600	SH		DFND		179,600	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	11,137,619	238,544	SH		DFND	1,2	238,544	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	2,567,950	55,000	SH	Call	DFND	1,2	0	0	0
UPWORK INC	COM	91688F104	1,434,420	117,000	SH		DFND		117,000	0	0
VARONIS SYS INC	COM	922280102	943,400	20,000	SH		DFND		20,000	0	0
VENTYX BIOSCIENCES INC	COM	92332V107	5,460,120	992,749	SH		DFND	1,2	992,749	0	0
VIGIL NEUROSCIENCE INC	COM	92673K108	5,900,712	1,730,414	SH		DFND	1,2	1,730,414	0	0
VISTAGEN THERAPEUTICS INC	COM	92840H400	4,269,144	808,550	SH		DFND	1,2	808,550	0	0
WEREWOLF THERAPEUTICS INC	COM	95075A107	4,061,729	626,810	SH		DFND	1,2	626,810	0	0
WIX COM LTD	SHS	M98068105	7,269,530	52,877	SH		DFND		52,877	0	0

Sphera Funds Management 13F-HRQuarterly holdings report by institutional manager