COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
10X GENOMICS INC | CL A COM | 88025U109 | 18,133,817 | 324,746 | SH | | DFND | 2 | 324,746 | 0 | 0 |
4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 813,150 | 45,000 | SH | | DFND | 2 | 45,000 | 0 | 0 |
89BIO INC | COM | 282559103 | 1,235,540 | 65,200 | SH | | DFND | 2 | 65,200 | 0 | 0 |
ABBOTT LABS | COM | 002824100 | 179,501,539 | 1,646,501 | SH | | DFND | 2 | 1,646,501 | 0 | 0 |
ABBVIE INC | COM | 00287Y109 | 831,823 | 6,174 | SH | | DFND | 2 | 6,174 | 0 | 0 |
ABCAM PLC | ADS | 000380204 | 62,961 | 2,573 | SH | | DFND | 2 | 2,573 | 0 | 0 |
ACCOLADE INC | COM | 00437E102 | 11,065,416 | 821,486 | SH | | DFND | 2 | 821,486 | 0 | 0 |
ACCOLADE INC | COM | 00437E102 | 49,833,248 | 3,699,573 | SH | | DFND | 3 | 3,699,573 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 382,320 | 13,500 | SH | | DFND | 2 | 13,500 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 113,280,000 | 4,000,000 | SH | | DFND | 1,2 | 4,000,000 | 0 | 0 |
AKERO THERAPEUTICS INC | COM | 00973Y108 | 1,265,299 | 27,100 | SH | | DFND | 2 | 27,100 | 0 | 0 |
ALIGN TECHNOLOGY INC | COM | 016255101 | 60,521,950 | 171,140 | SH | | DFND | 2 | 171,140 | 0 | 0 |
ALKERMES PLC | SHS | G01767105 | 2,557,210 | 81,700 | SH | | DFND | 2 | 81,700 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 4,682,021 | 24,650 | SH | | DFND | 2 | 24,650 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 166,197,500 | 875,000 | SH | | DFND | 1,2 | 875,000 | 0 | 0 |
ALPHABET INC | CAP STK CL C | 02079K107 | 725,820 | 6,000 | SH | | DFND | 2 | 6,000 | 0 | 0 |
AMEDISYS INC | COM | 023436108 | 21,426,038 | 234,318 | SH | | DFND | 3 | 234,318 | 0 | 0 |
AMERICAN WELL CORP | CL A | 03044L105 | 2,002,587 | 953,613 | SH | | DFND | 2 | 953,613 | 0 | 0 |
AMERISOURCEBERGEN CORP | COM | 03073E105 | 3,061,561 | 15,910 | SH | | DFND | 2 | 15,910 | 0 | 0 |
AMGEN INC | COM | 031162100 | 6,063,366 | 27,310 | SH | | DFND | 2 | 27,310 | 0 | 0 |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 2,988,080 | 32,800 | SH | | DFND | 2 | 32,800 | 0 | 0 |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 44,246,815 | 485,695 | SH | | DFND | 3 | 485,695 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 22,715,023 | 58,284 | SH | | DFND | 2 | 58,284 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 337,116,450 | 865,000 | SH | | DFND | 1,2 | 865,000 | 0 | 0 |
ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 | 738,162 | 20,700 | SH | | DFND | 2 | 20,700 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 173,740 | 7,000 | SH | | DFND | 2 | 7,000 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 52,618,400 | 2,120,000 | SH | | DFND | 1,2 | 2,120,000 | 0 | 0 |
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 6,126,392 | 85,600 | SH | | DFND | 2 | 85,600 | 0 | 0 |
ATRICURE INC | COM | 04963C209 | 36,951,538 | 748,613 | SH | | DFND | 3 | 748,613 | 0 | 0 |
AXONICS INC | COM | 05465P101 | 39,780,555 | 788,202 | SH | | DFND | 2 | 788,202 | 0 | 0 |
AXONICS INC | COM | 05465P101 | 72,435,352 | 1,435,216 | SH | | DFND | 3 | 1,435,216 | 0 | 0 |
AXSOME THERAPEUTICS INC | COM | 05464T104 | 41,273,725 | 574,363 | SH | | DFND | 3 | 574,363 | 0 | 0 |
BAXTER INTL INC | COM | 071813109 | 9,724,053 | 213,434 | SH | | DFND | 2 | 213,434 | 0 | 0 |
BEAM THERAPEUTICS INC | COM | 07373V105 | 73,439 | 2,300 | SH | | DFND | 2 | 2,300 | 0 | 0 |
BEAM THERAPEUTICS INC | COM | 07373V105 | 22,131,354 | 693,121 | SH | | DFND | 1,2 | 693,121 | 0 | 0 |
BECTON DICKINSON & CO | COM | 075887109 | 89,162,249 | 337,723 | SH | | DFND | 2 | 337,723 | 0 | 0 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 1,818,660 | 10,200 | SH | | DFND | 2 | 10,200 | 0 | 0 |
BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 | 638,000 | 25,000 | SH | | DFND | 2 | 25,000 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 7,291,590 | 25,598 | SH | | DFND | 2 | 25,598 | 0 | 0 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 31,257,155 | 360,604 | SH | | DFND | 2 | 360,604 | 0 | 0 |
BIO RAD LABS INC | CL A | 090572207 | 51,004,151 | 134,533 | SH | | DFND | 3 | 134,533 | 0 | 0 |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 90,900 | 18,000 | SH | | DFND | 2 | 18,000 | 0 | 0 |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 40,995,087 | 8,117,839 | SH | | DFND | 1,2 | 8,117,839 | 0 | 0 |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 143,957,939 | 2,661,452 | SH | | DFND | 2 | 2,661,452 | 0 | 0 |
BRIDGEBIO PHARMA INC | COM | 10806X102 | 1,666,680 | 96,900 | SH | | DFND | 2 | 96,900 | 0 | 0 |
CAREDX INC | COM | 14167L103 | 31,590,055 | 3,716,477 | SH | | DFND | 3 | 3,716,477 | 0 | 0 |
CASTLE BIOSCIENCES INC | COM | 14843C105 | 15,421,870 | 1,124,043 | SH | | DFND | 3 | 1,124,043 | 0 | 0 |
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 61,074,000 | 1,800,000 | SH | | DFND | 1,2 | 1,800,000 | 0 | 0 |
CENTENE CORP DEL | COM | 15135B101 | 7,859,544 | 116,524 | SH | | DFND | 2 | 116,524 | 0 | 0 |
CENTENE CORP DEL | COM | 15135B101 | 11,871,402 | 176,003 | SH | | DFND | 3 | 176,003 | 0 | 0 |
CHARLES RIV LABS INTL INC | COM | 159864107 | 1,135,350 | 5,400 | SH | | DFND | 2 | 5,400 | 0 | 0 |
CHARLES RIV LABS INTL INC | COM | 159864107 | 64,991,008 | 309,113 | SH | | DFND | 3 | 309,113 | 0 | 0 |
COOPER COS INC | COM NEW | 216648402 | 33,192,385 | 86,567 | SH | | DFND | 2 | 86,567 | 0 | 0 |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 1,083,502 | 19,300 | SH | | DFND | 2 | 19,300 | 0 | 0 |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 49,403,200 | 880,000 | SH | | DFND | 1,2 | 880,000 | 0 | 0 |
CVS HEALTH CORP | COM | 126650100 | 2,441,257 | 35,314 | SH | | DFND | 2 | 35,314 | 0 | 0 |
CYTOKINETICS INC | COM NEW | 23282W605 | 1,210,202 | 37,100 | SH | | DFND | 2 | 37,100 | 0 | 0 |
DANAHER CORPORATION | COM | 235851102 | 44,090,160 | 183,709 | SH | | DFND | 2 | 183,709 | 0 | 0 |
DENALI THERAPEUTICS INC | COM | 24823R105 | 1,299,916 | 44,050 | SH | | DFND | 2 | 44,050 | 0 | 0 |
DEXCOM INC | COM | 252131107 | 97,888,123 | 761,716 | SH | | DFND | 2 | 761,716 | 0 | 0 |
DICE THERAPEUTICS INC | COM | 23345J104 | 845,572 | 18,200 | SH | | DFND | 2 | 18,200 | 0 | 0 |
DOXIMITY INC | CL A | 26622P107 | 15,260,658 | 448,579 | SH | | DFND | 2 | 448,579 | 0 | 0 |
DR REDDYS LABS LTD | ADR | 256135203 | 5,787,187 | 91,700 | SH | | DFND | 2 | 91,700 | 0 | 0 |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 97,923,218 | 1,038,092 | SH | | DFND | 2 | 1,038,092 | 0 | 0 |
ELEVANCE HEALTH INC | COM | 036752103 | 12,720,467 | 28,631 | SH | | DFND | 2 | 28,631 | 0 | 0 |
ELEVANCE HEALTH INC | COM | 036752103 | 32,798,376 | 73,822 | SH | | DFND | 3 | 73,822 | 0 | 0 |
LILLY ELI & CO | COM | 532457108 | 44,625,792 | 95,155 | SH | | DFND | 2 | 95,155 | 0 | 0 |
EQUINIX INC | COM | 29444U700 | 31,358 | 40 | SH | | DFND | 2 | 40 | 0 | 0 |
ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 19,738 | 14,200 | SH | | DFND | 2 | 14,200 | 0 | 0 |
ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 5,829,749 | 4,194,064 | SH | | DFND | 1,2 | 4,194,064 | 0 | 0 |
ESSA PHARMA INC | COM NEW | 29668H708 | 51,300 | 19,000 | SH | | DFND | 2 | 19,000 | 0 | 0 |
ESSA PHARMA INC | COM NEW | 29668H708 | 21,274,874 | 7,879,583 | SH | | DFND | 1,2 | 7,879,583 | 0 | 0 |
EVERTEC INC | COM | 30040P103 | 27,217 | 739 | SH | | DFND | 2 | 739 | 0 | 0 |
EVOLENT HEALTH INC | CL A | 30050B101 | 39,921,371 | 1,317,537 | SH | | DFND | 2 | 1,317,537 | 0 | 0 |
EVOLENT HEALTH INC | CL A | 30050B101 | 64,562,786 | 2,130,785 | SH | | DFND | 3 | 2,130,785 | 0 | 0 |
EXACT SCIENCES CORP | COM | 30063P105 | 18,875,684 | 201,019 | SH | | DFND | 2 | 201,019 | 0 | 0 |
EXACT SCIENCES CORP | COM | 30063P105 | 75,660,207 | 805,753 | SH | | DFND | 3 | 805,753 | 0 | 0 |
EXELIXIS INC | COM | 30161Q104 | 171,990 | 9,000 | SH | | DFND | 2 | 9,000 | 0 | 0 |
EXELIXIS INC | COM | 30161Q104 | 48,252,750 | 2,525,000 | SH | | DFND | 1,2 | 2,525,000 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 76,160 | 16,000 | SH | | DFND | 2 | 16,000 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 23,037,348 | 4,839,779 | SH | | DFND | 1,2 | 4,839,779 | 0 | 0 |
GENERATION BIO CO | COM | 37148K100 | 66,000 | 12,000 | SH | | DFND | 2 | 12,000 | 0 | 0 |
GENERATION BIO CO | COM | 37148K100 | 19,845,540 | 3,608,280 | SH | | DFND | 1,2 | 3,608,280 | 0 | 0 |
GILEAD SCIENCES INC | COM | 375558103 | 8,681,936 | 112,650 | SH | | DFND | 2 | 112,650 | 0 | 0 |
GLOBUS MED INC | CL A | 379577208 | 38,560,783 | 647,645 | SH | | DFND | 2 | 647,645 | 0 | 0 |
GRACELL BIOTECHNOLOGIES INC | SPONSORED ADS | 38406L103 | 554,911 | 145,646 | SH | | DFND | 2 | 145,646 | 0 | 0 |
GRUPO AEROPORTUARIO DEL SURE | SPON ADR SER B | 40051E202 | 37,488 | 135 | SH | | DFND | 2 | 135 | 0 | 0 |
GUARDANT HEALTH INC | COM | 40131M109 | 2,942,653 | 82,197 | SH | | DFND | 2 | 82,197 | 0 | 0 |
HCA HEALTHCARE INC | COM | 40412C101 | 48,713,092 | 160,515 | SH | | DFND | 2 | 160,515 | 0 | 0 |
HOLOGIC INC | COM | 436440101 | 23,492,312 | 290,136 | SH | | DFND | 2 | 290,136 | 0 | 0 |
HUMANA INC | COM | 444859102 | 56,952,289 | 127,373 | SH | | DFND | 2 | 127,373 | 0 | 0 |
HUTCHMED CHINA LTD | SPONSORED ADS | 44842L103 | 21,666,996 | 1,805,583 | SH | | DFND | 3 | 1,805,583 | 0 | 0 |
IDEXX LABS INC | COM | 45168D104 | 57,475,703 | 114,441 | SH | | DFND | 2 | 114,441 | 0 | 0 |
ILLUMINA INC | COM | 452327109 | 15,754,035 | 84,026 | SH | | DFND | 2 | 84,026 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 1,479,371 | 23,765 | SH | | DFND | 2 | 23,765 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 162,908,250 | 2,617,000 | SH | | DFND | 1,2 | 2,617,000 | 0 | 0 |
INFOSYS LTD | SPONSORED ADR | 456788108 | 18,159 | 1,130 | SH | | DFND | 2 | 1,130 | 0 | 0 |
INHIBRX INC | COM | 45720L107 | 1,266,848 | 48,800 | SH | | DFND | 2 | 48,800 | 0 | 0 |
INSMED INC | COM PAR $.01 | 457669307 | 69,649,222 | 3,300,911 | SH | | DFND | 3 | 3,300,911 | 0 | 0 |
INSPIRE MED SYS INC | COM | 457730109 | 115,902,973 | 357,020 | SH | | DFND | 2 | 357,020 | 0 | 0 |
INSULET CORP | COM | 45784P101 | 93,305,094 | 323,594 | SH | | DFND | 2 | 323,594 | 0 | 0 |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 3,279,976 | 51,800 | SH | | DFND | 2 | 51,800 | 0 | 0 |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 199,458,000 | 3,150,000 | SH | | DFND | 1,2 | 3,150,000 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 253,877,114 | 742,461 | SH | | DFND | 2 | 742,461 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 34,112,960 | 99,763 | SH | | DFND | 3 | 99,763 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 3,307,018 | 80,600 | SH | | DFND | 2 | 80,600 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 381,566,691 | 9,299,700 | SH | | DFND | 1,2 | 9,299,700 | 0 | 0 |
IQVIA HLDGS INC | COM | 46266C105 | 36,439,712 | 162,120 | SH | | DFND | 2 | 162,120 | 0 | 0 |
ISHARES TR | MSCI CHINA ETF | 46429B671 | 183,434 | 4,100 | SH | | DFND | 2 | 4,100 | 0 | 0 |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 27,826,306 | 224,460 | SH | | DFND | 2 | 224,460 | 0 | 0 |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 7,973,626 | 64,319 | SH | | DFND | 3 | 64,319 | 0 | 0 |
JOHNSON & JOHNSON | COM | 478160104 | 3,513,162 | 21,225 | SH | | DFND | 2 | 21,225 | 0 | 0 |
JUMIA TECHNOLOGIES AG | SPONSORED ADS | 48138M105 | 61,560 | 18,000 | SH | | DFND | 2 | 18,000 | 0 | 0 |
KARUNA THERAPEUTICS INC | COM | 48576A100 | 2,190,185 | 10,100 | SH | | DFND | 2 | 10,100 | 0 | 0 |
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 24,500 | 10,000 | SH | | DFND | 2 | 10,000 | 0 | 0 |
KOSMOS ENERGY LTD | COM | 500688106 | 1,906,617 | 318,300 | SH | | DFND | 2 | 318,300 | 0 | 0 |
KRYSTAL BIOTECH INC | COM | 501147102 | 2,113,200 | 18,000 | SH | | DFND | 2 | 18,000 | 0 | 0 |
LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 1,686,414 | 6,988 | SH | | DFND | 2 | 6,988 | 0 | 0 |
LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | 19,035,299 | 275,754 | SH | | DFND | 2 | 275,754 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 160,233 | 29,950 | SH | | DFND | 2 | 29,950 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 51,252,802 | 9,579,963 | SH | | DFND | 1,2 | 9,579,963 | 0 | 0 |
MCKESSON CORP | COM | 58155Q103 | 1,408,414 | 3,296 | SH | | DFND | 2 | 3,296 | 0 | 0 |
MEDTRONIC PLC | SHS | G5960L103 | 124,264,345 | 1,410,492 | SH | | DFND | 2 | 1,410,492 | 0 | 0 |
MERCK & CO INC | COM | 58933Y105 | 35,389,421 | 306,694 | SH | | DFND | 2 | 306,694 | 0 | 0 |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 44,415 | 13,500 | SH | | DFND | 2 | 13,500 | 0 | 0 |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 17,127,493 | 5,205,925 | SH | | DFND | 1,2 | 5,205,925 | 0 | 0 |
MERUS N V | COM | N5749R100 | 1,171,685 | 44,500 | SH | | DFND | 2 | 44,500 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 6,082,169 | 50,059 | SH | | DFND | 2 | 50,059 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 179,212,500 | 1,475,000 | SH | | DFND | 1,2 | 1,475,000 | 0 | 0 |
MOLECULAR TEMPLATES INC | COM | 608550109 | 18,240 | 38,000 | SH | | DFND | 2 | 38,000 | 0 | 0 |
MOLECULAR TEMPLATES INC | COM | 608550109 | 5,372,161 | 11,192,003 | SH | | DFND | 1,2 | 11,192,003 | 0 | 0 |
MOLINA HEALTHCARE INC | COM | 60855R100 | 49,505,179 | 164,338 | SH | | DFND | 2 | 164,338 | 0 | 0 |
NATERA INC | COM | 632307104 | 11,326,832 | 232,775 | SH | | DFND | 2 | 232,775 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 2,150,040 | 22,800 | SH | | DFND | 2 | 22,800 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 244,237,000 | 2,590,000 | SH | | DFND | 1,2 | 2,590,000 | 0 | 0 |
NEVRO CORP | COM | 64157F103 | 5,556,126 | 218,573 | SH | | DFND | 2 | 218,573 | 0 | 0 |
OLINK HLDG AB | SPONSORED ADS | 680710100 | 4,492,950 | 239,624 | SH | | DFND | 2 | 239,624 | 0 | 0 |
OMNICELL COM | COM | 68213N109 | 21,610,726 | 293,345 | SH | | DFND | 2 | 293,345 | 0 | 0 |
OPTION CARE HEALTH INC | COM NEW | 68404L201 | 74,324,871 | 2,287,623 | SH | | DFND | 3 | 2,287,623 | 0 | 0 |
OUTSET MED INC | COM | 690145107 | 22,022,106 | 1,006,955 | SH | | DFND | 2 | 1,006,955 | 0 | 0 |
OUTSET MED INC | COM | 690145107 | 46,341,021 | 2,118,931 | SH | | DFND | 3 | 2,118,931 | 0 | 0 |
PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 | 33,052,535 | 2,485,153 | SH | | DFND | 2 | 2,485,153 | 0 | 0 |
PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 | 67,267,091 | 5,057,676 | SH | | DFND | 3 | 5,057,676 | 0 | 0 |
PENUMBRA INC | COM | 70975L107 | 80,585,733 | 234,220 | SH | | DFND | 2 | 234,220 | 0 | 0 |
PHREESIA INC | COM | 71944F106 | 19,804,630 | 638,653 | SH | | DFND | 2 | 638,653 | 0 | 0 |
POINT BIOPHARMA GLOBAL INC | COM | 730541109 | 11,381,145 | 1,256,197 | SH | | DFND | 3 | 1,256,197 | 0 | 0 |
PRIVIA HEALTH GROUP INC | COM | 74276R102 | 29,312,235 | 1,122,644 | SH | | DFND | 2 | 1,122,644 | 0 | 0 |
PROCEPT BIOROBOTICS CORP | COM | 74276L105 | 26,212,626 | 741,517 | SH | | DFND | 2 | 741,517 | 0 | 0 |
QUEST DIAGNOSTICS INC | COM | 74834L100 | 272,968 | 1,942 | SH | | DFND | 2 | 1,942 | 0 | 0 |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 11,731,603 | 16,327 | SH | | DFND | 2 | 16,327 | 0 | 0 |
RELAY THERAPEUTICS INC | COM | 75943R102 | 889,248 | 70,800 | SH | | DFND | 2 | 70,800 | 0 | 0 |
RELAY THERAPEUTICS INC | COM | 75943R102 | 51,496,000 | 4,100,000 | SH | | DFND | 1,2 | 4,100,000 | 0 | 0 |
RESMED INC | COM | 761152107 | 21,473,088 | 98,275 | SH | | DFND | 2 | 98,275 | 0 | 0 |
REVOLUTION MEDICINES INC | COM | 76155X100 | 1,899,250 | 71,000 | SH | | DFND | 2 | 71,000 | 0 | 0 |
REVOLUTION MEDICINES INC | COM | 76155X100 | 125,056,250 | 4,675,000 | SH | | DFND | 1,2 | 4,675,000 | 0 | 0 |
ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 1,104,772 | 55,600 | SH | | DFND | 2 | 55,600 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 1,616,313 | 34,375 | SH | | DFND | 2 | 34,375 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 144,821,600 | 3,080,000 | SH | | DFND | 1,2 | 3,080,000 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 1,297,512 | 11,330 | SH | | DFND | 2 | 11,330 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 21,631,683 | 188,890 | SH | | DFND | 3 | 188,890 | 0 | 0 |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 55,042 | 7,300 | SH | | DFND | 2 | 7,300 | 0 | 0 |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 16,080,747 | 2,132,725 | SH | | DFND | 1,2 | 2,132,725 | 0 | 0 |
SEAGEN INC | COM | 81181C104 | 4,234,120 | 22,000 | SH | | DFND | 2 | 22,000 | 0 | 0 |
SEER INC | COM CL A | 81578P106 | 581,288 | 136,133 | SH | | DFND | 2 | 136,133 | 0 | 0 |
SHOCKWAVE MED INC | COM | 82489T104 | 77,210,826 | 270,526 | SH | | DFND | 2 | 270,526 | 0 | 0 |
SIGHT SCIENCES INC | COM | 82657M105 | 2,370,432 | 286,284 | SH | | DFND | 2 | 286,284 | 0 | 0 |
SILK RD MED INC | COM | 82710M100 | 44,081,230 | 1,356,763 | SH | | DFND | 3 | 1,356,763 | 0 | 0 |
SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 797,904 | 1,800 | SH | | DFND | 2 | 1,800 | 0 | 0 |
SPDR SER TR | S&P OILGAS EXP | 78468R556 | 502,437 | 3,900 | SH | | DFND | 2 | 3,900 | 0 | 0 |
STRYKER CORPORATION | COM | 863667101 | 145,511,455 | 476,946 | SH | | DFND | 2 | 476,946 | 0 | 0 |
SUPERNUS PHARMACEUTICALS INC | COM | 868459108 | 19,546,695 | 650,256 | SH | | DFND | 2 | 650,256 | 0 | 0 |
TAIWAN SEMICONDUCTOR MFG LTD | SPONSORED ADS | 874039100 | 109,902 | 1,089 | SH | | DFND | 2 | 1,089 | 0 | 0 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 14,430,428 | 588,037 | SH | | DFND | 2 | 588,037 | 0 | 0 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 36,930,172 | 1,504,897 | SH | | DFND | 3 | 1,504,897 | 0 | 0 |
TELADOC HEALTH INC | COM | 87918A105 | 9,932,124 | 392,264 | SH | | DFND | 2 | 392,264 | 0 | 0 |
TENET HEALTHCARE CORP | COM NEW | 88033G407 | 54,443 | 669 | SH | | DFND | 2 | 669 | 0 | 0 |
THE CIGNA GROUP | COM | 125523100 | 14,141,959 | 50,399 | SH | | DFND | 2 | 50,399 | 0 | 0 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 50,140,697 | 96,101 | SH | | DFND | 2 | 96,101 | 0 | 0 |
TRANSMEDICS GROUP INC | COM | 89377M109 | 51,447,240 | 612,613 | SH | | DFND | 2 | 612,613 | 0 | 0 |
UNITED MICROELECTRONICS CORP | SPON ADR NEW | 910873405 | 21,287 | 2,698 | SH | | DFND | 2 | 2,698 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 53,830,238 | 111,997 | SH | | DFND | 2 | 111,997 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 47,165,203 | 98,130 | SH | | DFND | 3 | 98,130 | 0 | 0 |
VANECK ETF TRUST | GOLD MINERS ETF | 92189F106 | 993,630 | 33,000 | SH | | DFND | 2 | 33,000 | 0 | 0 |
VANECK ETF TRUST | JUNIOR GOLD MINE | 92189F791 | 178,300 | 5,000 | SH | | DFND | 2 | 5,000 | 0 | 0 |
VAXCYTE INC | COM | 92243G108 | 1,298,440 | 26,000 | SH | | DFND | 2 | 26,000 | 0 | 0 |
VEEVA SYS INC | CL A COM | 922475108 | 53,593,926 | 271,046 | SH | | DFND | 2 | 271,046 | 0 | 0 |
VENTYX BIOSCIENCES INC | COM | 92332V107 | 803,600 | 24,500 | SH | | DFND | 2 | 24,500 | 0 | 0 |
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 1,226,120 | 58,000 | SH | | DFND | 2 | 58,000 | 0 | 0 |
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 10,872,619 | 514,315 | SH | | DFND | 3 | 514,315 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 49,479,602 | 140,603 | SH | | DFND | 2 | 140,603 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 37,500,585 | 106,563 | SH | | DFND | 3 | 106,563 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 299,123,500 | 850,000 | SH | | DFND | 1,2 | 850,000 | 0 | 0 |
VIKING THERAPEUTICS INC | COM | 92686J106 | 534,930 | 33,000 | SH | | DFND | 2 | 33,000 | 0 | 0 |
VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 1,056,276 | 44,400 | SH | | DFND | 2 | 44,400 | 0 | 0 |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 16,359,827 | 4,494,458 | SH | | DFND | 1,2 | 4,494,458 | 0 | 0 |
XENON PHARMACEUTICALS INC | COM | 98420N105 | 920,150 | 23,900 | SH | | DFND | 2 | 23,900 | 0 | 0 |
ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 41,471,976 | 284,835 | SH | | DFND | 2 | 284,835 | 0 | 0 |
ZOETIS INC | CL A | 98978V103 | 1,118,676 | 6,496 | SH | | DFND | 2 | 6,496 | 0 | 0 |