COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
10X GENOMICS INC | CL A COM | 88025U109 | 12,145,320 | 294,432 | SH | | DFND | 2 | 294,432 | 0 | 0 |
89BIO INC | COM | 282559103 | 605,248 | 39,200 | SH | | DFND | 2 | 39,200 | 0 | 0 |
ABBOTT LABS | COM | 002824100 | 151,179,751 | 1,560,968 | SH | | DFND | 2 | 1,560,968 | 0 | 0 |
ABBVIE INC | COM | 00287Y109 | 709,973 | 4,763 | SH | | DFND | 2 | 4,763 | 0 | 0 |
ACCOLADE INC | COM | 00437E102 | 7,880,079 | 744,809 | SH | | DFND | 2 | 744,809 | 0 | 0 |
ACCOLADE INC | COM | 00437E102 | 40,025,346 | 3,783,114 | SH | | DFND | 3 | 3,783,114 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 334,125 | 13,500 | SH | | DFND | 2 | 13,500 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 99,000,000 | 4,000,000 | SH | | DFND | 1,2 | 4,000,000 | 0 | 0 |
AKERO THERAPEUTICS INC | COM | 00973Y108 | 1,264,500 | 25,000 | SH | | DFND | 2 | 25,000 | 0 | 0 |
ALIGN TECHNOLOGY INC | COM | 016255101 | 50,953,634 | 166,886 | SH | | DFND | 2 | 166,886 | 0 | 0 |
ALKERMES PLC | SHS | G01767105 | 2,288,417 | 81,700 | SH | | DFND | 2 | 81,700 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 4,364,630 | 24,645 | SH | | DFND | 2 | 24,645 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 154,023,870 | 869,700 | SH | | DFND | 1,2 | 869,700 | 0 | 0 |
ALPHABET INC | CAP STK CL C | 02079K107 | 791,100 | 6,000 | SH | | DFND | 2 | 6,000 | 0 | 0 |
AMEDISYS INC | COM | 023436108 | 9,936,546 | 106,387 | SH | | DFND | 3 | 106,387 | 0 | 0 |
AMGEN INC | COM | 031162100 | 13,027,603 | 48,473 | SH | | DFND | 2 | 48,473 | 0 | 0 |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 1,475,952 | 38,800 | SH | | DFND | 2 | 38,800 | 0 | 0 |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 28,721,760 | 755,041 | SH | | DFND | 3 | 755,041 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 25,444,311 | 51,755 | SH | | DFND | 2 | 51,755 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 422,691,183 | 859,775 | SH | | DFND | 1,2 | 859,775 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 102,128 | 5,200 | SH | | DFND | 2 | 5,200 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 41,636,800 | 2,120,000 | SH | | DFND | 1,2 | 2,120,000 | 0 | 0 |
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 5,726,045 | 84,600 | SH | | DFND | 2 | 84,600 | 0 | 0 |
ATRICURE INC | COM | 04963C209 | 32,743,128 | 747,560 | SH | | DFND | 3 | 747,560 | 0 | 0 |
AXONICS INC | COM | 05465P101 | 45,940,056 | 818,604 | SH | | DFND | 2 | 818,604 | 0 | 0 |
AXONICS INC | COM | 05465P101 | 80,489,942 | 1,434,247 | SH | | DFND | 3 | 1,434,247 | 0 | 0 |
AXSOME THERAPEUTICS INC | COM | 05464T104 | 44,134,626 | 631,487 | SH | | DFND | 3 | 631,487 | 0 | 0 |
BEAM THERAPEUTICS INC | COM | 07373V105 | 40,885 | 1,700 | SH | | DFND | 2 | 1,700 | 0 | 0 |
BEAM THERAPEUTICS INC | COM | 07373V105 | 16,669,560 | 693,121 | SH | | DFND | 1,2 | 693,121 | 0 | 0 |
BECTON DICKINSON & CO | COM | 075887109 | 78,652,582 | 304,230 | SH | | DFND | 2 | 304,230 | 0 | 0 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 9,503,850 | 53,200 | SH | | DFND | 2 | 53,200 | 0 | 0 |
BICYCLE THERAPEUTICS PLC | SPONSORED ADS | 088786108 | 787,528 | 39,200 | SH | | DFND | 2 | 39,200 | 0 | 0 |
BIO RAD LABS INC | CL A | 090572207 | 48,150,589 | 134,330 | SH | | DFND | 3 | 134,330 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 4,449,871 | 17,314 | SH | | DFND | 2 | 17,314 | 0 | 0 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 30,958,090 | 349,888 | SH | | DFND | 2 | 349,888 | 0 | 0 |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 51,660 | 18,000 | SH | | DFND | 2 | 18,000 | 0 | 0 |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 23,298,198 | 8,117,839 | SH | | DFND | 1,2 | 8,117,839 | 0 | 0 |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 139,724,376 | 2,646,295 | SH | | DFND | 2 | 2,646,295 | 0 | 0 |
BRIDGEBIO PHARMA INC | COM | 10806X102 | 2,075,319 | 78,700 | SH | | DFND | 2 | 78,700 | 0 | 0 |
CAREDX INC | COM | 14167L103 | 27,585,586 | 3,940,798 | SH | | DFND | 3 | 3,940,798 | 0 | 0 |
CASTLE BIOSCIENCES INC | COM | 14843C105 | 20,741,444 | 1,228,031 | SH | | DFND | 3 | 1,228,031 | 0 | 0 |
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 52,288,000 | 1,900,000 | SH | | DFND | 1,2 | 1,900,000 | 0 | 0 |
CENCORA INC | COM | 03073E105 | 3,075,147 | 17,087 | SH | | DFND | 2 | 17,087 | 0 | 0 |
CENTENE CORP DEL | COM | 15135B101 | 12,672,129 | 183,974 | SH | | DFND | 2 | 183,974 | 0 | 0 |
CENTENE CORP DEL | COM | 15135B101 | 17,913,553 | 260,069 | SH | | DFND | 3 | 260,069 | 0 | 0 |
CERTARA INC | COM | 15687V109 | 1,331,951 | 91,606 | SH | | DFND | 2 | 91,606 | 0 | 0 |
CHARLES RIV LABS INTL INC | COM | 159864107 | 2,312,564 | 11,800 | SH | | DFND | 2 | 11,800 | 0 | 0 |
CHARLES RIV LABS INTL INC | COM | 159864107 | 42,633,881 | 217,542 | SH | | DFND | 3 | 217,542 | 0 | 0 |
COOPER COS INC | COM NEW | 216648402 | 27,529,172 | 86,567 | SH | | DFND | 2 | 86,567 | 0 | 0 |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 835,176 | 18,400 | SH | | DFND | 2 | 18,400 | 0 | 0 |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 39,943,200 | 880,000 | SH | | DFND | 1,2 | 880,000 | 0 | 0 |
CVS HEALTH CORP | COM | 126650100 | 2,465,623 | 35,314 | SH | | DFND | 2 | 35,314 | 0 | 0 |
CYTOKINETICS INC | COM NEW | 23282W605 | 1,092,966 | 37,100 | SH | | DFND | 2 | 37,100 | 0 | 0 |
DANAHER CORPORATION | COM | 235851102 | 33,873,837 | 136,533 | SH | | DFND | 2 | 136,533 | 0 | 0 |
DEXCOM INC | COM | 252131107 | 63,978,889 | 685,733 | SH | | DFND | 2 | 685,733 | 0 | 0 |
DOXIMITY INC | CL A | 26622P107 | 8,476,478 | 399,457 | SH | | DFND | 2 | 399,457 | 0 | 0 |
DR REDDYS LABS LTD | ADR | 256135203 | 5,414,381 | 80,200 | SH | | DFND | 2 | 80,200 | 0 | 0 |
DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 1,228,864 | 83,200 | SH | | DFND | 2 | 83,200 | 0 | 0 |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 71,043,661 | 1,025,457 | SH | | DFND | 2 | 1,025,457 | 0 | 0 |
ELEVANCE HEALTH INC | COM | 036752103 | 35,023,443 | 80,436 | SH | | DFND | 2 | 80,436 | 0 | 0 |
ELEVANCE HEALTH INC | COM | 036752103 | 40,690,434 | 93,451 | SH | | DFND | 3 | 93,451 | 0 | 0 |
ELI LILLY & CO | COM | 532457108 | 43,798,117 | 81,541 | SH | | DFND | 2 | 81,541 | 0 | 0 |
EQUINIX INC | COM | 29444U700 | 29,050 | 40 | SH | | DFND | 2 | 40 | 0 | 0 |
ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 9,996 | 10,200 | SH | | DFND | 2 | 10,200 | 0 | 0 |
ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 4,110,183 | 4,194,064 | SH | | DFND | 1,2 | 4,194,064 | 0 | 0 |
ESSA PHARMA INC | COM NEW | 29668H708 | 58,710 | 19,000 | SH | | DFND | 2 | 19,000 | 0 | 0 |
ESSA PHARMA INC | COM NEW | 29668H708 | 24,347,911 | 7,879,583 | SH | | DFND | 1,2 | 7,879,583 | 0 | 0 |
EVERTEC INC | COM | 30040P103 | 27,476 | 739 | SH | | DFND | 2 | 739 | 0 | 0 |
EVOLENT HEALTH INC | CL A | 30050B101 | 33,549,947 | 1,232,095 | SH | | DFND | 2 | 1,232,095 | 0 | 0 |
EVOLENT HEALTH INC | CL A | 30050B101 | 66,577,895 | 2,445,020 | SH | | DFND | 3 | 2,445,020 | 0 | 0 |
EXACT SCIENCES CORP | COM | 30063P105 | 14,756,122 | 216,302 | SH | | DFND | 2 | 216,302 | 0 | 0 |
EXACT SCIENCES CORP | COM | 30063P105 | 61,637,930 | 903,517 | SH | | DFND | 3 | 903,517 | 0 | 0 |
EXELIXIS INC | COM | 30161Q104 | 135,470 | 6,200 | SH | | DFND | 2 | 6,200 | 0 | 0 |
EXELIXIS INC | COM | 30161Q104 | 51,778,491 | 2,369,725 | SH | | DFND | 1,2 | 2,369,725 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 25,016 | 11,800 | SH | | DFND | 2 | 11,800 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 10,260,331 | 4,839,779 | SH | | DFND | 1,2 | 4,839,779 | 0 | 0 |
GE HEALTHCARE TECHNOLOGIES I | COMMON STOCK | 36266G107 | 850,500 | 12,500 | SH | | DFND | 2 | 12,500 | 0 | 0 |
GENERATION BIO CO | COM | 37148K100 | 33,352 | 8,800 | SH | | DFND | 2 | 8,800 | 0 | 0 |
GENERATION BIO CO | COM | 37148K100 | 13,675,381 | 3,608,280 | SH | | DFND | 1,2 | 3,608,280 | 0 | 0 |
GILEAD SCIENCES INC | COM | 375558103 | 8,044,809 | 107,350 | SH | | DFND | 2 | 107,350 | 0 | 0 |
GLOBUS MED INC | CL A | 379577208 | 30,267,385 | 609,615 | SH | | DFND | 2 | 609,615 | 0 | 0 |
GRACELL BIOTECHNOLOGIES INC | SPONSORED ADS | 38406L103 | 109,440 | 38,000 | SH | | DFND | 2 | 38,000 | 0 | 0 |
GRUPO AEROPORTUARIO DEL SURE | SPON ADR SER B | 40051E202 | 165 | 135 | SH | | DFND | 2 | 135 | 0 | 0 |
GUARDANT HEALTH INC | COM | 40131M109 | 2,208,921 | 74,525 | SH | | DFND | 2 | 74,525 | 0 | 0 |
HCA HEALTHCARE INC | COM | 40412C101 | 38,285,065 | 155,643 | SH | | DFND | 2 | 155,643 | 0 | 0 |
HOLOGIC INC | COM | 436440101 | 20,135,438 | 290,136 | SH | | DFND | 2 | 290,136 | 0 | 0 |
HUMANA INC | COM | 444859102 | 82,730,780 | 170,046 | SH | | DFND | 2 | 170,046 | 0 | 0 |
HUTCHMED CHINA LTD | SPONSORED ADS | 44842L103 | 30,584,761 | 1,802,963 | SH | | DFND | 3 | 1,802,963 | 0 | 0 |
IDEXX LABS INC | COM | 45168D104 | 50,041,616 | 114,441 | SH | | DFND | 2 | 114,441 | 0 | 0 |
ILLUMINA INC | COM | 452327109 | 9,888,278 | 72,030 | SH | | DFND | 2 | 72,030 | 0 | 0 |
IMMUNOCORE HLDGS PLC | ADS | 45258D105 | 1,030,215 | 19,850 | SH | | DFND | 2 | 19,850 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 369,728 | 6,400 | SH | | DFND | 2 | 6,400 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 143,561,339 | 2,485,050 | SH | | DFND | 1,2 | 2,485,050 | 0 | 0 |
INFOSYS LTD | SPONSORED ADR | 456788108 | 19,600 | 1,130 | SH | | DFND | 2 | 1,130 | 0 | 0 |
INHIBRX INC | COM | 45720L107 | 895,480 | 48,800 | SH | | DFND | 2 | 48,800 | 0 | 0 |
INSMED INC | COM PAR $.01 | 457669307 | 79,859,059 | 3,162,735 | SH | | DFND | 3 | 3,162,735 | 0 | 0 |
INSPIRE MED SYS INC | COM | 457730109 | 13,963,826 | 70,368 | SH | | DFND | 2 | 70,368 | 0 | 0 |
INSULET CORP | COM | 45784P101 | 42,162,617 | 264,359 | SH | | DFND | 2 | 264,359 | 0 | 0 |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 2,047,137 | 39,300 | SH | | DFND | 2 | 39,300 | 0 | 0 |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 163,091,186 | 3,130,950 | SH | | DFND | 1,2 | 3,130,950 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 200,333,812 | 685,394 | SH | | DFND | 2 | 685,394 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 41,974,305 | 143,605 | SH | | DFND | 3 | 143,605 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 6,064,632 | 133,700 | SH | | DFND | 2 | 133,700 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 412,776,000 | 9,100,000 | SH | | DFND | 1,2 | 9,100,000 | 0 | 0 |
IQVIA HLDGS INC | COM | 46266C105 | 30,539,535 | 155,220 | SH | | DFND | 2 | 155,220 | 0 | 0 |
ISHARES TR | MSCI CHINA ETF | 46429B671 | 177,489 | 4,100 | SH | | DFND | 2 | 4,100 | 0 | 0 |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 28,432,790 | 219,660 | SH | | DFND | 2 | 219,660 | 0 | 0 |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 6,027,503 | 46,566 | SH | | DFND | 3 | 46,566 | 0 | 0 |
JOHNSON & JOHNSON | COM | 478160104 | 3,554,682 | 22,823 | SH | | DFND | 2 | 22,823 | 0 | 0 |
KARUNA THERAPEUTICS INC | COM | 48576A100 | 1,166,721 | 6,900 | SH | | DFND | 2 | 6,900 | 0 | 0 |
KOSMOS ENERGY LTD | COM | 500688106 | 2,323,120 | 284,000 | SH | | DFND | 2 | 284,000 | 0 | 0 |
KRYSTAL BIOTECH INC | COM | 501147102 | 1,450,000 | 12,500 | SH | | DFND | 2 | 12,500 | 0 | 0 |
LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 1,404,937 | 6,988 | SH | | DFND | 2 | 6,988 | 0 | 0 |
LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | 18,683,604 | 278,154 | SH | | DFND | 2 | 278,154 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 108,811 | 23,350 | SH | | DFND | 2 | 23,350 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 45,574,628 | 9,779,963 | SH | | DFND | 1,2 | 9,779,963 | 0 | 0 |
MCKESSON CORP | COM | 58155Q103 | 2,359,061 | 5,425 | SH | | DFND | 2 | 5,425 | 0 | 0 |
MEDTRONIC PLC | SHS | G5960L103 | 50,267,313 | 641,492 | SH | | DFND | 2 | 641,492 | 0 | 0 |
MERCK & CO INC | COM | 58933Y105 | 30,050,693 | 291,896 | SH | | DFND | 2 | 291,896 | 0 | 0 |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 16,129 | 12,700 | SH | | DFND | 2 | 12,700 | 0 | 0 |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 6,611,525 | 5,205,925 | SH | | DFND | 1,2 | 5,205,925 | 0 | 0 |
MERUS N V | COM | N5749R100 | 1,049,310 | 44,500 | SH | | DFND | 2 | 44,500 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 3,021,233 | 29,250 | SH | | DFND | 2 | 29,250 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 151,430,887 | 1,466,075 | SH | | DFND | 1,2 | 1,466,075 | 0 | 0 |
MOLECULAR TEMPLATES INC | COM NEW | 608550208 | 11,332 | 1,793 | SH | | DFND | 2 | 1,793 | 0 | 0 |
MOLECULAR TEMPLATES INC | COM NEW | 608550208 | 6,508,462 | 1,029,820 | SH | | DFND | 1,2 | 1,029,820 | 0 | 0 |
MOLINA HEALTHCARE INC | COM | 60855R100 | 51,950,236 | 158,438 | SH | | DFND | 2 | 158,438 | 0 | 0 |
NATERA INC | COM | 632307104 | 11,402,606 | 257,686 | SH | | DFND | 2 | 257,686 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 3,285,000 | 29,200 | SH | | DFND | 2 | 29,200 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 287,364,375 | 2,554,350 | SH | | DFND | 1,2 | 2,554,350 | 0 | 0 |
NEVRO CORP | COM | 64157F103 | 3,808,847 | 198,171 | SH | | DFND | 2 | 198,171 | 0 | 0 |
OLINK HLDG AB | SPONSORED ADS | 680710100 | 3,204,526 | 217,256 | SH | | DFND | 2 | 217,256 | 0 | 0 |
OMNICELL COM | COM | 68213N109 | 10,777,126 | 239,279 | SH | | DFND | 2 | 239,279 | 0 | 0 |
OPTION CARE HEALTH INC | COM NEW | 68404L201 | 73,896,879 | 2,284,293 | SH | | DFND | 3 | 2,284,293 | 0 | 0 |
OUTSET MED INC | COM | 690145107 | 9,864,265 | 906,642 | SH | | DFND | 2 | 906,642 | 0 | 0 |
OUTSET MED INC | COM | 690145107 | 16,339,453 | 1,501,788 | SH | | DFND | 3 | 1,501,788 | 0 | 0 |
PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 | 17,119,938 | 2,050,292 | SH | | DFND | 2 | 2,050,292 | 0 | 0 |
PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 | 43,377,382 | 5,194,896 | SH | | DFND | 3 | 5,194,896 | 0 | 0 |
PENUMBRA INC | COM | 70975L107 | 57,393,631 | 237,252 | SH | | DFND | 2 | 237,252 | 0 | 0 |
PFIZER INC | COM | 717081103 | 316,939 | 9,555 | SH | | DFND | 2 | 9,555 | 0 | 0 |
PHREESIA INC | COM | 71944F106 | 10,816,449 | 579,039 | SH | | DFND | 2 | 579,039 | 0 | 0 |
POINT BIOPHARMA GLOBAL INC | COM | 730541109 | 15,682,237 | 2,351,160 | SH | | DFND | 3 | 2,351,160 | 0 | 0 |
PRIVIA HEALTH GROUP INC | COM | 74276R102 | 24,269,094 | 1,055,178 | SH | | DFND | 2 | 1,055,178 | 0 | 0 |
PROCEPT BIOROBOTICS CORP | COM | 74276L105 | 29,144,992 | 888,296 | SH | | DFND | 2 | 888,296 | 0 | 0 |
PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 500,400 | 30,000 | SH | | DFND | 2 | 30,000 | 0 | 0 |
QUEST DIAGNOSTICS INC | COM | 74834L100 | 161,343 | 1,324 | SH | | DFND | 2 | 1,324 | 0 | 0 |
RECURSION PHARMACEUTICALS IN | CL A | 75629V104 | 1,331,750 | 174,085 | SH | | DFND | 2 | 174,085 | 0 | 0 |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 12,294,199 | 14,939 | SH | | DFND | 2 | 14,939 | 0 | 0 |
RELAY THERAPEUTICS INC | COM | 75943R102 | 84,100 | 10,000 | SH | | DFND | 2 | 10,000 | 0 | 0 |
RELAY THERAPEUTICS INC | COM | 75943R102 | 40,998,750 | 4,875,000 | SH | | DFND | 1,2 | 4,875,000 | 0 | 0 |
RESMED INC | COM | 761152107 | 11,341,038 | 76,696 | SH | | DFND | 2 | 76,696 | 0 | 0 |
REVOLUTION MEDICINES INC | COM | 76155X100 | 2,070,464 | 74,800 | SH | | DFND | 2 | 74,800 | 0 | 0 |
REVOLUTION MEDICINES INC | COM | 76155X100 | 128,620,656 | 4,646,700 | SH | | DFND | 1,2 | 4,646,700 | 0 | 0 |
RHYTHM PHARMACEUTICALS INC | COM | 76243J105 | 1,680,403 | 73,300 | SH | | DFND | 2 | 73,300 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 171,864 | 8,351 | SH | | DFND | 2 | 8,351 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 72,132,900 | 3,505,000 | SH | | DFND | 1,2 | 3,505,000 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 1,321,298 | 10,900 | SH | | DFND | 2 | 10,900 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 27,983,879 | 230,852 | SH | | DFND | 3 | 230,852 | 0 | 0 |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 36,920 | 5,200 | SH | | DFND | 2 | 5,200 | 0 | 0 |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 15,142,348 | 2,132,725 | SH | | DFND | 1,2 | 2,132,725 | 0 | 0 |
SEAGEN INC | COM | 81181C104 | 4,667,300 | 22,000 | SH | | DFND | 2 | 22,000 | 0 | 0 |
SEER INC | COM CL A | 81578P106 | 272,771 | 123,426 | SH | | DFND | 2 | 123,426 | 0 | 0 |
SHOCKWAVE MED INC | COM | 82489T104 | 50,626,949 | 254,279 | SH | | DFND | 2 | 254,279 | 0 | 0 |
SILK RD MED INC | COM | 82710M100 | 21,444,124 | 1,430,562 | SH | | DFND | 3 | 1,430,562 | 0 | 0 |
SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 1,111,448 | 2,600 | SH | | DFND | 2 | 2,600 | 0 | 0 |
SPDR SER TR | S&P OILGAS EXP | 78468R556 | 576,849 | 3,900 | SH | | DFND | 2 | 3,900 | 0 | 0 |
STRUCTURE THERAPEUTICS INC | SPONSORD ADS | 86366E106 | 847,056 | 16,800 | SH | | DFND | 2 | 16,800 | 0 | 0 |
STRYKER CORPORATION | COM | 863667101 | 129,970,765 | 475,613 | SH | | DFND | 2 | 475,613 | 0 | 0 |
SUPERNUS PHARMACEUTICALS INC | COM | 868459108 | 16,007,142 | 580,600 | SH | | DFND | 2 | 580,600 | 0 | 0 |
TAIWAN SEMICONDUCTOR MFG LTD | SPONSORED ADS | 874039100 | 1,963 | 1,089 | SH | | DFND | 2 | 1,089 | 0 | 0 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 7,609,484 | 366,369 | SH | | DFND | 2 | 366,369 | 0 | 0 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 36,895,828 | 1,776,400 | SH | | DFND | 3 | 1,776,400 | 0 | 0 |
TELADOC HEALTH INC | COM | 87918A105 | 6,611,515 | 355,649 | SH | | DFND | 2 | 355,649 | 0 | 0 |
TENET HEALTHCARE CORP | COM NEW | 88033G407 | 46,123 | 700 | SH | | DFND | 2 | 700 | 0 | 0 |
THE CIGNA GROUP | COM | 125523100 | 35,902,357 | 125,502 | SH | | DFND | 2 | 125,502 | 0 | 0 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 33,644,108 | 66,468 | SH | | DFND | 2 | 66,468 | 0 | 0 |
TRANSMEDICS GROUP INC | COM | 89377M109 | 29,386,351 | 536,737 | SH | | DFND | 2 | 536,737 | 0 | 0 |
UNITED MICROELECTRONICS CORP | SPON ADR NEW | 910873405 | 18,911 | 2,698 | SH | | DFND | 2 | 2,698 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 80,775,272 | 160,208 | SH | | DFND | 2 | 160,208 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 49,409,107 | 97,997 | SH | | DFND | 3 | 97,997 | 0 | 0 |
VANECK ETF TRUST | GOLD MINERS ETF | 92189F106 | 888,030 | 33,000 | SH | | DFND | 2 | 33,000 | 0 | 0 |
VANECK ETF TRUST | JUNIOR GOLD MINE | 92189F791 | 161,150 | 5,000 | SH | | DFND | 2 | 5,000 | 0 | 0 |
VAXCYTE INC | COM | 92243G108 | 1,554,890 | 30,500 | SH | | DFND | 2 | 30,500 | 0 | 0 |
VEEVA SYS INC | CL A COM | 922475108 | 45,593,145 | 224,100 | SH | | DFND | 2 | 224,100 | 0 | 0 |
VENTYX BIOSCIENCES INC | COM | 92332V107 | 850,885 | 24,500 | SH | | DFND | 2 | 24,500 | 0 | 0 |
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 945,400 | 58,000 | SH | | DFND | 2 | 58,000 | 0 | 0 |
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 13,013,235 | 798,358 | SH | | DFND | 3 | 798,358 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 44,755,181 | 128,703 | SH | | DFND | 2 | 128,703 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 21,275,429 | 61,182 | SH | | DFND | 3 | 61,182 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 282,660,459 | 812,850 | SH | | DFND | 1,2 | 812,850 | 0 | 0 |
VIATRIS INC | COM | 92556V106 | 1,743,721 | 176,848 | SH | | DFND | 2 | 176,848 | 0 | 0 |
VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 978,232 | 63,770 | SH | | DFND | 2 | 63,770 | 0 | 0 |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 25,843,134 | 4,494,458 | SH | | DFND | 1,2 | 4,494,458 | 0 | 0 |
XENON PHARMACEUTICALS INC | COM | 98420N105 | 816,424 | 23,900 | SH | | DFND | 2 | 23,900 | 0 | 0 |
ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 31,970,131 | 284,888 | SH | | DFND | 2 | 284,888 | 0 | 0 |
ZOETIS INC | CL A | 98978V103 | 1,124,259 | 6,462 | SH | | DFND | 2 | 6,462 | 0 | 0 |