| Document and Entity Information | May 22, 2023 |
| Cover [Abstract] | |
| Amendment Flag | false |
| Entity Central Index Key | 0001718852 |
| Document Type | 8-K |
| Document Period End Date | May 22, 2023 |
| Entity Registrant Name | PROMETHEUS BIOSCIENCES, INC. |
| Entity Incorporation State Country Code | DE |
| Entity File Number | 001-40187 |
| Entity Tax Identification Number | 81-4282653 |
| Entity Address, Address Line One | 3050 Science Park Road |
| Entity Address, City or Town | San Diego |
| Entity Address, State or Province | CA |
| Entity Address, Postal Zip Code | 92121 |
| City Area Code | (858) |
| Local Phone Number | 422-4300 |
| Written Communications | false |
| Soliciting Material | true |
| Pre Commencement Tender Offer | false |
| Pre Commencement Issuer Tender Offer | false |
| Security 12b Title | Common Stock, $0.0001 par value per share |
| Trading Symbol | RXDX |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | false |
