111 (YI) 20-F2021 FY Annual report (foreign)

Filed: 29 Apr 22, 6:54am

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Removed: Anshun, appeal, arm, assigned, attribute, conducing, doubtful, enhancement, exposing, formal, geographical, Harbor, highlighting, hindering, Hongkou, HongQiao, Huiyuan, impermissible, injunctive, involuntary, lapse, length, liquidate, Liuying, Longyan, losing, margin, measurable, medium, merge, owe, pharmacopoeia, pledger, relinquish, remeasured, remediate, reviewed, Room, selectively, Shuhong, sought, Southwest, Subtopic, Tabular, touch, uncooperative, unresolved, WFOE, Xixi, Youzhan, Yuan, Zhejiang

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Exhibit 13.1

Certification by the Principal Executive Officer

Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

In connection with the Annual Report of 111, Inc. (the “Company”) on Form 20-F for the year ended December 31, 2021 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Junling Liu, Chief Executive Officer of the Company, certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

(1)The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: April 29, 2022

By:	/s/ Junling Liu
	Name:Junling Liu
	Title: Chief Executive Officer