Ikarian Capital 13FHR Quarterly holdings report by institutional manager | SEC 14 Feb 24

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABBVIE INC	COM	00287Y109	20,533,525	132,500	SH	Call	SOLE		132,500	0	0
ABEONA THERAPEUTICS INC	COM NEW	00289Y206	3,006,000	600,000	SH		SOLE		600,000	0	0
ACELYRIN INC	COM	00445A100	14,852,898	1,991,005	SH		SOLE		1,991,005	0	0
ACELYRIN INC	COM	00445A100	2,513,274	336,900	SH	Call	SOLE		336,900	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	20,456	19,482	SH		SOLE		19,482	0	0
ACUMEN PHARMACEUTICALS INC	COM	00509G209	1,210,617	315,265	SH		SOLE		315,265	0	0
AEON BIOPHARMA INC	CL A	00791X100	1,857,434	257,977	SH		SOLE		257,977	0	0
ALEXANDRIA REAL ESTATE EQ IN	COM	015271109	9,292,241	73,300	SH	Put	SOLE		73,300	0	0
ALLAKOS INC	COM	01671P100	647,163	237,056	SH		SOLE		237,056	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	32,482,277	169,700	SH	Call	SOLE		169,700	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	18,873,026	98,600	SH	Put	SOLE		98,600	0	0
ALPINE IMMUNE SCIENCES INC	COM	02083G100	9,286,947	487,248	SH		SOLE		487,248	0	0
AMGEN INC	COM	031162100	10,080,700	35,000	SH	Call	SOLE		35,000	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	12,916,799	877,500	SH		SOLE		877,500	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	19,112,448	1,298,400	SH	Call	SOLE		1,298,400	0	0
ANEBULO PHARMACEUTICALS INC	COM	034569103	382,026	157,862	SH		SOLE		157,862	0	0
ANNEXON INC	COM	03589W102	12,031,001	2,650,000	SH		SOLE		2,650,000	0	0
ANNOVIS BIO INC	COM	03615A108	63,580	3,400	SH	Put	SOLE		3,400	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	2,056,849	34,361	SH		SOLE		34,361	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	8,979,000	150,000	SH	Call	SOLE		150,000	0	0
ARCUS BIOSCIENCES INC	COM	03969F109	7,640,000	400,000	SH	Call	SOLE		400,000	0	0
ARGENX SE	SPONSORED ADR	04016X101	26,538,467	70,000	SH		SOLE		70,000	0	0
ARGENX SE	SPONSORED ADR	04016X101	29,711,583	78,100	SH	Call	SOLE		78,100	0	0
ARGENX SE	SPONSORED ADR	04016X101	29,711,583	78,100	SH	Put	SOLE		78,100	0	0
ASLAN PHARMACEUTICALS LTD	SPON ADS NEW	04522R200	6,531	35,420	SH		SOLE		35,420	0	0
ASTRIA THERAPEUTICS INC	COM	04635X102	2,878,517	374,807	SH		SOLE		374,807	0	0
AUTOLUS THERAPEUTICS PLC	SPON ADS	05280R100	1,691,750	262,694	SH		SOLE		262,694	0	0
AVROBIO INC	COM	05455M100	976,833	718,259	SH		SOLE		718,259	0	0
BIOMEA FUSION INC	COM	09077A106	11,290,752	777,600	SH	Call	SOLE		777,600	0	0
BIOMEA FUSION INC	COM	09077A106	7,260,000	500,000	SH	Put	SOLE		500,000	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	1,561,157	555,572	SH		SOLE		555,572	0	0
BRAINSTORM CELL THERAPEUTICS	COM NEW	10501E201	24,636	90,242	SH		SOLE		90,242	0	0
BRIDGEBIO PHARMA INC	COM	10806X102	19,100,096	473,126	SH		SOLE		473,126	0	0
CABALETTA BIO INC	COM	12674W109	4,917,275	216,620	SH		SOLE		216,620	0	0
CABALETTA BIO INC	COM	12674W109	4,540,000	200,000	SH	Put	SOLE		200,000	0	0
CATALYST PHARMACEUTICALS INC	COM	14888U101	8,503,541	505,862	SH		SOLE		505,862	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	7,932	200	SH	Put	SOLE		200	0	0
CHEMOMAB THERAPEUTICS LTD	SPONSORED ADS	16385C104	108,829	213,392	SH		SOLE		213,392	0	0
COHERUS BIOSCIENCES INC	COM	19249H103	1,134,821	340,787	SH		SOLE		340,787	0	0
CORBUS PHARMACEUTICALS HLDGS	COM NEW	21833P301	1,183,230	195,899	SH		SOLE		195,899	0	0
CORCEPT THERAPEUTICS INC	COM	218352102	8,811,824	271,300	SH	Call	SOLE		271,300	0	0
CORCEPT THERAPEUTICS INC	COM	218352102	8,811,824	271,300	SH	Put	SOLE		271,300	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	24,207,564	680,370	SH		SOLE		680,370	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	3,558,000	100,000	SH	Call	SOLE		100,000	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	4,416,180	70,546	SH		SOLE		70,546	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	244,140	3,900	SH	Call	SOLE		3,900	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	40,652,440	649,400	SH	Put	SOLE		649,400	0	0
CYTOKINETICS INC	COM NEW	23282W605	2,504,699	30,000	SH		SOLE		30,000	0	0
CYTOKINETICS INC	COM NEW	23282W605	50,386,215	603,500	SH	Call	SOLE		603,500	0	0
CYTOKINETICS INC	COM NEW	23282W605	292,215	3,500	SH	Put	SOLE		3,500	0	0
DISC MEDICINE INC	COM	254604101	11,262,160	194,982	SH		SOLE		194,982	0	0
DYNE THERAPEUTICS INC	COM	26818M108	3,802,470	285,900	SH		SOLE		285,900	0	0
DYNE THERAPEUTICS INC	COM	26818M108	8,081,080	607,600	SH	Call	SOLE		607,600	0	0
DYNE THERAPEUTICS INC	COM	26818M108	3,325,000	250,000	SH	Put	SOLE		250,000	0	0
EDGEWISE THERAPEUTICS INC	COM	28036F105	2,953,800	270,000	SH		SOLE		270,000	0	0
ELEVATION ONCOLOGY INC	COM	28623U101	629,331	1,171,939	SH		SOLE		1,171,939	0	0
ELI LILLY & CO	COM	532457108	40,804,400	70,000	SH	Put	SOLE		70,000	0	0
ESPERION THERAPEUTICS INC NE	COM	29664W105	1,009,532	337,636	SH		SOLE		337,636	0	0
EYEPOINT PHARMACEUTICALS INC	COM NEW	30233G209	8,507,483	368,130	SH		SOLE		368,130	0	0
EYEPOINT PHARMACEUTICALS INC	COM NEW	30233G209	9,036,010	391,000	SH	Call	SOLE		391,000	0	0
EYEPOINT PHARMACEUTICALS INC	COM NEW	30233G209	6,544,752	283,200	SH	Put	SOLE		283,200	0	0
FINCH THERAPEUTICS GROUP INC	COM NEW	31773D200	24,881	6,892	SH		SOLE		6,892	0	0
FUSION PHARMACEUTICALS INC	COM	36118A100	4,805,001	500,000	SH		SOLE		500,000	0	0
HOOKIPA PHARMA INC	COM	43906K100	429,929	530,776	SH		SOLE		530,776	0	0
ICOSAVAX INC	COM	45114M109	6,934,400	440,000	SH		SOLE		440,000	0	0
IMMATICS N.V	SHS	N44445109	516,296	49,031	SH		SOLE		49,031	0	0
IMMUNIC INC	COM	4525EP101	675,001	450,000	SH	Call	SOLE		450,000	0	0
IMMUNOGEN INC	COM	45253H101	2,673,303	90,162	SH		SOLE		90,162	0	0
IMMUNOGEN INC	COM	45253H101	13,544,120	456,800	SH	Call	SOLE		456,800	0	0
IMMUNOVANT INC	COM	45258J102	9,832,889	233,394	SH		SOLE		233,394	0	0
IMMUNOVANT INC	COM	45258J102	12,668,491	300,700	SH	Call	SOLE		300,700	0	0
IMMUNOVANT INC	COM	45258J102	6,938,811	164,700	SH	Put	SOLE		164,700	0	0
INFLARX NV	COM	N44821101	1,122,425	688,604	SH		SOLE		688,604	0	0
INSMED INC	COM PAR $.01	457669307	6,198	200	SH	Call	SOLE		200	0	0
ITEOS THERAPEUTICS INC	COM	46565G104	3,793,857	346,471	SH		SOLE		346,471	0	0
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	5,141,400	41,800	SH	Call	SOLE		41,800	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	18,547,486	58,600	SH	Call	SOLE		58,600	0	0
KARYOPHARM THERAPEUTICS INC	COM	48576U106	346,000	400,000	SH		SOLE		400,000	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	808,503	853,391	SH		SOLE		853,391	0	0
KODIAK SCIENCES INC	COM	50015M109	1,255,158	412,881	SH		SOLE		412,881	0	0
KRYSTAL BIOTECH INC	COM	501147102	12,406,000	100,000	SH	Call	SOLE		100,000	0	0
KRYSTAL BIOTECH INC	COM	501147102	51,112,720	412,000	SH	Put	SOLE		412,000	0	0
LANTHEUS HLDGS INC	COM	516544103	930,000	15,000	SH		SOLE		15,000	0	0
LANTHEUS HLDGS INC	COM	516544103	16,740,000	270,000	SH	Call	SOLE		270,000	0	0
LARIMAR THERAPEUTICS INC	COM	517125100	2,743,050	602,868	SH		SOLE		602,868	0	0
LONGBOARD PHARMACEUTICALS IN	COM	54300N103	5,906,156	979,462	SH		SOLE		979,462	0	0
LYRA THERAPEUTICS INC	COM	55234L105	6,572,971	1,254,384	SH		SOLE		1,254,384	0	0
MARINUS PHARMACEUTICALS INC	COM NEW	56854Q200	8,109,771	746,069	SH		SOLE		746,069	0	0
MILESTONE PHARMACEUTICALS IN	COM	59935V107	772,922	462,828	SH		SOLE		462,828	0	0
MIND MEDICINE MINDMED INC	COM NEW	60255C885	2,195,999	600,000	SH		SOLE		600,000	0	0
MODERNA INC	COM	60770K107	2,441,100	24,546	SH		SOLE		24,546	0	0
MODERNA INC	COM	60770K107	4,405,635	44,300	SH	Put	SOLE		44,300	0	0
MOONLAKE IMMUNOTHERAPEUTICS	CLASS A ORD	61559X104	12,114,234	200,600	SH	Put	SOLE		200,600	0	0
MORPHOSYS AG	SPONSORED ADS	617760202	3,960,000	400,000	SH	Call	SOLE		400,000	0	0
NOVAVAX INC	COM NEW	670002401	3,423,360	713,200	SH	Call	SOLE		713,200	0	0
NOVAVAX INC	COM NEW	670002401	4,383,360	913,200	SH	Put	SOLE		913,200	0	0
NUVALENT INC	COM	670703107	18,996,671	258,142	SH		SOLE		258,142	0	0
NUVALENT INC	COM	670703107	7,682,796	104,400	SH	Call	SOLE		104,400	0	0
NUVALENT INC	COM	670703107	3,561,756	48,400	SH	Put	SOLE		48,400	0	0
NUVATION BIO INC	COM CL A	67080N101	1,846,506	1,222,852	SH		SOLE		1,222,852	0	0
PRAXIS PRECISION MEDICINES I	COM NEW	74006W207	4,456,000	200,000	SH		SOLE		200,000	0	0
PROQR THRAPEUTICS N V	SHS EURO	N71542109	935,797	472,625	SH		SOLE		472,625	0	0
PROTAGONIST THERAPEUTICS INC	COM	74366E102	7,314,669	319,000	SH		SOLE		319,000	0	0
PROTARA THERAPEUTICS INC	COM STK	74365U107	352,802	188,664	SH		SOLE		188,664	0	0
PROTHENA CORP PLC	SHS	G72800108	21,804,000	600,000	SH	Call	SOLE		600,000	0	0
PROTHENA CORP PLC	SHS	G72800108	15,204,656	418,400	SH	Put	SOLE		418,400	0	0
RAPT THERAPEUTICS INC	COM	75382E109	1,461,180	58,800	SH	Put	SOLE		58,800	0	0
RELMADA THERAPEUTICS INC	COM	75955J402	167,128	40,369	SH		SOLE		40,369	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	674,080	421,300	SH		SOLE		421,300	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	1,732,160	1,082,600	SH	Call	SOLE		1,082,600	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	692,160	432,600	SH	Put	SOLE		432,600	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	7,184,588	239,726	SH		SOLE		239,726	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	4,495,500	150,000	SH	Call	SOLE		150,000	0	0
ROIVANT SCIENCES LTD	SHS	G76279101	1,704,950	151,821	SH		SOLE		151,821	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	12,790,475	132,640	SH		SOLE		132,640	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	17,608,118	182,600	SH	Call	SOLE		182,600	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	9,816,574	101,800	SH	Put	SOLE		101,800	0	0
SOLENO THERAPEUTICS INC	COM	834203309	23,757,281	590,243	SH		SOLE		590,243	0	0
SOLENO THERAPEUTICS INC	COM	834203309	853,300	21,200	SH	Call	SOLE		21,200	0	0
SPDR SER TR	S&P HOMEBUILD	78464A888	19,132,000	200,000	SH		SOLE		200,000	0	0
SPDR SER TR	S&P BIOTECH	78464A870	49,109,500	550,000	SH	Put	SOLE		550,000	0	0
STOKE THERAPEUTICS INC	COM	86150R107	63,731	12,116	SH		SOLE		12,116	0	0
STRUCTURE THERAPEUTICS INC	SPONSORED ADS	86366E106	591,998	14,524	SH		SOLE		14,524	0	0
SYNLOGIC INC	COM NEW	87166L209	78,726	20,448	SH		SOLE		20,448	0	0
TARSUS PHARMACEUTICALS INC	COM	87650L103	10,500,010	518,519	SH		SOLE		518,519	0	0
TARSUS PHARMACEUTICALS INC	COM	87650L103	2,025,000	100,000	SH	Call	SOLE		100,000	0	0
TEMPEST THERAPEUTICS INC	COM	87978U108	464,640	105,600	SH		SOLE		105,600	0	0
TERNS PHARMACEUTICALS INC	COM	880881107	1,073,966	165,480	SH		SOLE		165,480	0	0
TRACON PHARMACEUTICALS INC	COM NEW	89237H209	484,244	2,765,530	SH		SOLE		2,765,530	0	0
TYRA BIOSCIENCES INC	COM	90240B106	667,155	48,170	SH		SOLE		48,170	0	0
UNIQURE NV	SHS	N90064101	1,065,361	157,365	SH		SOLE		157,365	0	0
VENTYX BIOSCIENCES INC	COM	92332V107	14,607	5,914	SH		SOLE		5,914	0	0
VERONA PHARMA PLC	SPONSORED ADS	925050106	257,302	367,468	SH		SOLE		367,468	0	0
VERVE THERAPEUTICS INC	COM	92539P101	575,722	41,300	SH	Put	SOLE		41,300	0	0
VOYAGER THERAPEUTICS INC	COM	92915B106	2,581,433	305,857	SH		SOLE		305,857	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	7,097,340	154,089	SH	Put	SOLE		154,089	0	0

Ikarian Capital 13F-HRQuarterly holdings report by institutional manager