Total Advertiser revenue increased by $29.9 million, or 43%, in the three months ended June 30, 2022 as compared to the three months ended June 30, 2021, driven primarily by a 24% increase in Media Transactions Measured and a 10% increase in Measured Transaction Fees, and by the acquisition of OpenSlate. Total Advertiser revenue increased by $55.3 million, or 42%, in the six months ended June 30, 2022 as compared to the six months ended June 30, 2021, driven primarily by a 25% increase in Media Transactions Measured and a 9% increase in Measured Transaction Fees, and by the acquisition of OpenSlate.
Activation revenue increased by $22.6 million, or 60%, in the three months ended June 30, 2022 as compared to the three months ended June 30, 2021, driven by greater adoptions of our Authentic Brand Suitability (ABS) solution as well as by new customers activating our core (non-ABS) programmatic solutions. In addition, revenue from OpenSlate’s pre-campaign social activation tools and the implementation of pricing tiers based on enhanced programmatic integrations contributed to year over year growth. Activation revenue increased by $41.7 million, or 58%, in the six months ended June 30, 2022 as compared to the six months ended June 30, 2021, driven by greater adoptions of our Authentic Brand Suitability (ABS) solution as well as by new customers activating our core (non-ABS) programmatic solutions. In addition, revenue from OpenSlate’s pre-campaign social activation tools and the implementation of pricing tiers based on enhanced programmatic integrations contributed to year over year growth.
Measurement revenue grew $7.2 million, or 23%, in the three months ended June 30, 2022 as compared to the three months ended June 30, 2021, primarily driven by new customers and notable expansions by existing customers, both within and outside the United States. Measurement revenue grew $13.5 million, or 23%, in the six months ended June 30, 2022 as compared to the six months ended June 30, 2021, primarily driven by new customers and notable expansions by existing customers, both within and outside the United States.
Supply-side revenue grew $3.4 million, or 49%, in the three months ended June 30, 2022 as compared to the three months ended June 30, 2021, driven primarily by new platform customers and by the acquisitions of Meetrics and OpenSlate. Supply-side revenue grew $7.2 million, or 55%, in the six months ended June 30, 2022 as compared to the six months ended June 30, 2021, driven primarily by new platform customers and by the acquisitions of Meetrics and OpenSlate.
Cost of Revenue (exclusive of depreciation and amortization shown below)
Cost of revenue increased by $6.5 million, or 53%, from $12.3 million in the three months ended June 30, 2021 to $18.8 million in the three months ended June 30, 2022. Cost of revenue increased by $13.2 million, or 59%, from $22.5 million in the six months ended June 30, 2021 to $35.7 million in the six months ended June 30, 2022. The increase in the three months ended June 30, 2022 and in the six months ended June 30, 2022 was primarily due to higher partner costs from revenue-sharing arrangements with Activation programmatic partners, as well as higher software and other technology costs to support increased volumes.
Product Development Expenses
Product development expenses increased by $8.1 million, or 54%, from $15.1 million in the three months ended June 30, 2021 to $23.2 million in the three months ended June 30, 2022. The increase was primarily due to an increase in personnel costs of $2.9 million, which reflects continued hiring of resources to support product-development efforts, $3.1 million of additional stock-based compensation expenses, and $1.3 million in additional costs for outsourced engineering services. Product development expenses increased by $15.5 million, or 53%, from $29.3 million in the six months ended June 30, 2021 to $44.8 million in the six months ended June 30, 2022. The increase was primarily due to an increase in personnel costs of $5.5 million, which reflects continued hiring of resources to support product-development efforts, $6.2 million of additional stock-based compensation expenses, and $2.2 million in additional costs for outsourced engineering services.