COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
10X GENOMICS INC | CL A COM | 88025U109 | 338,700 | 15,000 | SH | | SOLE | | 15,000 | 0 | 0 |
4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 64,860 | 6,000 | SH | | SOLE | | 6,000 | 0 | 0 |
89BIO INC | COM | 282559103 | 48,544 | 6,560 | SH | | SOLE | | 6,560 | 0 | 0 |
AA MISSION ACQUISITION CORP | ORD SHS CL A | G1000R101 | 10,122,194 | 1,010,199 | SH | | SOLE | | 1,010,199 | 0 | 0 |
AA MISSION ACQUISITION CORP | *W EXP 08/01/203 | G1000R127 | 30,306 | 505,099 | SH | | SOLE | | 505,099 | 0 | 0 |
ABCELLERA BIOLOGICS INC | COM | 00288U106 | 298,951 | 114,981 | SH | | SOLE | | 114,981 | 0 | 0 |
ABEONA THERAPEUTICS INC | COM NEW | 00289Y206 | 153,715 | 24,322 | SH | | SOLE | | 24,322 | 0 | 0 |
ABIVAX SA | SPONSORED ADS | 00370M103 | 6,008,970 | 521,612 | SH | | SOLE | | 521,612 | 0 | 0 |
ABSCI CORPORATION | COM | 00091E109 | 3,841,965 | 1,005,750 | SH | | SOLE | | 1,005,750 | 0 | 0 |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 355,278 | 23,100 | SH | | SOLE | | 23,100 | 0 | 0 |
ACASTI PHARMA INC | CL A | 00439U104 | 2,878,713 | 959,571 | SH | | SOLE | | 959,571 | 0 | 0 |
ACELYRIN INC | COM | 00445A100 | 263,755 | 53,500 | SH | | SOLE | | 53,500 | 0 | 0 |
ACHIEVE LIFE SCIENCES INC | COM | 004468500 | 431 | 91 | SH | | SOLE | | 91 | 0 | 0 |
ACLARIS THERAPEUTICS INC | COM | 00461U105 | 103,500 | 90,000 | SH | | SOLE | | 90,000 | 0 | 0 |
ADAGIO MED HLDGS INC | COM | 00534B100 | 384,061 | 148,861 | SH | | SOLE | | 148,861 | 0 | 0 |
ADDEX THERAPEUTICS LTD | SPONSORED ADS | 00654J206 | 9,770 | 1,000 | SH | | SOLE | | 1,000 | 0 | 0 |
AEROVATE THERAPEUTICS INC | COM | 008064107 | 236,327 | 113,075 | SH | | SOLE | | 113,075 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 946,359 | 21,300 | SH | | SOLE | | 21,300 | 0 | 0 |
AGRICULTURE & NAT SOL ACQ CO | SHS CL A | G0131Y100 | 831,747 | 80,362 | SH | | SOLE | | 80,362 | 0 | 0 |
AI TRANSN ACQUISITION CORP | RIGHT 09/01/2028 | G01490104 | 1,275 | 7,500 | SH | | SOLE | | 7,500 | 0 | 0 |
AI TRANSN ACQUISITION CORP | ORD SHS | G01490112 | 78,600 | 7,500 | SH | | SOLE | | 7,500 | 0 | 0 |
AIMFINITY INVESTMENT CORP I | *W EXP 99/99/999 | G0135E126 | 362 | 18,000 | SH | | SOLE | | 18,000 | 0 | 0 |
AKERO THERAPEUTICS INC | COM | 00973Y108 | 660,071 | 23,007 | SH | | SOLE | | 23,007 | 0 | 0 |
AKERO THERAPEUTICS INC | COM | 00973Y108 | 645,525 | 22,500 | SH | Call | SOLE | | 0 | 0 | 0 |
ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 1,628,923 | 302,212 | SH | | SOLE | | 302,212 | 0 | 0 |
ALECTOR INC | COM | 014442107 | 1,998,217 | 428,802 | SH | | SOLE | | 428,802 | 0 | 0 |
ALGONQUIN PWR UTILS CORP | COM | 015857105 | 436,000 | 80,000 | SH | | SOLE | | 80,000 | 0 | 0 |
ALKERMES PLC | SHS | G01767105 | 2,083,324 | 74,431 | SH | | SOLE | | 74,431 | 0 | 0 |
ALTO NEUROSCIENCE INC | COM SHS | 02157Q109 | 1,144 | 100 | SH | Put | SOLE | | 100 | 0 | 0 |
AMPLIFY ENERGY CORP NEW | COM | 03212B103 | 120,642 | 18,475 | SH | | SOLE | | 18,475 | 0 | 0 |
AMYLYX PHARMACEUTICALS INC | COM | 03237H101 | 715,735 | 220,906 | SH | | SOLE | | 220,906 | 0 | 0 |
AMYLYX PHARMACEUTICALS INC | COM | 03237H101 | 32,400 | 10,000 | SH | Call | SOLE | | 0 | 0 | 0 |
ANAPTYSBIO INC | COM | 032724106 | 6,456,120 | 192,720 | SH | | SOLE | | 192,720 | 0 | 0 |
ANI PHARMACEUTICALS INC | COM | 00182C103 | 101,422 | 1,700 | SH | | SOLE | | 1,700 | 0 | 0 |
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 497,548 | 17,252 | SH | | SOLE | | 17,252 | 0 | 0 |
APOGEE THERAPEUTICS INC | COM | 03770N101 | 3,358,929 | 57,183 | SH | | SOLE | | 57,183 | 0 | 0 |
APPLIED THERAPEUTICS INC | COM | 03828A101 | 74,180 | 8,727 | SH | | SOLE | | 8,727 | 0 | 0 |
APPLIED THERAPEUTICS INC | COM | 03828A101 | 4,506,700 | 530,200 | SH | Call | SOLE | | 0 | 0 | 0 |
ARBUTUS BIOPHARMA CORP | COM | 03879J100 | 8,043,886 | 2,089,321 | SH | | SOLE | | 2,089,321 | 0 | 0 |
ARCELLX INC | COMMON STOCK | 03940C100 | 330,867 | 3,962 | SH | | SOLE | | 3,962 | 0 | 0 |
ARDELYX INC | COM | 039697107 | 44,096 | 6,400 | SH | | SOLE | | 6,400 | 0 | 0 |
ARES ACQUISITION CORP II | SHS CLASS A | G33033104 | 1,505,002 | 138,966 | SH | | SOLE | | 138,966 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 59,629 | 110 | SH | | SOLE | | 110 | 0 | 0 |
ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 | 226,726 | 11,705 | SH | | SOLE | | 11,705 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 502,452 | 20,400 | SH | | SOLE | | 20,400 | 0 | 0 |
ASCENDIS PHARMA A/S | SPONSORED ADR | 04351P101 | 24,098,933 | 161,402 | SH | | SOLE | | 161,402 | 0 | 0 |
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 54,537 | 700 | SH | | SOLE | | 700 | 0 | 0 |
ASTRIA THERAPEUTICS INC | COM | 04635X102 | 1,027,057 | 93,284 | SH | | SOLE | | 93,284 | 0 | 0 |
AURA BIOSCIENCES INC | COM | 05153U107 | 656,337 | 73,663 | SH | | SOLE | | 73,663 | 0 | 0 |
AVADEL PHARMACEUTICALS PLC | COM SHS | G29687103 | 1,061,004 | 80,900 | SH | | SOLE | | 80,900 | 0 | 0 |
AVANGRID INC | COM | 05351W103 | 823,170 | 23,000 | SH | | SOLE | | 23,000 | 0 | 0 |
AVIDITY BIOSCIENCES INC | COM | 05370A108 | 27,558 | 600 | SH | | SOLE | | 600 | 0 | 0 |
AXSOME THERAPEUTICS INC | COM | 05464T104 | 53,922 | 600 | SH | | SOLE | | 600 | 0 | 0 |
BAUSCH HEALTH COS INC | COM | 071734107 | 30,192 | 3,700 | SH | | SOLE | | 3,700 | 0 | 0 |
BAUSCH PLUS LOMB CORP | COMMON SHARES | 071705107 | 11,574 | 600 | SH | | SOLE | | 600 | 0 | 0 |
BEAM THERAPEUTICS INC | COM | 07373V105 | 1,075,550 | 43,900 | SH | | SOLE | | 43,900 | 0 | 0 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 219,571 | 978 | SH | | SOLE | | 978 | 0 | 0 |
BEYOND AIR INC | COM | 08862L103 | 109,467 | 282,131 | SH | | SOLE | | 282,131 | 0 | 0 |
BICARA THERAPEUTICS INC | COM | 055477103 | 1,030,007 | 40,440 | SH | | SOLE | | 40,440 | 0 | 0 |
BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 | 266,000 | 35,000 | SH | | SOLE | | 35,000 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 5,742,510 | 29,625 | SH | | SOLE | | 29,625 | 0 | 0 |
BIOHAVEN LTD | COM | G1110E107 | 131,771 | 2,637 | SH | | SOLE | | 2,637 | 0 | 0 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 84,348 | 1,200 | SH | | SOLE | | 1,200 | 0 | 0 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 351,450 | 5,000 | SH | Call | SOLE | | 0 | 0 | 0 |
BIOMX INC | COM NEW | 09090D301 | 441,354 | 432,700 | SH | | SOLE | | 432,700 | 0 | 0 |
BIONTECH SE | SPONSORED ADS | 09075V102 | 1,187,700 | 10,000 | SH | | SOLE | | 10,000 | 0 | 0 |
BLACK HAWK ACQUISITION CORP | RIGHT 06/20/2025 | G1148A119 | 3,480 | 3,000 | SH | | SOLE | | 3,000 | 0 | 0 |
BLACK HAWK ACQUISITION CORP | USD CL A SHS | G1148A101 | 153,600 | 15,000 | SH | | SOLE | | 15,000 | 0 | 0 |
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 471,750 | 5,100 | SH | | SOLE | | 5,100 | 0 | 0 |
BOLT BIOTHERAPEUTICS INC | COM | 097702104 | 158,738 | 244,966 | SH | | SOLE | | 244,966 | 0 | 0 |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 209,500 | 2,500 | SH | | SOLE | | 2,500 | 0 | 0 |
BRIDGEBIO PHARMA INC | COM | 10806X102 | 36,878,046 | 1,448,470 | SH | | SOLE | | 1,448,470 | 0 | 0 |
CAPRICOR THERAPEUTICS INC | COM NEW | 14070B309 | 369,709 | 24,307 | SH | | SOLE | | 24,307 | 0 | 0 |
CARA THERAPEUTICS INC | COM | 140755109 | 49,116 | 159,469 | SH | | SOLE | | 159,469 | 0 | 0 |
CASI PHARMACEUTICALS INC | ORD SHS | G1933S101 | 399,384 | 64,835 | SH | | SOLE | | 64,835 | 0 | 0 |
CELCUITY INC | COM | 15102K100 | 44,730 | 3,000 | SH | | SOLE | | 3,000 | 0 | 0 |
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 169,950 | 5,000 | SH | | SOLE | | 5,000 | 0 | 0 |
CELLECTAR BIOSCIENCES INC | COM NEW | 15117F807 | 2,187,425 | 1,022,161 | SH | | SOLE | | 1,022,161 | 0 | 0 |
CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 372,599 | 23,302 | SH | | SOLE | | 23,302 | 0 | 0 |
CG ONCOLOGY INC | COM | 156944100 | 5,399,314 | 143,104 | SH | | SOLE | | 143,104 | 0 | 0 |
CHIMERIX INC | COM | 16934W106 | 223,718 | 240,557 | SH | | SOLE | | 240,557 | 0 | 0 |
CONTEXT THERAPEUTICS INC | COM | 21077P108 | 732,717 | 373,835 | SH | | SOLE | | 373,835 | 0 | 0 |
CONTINEUM THERAPEUTICS INC | CL A | 21217B100 | 171,628 | 8,967 | SH | | SOLE | | 8,967 | 0 | 0 |
CORBUS PHARMACEUTICALS HLDGS | COM NEW | 21833P301 | 82,520 | 4,000 | SH | | SOLE | | 4,000 | 0 | 0 |
CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 4,518,518 | 88,425 | SH | | SOLE | | 88,425 | 0 | 0 |
CULLINAN THERAPEUTICS INC | COM | 230031106 | 909,953 | 54,358 | SH | | SOLE | | 54,358 | 0 | 0 |
CVS HEALTH CORP | COM | 126650100 | 62,880 | 1,000 | SH | | SOLE | | 1,000 | 0 | 0 |
CYTOKINETICS INC | COM NEW | 23282W605 | 48,110,410 | 911,182 | SH | | SOLE | | 911,182 | 0 | 0 |
CYTOKINETICS INC | COM NEW | 23282W605 | 797,280 | 15,100 | SH | Call | SOLE | | 0 | 0 | 0 |
CYTOMX THERAPEUTICS INC | COM | 23284F105 | 1,066,672 | 903,959 | SH | | SOLE | | 903,959 | 0 | 0 |
DAY ONE BIOPHARMACEUTICALS I | COM | 23954D109 | 739,836 | 53,111 | SH | | SOLE | | 53,111 | 0 | 0 |
DELCATH SYS INC | COM NEW | 24661P807 | 280,400 | 31,052 | SH | | SOLE | | 31,052 | 0 | 0 |
DENALI THERAPEUTICS INC | COM | 24823R105 | 2,966,191 | 101,826 | SH | | SOLE | | 101,826 | 0 | 0 |
DIANTHUS THERAPEUTICS INC | COM | 252828108 | 3,251,046 | 118,738 | SH | | SOLE | | 118,738 | 0 | 0 |
DIREXION SHS ETF TR | DAILY S&P BIOTEC | 25460G716 | 49,056 | 8,400 | SH | | SOLE | | 8,400 | 0 | 0 |
DISC MEDICINE INC | COM | 254604101 | 1,108,795 | 22,564 | SH | | SOLE | | 22,564 | 0 | 0 |
DYNE THERAPEUTICS INC | COM | 26818M108 | 14,368 | 400 | SH | | SOLE | | 400 | 0 | 0 |
EA SERIES TRUST | ALPHA ARCH 1-3 | 02072L565 | 35,226,001 | 323,382 | SH | | SOLE | | 323,382 | 0 | 0 |
EDGEWISE THERAPEUTICS INC | COM | 28036F105 | 485,171 | 18,178 | SH | | SOLE | | 18,178 | 0 | 0 |
ELI LILLY & CO | COM | 532457108 | 1,018,831 | 1,150 | SH | | SOLE | | 1,150 | 0 | 0 |
ELIEM THERAPEUTICS INC | COM | 28658R106 | 831,925 | 163,443 | SH | | SOLE | | 163,443 | 0 | 0 |
EMBRACE CHANGE ACQUISITN COR | RIGHT 10/25/2026 | G3034H141 | 1,446 | 13,144 | SH | | SOLE | | 13,144 | 0 | 0 |
EMBRACE CHANGE ACQUISITN COR | *W EXP 10/25/202 | G3034H125 | 265 | 18,000 | SH | | SOLE | | 18,000 | 0 | 0 |
ENDEAVOR GROUP HLDGS INC | CL A COM | 29260Y109 | 3,507,368 | 122,807 | SH | | SOLE | | 122,807 | 0 | 0 |
ENGENE HOLDINGS INC | COM | 29286M105 | 13,002 | 1,970 | SH | | SOLE | | 1,970 | 0 | 0 |
ENVVENO MEDICAL CORPORATION | COM | 29415J106 | 1,170,164 | 348,263 | SH | | SOLE | | 348,263 | 0 | 0 |
EQUILLIUM INC | COM | 29446K106 | 6,089 | 7,318 | SH | | SOLE | | 7,318 | 0 | 0 |
ESTABLISHMENT LABS HLDGS INC | COM | G31249108 | 86,540 | 2,000 | SH | | SOLE | | 2,000 | 0 | 0 |
EXACT SCIENCES CORP | COM | 30063P105 | 1,035,424 | 15,200 | SH | | SOLE | | 15,200 | 0 | 0 |
EYEPOINT PHARMACEUTICALS INC | COM NEW | 30233G209 | 15,980 | 2,000 | SH | | SOLE | | 2,000 | 0 | 0 |
FIBROGEN INC | COM | 31572Q808 | 48,193 | 120,663 | SH | | SOLE | | 120,663 | 0 | 0 |
FORTE BIOSCIENCES INC | COM NEW | 34962G208 | 33,540 | 6,000 | SH | | SOLE | | 6,000 | 0 | 0 |
FULCRUM THERAPEUTICS INC | COM | 359616109 | 199,213 | 55,802 | SH | | SOLE | | 55,802 | 0 | 0 |
FULCRUM THERAPEUTICS INC | COM | 359616109 | 53,550 | 15,000 | SH | Call | SOLE | | 0 | 0 | 0 |
FUTURETECH II ACQUISITION CO | *W EXP 08/18/202 | 36119D111 | 762 | 30,000 | SH | | SOLE | | 30,000 | 0 | 0 |
GALECTIN THERAPEUTICS INC | COM NEW | 363225202 | 152,075 | 55,300 | SH | Put | SOLE | | 55,300 | 0 | 0 |
GERON CORP | COM | 374163103 | 2,529,502 | 557,159 | SH | | SOLE | | 557,159 | 0 | 0 |
GLOBAL STAR ACQUISITION INC | RIGHT 06/21/2024 | 37962G128 | 11,513 | 88,560 | SH | | SOLE | | 88,560 | 0 | 0 |
GLOBAL STAR ACQUISITION INC | *W EXP 07/15/202 | 37962G110 | 2,400 | 120,000 | SH | | SOLE | | 120,000 | 0 | 0 |
GLYCOMIMETICS INC | COM | 38000Q102 | 7,723 | 45,700 | SH | | SOLE | | 45,700 | 0 | 0 |
GOSSAMER BIO INC | COM | 38341P102 | 411,287 | 416,958 | SH | | SOLE | | 416,958 | 0 | 0 |
GOSSAMER BIO INC | COM | 38341P102 | 19,728 | 20,000 | SH | Call | SOLE | | 0 | 0 | 0 |
GRAIL INC | COM | 384747101 | 60,558 | 4,401 | SH | | SOLE | | 4,401 | 0 | 0 |
GREENLIGHT CAPITAL RE LTD | CLASS A | G4095J109 | 59,855 | 4,385 | SH | | SOLE | | 4,385 | 0 | 0 |
HELIX ACQUISITION CORP II | CL A ORD SHS | G4444H101 | 4,223,202 | 404,138 | SH | | SOLE | | 404,138 | 0 | 0 |
IBIO INC | CON NEW | 451033708 | 1,057,191 | 476,212 | SH | | SOLE | | 476,212 | 0 | 0 |
ICHOR HOLDINGS | SHS | G4740B105 | 3,435 | 108 | SH | | SOLE | | 108 | 0 | 0 |
IDEAYA BIOSCIENCES INC | COM | 45166A102 | 31,680 | 1,000 | SH | | SOLE | | 1,000 | 0 | 0 |
IKENA ONCOLOGY INC | COM | 45175G108 | 77,219 | 44,635 | SH | | SOLE | | 44,635 | 0 | 0 |
IMMUNOVANT INC | COM | 45258J102 | 32,264,967 | 1,131,707 | SH | | SOLE | | 1,131,707 | 0 | 0 |
IMMUNOVANT INC | COM | 45258J102 | 290,802 | 10,200 | SH | Call | SOLE | | 0 | 0 | 0 |
INDIVIOR PLC | ORD | G4766E116 | 527,056 | 54,057 | SH | | SOLE | | 54,057 | 0 | 0 |
INSMED INC | COM PAR $.01 | 457669307 | 265,282 | 3,634 | SH | | SOLE | | 3,634 | 0 | 0 |
INSTIL BIO INC | COM NEW | 45783C200 | 1,595,955 | 23,707 | SH | | SOLE | | 23,707 | 0 | 0 |
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 16,440 | 800 | SH | | SOLE | | 800 | 0 | 0 |
INTELLIGENT BIO SOLUTIONS IN | COM | 36151G600 | 9,323 | 5,389 | SH | | SOLE | | 5,389 | 0 | 0 |
INTRA-CELLULAR THERAPIES INC | COM | 46116X101 | 980,478 | 13,400 | SH | | SOLE | | 13,400 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 28,042 | 700 | SH | | SOLE | | 700 | 0 | 0 |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 147,423 | 15,700 | SH | | SOLE | | 15,700 | 0 | 0 |
IRON HORSE ACQUISITIONS CORP | *W EXP 99/99/999 | 462837113 | 768 | 25,000 | SH | | SOLE | | 25,000 | 0 | 0 |
IRON HORSE ACQUISITIONS CORP | RIGHT 99/99/9999 | 462837121 | 4,250 | 25,000 | SH | | SOLE | | 25,000 | 0 | 0 |
IRON HORSE ACQUISITIONS CORP | COM | 462837105 | 254,750 | 25,000 | SH | | SOLE | | 25,000 | 0 | 0 |
ITEOS THERAPEUTICS INC | COM | 46565G104 | 3,846,485 | 376,737 | SH | | SOLE | | 376,737 | 0 | 0 |
ITERIS INC NEW | COM | 46564T107 | 71,400 | 10,000 | SH | | SOLE | | 10,000 | 0 | 0 |
JANUX THERAPEUTICS INC | COM | 47103J105 | 590,590 | 13,000 | SH | | SOLE | | 13,000 | 0 | 0 |
JASPER THERAPEUTICS INC | COM NEW | 471871202 | 297,499 | 15,816 | SH | | SOLE | | 15,816 | 0 | 0 |
JVSPAC ACQUISITION CORP | RIGHT 11/26/2026 | G5212E113 | 8,109 | 30,000 | SH | | SOLE | | 30,000 | 0 | 0 |
JVSPAC ACQUISITION CORP | SHS CL A | G5212E105 | 310,200 | 30,000 | SH | | SOLE | | 30,000 | 0 | 0 |
KALA BIO INC | COM NEW | 483119202 | 1,744,582 | 306,067 | SH | | SOLE | | 306,067 | 0 | 0 |
KALVISTA PHARMACEUTICALS INC | COM | 483497103 | 163,776 | 14,143 | SH | | SOLE | | 14,143 | 0 | 0 |
KEEN VISION ACQUISITION CORP | UNIT 99/99/9999 | G52443101 | 804,750 | 75,000 | SH | | SOLE | | 75,000 | 0 | 0 |
KEROS THERAPEUTICS INC | COM | 492327101 | 25,845,099 | 445,068 | SH | | SOLE | | 445,068 | 0 | 0 |
KEROS THERAPEUTICS INC | COM | 492327101 | 17,421 | 300 | SH | Call | SOLE | | 0 | 0 | 0 |
KEZAR LIFE SCIENCES INC | COM | 49372L209 | 1,034,753 | 1,338,273 | SH | | SOLE | | 1,338,273 | 0 | 0 |
KINIKSA PHARMACEUTICALS INTL | ORD SHS CL A | G52694109 | 10,912,333 | 436,668 | SH | | SOLE | | 436,668 | 0 | 0 |
KIORA PHARMACEUTICALS INC | COM | 49721T507 | 719,377 | 196,551 | SH | | SOLE | | 196,551 | 0 | 0 |
KORRO BIO INC | COM | 500946108 | 1,652,652 | 49,451 | SH | | SOLE | | 49,451 | 0 | 0 |
KRYSTAL BIOTECH INC | COM | 501147102 | 18,203 | 100 | SH | | SOLE | | 100 | 0 | 0 |
KURA ONCOLOGY INC | COM | 50127T109 | 586,200 | 30,000 | SH | | SOLE | | 30,000 | 0 | 0 |
KYMERA THERAPEUTICS INC | COM | 501575104 | 561,144 | 11,856 | SH | | SOLE | | 11,856 | 0 | 0 |
LEXEO THERAPEUTICS INC | COM | 52886X107 | 516,781 | 57,166 | SH | | SOLE | | 57,166 | 0 | 0 |
LIQUIDIA CORPORATION | COM NEW | 53635D202 | 92,850 | 9,285 | SH | | SOLE | | 9,285 | 0 | 0 |
LUMOS PHARMA INC | COM | 55028X109 | 38,700 | 10,000 | SH | | SOLE | | 10,000 | 0 | 0 |
MADRIGAL PHARMACEUTICALS INC | COM | 558868105 | 10,611 | 50 | SH | | SOLE | | 50 | 0 | 0 |
MARAVAI LIFESCIENCES HLDGS I | COM CL A | 56600D107 | 5,817 | 700 | SH | | SOLE | | 700 | 0 | 0 |
MARKER THERAPEUTICS INC | COM NEW | 57055L206 | 6,858 | 2,432 | SH | | SOLE | | 2,432 | 0 | 0 |
MASIMO CORP | COM | 574795100 | 519,187 | 3,894 | SH | | SOLE | | 3,894 | 0 | 0 |
MCKESSON CORP | COM | 58155Q103 | 914,677 | 1,850 | SH | | SOLE | | 1,850 | 0 | 0 |
MCKESSON CORP | COM | 58155Q103 | 1,483,260 | 3,000 | SH | Call | SOLE | | 0 | 0 | 0 |
MERCK & CO INC | COM | 58933Y105 | 129,458 | 1,140 | SH | | SOLE | | 1,140 | 0 | 0 |
MEREO BIOPHARMA GROUP PLC | SPON ADS | 589492107 | 41,100 | 10,000 | SH | | SOLE | | 10,000 | 0 | 0 |
MERUS N V | COM | N5749R100 | 7,658,169 | 153,286 | SH | | SOLE | | 153,286 | 0 | 0 |
MILESTONE PHARMACEUTICALS IN | COM | 59935V107 | 42,455 | 27,931 | SH | | SOLE | | 27,931 | 0 | 0 |
MINERALYS THERAPEUTICS INC | COM | 603170101 | 8,833,046 | 729,401 | SH | | SOLE | | 729,401 | 0 | 0 |
MIRUM PHARMACEUTICALS INC | COM | 604749101 | 939,900 | 24,100 | SH | | SOLE | | 24,100 | 0 | 0 |
MITEK SYS INC | COM NEW | 606710200 | 1,734 | 200 | SH | | SOLE | | 200 | 0 | 0 |
MKDWELL TECH INC | *W EXP 07/31/202 | G6209W116 | 60 | 3,270 | SH | | SOLE | | 3,270 | 0 | 0 |
MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 1,182,702 | 23,457 | SH | | SOLE | | 23,457 | 0 | 0 |
MOVANO INC | COM | 62459M206 | 416,494 | 1,159,826 | SH | | SOLE | | 1,159,826 | 0 | 0 |
NABORS ENERGY TRANSITION COR | CL A | G6363K106 | 638,534 | 59,900 | SH | | SOLE | | 59,900 | 0 | 0 |
NCR ATLEOS CORPORATION | COM SHS | 63001N106 | 28,530 | 1,000 | SH | | SOLE | | 1,000 | 0 | 0 |
NCR VOYIX CORPORATION | COM | 62886E108 | 27,140 | 2,000 | SH | | SOLE | | 2,000 | 0 | 0 |
NEKTAR THERAPEUTICS | COM | 640268108 | 88,080 | 67,754 | SH | | SOLE | | 67,754 | 0 | 0 |
NEUROGENE INC | COM | 64135M105 | 23,204 | 553 | SH | | SOLE | | 553 | 0 | 0 |
NEXTCURE INC | COM | 65343E108 | 164,418 | 120,013 | SH | | SOLE | | 120,013 | 0 | 0 |
NORDSTROM INC | COM | 655664100 | 44,980 | 2,000 | SH | | SOLE | | 2,000 | 0 | 0 |
NOVO-NORDISK A S | ADR | 670100205 | 1,190,700 | 10,000 | SH | Call | SOLE | | 0 | 0 | 0 |
NOVO-NORDISK A S | ADR | 670100205 | 2,381,400 | 20,000 | SH | Put | SOLE | | 20,000 | 0 | 0 |
NUVALENT INC | COM | 670703107 | 1,068,217 | 10,442 | SH | | SOLE | | 10,442 | 0 | 0 |
NUVEI CORPORATION | SUB VTG SHS | 67079A102 | 166,750 | 5,000 | SH | | SOLE | | 5,000 | 0 | 0 |
OAK WOODS ACQUISITION CORP | CL A | 67190B104 | 333,000 | 30,000 | SH | | SOLE | | 30,000 | 0 | 0 |
OKLO INC | COM CL A | 02156V109 | 8,090 | 1,000 | SH | | SOLE | | 1,000 | 0 | 0 |
OMNIAB INC | COM | 68218J103 | 5,656,787 | 1,337,302 | SH | | SOLE | | 1,337,302 | 0 | 0 |
OPTION CARE HEALTH INC | COM NEW | 68404L201 | 626,000 | 20,000 | SH | | SOLE | | 20,000 | 0 | 0 |
ORGANON & CO | COMMON STOCK | 68622V106 | 59,303 | 3,100 | SH | | SOLE | | 3,100 | 0 | 0 |
ORUKA THERAPEUTICS INC | COM | 687604108 | 274,193 | 11,187 | SH | | SOLE | | 11,187 | 0 | 0 |
OVID THERAPEUTICS INC | COM | 690469101 | 44,537 | 37,743 | SH | | SOLE | | 37,743 | 0 | 0 |
PERCEPTIVE CAP SOLUTIONS COR | CL A ORD SHS | G70077105 | 7,515,000 | 750,000 | SH | | SOLE | | 750,000 | 0 | 0 |
PERIMETER SOLUTIONS SA | COMMON STOCK | L7579L106 | 121,050 | 9,000 | SH | | SOLE | | 9,000 | 0 | 0 |
PERRIGO CO PLC | SHS | G97822103 | 26,230 | 1,000 | SH | | SOLE | | 1,000 | 0 | 0 |
PFIZER INC | COM | 717081103 | 1,040,393 | 35,950 | SH | | SOLE | | 35,950 | 0 | 0 |
PHARVARIS N V | COM | N69605108 | 37,040 | 2,000 | SH | | SOLE | | 2,000 | 0 | 0 |
PHATHOM PHARMACEUTICALS INC | COM | 71722W107 | 3,616 | 200 | SH | | SOLE | | 200 | 0 | 0 |
PIERIS PHARMACEUTICALS INC | COM NEW | 720795202 | 2,398,148 | 144,641 | SH | | SOLE | | 144,641 | 0 | 0 |
PLIANT THERAPEUTICS INC | COM | 729139105 | 2,759,095 | 246,128 | SH | | SOLE | | 246,128 | 0 | 0 |
PMV PHARMACEUTICALS INC | COM | 69353Y103 | 150,502 | 101,008 | SH | | SOLE | | 101,008 | 0 | 0 |
POLYPID LTD | COM | M8001Q126 | 323,023 | 93,902 | SH | | SOLE | | 93,902 | 0 | 0 |
POWERSCHOOL HOLDINGS INC | COM CL A | 73939C106 | 684,300 | 30,000 | SH | | SOLE | | 30,000 | 0 | 0 |
PROPERTYGURU GROUP LTD | ORD SHS | G7258M108 | 132,200 | 20,000 | SH | | SOLE | | 20,000 | 0 | 0 |
PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 44,158,275 | 981,295 | SH | | SOLE | | 981,295 | 0 | 0 |
PTC THERAPEUTICS INC | COM | 69366J200 | 742,000 | 20,000 | SH | | SOLE | | 20,000 | 0 | 0 |
PURETECH HEALTH PLC | ADS | 746237106 | 61,845 | 3,000 | SH | | SOLE | | 3,000 | 0 | 0 |
PYXIS ONCOLOGY INC | COMMON STOCK | 747324101 | 36,700 | 10,000 | SH | | SOLE | | 10,000 | 0 | 0 |
Q32 BIO INC | COM | 746964105 | 2,866,612 | 64,245 | SH | | SOLE | | 64,245 | 0 | 0 |
QUINCE THERAPEUTICS INC | COM | 22053A107 | 110,964 | 142,958 | SH | | SOLE | | 142,958 | 0 | 0 |
RALLYBIO CORP | COM | 75120L100 | 15,561 | 13,300 | SH | | SOLE | | 13,300 | 0 | 0 |
RAPT THERAPEUTICS INC | COM | 75382E109 | 15,075 | 7,500 | SH | | SOLE | | 7,500 | 0 | 0 |
RECURSION PHARMACEUTICALS IN | CL A | 75629V104 | 98,850 | 15,000 | SH | | SOLE | | 15,000 | 0 | 0 |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 915,630 | 871 | SH | | SOLE | | 871 | 0 | 0 |
REGENXBIO INC | COM | 75901B107 | 5,968,894 | 569,008 | SH | | SOLE | | 569,008 | 0 | 0 |
REGENXBIO INC | COM | 75901B107 | 186,722 | 17,800 | SH | Call | SOLE | | 0 | 0 | 0 |
RENOVORX INC | COM NEW | 75989R107 | 334,104 | 315,192 | SH | | SOLE | | 315,192 | 0 | 0 |
REVANCE THERAPEUTICS INC | COM | 761330109 | 945,442 | 182,166 | SH | | SOLE | | 182,166 | 0 | 0 |
REVOLUTION MEDICINES INC | COM | 76155X100 | 2,011,318 | 44,351 | SH | | SOLE | | 44,351 | 0 | 0 |
REZOLUTE INC | COM NEW | 76200L309 | 7,622,769 | 1,571,705 | SH | | SOLE | | 1,571,705 | 0 | 0 |
ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 79,421 | 4,300 | SH | | SOLE | | 4,300 | 0 | 0 |
ROIVANT SCIENCES LTD | SHS | G76279101 | 34,913,693 | 3,025,450 | SH | | SOLE | | 3,025,450 | 0 | 0 |
ROYALTY PHARMA PLC | SHS CLASS A | G7709Q104 | 31,024,681 | 1,096,666 | SH | | SOLE | | 1,096,666 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 372,913 | 51,650 | SH | | SOLE | | 51,650 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 68,590 | 9,500 | SH | Call | SOLE | | 0 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 886,719 | 7,100 | SH | | SOLE | | 7,100 | 0 | 0 |
SAVARA INC | COM | 805111101 | 3,148,768 | 742,634 | SH | | SOLE | | 742,634 | 0 | 0 |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 96,120 | 12,000 | SH | | SOLE | | 12,000 | 0 | 0 |
SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 732,472 | 40,290 | SH | | SOLE | | 40,290 | 0 | 0 |
SOLENO THERAPEUTICS INC | COM | 834203309 | 504,900 | 10,000 | SH | | SOLE | | 10,000 | 0 | 0 |
SOLID BIOSCIENCES INC | COM NEW | 83422E204 | 7,984,776 | 1,145,592 | SH | | SOLE | | 1,145,592 | 0 | 0 |
SPDR SER TR | BLOOMBERG 1-3 MO | 78468R663 | 2,000,173 | 21,786 | SH | | SOLE | | 21,786 | 0 | 0 |
SPDR SER TR | S&P BIOTECH | 78464A870 | 3,952,000 | 40,000 | SH | Put | SOLE | | 40,000 | 0 | 0 |
SPERO THERAPEUTICS INC | COM | 84833T103 | 996,235 | 743,459 | SH | | SOLE | | 743,459 | 0 | 0 |
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 3,204 | 100 | SH | | SOLE | | 100 | 0 | 0 |
SPRUCE BIOSCIENCES INC | COM | 85209E109 | 191,725 | 403,716 | SH | | SOLE | | 403,716 | 0 | 0 |
SPYRE THERAPEUTICS INC | COM NEW | 00773J202 | 369,390 | 12,560 | SH | | SOLE | | 12,560 | 0 | 0 |
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 6,741,466 | 350,206 | SH | | SOLE | | 350,206 | 0 | 0 |
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 2,021,250 | 105,000 | SH | Call | SOLE | | 0 | 0 | 0 |
SYROS PHARMACEUTICALS INC | COM NEW | 87184Q206 | 96,750 | 45,000 | SH | | SOLE | | 45,000 | 0 | 0 |
TARGET HOSPITALITY CORP | COM | 87615L107 | 511,465 | 65,741 | SH | | SOLE | | 65,741 | 0 | 0 |
TARSUS PHARMACEUTICALS INC | COM | 87650L103 | 851,851 | 25,900 | SH | | SOLE | | 25,900 | 0 | 0 |
TARSUS PHARMACEUTICALS INC | COM | 87650L103 | 164,450 | 5,000 | SH | Call | SOLE | | 0 | 0 | 0 |
TAYSHA GENE THERAPIES INC | COM SHS | 877619106 | 505,314 | 251,400 | SH | | SOLE | | 251,400 | 0 | 0 |
TECTONIC THERAPEUTIC INC | COM | 878972108 | 3,852,918 | 127,159 | SH | | SOLE | | 127,159 | 0 | 0 |
TENAX THERAPEUTICS INC | COM NEW | 88032L605 | 215,984 | 62,423 | SH | | SOLE | | 62,423 | 0 | 0 |
TERNS PHARMACEUTICALS INC | COM | 880881107 | 206,015 | 24,702 | SH | | SOLE | | 24,702 | 0 | 0 |
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 1,949,241 | 108,171 | SH | | SOLE | | 108,171 | 0 | 0 |
TG THERAPEUTICS INC | COM | 88322Q108 | 116,950 | 5,000 | SH | | SOLE | | 5,000 | 0 | 0 |
TG THERAPEUTICS INC | COM | 88322Q108 | 23,390 | 1,000 | SH | Put | SOLE | | 1,000 | 0 | 0 |
THERAPEUTICSMD INC | COM NEW | 88338N206 | 448,466 | 270,160 | SH | | SOLE | | 270,160 | 0 | 0 |
TMT ACQUISITION CORP | SHS | G89229119 | 562,000 | 50,000 | SH | | SOLE | | 50,000 | 0 | 0 |
TMT ACQUISITION CORP | RIGHT 03/27/2028 | G89229135 | 10,128 | 37,100 | SH | | SOLE | | 37,100 | 0 | 0 |
TOURMALINE BIO INC | COM | 89157D105 | 289,495 | 11,260 | SH | | SOLE | | 11,260 | 0 | 0 |
TRIPADVISOR INC | COM | 896945201 | 57,960 | 4,000 | SH | | SOLE | | 4,000 | 0 | 0 |
ULTRA CLEAN HLDGS INC | COM | 90385V107 | 39,930 | 1,000 | SH | | SOLE | | 1,000 | 0 | 0 |
VAXCYTE INC | COM | 92243G108 | 1,153,784 | 10,097 | SH | | SOLE | | 10,097 | 0 | 0 |
VENTYX BIOSCIENCES INC | COM | 92332V107 | 213,542 | 97,955 | SH | | SOLE | | 97,955 | 0 | 0 |
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 287,700 | 10,000 | SH | | SOLE | | 10,000 | 0 | 0 |
VERU INC | COM | 92536C103 | 39,219 | 51,000 | SH | | SOLE | | 51,000 | 0 | 0 |
VIGIL NEUROSCIENCE INC | COM | 92673K108 | 73,906 | 21,737 | SH | | SOLE | | 21,737 | 0 | 0 |
VIKING THERAPEUTICS INC | COM | 92686J106 | 449,501 | 7,100 | SH | | SOLE | | 7,100 | 0 | 0 |
VIR BIOTECHNOLOGY INC | COM | 92764N102 | 2,390,696 | 319,185 | SH | | SOLE | | 319,185 | 0 | 0 |
VIRIDIAN THERAPEUTICS INC | COM | 92790C104 | 209,436 | 9,206 | SH | | SOLE | | 9,206 | 0 | 0 |
VISTAGEN THERAPEUTICS INC | COM | 92840H400 | 490,865 | 163,078 | SH | | SOLE | | 163,078 | 0 | 0 |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 237,709 | 40,634 | SH | | SOLE | | 40,634 | 0 | 0 |
VYNE THERAPEUTICS INC | COM | 92941V308 | 287,386 | 152,865 | SH | | SOLE | | 152,865 | 0 | 0 |
WEST PHARMACEUTICAL SVSC INC | COM | 955306105 | 60,032 | 200 | SH | | SOLE | | 200 | 0 | 0 |
WISDOMTREE TR | FLOATNG RAT TREA | 97717Y527 | 502,200 | 10,000 | SH | | SOLE | | 10,000 | 0 | 0 |
XENCOR INC | COM | 98401F105 | 6,882,889 | 342,262 | SH | | SOLE | | 342,262 | 0 | 0 |
XENON PHARMACEUTICALS INC | COM | 98420N105 | 1,098,541 | 27,903 | SH | | SOLE | | 27,903 | 0 | 0 |
ZAI LAB LTD | ADR | 98887Q104 | 12,853,440 | 532,454 | SH | | SOLE | | 532,454 | 0 | 0 |
ZURA BIO LTD | CLASS A ORD SHS | G9TY5A101 | 15,308,835 | 3,770,649 | SH | | SOLE | | 3,770,649 | 0 | 0 |