Eterna Therapeutics (ERNA) 10-K14 Mar 242023 FY Annual reportFinancial data

Company Profile

Document and Entity Information

Document and Entity Information - USD ($) $ in Millions	12 Months Ended
Document and Entity Information - USD ($) $ in Millions	Dec. 31, 2023	Mar. 12, 2024	Jun. 30, 2023
Cover [Abstract]
Document Type	10-K
Amendment Flag	false
Document Annual Report	true
Document Period End Date	Dec. 31, 2023
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	FY
Document Transition Report	false
Entity File Number	1-11460
Entity Registrant Name	Eterna Therapeutics Inc.
Entity Central Index Key	0000748592
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	31-1103425
Entity Address, Address Line One	1035 Cambridge Street, Suite 18A,
Entity Address, City or Town	Cambridge
Entity Address, State or Province	MA
Entity Address, Postal Zip Code	02141
City Area Code	212
Local Phone Number	582-1199
Title of 12(b) Security	Common Stock, $0.005 par value
Trading Symbol	ERNA
Security Exchange Name	NASDAQ
Entity Well-known Seasoned Issuer	No
Entity Voluntary Filers	No
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
ICFR Auditor Attestation Flag	false
Document Financial Statement Error Correction [Flag]	false
Entity Shell Company	false
Entity Public Float			$ 9.7
Entity Common Stock, Shares Outstanding		5,410,331
Auditor Firm ID	248
Auditor Name	GRANT THORNTON LLP
Auditor Location	New York, New York

CONSOLIDATED BALANCE SHEETS

CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Current assets:
Cash	$ 7,575	$ 11,446
Other receivables	425	951
Prepaid expenses and other current assets	1,599	1,284
Total current assets	9,599	13,681
Restricted cash	4,095	4,095
Property and equipment, net	493	236
Right-of-use assets - operating leases	32,781	1,030
Goodwill	2,044	2,044
Investment in non-controlling interest	0	59
Other assets	120	1,134
Total assets	49,132	22,279
Current liabilities:
Accounts payable	1,067	1,620
Accrued expenses	1,893	3,626
Income taxes payable	2	0
Operating lease liabilities, current	2,216	295
Deferred revenue, current	190	0
Total current liabilities	6,573	7,654
Convertible notes, net	6,773	0
Warrant liabilities	116	331
Operating lease liabilities, non-current	32,854	887
Deferred revenue, non-current	392	0
Contingent consideration liability	107	0
Total liabilities	46,899	10,172
Stockholder's equity:
Common stock, $0.005 par value, 100,000 shares authorized at December 31, 2023 and 2022; 5,410 and 5,127 issued and outstanding at December 31, 2023 and 2022, respectively	27	26
Additional paid-in capital	189,186	177,377
Accumulated deficit	(186,981)	(165,297)
Total stockholders' equity	2,233	12,107
Total liabilities and stockholders' equity	49,132	22,279
Related Party [Member]
Current liabilities:
Other current liabilities	1,205	1,750
Other liabilities	0	1,206
Nonrelated Party [Member]
Current liabilities:
Other current liabilities	0	363
Other liabilities	84	94
Series A Preferred Stock [Member]
Stockholder's equity:
Preferred stock, $0.005 par value, 1,000 shares authorized, 156 designated and outstanding of Series A convertible preferred stock at December 31, 2023 and 2022, $156 liquidation preference	$ 1	$ 1

CONSOLIDATED BALANCE SHEETS (Pa

CONSOLIDATED BALANCE SHEETS (Parenthetical) - USD ($) shares in Thousands, $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Stockholder's equity:
Preferred stock, par value (in dollars per share)	$ 0.005	$ 0.005
Preferred stock, shares authorized (in shares)	1,000	1,000
Preferred stock, shares issued (in shares)	156	156
Preferred stock, shares outstanding (in shares)	156	156
Preferred stock, liquidation preference	$ 156	$ 156
Common stock, par value (in dollars per share)	$ 0.005	$ 0.005
Common stock, shares authorized (in shares)	100,000	100,000
Common stock, shares issued (in shares)	5,410	5,127
Common stock, shares outstanding (in shares)	5,410	5,127

CONSOLIDATED STATEMENTS OF OPER

CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
CONSOLIDATED STATEMENTS OF OPERATIONS [Abstract]
Revenue	$ 68	$ 0
Cost of revenues	236	0
Gross loss	(168)	0
Operating expenses:
Research and development	5,920	10,392
General and administrative	14,587	16,835
Acquisition of Exacis in-process research and development	460	0
Impairment of in-process research and development	0	5,990
Total operating expenses	20,967	33,217
Loss from operations	(21,135)	(33,217)
Other expense, net:
Change in fair value of warrant liabilities	215	10,795
Change in fair value of contingent consideration	118	0
Loss on non-controlling investment	(59)	(941)
Interest income	138	0
Interest expense	(614)	(30)
Other expense, net	(334)	(1,141)
Total other (expense) income, net	(536)	8,683
Loss before income taxes	(21,671)	(24,534)
Benefit (provision) for income taxes	3	(45)
Net loss	(21,668)	(24,579)
Series A convertible preferred stock dividend	(16)	(16)
Net loss attributable to common stockholders	$ (21,684)	$ (24,595)
Net loss per common share - basic (in dollars per share)	$ (4.08)	$ (8.06)
Net loss per common share - diluted (in dollars per share)	$ (4.08)	$ (8.06)
Weighted average shares outstanding - basic (in shares)	5,314	3,051
Weighted average shares outstanding - diluted (in shares)	5,314	3,051

CONSOLIDATED STATEMENTS OF STOC

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) shares in Thousands, $ in Thousands	Preferred Stock [Member] Series A Convertible Preferred Stock [Member]	Common Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Total	Series A Convertible Preferred Stock [Member]
Balance at Dec. 31, 2021	$ 1	$ 13	$ 166,191	$ (140,702)	$ 25,503
Balance (in shares) at Dec. 31, 2021	156	2,601
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock in connection with private offering	$ 0	$ 1	(1)	0	0
Issuance of common stock in connection with private offering (in shares)	0	275
Issuance of common stock from vested restricted stock units	$ 0	$ 0	(5)	0	(5)
Issuance of common stock from vested restricted stock units (in shares)	0	2
Issuance of common stock and warrants in connection with November 2022 private offering, net.	$ 0	$ 12	7,383	0	7,395
Issuance of common stock and warrants in connection with November 2022 private offering, net. (in shares)	0	2,185
Forfeiture of unvested restricted stock	$ 0	$ 0	0	0	0
Forfeiture of unvested restricted stock (in shares)	0	(4)
Cash dividends to Series A convertible preferred stockholders	$ 0	$ 0	0	(16)	(16)	$ (16)
Cash dividends to Series A convertible preferred stockholders (in shares)	0	0
Stock-based compensation	$ 0	$ 0	2,935	0	2,935
Net loss	0	0	0	(24,579)	(24,579)
Balance at Dec. 31, 2022	$ 1	$ 26	177,377	(165,297)	12,107
Balance (in shares) at Dec. 31, 2022	156	5,127
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock in connection with Exacis asset acquisition	$ 0	$ 0	208	0	208
Issuance of common stock in connection with Exacis asset acquisition (in shares)	0	69
Issuance of common stock related to stock purchase agreement with Lincoln Park Capital Fund, LLC, net	$ 0	$ 1	579	0	580
Issuance of common stock related to stock purchase agreement with Lincoln Park Capital Fund, LLC, net (in shares)	0	214
Issuance of note warrants	$ 0	$ 0	9,014	0	9,014
Repricing of warrants in connection with December 2023 financing	0	0	766	0	766
Cash dividends to Series A convertible preferred stockholders	$ 0	$ 0	0	(16)	(16)	$ (16)
Cash dividends to Series A convertible preferred stockholders (in shares)	0	0
Stock-based compensation	$ 0	$ 0	1,242	0	1,242
Net loss	0	0	0	(21,668)	(21,668)
Balance at Dec. 31, 2023	$ 1	$ 27	$ 189,186	$ (186,981)	$ 2,233
Balance (in shares) at Dec. 31, 2023	156	5,410

CONSOLIDATED STATEMENTS OF CASH

CONSOLIDATED STATEMENTS OF CASH FLOWS $ in Thousands	12 Months Ended
CONSOLIDATED STATEMENTS OF CASH FLOWS $ in Thousands	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)
Cash flows from operating activities:
Net loss	$ (21,668)	$ (24,579)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	84	161
Stock-based compensation	1,242	2,935
Commitment shares issued to Lincoln Park Capital, LLC	249	0
Loss on shares sold to Lincoln Park Capital, LLC	11	0
Amortization of right-of-use asset	1,039	336
Impairment of right-of-use asset	0	772
Non-cash component of acquisition of Exacis in-process research and development	433	0
Gain on remeasurement of operating lease liability and right-of-use-asset	0	(642)
Impairment of in-process research and development	0	5,990
Loss on disposal of fixed assets	1	280
Gain on lease termination	0	(85)
Accrued interest expense	176	0
Paid-in-kind interest expense	113	0
Amortization of debt discount and debt issuance costs	303	0
Change in fair value of warrant liabilities	(215)	(10,795)
Change in fair value of contingent consideration liability	(118)	0
Loss on non-controlling investment	59	941
Changes in operating assets and liabilities:
Other receivables	527	(262)
Prepaid expenses and other current assets	(556)	(187)
Other non-current assets	1,014	(646)
Accounts payable and accrued expenses	(2,898)	2,034
Operating lease liability	1,338	(340)
Due to related party	(1,750)	2,956
Deferred revenue	582	0
Other liabilities	(374)	155
Net cash used in operating activities	(20,408)	(20,976)
Cash flows from investing activities:
Purchase of property and equipment	(19)	(297)
Proceeds from the sale of fixed assets	0	250
Net cash used in investing activities	(19)	(47)
Cash flows from financing activities:
Proceeds received from the convertible notes financings	16,503	0
Fees paid related to the Convertible Notes Financings	(251)	0
Proceeds received under promissory note	1,500	0
Principal payment made on promissory note	(1,500)	0
Proceeds from sale of common stock pursuant to stock purchase agreement with Lincoln Park Capital Fund, LLC	320	0
Proceeds from issuance of common stock and warrants in connection with private offering	0	19,706
Fees paid in connection with private offering	0	(110)
Issuance of common stock from exercise of pre-funded warrants	0	7
Payroll tax remitted on net share settlement of equity awards	0	(5)
Dividends paid to Series A convertible preferred stockholders	(16)	(16)
Cash paid for fractional shares in connection with reverse stock split	0	(1)
Principal payments on finance leases	0	(2)
Net cash provided by financing activities	16,556	19,579
Net decrease in cash and cash equivalents	(3,871)	(1,444)
Cash, cash equivalents and restricted cash at beginning of period	15,541	16,985
Cash, cash equivalents and restricted cash at end of period	11,670	15,541
Cash paid during the period for:
Interest	20	30
Income taxes	4	15
Supplemental disclosure of non-cash investing and financing activities:
Contingent consideration for Exacis asset acquisition	225	0
Issuance of common stock for Exacis asset acquisition	208	0
Note warrants issued	9,219	0
Repricing of warrants in connection with December 2023 financing	766	0
Unpaid fees incurred in connection with the December 2023 financing	116	0
Paid-in-kind interest added to convertible notes principal	113	0
Initial measurement of ROU assets	34,410	1,706
Initial measurement of lease liabilities	34,170	1,706
Adjustment to lease liability and ROU asset due to remeasurement	(1,620)	0
Accrual for purchases of property and equipment	323	0
Conversion of Warrant Liability to Equity	0	867
Unpaid fees incurred in connection with November 2022 private offering	0	208
Initial measurement of finance lease liabilities	0	10
Reconciliation of cash, cash equivalents and restricted cash at end of period:
Cash and cash equivalents	7,575	11,446
Restricted cash	4,095	4,095
Total cash, cash equivalents and restricted cash at end of period	$ 11,670	$ 15,541

Organization and Description of

Organization and Description of Business Operations	12 Months Ended
Organization and Description of Business Operations	Dec. 31, 2023
Organization and Description of Business Operations [Abstract]
Organization and Description of Business Operations	1) Organization and Description of Business Operations Eterna Therapeutics Inc. is a life science company committed to realizing the potential of mRNA cell engineering to provide patients with transformational new medicines. Eterna has in-licensed a portfolio of over 100 patents covering key mRNA cell engineering technologies, including technologies for mRNA cell reprogramming, mRNA gene editing, the NoveSliceTM and UltraSliceTM gene-editing proteins, and the ToRNAdoTM mRNA delivery system, which Eterna collectively refers to as our “mRNA technology platform.” Eterna refers to aspects of its mRNA technology platform as “mRNA delivery,” “mRNA gene editing” and “mRNA cell reprogramming.” Eterna licenses its mRNA technology platform from Factor Bioscience Limited (“Factor Limited”) under an exclusive license agreement. As used herein, the “Company” or “Eterna” refers collectively to Eterna and its consolidated subsidiaries (Eterna LLC, Novellus, Inc. and Novellus Therapeutics Limited) unless otherwise stated or the context otherwise requires.

Liquidity and Capital Resources

Liquidity and Capital Resources	12 Months Ended
Liquidity and Capital Resources	Dec. 31, 2023
Liquidity and Capital Resources [Abstract]
Liquidity and Capital Resources	2) Liquidity and Capital Resources The Company has incurred significant operating losses and has an accumulated deficit as a result of its efforts to develop product candidates, including conducting clinical trials and providing general and administrative support for operations. As of December 31, 2023, the Company had an unrestricted cash balance of approximately $7.6 million and an accumulated deficit of approximately $187.0 million. For the year ended December 31, 2023, the Company incurred a net loss of $21.7 million, and the Company used cash of $20.4 million in operating activities. In October 2022, the Company entered into a sublease for approximately 45,500 square feet of office and laboratory space in Somerville, Massachusetts. Pursuant to the sublease, the Company delivered to the sublessor a security deposit in the form of a letter of credit in the amount of $4.1 million, which will be reduced on an incremental basis throughout the term of the sublease. The letter of credit was issued by the Company’s commercial bank, which required that the Company cash collateralize the letter of credit by depositing $4.1 million in a restricted cash account with such bank. The amount of required restricted cash collateral will decline in parallel with the reduction in the amount of the letter of credit over the term of the sublease. In April 2023, the Company entered into a standby equity purchase agreement (the “SEPA”) and a registration rights agreement with Lincoln Park Capital Fund, LLC (“Lincoln Park”), pursuant to which Lincoln Park committed to purchase up to $10.0 million of the Company’s common stock in an “equity line” financing arrangement. During the year ended December 31, 2023, the Company issued and sold approximately 214,000 shares of common stock under the SEPA for gross proceeds of $0.3 million . In July and December 2023, the Company received $16.5 million in gross proceeds from the issuance of convertible notes and in January 2024 received an additional $1.4 million in gross proceeds from the issuance of additional convertible notes. See Notes 6 and 18 for additional information regarding these financings. In connection with preparing the accompanying consolidated financial statements as of and for the year ended December 31, 2023, the Company’s management concluded that there is substantial doubt regarding the Company’s ability to continue as a going concern because it does not expect to have sufficient cash or working capital resources to fund operations for the twelve-month period subsequent to the issuance date of these consolidated financial statements. The Company will need to raise additional capital, which could be through the sales of shares of its common stock under the SEPA, public or private equity offerings, debt financings, out-licensing the Company’s intellectual property, strategic partnerships or other means. Other than the SEPA, the Company currently has no arrangements for capital, and no assurances can be given that it will be able to raise capital when needed, on acceptable terms, or at all. The accompanying consolidated financial statements have been prepared on a going-concern basis, which contemplates the realization of assets and the satisfaction of liabilities in the normal course of business. The accompanying consolidated financial statements do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and classifications of liabilities that may result from uncertainty related to the Company’s ability to continue as a going concern.

Basis of Accounting Presentatio

Basis of Accounting Presentation and Summary of Significant Accounting Policies	12 Months Ended
	Dec. 31, 2023
Basis of Accounting Presentation and Summary of Significant Accounting Policies [Abstract]
Basis of Accounting Presentation and Summary of Significant Accounting Policies	3) Basis of Accounting Presentation and Summary of Significant Accounting Policies Basis of Accounting Presentation The consolidated financial statements have been prepared in conformity with U.S. generally accepted accounting principles (“GAAP”). Any reference in these notes to applicable guidance is meant to refer to GAAP as found in the Accounting Standards Codification (“ASC”) and Accounting Standards Updates (“ASU”) of the Financial Accounting Standards Board (“FASB”). All significant intercompany balances and transactions have been eliminated in consolidation. Summary of Significant Accounting Policies Use of Estimates The preparation of consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect: (a) the reported amounts of assets and liabilities; (b) disclosure of contingent assets and liabilities at the date of the consolidated financial statements; (c) the reported amounts of expenses during the reporting period; and (d) the reported amount of the fair value of assets acquired in connection with business combinations. On an ongoing basis, the Company evaluates its estimates, including those related to the recoverability and useful lives of long-lived assets; stock-based compensation assumptions; valuation assumptions of warrants; contingencies; contingent consideration and the provision for income taxes, including the valuation allowance. The Company bases its estimates on a combination of historical experience and various other assumptions that it believes are reasonable under the circumstances. Actual results may differ materially from these estimates. Cash, Cash Equivalents and Restricted Cash The Company classifies highly liquid investments with a remaining contractual maturity at date of purchase of three months or less as cash equivalents. The Company had no cash equivalents as of December 31, 2023 or 2022. Restricted cash consists of a cash collateralization of $4.1 million for a security deposit in the form of a letter of credit issued by the Company’s commercial bank and delivered to the sublessor of office and laboratory space the Company subleases in Somerville, Massachusetts. The amount of required restricted cash collateral will decline in parallel with the reduction in the amount of the letter of credit over the term of the sublease. Property and Equipment Property and equipment are recorded at cost and are depreciated over their estimated useful lives using the straight-line method. Laboratory and manufacturing equipment are depreciated over an estimated useful life of seven years. Leasehold improvements are depreciated over the shorter of their estimated useful life, or the lease term. Furniture and fixtures are depreciated over an estimated useful life of five years. Computer equipment are depreciated over an estimated useful life of three years. Upon retirement or other disposition of these assets, the cost and related accumulated depreciation of these assets are removed from the accounts and the resulting gain or losses are reflected in the results of operations. Expenditures for maintenance and repairs are charged to operations. Renewals and betterments are capitalized. Goodwill Goodwill represents the excess of the purchase price over the fair value of identifiable net assets acquired in the acquisition of IRX Therapeutics, Inc. (“IRX”) in November 2018, which was accounted for as a business combination. Goodwill is not amortized but is tested for impairment annually or more frequently if events occur or circumstances indicate it is more likely than not that the fair value of a reporting unit is less than its carrying value. Events that would indicate impairment and trigger an interim impairment assessment include, but are not limited to, macroeconomic conditions, industry and market considerations, cost factors, overall financial performance and other relevant events. Management evaluates the Company as a single reporting unit, therefore, goodwill is tested for impairment at the entity level. Goodwill is tested for impairment as of December 31st of each year, or more frequently as warranted by events or changes in circumstances mentioned above. Accounting guidance also permits an optional qualitative assessment for goodwill to determine whether it is more likely than not that the carrying value of a reporting unit exceeds its fair value. If, after this qualitative assessment, the Company determines that it is not more likely than not that the fair value of a reporting unit is less than its carrying amount, then no further quantitative testing would be necessary. A quantitative assessment is performed if the qualitative assessment results in a more likely than not determination or if a qualitative assessment is not performed. The quantitative assessment considers whether the carrying amount of a reporting unit exceeds its fair value, in which case an impairment charge is recorded to the extent the reporting unit’s carrying value exceeds its fair value. In-Process Research & Development In-process research and development (“IPR&D”) assets represent the fair value assigned to technologies that were acquired in connection with the acquisition of IRX in November 2018, which have not reached technological feasibility and have no alternative future use. IPR&D assets are considered to be indefinite lived until the completion or abandonment of the associated research and development projects. During the period that the IPR&D assets are considered indefinite-lived, they are tested for impairment on an annual basis or more frequently if the Company becomes aware of any events occurring or changes in circumstances that indicate that the fair value of the IPR&D assets are less than their carrying amounts. If and when development is complete, which generally occurs upon regulatory approval, and the Company is able to commercialize products associated with the IPR&D assets, these assets are then deemed definite-lived and are amortized based on their estimated useful lives beginning at that point in time. If development is terminated or abandoned, the Company may have a full or partial impairment charge related to the IPR&D assets, calculated as the excess of carrying value of the IPR&D assets over fair value. Revenue Recognition The Company recognizes the related revenue under ASC 606, Revenue from Contracts with Customers (“ASC 606”). Under ASC 606, the Company recognizes revenue when a customer obtains control of promised services or goods in an amount that reflects the consideration to which the Company expects to receive in exchange for those goods or services. In general, the Company applies the following steps when recognizing revenue from contracts with customers: (i) identify the contract, (ii) identify the performance obligations, (iii) determine the transaction price, (iv) allocate the transaction price to the performance obligations and (v) recognize revenue when a performance obligation is satisfied. Recognition of revenue is driven by satisfaction of the performance obligations using one of two methods: revenue is either recognized over time or at a point in time. Contracts containing multiple performance obligations classify those performance obligations into separate units of account either as standalone or combined units of account. Allocation of revenue to individual elements that qualify for separate accounting is based on the separate selling prices determined for each component, and total contract consideration is then allocated across the components of the arrangement. If separate selling prices are not available, the Company will use its best estimate of such selling prices, consistent with the overall pricing strategy and after consideration of relevant market factors. The Company estimates the amount of consideration it expects to recognize as revenue that is not probable of having a significant reversal of such recognized revenue, and it places a constraint on the remaining contractual consideration. As it becomes evident that the constrained amounts are no longer at risk of a significant reversal of revenue, the Company will remove the constraint from the related revenue and recognize a cumulative catch-up adjustment to revenue in the period in which the constraint was removed. The Company has one revenue generating contract. Such contract relates to an option and license agreement as well as certain development activities. See Note 5. Contract Assets: A contract asset is an entity’s right to payment for goods and services already transferred to a customer if that right to payment is conditional on something other than the passage of time. Generally, an entity will recognize a contract asset when it has fulfilled a contract obligation but must perform other obligations before being entitled to payment. Contract assets consist primarily of the cost of project contract work performed by third parties whereby the Company expects to recognize any related revenue at a later date, upon satisfaction of the contract obligations. The Company had no contract assets as of December 31, 2023 or 2022. Contract Liabilities: Contract liabilities consist primarily of consideration received, usually in the form of payment, on project work to be performed whereby the Company expects to recognize any related revenue at a later date, upon satisfaction of the contract obligations. As of December 31, 2023, contract liabilities were $0.6 million and are recognized as deferred revenue in the accompanying consolidated balance sheet. The Company recognized $0.1 million of revenue during the year ended December 31, 2023 from contract liabilities that arose in 2023. There were no contract liabilities as of December 31, 2022. Research and Development The Company expenses its research and development costs as incurred. Research and development expenses consist of costs incurred for company-sponsored research and development activities, as well as support for selected investigator-sponsored research. Upfront payments and milestone payments made for the licensing of technology are expensed as research and development in the period in which they are incurred if the technology is not expected to have any alternative future uses other than the specific research and development project for which it was intended. The major components of research and development costs include salaries and employee benefits, stock-based compensation expense, supplies and materials, preclinical study costs, expensed licensed technology, consulting, scientific advisors and other third-party costs, and allocations of various overhead costs related to our product development efforts. The Company has contracted with third parties to perform various studies. The financial terms of these agreements vary from contract to contract and may result in uneven payment flows. The Company accrues for third party expenses based on estimates of the services received and efforts expended during the reporting period. If the actual timing of the performance of the services or the level of effort varies from the estimate, the accrual is adjusted accordingly. The expenses for some third-party services may be recognized on a straight-line basis if the expected costs are expected to be incurred ratably during the period. Payments under the contracts depend on factors such as the achievement of certain events or milestones, the successful enrollment of patients, the allocation of responsibilities among the parties to the agreement, and the completion of portions of the clinical study or trial or similar conditions. Income Taxes The Company records deferred tax liabilities and assets based on the differences between the consolidated financial statements carrying amounts and the tax basis of assets and liabilities, using enacted tax rates in effect in the years the differences are expected to reverse and establishing a valuation allowance when it was more likely than not that some portion or all of the deferred tax assets would not be realized. Income tax expense consists of the tax payable for the period and the change during the period in deferred tax assets and liabilities. Tax benefits from uncertain tax positions are recognized only if it is more likely than not that the tax position will be sustained on examination by the taxing authorities, based on the technical merits of the position. The tax benefits recognized in the consolidated financial statements from such a position are measured based on the largest benefit that has a greater than 50% likelihood of being realized upon ultimate resolution. The Company has no material uncertain tax positions for any of the reporting periods presented. Loss Per Share The Company calculates basic and diluted net loss per share attributable to common stockholders in conformity with the two-class method required for participating securities. The Company’s convertible notes contractually entitle the holders of such notes to participate in dividends but does not contractually require the holders to participate in the Company’s losses. As such, the two-class method is not applicable during periods with a net loss. Basic net loss per share is calculated by dividing net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during the period, without consideration for potentially dilutive securities. Diluted net loss per share is calculated by dividing net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding plus dilutive securities. Shares of common stock issuable upon exercise, conversion or vesting of stock options, restricted stock units, warrants and the outstanding Series A convertible preferred stock are considered potential shares of common stock and are included in the calculation of diluted net loss per share using the treasury method when their effect is dilutive. The Company’s convertible notes are also considered potential shares of common stock and are included in the calculation of diluted net loss per share using the “if-converted” method, and the more dilutive of either the two-class method or the if-converted method is reported. Diluted net loss per share is the same as basic net loss per share for periods in which the effect of potentially dilutive shares of common stock is antidilutive. Segment Reporting The Company’s chief operating decision maker, who is the chief executive officer, reviews operating results on a consolidated basis to make decisions about allocating resources and assessing performance of the Company. As a result, in accordance with ASC No. 280, Segment Reporting, Concentration of Credit Risk The Company maintains its cash balances in financial institutions located in the United States. Accounts at each institution are insured by the Federal Deposit Insurance Corporation (“FDIC”) up to $250,000. The Company’s cash balances are uninsured for deposit accounts that exceed the FDIC insurance limit. In the Company’s business, vendor concentrations could be indicative of vulnerabilities in the Company’s supply chain, which could ultimately impact the Company’s ability to continue its research and development activities. For the years ended December 31, 2023 and 2022, there was no vendor concentration related to the Company’s research and development activities. Fair Value of Financial Instruments Fair value is defined as the price that would be received to sell an asset, or paid to transfer a liability, in an orderly transaction between willing market participants. A fair value hierarchy has been established for valuation inputs that gives the highest priority to quoted prices in active markets for identical assets or liabilities and the lowest priority to unobservable inputs. The fair value hierarchy is as follows: • Level 1 Inputs – Valued based on quoted prices in active markets for identical assets or liabilities that the reporting entity has the ability to access at the measurement date. • Level 2 Inputs – Valued based on inputs other than quoted prices included in Level 1 that are observable for the asset or liability, either directly or indirectly. These might include quoted prices for similar assets or liabilities in active markets, quoted prices for identical or similar assets or liabilities in markets that are not active, inputs other than quoted prices that are observable for the asset or liability (such as interest rates, volatilities, prepayment speeds, credit risks, etc.) or inputs that are derived principally from or corroborated by market data by correlation or other means. • Level 3 Inputs – Valued based on inputs for which there is little or no market value, which require the reporting entity to develop its own assumptions. The carrying amounts reported on the balance sheet for cash and cash equivalents, other receivables, prepaid assets and other current assets, accounts payable and accrued expenses, other current liabilities and other liabilities approximate fair value due to their short maturities. Leases The Company accounts for its leases under ASC Topic 842, Leases. The Company has elected the practical expedient to not separate non-lease components from the lease components to which they relate and instead account for each as a single lease component for all underlying asset classes. Some leasing arrangements require variable payments that are dependent on usage or may vary for other reasons, such as payments for insurance, tax payments and other miscellaneous costs. The variable portion of payments contemplated in the lease that do not depend on an index or rate are not included in the ROU assets or lease liabilities. Rather, variable payments that do not depend on an index or rate are expensed when the obligation for those payments is incurred and are included in lease expenses. Accordingly, all expenses associated with a lease contract are accounted for as lease expenses. The Company has also elected not to recognize ROU and lease liabilities for short-term leases that have a term of 12 months or less. The Company accounts for lease modifications as a separate contract when the modification (i) grants the lessee an additional right of use not included in the original lease contract, and (ii) increases the lease payments commensurate with the stand-alone price for the additional right of use. In this case, the Company would be treated as a new lease and measured in accordance with ASC 842 at the commencement date of the new lease without any impact on the existing lease. Otherwise, the Company accounts for lease modifications as a continuance of the existing lease, in which case, the Company reassesses the lease classification, remeasures the lease liability using an updated discount rate, and unless there is a full or partial termination of the lease, adjusts the ROU asset by the amount of change to the lease liability. For a full or partial lease termination, the lessee reduces the carrying amount of the ROU asset on a basis proportionate to the full or partial termination of the lease, and any difference between the adjustment to the ROU asset and the lease liability is recognized as a gain or loss in the current period. Commitment and Contingencies The Company follows ASC No.450-20, Loss Contingencies, Stock-Based Compensation The Company recognizes stock-based compensation expense for equity awards granted to employees, directors and certain consultants. The Company estimates the fair value of stock options using the Black-Scholes option pricing model. The fair value of stock options granted is recognized as expense over the requisite service period on a straight-line basis. Warrants The Company accounts for common stock warrants as either equity-classified or liability-classified instruments based on an assessment of the specific terms of the warrants and applicable authoritative guidance in ASC 480, Distinguishing Liabilities from Equity, and ASC 815, Derivatives and Hedging. Convertible Notes The Company accounts for its convertible notes as a long-term liability equal to the proceeds received from issuance, including the embedded conversion feature, plus any interest paid-in-kind, net of the unamortized debt issuance costs and debt discount on the consolidated balance sheets. The Company evaluates all embedded features contained in the convertible notes, such as the conversion feature, the paid-in-kind feature and the redemption feature in the event of a default, to determine if such features require bifurcation as a derivative. The conversion feature included in the convertible notes is not required to be accounted for separately as an embedded derivative because the conversion feature is considered both indexed to the Company’s own stock and qualifies to be classified in stockholders’ equity. The paid-in-kind feature is considered to be a commitment to originate a loan, and the terms of the additional loans have the same terms as the original debt instrument. Therefore, the paid-in-kind feature qualifies for the scope exception under the applicable accounting guidance and is not required to be bifurcated as a derivative. The redemption feature in the event of a default was determined to be clearly and closely related to the convertible notes and not required to be bifurcated as a derivative. Proceeds from the sale of convertible notes with stock purchase warrants are allocated to the two elements based on their relative fair values. The portion of the proceeds allocated to warrants are recorded as a debt discount to the convertible note proceeds and presented on a net basis in the consolidated balance sheet. Debt issuance costs directly attributable to the transaction are capitalized and allocated to the convertible notes and warrants in the same manner as the proceeds. The amount of debt issuance costs allocated to the convertible notes represent a reduction of the face value of the convertible note proceeds. The Company amortizes debt issuance costs and debt discounts over the contractual term of the convertible notes, using the effective interest method, as interest expense on the consolidated statements of operations. Recent Accounting Standards In June 2022, the Financial Accounting Standard Board (the “FASB”) issued Accounting Standards Update (“ASU”) No. 2022-03, Fair Value Measurement (Topic 820): Fair Value Measurement of Equity Securities Subject to Contractual Sale Restrictions (“ASU 2022-03”). The FASB issued ASU 2022-03 to (1) clarify the guidance in Topic 820, Fair Value Measurement, when measuring the fair value of an equity security subject to contractual restrictions that prohibit the sale of an equity security, (2) to amend a related illustrative example, and (3) to introduce new disclosure requirements for equity related securities subject to contractual sale restrictions that are measured at fair value in accordance with Topic 820. ASU 2022-03 clarifies that a contractual restriction on the sale of an equity security is not considered part of the unit of account of the equity security and, therefore, is not considered in measuring fair value. The guidance is effective for fiscal years beginning after December 15, 2023, and interim periods within those fiscal years with early adoption permitted. The Company does not expect a material impact to its consolidated financial statements as a result of adopting this ASU. In October 2023, the FASB issued ASU No. 2023-06, Disclosure Improvements – Codification Amendment in Response to the SEC’s Disclosure Update and Simplification Initiative. This ASU modified the disclosure and presentation requirements of a variety of codification topics by aligning them with the SEC’s regulations. The amendments to the various topics should be applied prospectively, and the effective date will be determined for each individual disclosure based on the effective date of the SEC’s removal of the related disclosure. If the SEC has not removed the applicable requirements from Regulation S-X or Regulation S-K by June 30, 2027, then this ASU will not become effective. Early adoption is prohibited. The Company does not expect the amendments in this ASU to have a material impact on its consolidated financial statements. In November 2023, the FASB issued ASU No. 2023-07, Segment Reporting – Improvements to Reportable Segment Disclosures, which provides updates to qualitative and quantitative reportable segment disclosure requirements, including enhanced disclosures about significant segment expenses and increased interim disclosure requirements, among others. ASU No. 2023-07 is effective for fiscal years beginning after December 15, 2023, and interim periods in fiscal years beginning after December 15, 2024. Early adoption is permitted, and the amendments should be applied retrospectively. The Company does not expect the amendments in this ASU to have a material impact on its consolidated financial statements. In December 2023, the FASB issued ASU No. 2023-09, Improvements to Income Tax Disclosures, which requires disclosure of disaggregated income taxes paid, prescribes standard categories for the components of the effective tax rate reconciliation, and modifies other income tax-related disclosures. ASU No. 2023-09 is effective for fiscal years beginning after December 15, 2024 and allows for adoption on a prospective basis, with a retrospective option. Early adoption is permitted. The Company does not expect the amendments in this ASU to have a material impact on its consolidated financial statements.

Asset Acquisition

Asset Acquisition	12 Months Ended
Asset Acquisition	Dec. 31, 2023
Asset Acquisition [Abstract]
Asset Acquisition	4) Asset Acquisition In April 2023, the Company entered into an asset purchase agreement (the “Exacis Purchase Agreement”), with Exacis Biotherapeutics Inc. (“Exacis”), the stockholders party thereto and, with respect to specified provisions therein, Factor Limited (the “Exacis Acquisition”). Pursuant to the Exacis Purchase Agreement, the Company acquired from Exacis substantially all of Exacis’ intellectual property assets (the “Exacis Assets”), including all of Exacis’ right, title and interest in and to an exclusive license agreement by and between Exacis and Factor Limited (the “Purchased License”). The Company assumed none of Exacis’ liabilities, other than liabilities under the Purchased License that accrue subsequent to the closing date. In consideration for the Exacis Assets, on the closing date of the transaction, the Company issued to Exacis an aggregate of approximately 69,000 shares of the Company’s common stock, which shares are subject to a 12-month lockup, pursuant to which Exacis may not sell or otherwise transfer such shares. The shares were issued to Exacis at a price based on the Company having an assumed equity valuation of $75.0 million, divided by the number of issued and outstanding shares of common stock as of the close of business two trading days prior to the closing date. For accounting purposes, the shares issued were valued at $3.00 per share, which was the closing price of the Company’s common stock on the date of issuance. The Company additionally agreed to make the following contingent payments: (i) if, at any time during the three-year period commencing on the closing date and ending on the three-year anniversary of the closing date, the Company’s market capitalization equals or exceeds $100.0 million for at least ten (ii) if, at any time during the three-year period commencing on the closing date and ending on the three-year anniversary of the closing date, the Company’s market capitalization equals or exceeds $200.0 million for at least ten (iii) during the five-year period commencing on the closing date and ending on the five-year anniversary of the closing date, the Company will pay or deliver to Exacis 20% of all cash or other consideration (collectively, “License Contingent Consideration”) actually received by the Company during such five-year period from (i) third-party licensees or sublicensees of the intellectual property rights acquired by the Company from Exacis pursuant to the Exacis Purchase Agreement, or (ii) subject to certain exceptions, the sale of such intellectual property rights; provided, that the License Contingent Consideration shall not in any event exceed $45.0 million. The Company accounted for the Exacis Acquisition as an asset acquisition because it determined that substantially all of the fair value of the assets acquired was concentrated in the Purchased License. Assets acquired in an asset acquisition are recognized based on their cost to the acquirer and generally allocated to the assets on a relative fair value basis. The Company’s cost for acquiring the Exacis Assets includes the issuance of the shares of the Company’s common stock, direct acquisition-related costs and contingent consideration. The Market Cap Contingent Consideration is indexed to or settled in the Company’s own shares. As a result, the Company classified the Market Cap Contingent Consideration as a liability measured at fair value because the financial instrument embodies a conditional obligation (the Company would only issue the shares on the condition that the market capitalization thresholds are met), and at inception, the monetary value of the obligation is based solely on a fixed monetary amount ($2.0 million of shares for each target), which will be settleable with a variable number of the Company’s shares. The Company used a Monte Carlo simulation model to estimate the fair value of the Market Cap Contingent Consideration as of the acquisition date using the following assumptions: Stock price $ 3.00 Risk-free rate 3.58 % Volatility 100 % Dividend yield 0 % Expected term 3.0 years The License Contingent Consideration is to be settled in cash and is generally recognized when the liability is probable and estimable. As of the acquisition date and as of December 31, 2023, the Company concluded that paying the License Contingent Consideration was not probable or estimable. Therefore, there was no applicable contingent consideration liability recognized. The table below shows the total fair value of the consideration paid for the Exacis Assets (in thousands). Fair Value of Shares issued $ 208 Contingent consideration 225 Direct costs 27 Total fair value $ 460 The Company allocated 100% of the fair value of the consideration to the Purchased License, which the Company determined is an IPR&D asset. IPR&D assets acquired through an asset purchase that have no alternative future uses and no separate economic values from their original intended purpose are expensed in the period the cost is incurred. As a result, the Company expensed the fair value of the Purchased License during the year ended December 31, 2023.

Contract with Customer

Contract with Customer	12 Months Ended
Contract with Customer	Dec. 31, 2023
Contract with Customer [Abstract]
Contract with Customer	5) Contract with Customer On February 21, 2023, the Company and Lineage Cell Therapeutics, Inc. (“Lineage”) entered into an exclusive option and license agreement (the “Lineage Agreement”), which provided Lineage with the option (the “Option Right”) to obtain an exclusive sublicense of intellectual property from the Company and to request the Company to develop a customized cell line. The Lineage Agreement was amended in August 2023 to provide for changes specifically related to the cell line customization activities such as (i) payment terms, (ii) certain definitions, (iii) certain courses of action if the customized cell line selected by Lineage is not successful and (iv) documentation requirements. Lineage paid the Company a $0.3 million non-refundable up-front payment (the “Option Fee”) for the Option Right and paid an initial payment of $0.4 million to commence the cell line customization activities, per the amended payment terms. If Lineage obtains the sublicense, the Company would be entitled to receive additional license fees, including milestone payments and royalties. Pursuant to ASC 606, the Company determined that the Option Right was an unexercised right held by Lineage under the Lineage Agreement at contract inception, as the cell line customization activities and the sublicense were optional purchases at contract inception. These optional purchases of goods and services would be treated as separate contracts if and when Lineage determines that it will make such purchases. Therefore, 100% of the Option Fee was allocated to the Option Right. The Option Fee will remain in deferred revenue until such time that Lineage enters into the sublicense or when the Option Right expires. The Option Right and the cell line customization activities are accounted for as separate contracts, and the Company has determined that the amended terms discussed above represent a modification to the cell line customization contract. Because there were no goods or services transferred to Lineage before entering into the amendment, and therefore, no previously recognized revenue, there was no catch-up adjustment to revenue required at the time of the amendment. Lineage will make payments to the Company for the cell line customization activities over the development period. The Company will only earn the remaining full amount of the cell line customization fee if it makes certain progress towards delivery of the customized cell line. The Company has determined that $0.4 million of consideration received could be recognized without the probability of being reversed, and it has placed a constraint on the remaining contractual customization fee. The $0.4 million is being recognized equally over the development period, which is expected to be approximately 20 to 25 months, as the level of effort to perform the services is happening at the same rate over time. If the development period is expected to be longer or shorter than originally planned, the Company will recognize a cumulative catch-up adjustment in the period that such determination is made. For the year ended December 31, 2023, the Company recognized approximately $0.1 million of revenue for the customization activities. The granting of the license that the Company may provide to Lineage if Lineage exercises the Option Right is not considered a performance obligation at this time, as it is an optional request that the customer may make in the future and will be accounted for as a separate contract when the customer exercises the Option Right. The Company recognizes direct labor and supplies used in the customization activities as incurred and are recorded as a cost of revenue. As provided for in the A&R Factor License Agreement discussed in Note 11, the Company is obligated to pay Factor Limited 20% of any amounts the Company receives from a customer that is related to the licensed technology under the A&R Factor License Agreement, which is also recorded as a cost of revenue.

Promissory Note and Convertible

Promissory Note and Convertible Note Financings	12 Months Ended
Promissory Note and Convertible Note Financings	Dec. 31, 2023
Promissory Note and Convertible Note Financings [Abstract]
Promissory Note and Convertible Note Financings	6) Promissory Note and Convertible Note Financings On July 14, 2023, the Company received $8.7 million from a private placement in which the Company issued $8.7 million in aggregate principal amount of convertible notes (the “July 2023 convertible notes”) and warrants to purchase an aggregate of approximately 6.1 million shares of its common stock (the “July 2023 warrants”). The Company recognized approximately $0.2 million in fees associated with the transaction On December 8, 2023, the Company received $1.5 million in exchange for the issuance of 6% promissory note with an aggregate principal amount of $1.5 million to Charles Cherington. The promissory note was to mature on January 8, 2024, and interest accrued at a rate of 6.0% per annum, payable at maturity. On December 14, 2023, the Company repaid the $1.5 million of principal and $1,500 of accrued interest due under the promissory note. There are no further obligations under the promissory note On December 14, 2023, the Company entered into a purchase agreement with certain purchasers for the private placement of $9.2 million of convertible notes (the “December 2023 convertible notes” and together with the July 2023 convertible notes, the “convertible notes”) and warrants to purchase an aggregate of approximately 9.6 million shares of the Company’s common stock (the “December 2023 warrants” and together with the July 2023 warrants, the “note warrants”). There were two closings under this purchase agreement. The first closing occurred on December 15, 2023, and the Company received $7.8 million and issued $7.8 million of December 2023 convertible notes and December 2023 warrants to purchase approximately 8.1 million shares of our common stock. The second closing, in which the Company received the reaming $1.4 million under the purchase agreement, occurred in January 2024. See Note 18 for additional information regarding the second closing See Note 16 for more information on the note warrants . The July 2023 convertible notes bear interest at 6% per annum, and the December 2023 convertible notes bear interest at 12% per annum, both of which are payable quarterly in arrears. At the Company’s election, it may pay interest either in cash or in-kind by increasing the outstanding principal amount of the convertible notes. The July 2023 convertible notes mature on July 14, 2028, and the December 2023 convertible notes issued on December 15, 2023 mature on December 15, 2028, unless earlier converted or repurchased. The Company does not have the option to redeem any of the convertible notes prior to maturity At the option of the holders, the convertible notes may be converted from time-to-time in whole or in part into shares of the Company’s common stock at an initial conversion rate of, with respect to the July 2023 convertible notes, $2.86 per share and, with respect to the December 2023 convertible notes, $1.9194 per share, subject to customary adjustments for stock splits, stock dividends, recapitalization and the like. As of December 31, 2023, none of the convertible notes were converted into shares of common stock The convertible notes do not contain any ratchet or other financial antidilution provisions. The convertible notes contain conversion limitations such that no conversion may be made if the aggregate number of shares of common stock beneficially owned by the holder thereof would exceed 4.99%, 9.99% or 19.99% immediately after conversion thereof, subject to certain increases not in excess of either 9.99% or 19.99% at the option of such holder The convertible notes provide for customary events of default which include (subject in certain cases to customary grace and cure periods), among others: nonpayment of principal or interest, breach of covenants or other agreements in the convertible notes; the occurrence of a material adverse effect event (as defined in the related securities purchase agreement) and certain events of bankruptcy. Generally, if an event of default occurs and is continuing under the convertible notes, the holder thereof may require the Company to repurchase some or all of their convertible notes at a repurchase price equal to 100% of the principal amount of the convertible notes being repurchased, plus accrued and unpaid interest thereon In connection with the issuance of the December 2023 convertible notes, the Company agreed to reduce the exercise price of the warrants the Company issued in a private placement in December 2022 (see Note 16) to purchase an aggregate of approximately 4.4 million shares of the Company’s common stock from $3.28 to $1.43 per share and of the July 2023 warrants from $2.61 to $1.43 per share. The effect of the reduction of the exercise price of these warrants was approximately $1.6 million and measured as the excess of the fair value of the modified instruments over the fair value of the instruments immediately before they were modified. The change in the fair value of the repriced warrants is considered an issuance cost to the December 2023 convertible notes and December 2023 warrants. As such, the $1.6 million was allocated to each of those respective instruments based on their relative fair values, or approximately $0.8 million to each of the December 2023 convertible notes and December 2023 warrants The Company determined that there were no embedded derivatives within the convertible notes that required bifurcation from the host agreement. The Company allocated the gross proceeds received, the fees incurred, and as applicable, the impact of repricing the warrants discussed above, over the July 2023 convertible notes and July 2023 warrants and over the December 2023 convertible notes and December 2023 warrants, as applicable, based on their relative fair values as follows (in thousands): Allocation of Proceeds and Costs: Allocation of Relative Allocation Proceeds Costs Proceeds, July 2023 convertible notes $ 8,715 39.94 % $ 3,481 $ (80 ) $ 3,401 July 2023 warrants 13,103 60.06 % 5,234 (121 ) 5,113 $ 21,818 100.00 % $ 8,715 $ (201 ) $ 8,514 Allocation of Proceeds and Costs: Allocation of Relative Allocation Proceeds Costs Warrant Proceeds, December 2023 convertible notes $ 9,059 48.83 % $ 3,803 $ (81 ) $ (766 ) $ 2,956 December 2023 warrants 9,495 51.17 % 3,985 (85 ) (802 ) 3,098 $ 18,554 100.00 % $ 7,788 $ (166 ) $ (1,568 ) $ 6,054 The Company estimated the fair values of the convertible notes as of July 14, 2023 and December 15, 2023 based off a valuation performed by a third-party specialist using a binomial tree model and the following assumptions: Stock Credit Volatility Risk-Free July 2023 convertible notes $ 2.81 2,500 108 % 4.60 % December 2023 convertible notes $ 1.51 2,000 109 % 3.90 % The fair value of the note warrants, all of which qualified for equity classification, was determined using the Black-Scholes pricing model as of each of July 14, 2023 and December 15, 2023 using the following assumptions: Stock Exercise Expected Volatility Dividend Risk-Free July 2023 warrants $ 2.81 $ 2.61 5 years 98 % 0.00 % 4.04 % December 2023 warrants $ 1.51 $ 1.43 5 years 101 % 0.00 % 3.91 % The amount of proceeds allocated to the note warrants resulted in a corresponding reduction in the carrying value of the respective convertible notes as a debt discount, which is amortized with the debt issuance costs as a component of interest expense based on the effective interest rate method over the contractual terms of the convertible notes. The following table shows the activity that occurred during the year ended December 31, 2023 for the convertible notes on the accompanying consolidated balance sheet: Gross convertible notes at issuance $ 16,503 Debt discount and debt issuance costs (10,146 ) Amortization of debt discount and debt issuance costs 303 Paid-in-kind interest added to principal 113 Convertible notes, net, at December 31, 2023 $ 6,773 The future minimum principal payments under the convertible notes as of December 31, 2023 are as follows: Years ending December 31, Principal Payments 2024 $ - 2025 - 2026 - 2027 - 2028 16,616 Total $ 16,616 The Company has recognized approximately $0.6 million in interest expense for the year ended December 31, 2023 for the convertible notes, which includes $0.3 million for the amortization of the debt discount and debt issuance costs. Of the remaining $0.3 million in interest expense, $0.1 million was paid in-kind and added to the principal of the respective notes and $0.2 million of interest is in accrued expenses in the accompanying consolidated balance sheet.

Property and Equipment

Property and Equipment	12 Months Ended
Property and Equipment	Dec. 31, 2023
Property and Equipment [Abstract]
Property and Equipment	7) Property and Equipment Property and equipment consist of the following (in thousands): As of December 31, 2023 2022 Laboratory and manufacturing equipment $ 40 $ 28 Furniture and fixtures 19 - Leasehold improvements 274 - Computer equipment and programs 274 240 607 268 Less accumulated depreciation and amortization (114 ) (32 ) Property and equipment, net $ 493 $ 236 During the year ended December 31, 2023, the Company recognized a de minimis Depreciation expense totaled $0.1 million and $0.2 million for the years ended December 31, 2023 and 2022, respectively. No depreciation expense is recorded on fixed assets in process until such time as the assets are completed and are placed into service.

Leases

Leases	12 Months Ended
Leases	Dec. 31, 2023
Leases [Abstract]
Leases	8) Leases Operating Leases T he . Until March 2022, the Company also leased a facility in Brooklyn, New York. In March 2022, the Company entered into an agreement to assign that lease to an unaffiliated third party, who also agreed to purchase certain equipment from the Company for $50,000, which partially reimbursed the Company for certain existing unamortized leasehold improvements, and to reimburse the Company for the approximately $63,000 security deposit under the lease. Under the assignment agreement, the unaffiliated third party assumed all of the obligations, liabilities, covenants and conditions of the Company as tenant under the lease. As a result of the lease assignment, the Company wrote off the remaining ROU asset balance of approximately $1.4 million and the corresponding lease liability of approximately $1.5 million. The Company had also leased a facility in San Diego, California. During the second quarter of 2022, the Company determined to consolidate its research and development efforts in Cambridge, Massachusetts and sublease its San Diego lab and office space. As a result, the Company recognized an impairment charge of approximately $0.8 million on the San Diego lease ROU asset during the year ended December 31, 2022. In November 2022, the Company entered into a lease termination agreement, effective January 31, 2023; and as of December 31, 2023, there was no lease liability or ROU asset balances remaining for the San Diego lease. In October 2022, the Company entered into a sublease with a subsidiary of Bristol-Myers Squibb Company, as sublessor (“Sublessor”), for office, laboratory and research and development space of approximately 45,500 square feet in Somerville, Massachusetts. The lease expires in November 2033 and is subject to a five-year extension. Rent payments under the sublease began on November 29, 2023. The Company pays base rent of approximately $0.5 million per month during the first year of the term, which will increase 3% per year thereafter. The Company also makes monthly payments for parking, which are based on market rates that can change from time to time, and pay its share of traditional lease expenses, including certain taxes, operating expenses and utilities. The Company paid the Sublessor a security deposit in the form of a letter of credit in the amount of approximately $4.1 million. Provided there are no events of default by the Company under the sublease, the letter of credit will be reduced on an incremental basis throughout the term. The Sublessor agreed to provide the Company with a tenant improvement allowance (“TIA”) of $190 per rentable square foot, or $8.6 million. Tenant improvements in excess of this amount will be at the Company’s own cost. Construction was substantially complete in January 2024 and the total out-of-pocket costs for the improvements is estimated to be approximately $2.1 million. As of December 31, 2023, the Company received the entire $8.6 million TIA. The Company obtained access and control of the premises on June 21, 2023, and as such, the Company determined that the commencement date for accounting purposes was June 21, 2023. The Company also performed an analysis on the accounting ownership of the tenant improvement assets and determined that such assets were sublessor/lessor owned. As a result, TIA payments made by the Sublessor to the Company for the tenant improvement assets are considered a reimbursement rather than a lease incentive and not included as part of the consideration of the contract. Amounts paid by the Company for sublessor/lessor owned assets in excess of the TIA are considered non-cash lease payments and are added to the consideration in the contract. The Company measured the lease liability and corresponding ROU asset for the sublease as of June 21, 2023, which includes lease payments the Company must make over the ten-year lease term. The Company did not include the option to extend the lease for an additional five years in the initial measurement because the Company was not reasonably certain as of June 21, 2023 that it would exercise its right to extend the lease term. As a result, the Company recorded a lease liability of $34.4 million, which included $0.6 million for the incremental amount above the TIA that the Company expected to pay for sublessor/lessor owned assets as of the initial measurement date, and a corresponding ROU asset of $34.7 million as of June 30, 2023. In December 2023, the Company incurred additional out-of-pocket expenses of approximately $0.4 million for sublessor/lessor owned assets as a result of out-of-scope changes. These cost changes were accounted for as a lease modification of the existing lease. The Company determined that the lease continued to be classified as an operating lease after modification and remeasured the liability for the remaining unpaid lease payments, including the aggregate $1.0 million of unpaid out-of-pocket costs above the TIA that the Company will pay for sublessor/lessor owned assets, as well as remeasuring any variable lease payment that is based on an index or rate. The Company also requested a third-party specialist to reassess the incremental borrowing rate, which is the rate of interest that a lessee would have to pay to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment. This reassessment resulted in an increased incremental borrowing rate from 12.7% as of the initial measurement date to 14.4% as of the modification date. The remeasurement resulted in a decrease to the lease liability of approximately $1.6 million with a corresponding adjustment to the ROU asset. For the years ended December 31, 2023 and 2022, the net operating lease expenses were as follows (in thousands): Years ended December 31, 2023 2022 Operating lease expense $ 3,399 $ 595 Sublease income (84 ) (84 ) Variable lease expense 136 150 Total lease expense $ 3,451 $ 661 The tables below show the beginning balances of the operating ROU assets and lease liabilities as of January 1, 2023 and the ending balances as of December 31 2023, including the changes during the period (in thousands). Operating Lease ROU Assets Operating lease ROU assets at January 1, 2023 $ 1,030 Recognition of ROU asset for Somerville Sublease 34,410 Adjustment to ROU asset for remeasurement of Somvervile Sublease liability (1,620 ) Amortization of operating lease ROU assets (1,039 ) Operating lease ROU assets at December 31, 2023 $ 32,781 Operating Lease Liabilities Operating lease liabilities at January 1, 2023 $ 1,182 Recognition of lease liability for Somerville Sublease 34,169 Accretion of interest for Somerville Sublease 1,858 Adjustment to lease liablity due to remeasurement of Somerville Sublease (1,620 ) Principal payments on operating lease liabilities (519 ) Operating lease liabilities at December 31, 2023 35,070 Less non-current portion 32,854 Current portion at December 31, 2023 $ 2,216 As of December 31, 2023, the Company’s operating leases had a weighted-average remaining life of 9.8 years with a weighted-average discount rate of 14.24%. The maturities of the operating lease liabilities are as follows (in thousands): As of December 31, 2023 2024 $ 6,972 2025 6,075 2026 6,238 2027 6,308 2028 6,406 Thereafter 33,879 Total payments 65,878 Less imputed interest (30,808 ) Total operating lease liabilities $ 35,070 Manhattan Sublease In April 2019, the Company entered into a sublease with an unaffiliated third party (the “Subtenant”), whereby the Subtenant agreed to sublease approximately 999 square feet of space rented by the Company in the borough of Manhattan in New York, New York commencing on May 15, 2019. The term of this sublease expires on October 31, 2026 with no option to extend. Rent payments by the Subtenant under the sublease began on September 1, 2019. The sublease stipulates an annual rent increase of 2.25%. The Subtenant is also responsible for paying to the Company all tenant energy costs, annual operating costs, and annual tax costs attributable to the subleased space during the term of the sublease. The Company received sublease payments of approximately $0.1 million for each of the years ended December 31, 2023 and 2022, respectively. In accordance with ASC Topic 842, the Company treats the sublease as a separate lease, as the Company was not relieved of the primary obligation under the related lease. The Company continues to account for the related lease as a lessee and in the same manner as prior to the commencement date of the sublease. The Company accounts for the sublease as a lessor of the lease. The sublease is classified as an operating lease, as it does not meet the criteria of a sale-type or direct financing lease. The following tables shows the future payments the Company expects to receive from the Subtenant over the remaining term of the sublease (in thousands): As of December 31, 2023 2024 $ 86 2025 88 2026 75 Total payments $ 249

Fair Value of Financial Instrum

Fair Value of Financial Instruments	12 Months Ended
Fair Value of Financial Instruments	Dec. 31, 2023
Fair Value of Financial Instruments [Abstract]
Fair Value of Financial Instruments	9) Fair Value of Financial Instruments The following tables summarize the liabilities that are measured at fair value as of December 31, 2023 and, 2022 (in thousands): As of December 31, Description Level 2023 2022 Liabilities: Warrant liabilities - Common Warrants 3 $ 116 $ 331 Market Cap Contingent Consideration 3 $ 107 $ - The Company uses a Black-Scholes option pricing model to estimate the fair value of its warrant liabilities and a Monte Carlo simulation model to estimate the fair value of the Market Cap Contingent Consideration, both of which are considered a Level 3 fair value measurement. The Company remeasures the fair value of the warrant liabilities and the Market Cap Contingent Consideration at each reporting period and changes in the fair values are recognized in the statement of operations. Certain inputs used in Black-Scholes and Monte Carlo models may fluctuate in future periods based upon factors that are outside of the Company’s control. A significant change in one or more of these inputs used in the calculation of the fair value may cause a significant change to the fair value of the Company’s warrant liabilities or contingent consideration liabilities, which could also result in material non-cash gains or losses being reported in the Company’s consolidated statement of operations . The following table presents the changes in the liabilities measured at fair value from January 1, 2023, or from the initial measurement date if later than January 1, 2023, through December 31, 2023 (in thousands): Warrant Contingent Fair value at January 1, 2023 $ 331 $ - Initial measurement - 225 Change in fair value (215 ) (118 ) Fair value at December 31, 2023 $ 116 $ 107 The Black-Scholes valuation assumptions used at December 31, 2023 for the warrant liabilities were 3.69 years expected term, 3.93% risk-free rate, 103% volatility and 0% dividend yield. With the assistance of a third-party specialist, the Company assesses the fair value of the Market Cap Contingent Consideration at each quarterly reporting period using the Monte Carlo model, and as of June 30, 2023, determined that the fair value of the contingent consideration had been reduced by approximately $0.1 million from the initial measurement. The Company assessed the fair value of the Market Cap Contingent Consideration as of September 30, 2023 and as of December 31, 2023, and determined that there was no material change to the Market Cap Contingent Consideration for either period, and therefore, did not recognize a change in the fair value of the Market Cap Contingent Consideration since the June 30, 2023 remeasurement. The Company assessed the fair value as of December 31, 2023, and the inputs used for that assessment was risk-free rate of 4.07%, expected term of 2.3 years, stock price of $1.80, volatility of 108% and dividend yield of 0%. The table below is provided for comparative purposes only and presents information about the fair value of the convertible notes relative to the carrying values recognized in the consolidated balance sheet as of December 31, 2023 (in thousands). The Company did not have any of the convertible notes or similar instruments outstanding as of December 31, 2022. December 31, 2023 Level Carrying Fair Convertible Notes 3 $ 16,616 $ 17,594 The carrying value in the table above is shown before the allocation of the proceeds to the note warrants. The Company assesses the fair value of the convertible notes using the binomial model, which is considered a Level 3 measurement. The weighted average inputs used in the binomial model as of December 31, 2023 was stock price of $1.80, credit spread of 1,891, volatility of 109% and risk-free rate of 3.87%.

Goodwill and In-Process Researc

Goodwill and In-Process Research & Development	12 Months Ended
Goodwill and In-Process Research & Development	Dec. 31, 2023
Goodwill and In-Process Research & Development [Abstract]
Goodwill and In-Process Research & Development	10) Goodwill and In-Process Research & Development Goodwill In November 2018, the Company acquired IRX, which was accounted for as a business combination. The Company recorded goodwill in the amount of $2.0 million related to the acquisition. The Company performed its annual qualitative assessment as of December 31, 2023 and 2022, and based on the assessments, the Company determined that it was more likely than not that the fair value of the entity exceeded its carrying value for such years and that the performance of the quantitative impairment test was not required. Therefore, no impairment was required for any of the periods presented. In-Process Research & Development In 2018, Company recorded IPR&D in the amount of $6.0 million, which represented the fair value assigned to technologies that were acquired in connection with the acquisition of IRX in November 2018 and which had not reached technological feasibility and had no alternative future use. In June 2022, the Company received results from the INSPIRE phase 2 trial of IRX-2, a multi-cytokine biologic immunotherapy, in patients with newly diagnosed stage II, III or IVA squamous cell carcinoma of the oral cavity. The IRX-2 multi-cytokine biologic immunotherapy represents substantially all the fair value assigned to the technologies of IRX that the Company acquired. Despite outcomes that favored IRX-2 in certain predefined subgroups, the INSPIRE trial did not meet its primary endpoint of event-free survival. Significant additional clinical development work would be required to advance IRX-2 in the form of additional Phase 2 and 3 studies to further evaluate the treatment effect of IRX-2 in patient subgroups and in combination with checkpoint inhibitor therapies. The INSPIRE trial was the only Company-sponsored study of IRX-2. Based on the totality of available information, the Company decided not to further develop IRX-2. As such, the Company determined that the carrying value of the IPR&D asset was impaired and recognized a non-cash impairment charge of approximately $6.0 million on the consolidated statement of operations during 2022, which reduced the value of the asset to zero.

Related Party Transactions

Related Party Transactions	12 Months Ended
Related Party Transactions	Dec. 31, 2023
Related Party Transactions [Abstract]
Related Party Transactions	11) Related Party Transactions Agreements with Factor Bioscience Inc. and Affiliates As of December 31, 2023, the Company had the agreements described below with Factor Bioscience Inc. and/or Dr. Matthew Angel. These agreements have been deemed related party transactions because the Company’s former chief executive officer, Dr. Angel, is the chairman and chief executive officer of Factor Bioscience Inc. and a director of its subsidiary, Factor Bioscience Limited (“Factor Limited” and together with Factor Bioscience Inc. and its other affiliates, “Factor Bioscience”). Dr. Angel resigned as the Company’s chief executive officer effective December 31, 2023. In September 2022, the Company entered into a Master Services Agreement (the “MSA”) with Factor Bioscience, pursuant to which Factor Bioscience agreed to provide services to the Company as agreed between the Company and Factor Bioscience and as set forth in one or more work orders under the MSA, including the first work order included in the MSA (“WO1”). The MSA contains customary confidentiality provisions and representations and warranties of the parties, and the MSA may be terminated by either party upon 30 days’ prior notice, subject to any superseding termination provisions contained in a particular work order. Under WO1, Factor Bioscience agreed to provide the Company with mRNA cell engineering research support services, including access to certain facilities, equipment, materials and training, and the Company agreed to pay Factor Bioscience an initial fee of $5.0 million, payable in 12 equal monthly installments of approximately $0.4 million. Of the $5.0 million, the Company allocated $3.5 million to the License Fee Obligation (as defined below). Following the initial 12-month period, the Company agreed to continue paying Factor Bioscience the monthly fee of $0.4 million until such time as WO1 is terminated. Upon entering into the MSA, the Company paid a deposit of $0.4 million, which will be applied to the last month of WO1. The Company may terminate WO1 on or after the second anniversary of the date of the MSA, subject to providing Factor Bioscience with 120 days’ prior notice. Factor Bioscience may terminate WO1 only on and after the fourth anniversary of the date of the MSA, subject to providing the Company with 120 days’ prior notice. In connection with entering into the MSA, Factor Limited entered into a waiver agreement with Eterna LLC, pursuant to which Factor Limited agreed to waive payment of $3.5 million otherwise payable to it (the “License Fee Obligation”) in October 2022 by Eterna LLC under the exclusive license agreement entered into in April 2021 by and among Eterna LLC, Novellus Limited and Factor Limited (the “Original Factor License Agreement”). Under the terms of the waiver agreement, the License Fee Obligation is waived conditionally on the Company paying Factor Bioscience a minimum of $3.5 million due under the MSA. Because the License Fee Obligation was conditionally waived until the Company paid Factor Bioscience a minimum of $3.5 million under the MSA, the Company recorded a liability of $3.5 million. As of December 31, 2023, there was approximately $1.2 million of the unamortized License Fee Obligation remaining, which is recorded on the accompanying consolidated balance sheet in the “due to related party, current” line item. In September 2022, Novellus Inc. (“Novellus”) and the Company entered into a Second Amendment to the Limited Waiver and Assignment Agreement (the “Waiver and Assignment Agreement”) with Drs. Matthew Angel and Christopher Rohde (the “Founders”) whereby the Company agreed to be responsible for all future, reasonable and substantiated legal fees, costs, settlements and judgments incurred by the Founders, the Company or Novellus. for certain claims and actions and any pending or future litigation brought against the Founders, Novellus and/or the Company by or on behalf of the Westman and Sowyrda legal matters described in Note 13 (the “Covered Claims”). The Founders will continue to be solely responsible for any payments made to satisfy a judgement or settlement of any pending or future wage act claims. Under the Waiver and Assignment Agreement, the Founders agreed that they are not entitled to, and waived any right to, indemnification or advancement of past, present or future legal fees, costs, judgments, settlement or other liabilities they may have been entitled to receive from the Company or Novellus in respect of the Covered Claims. The Company and the Founders will share in any recoveries up to the point at which the parties have been fully compensated for legal fees, costs and expenses incurred, with the Company retaining any excess recoveries. The Company has the sole authority to direct and control the prosecution, defense and settlement of the Covered Claims. In November 2022, following the expiration of one of the milestone deadlines for certain regulatory filings required under the Third Amended and Restated Exclusive License Agreement between Novellus Limited and Factor Limited entered into in November 2020 (the “Novellus-Factor License Agreement”), which permitted Factor Limited to terminate the license granted to Novellus Limited thereunder, the Company entered into the first amendment to the Original Factor License Agreement (as amended, the “2021 Factor License Agreement”), pursuant to which, among other things, Factor Limited granted to Eterna LLC an exclusive, sublicensable license under certain patents owned by Factor Limited (the “Factor Patents”) for the purpose of identifying and pursuing certain opportunities to grant to third parties sublicenses to the Factor Patents. The Original Factor License Agreement also (i) terminated the Novellus-Factor License Agreement, (ii) confirmed Factor Limited’s grant to Eterna LLC of the rights and licenses Novellus Limited previously granted to Eterna LLC under the Novellus-Factor License Agreement on the same terms and conditions as granted by Novellus Limited to Eterna LLC under such agreement, (iii) confirmed that the sublicense granted by Novellus Limited in accordance with the Novellus-Factor License Agreement to NoveCite, Inc., a company which the Company has a 25% non-controlling interest (“NoveCite”), survived termination of the Novellus-Factor License Agreement; and (iv) removed Novellus Limited from the Original Factor License Agreement and the license agreement entered into on October 6, 2020 between Novellus Limited and NoveCite, Inc, as amended, and replaced Novellus Limited with Factor Limited as the direct licensor to Eterna LLC and NoveCite under such agreements, respectively. On February 20, 2023, the Company, entered into an exclusive license agreement (the “Feb 2023 Factor Exclusive License Agreement”) with Factor Limited, pursuant to which Factor Limited granted to the Company an exclusive, sublicensable, worldwide license under certain patents owned by Factor Limited for the purpose of, among other things, identifying and pursuing certain opportunities to develop products in respect of such patents and to otherwise grant to third parties sublicenses to such patents. The Feb 2023 Factor Exclusive License Agreement, which terminated and superseded the Amended Factor License Agreement, was subsequently terminated and superseded by the A&R Factor License Agreement (as defined below). On November 14, 2023, the Company entered into an amended and restated exclusive license agreement (the “A&R Factor License Agreement”) with Factor Limited to replace in its entirety the exclusive license agreement between the parties dated February 20, 2023 and the amendment thereto. Under the terms of the A&R Factor License Agreement, Factor Limited granted to the Company an exclusive, sublicensable license under certain patents owned by Factor Limited (the “Factor Patents”). The A&R Factor License Agreement also provides for, among other things, the expansion of the Company’s license rights to include (i) the field of use of the Factor Patents to include veterinary uses (ii) know-how that is necessary or reasonably useful to practice to the licensed patents, (iii) the ability to sublicense through multiple tiers (as opposed to only permitting a direct sublicense) and (iv) the transfer of technology to the Company, subject to the use restrictions in the A&R Factor License Agreement. The term of the A&R Factor License Agreement expires on November 22, 2027, but will be automatically extended for an additional five years (such period, the “Renewal Term”) if the Company pays at least $6.0 million to Factor Limited from fees from sublicenses to the Factor Patents (“Sublicense Fees”), other cash on hand or a combination of both sources of funds. The Company will pay to Factor Limited 20% of any Sublicense Fee received by the Company during the term of the A&R Factor License Agreement. Beginning in September 2024, the Company will also begin paying Factor Limited a monthly maintenance fee of approximately $0.4 million until the expiration of the A&R Factor License Agreement, including any Renewal Term. The Company may terminate the A&R Factor License Agreement upon 120 days’ written notice to Factor Limited, and both parties have additional customary termination rights. Under the A&R Factor License Agreement, the Company is obligated to pay the expenses incurred by Factor Limited in preparing, filing, prosecuting and maintaining the Factor Patents and the Company agreed to bear all costs and expenses associated with enforcing and defending the Factor Patents in any action or proceeding arising from pursuit of sublicensing opportunities under the license granted under the A&R Factor License Agreement. Exacis Asset Acquisition On April 26, 2023, the Company entered into the Exacis Purchase Agreement to acquire the Exacis Assets, including all of Exacis’ right, title and interest in the Purchased License. The Company assumed none of Exacis’ liabilities, other than liabilities under the Purchased License that accrue subsequent to the closing date. See Note 4. The Exacis Acquisition was deemed a related party transaction because Dr. Gregory Fiore, who was the chief executive officer of Exacis at the time of the Exacis Acquisition, was also a member of the Company’s board of directors at the time of the Exacis Acquisition. Additionally, Dr. Angel, who was the Company’s chief executive officer at the time of the Exacis Acquisition, was chairman of Exacis’ scientific advisory board, and an affiliate of Factor Bioscience was the majority stockholder of Exacis at the time of the Exacis Acquisition. In October 2022, the Company entered into an Option Agreement on October 8, 2022 with Exacis (the “Exacis Option Agreement”), pursuant to which Exacis granted the Company the option to negotiate and enter into an exclusive worldwide license to certain of the technology licensed by Exacis for the treatment of cancer in humans. The Exacis Option Agreement provided for the Company paying Exacis a fee of $250,000 for the option, which would be creditable against the fees or purchase price payable under any such license if entered into by the Company in accordance with Exacis Option Agreement. The Company did not exercise the option, and the Exacis Option Agreement terminated on December 31, 2022. Consulting Agreement with Former Director In May 2023, the Company entered into a consulting agreement with Dr. Fiore, whereby Dr. Fiore agreed to provide business development consulting services to the Company for a monthly retainer of $20,000. The consulting agreement was terminable for any reason by either party upon 15 days’ written notice. The Company terminated the consulting agreement, effective July 31, 2023. Dr. Fiore served on the Company’s board of directors from June 2022 to October 4, 2023. July 2023 and December 2023 Financings Investors in the July 2023 convertible note financing included Brant Binder, Richard Wagner, Charles Cherington and Nicholas Singer, and investors in the December 2023 convertible note financing included Messrs. Cherington and Singer. Each of them participated in the applicable financing under the same terms and subject to the same conditions as all the other investors. See Note 6 for additional information regarding the financings. Mr. Binder served on the Company’s board of directors from July 6, 2023 to August 8, 2023, Mr. Wagner served on the Company’s board of directors from July 6, 2023 to August 8, 2023, Mr. Cherington served on the Company’s board of directors from March 2021 to July 6, 2023, and Mr. Singer served on the Company’s board of directors from June 2022 to July 6, 2023. Q4-22 PIPE In November 2022, the Company entered into a securities purchase agreement with certain investors providing for the issuance of approximately of 2,185,000 units, each unit consisting of (i) one share of the Company’s common stock and (ii) two warrants to purchase shares of the Company’s common stock, at a purchase price of $3.53 per unit. The financing closed in December 2022. Messrs. Cherington and Singer invested in the financing on the same terms and subject to the same conditions as all other investors in the financing. Mr. Cherington served on the Company’s board of directors from March 2021 to July 6, 2023, and Mr. Singer served on the Company’s board of directors from June 2022 to July 6, 2023.

Accrued Expenses

Accrued Expenses	12 Months Ended
Accrued Expenses	Dec. 31, 2023
Accrued Expenses [Abstract]
Accrued Expenses	12) Accrued Expenses Accrued expenses consisted of the following (in thousands): As of December 31, 2023 2022 Legal fees and related $ 643 $ 1,139 Professional fees 239 124 Somerville facility 218 138 Convertible Notes interest 176 - Accrued compensation 109 1,065 Clinical 18 570 Other 490 590 Total accrued expenses $ 1,893 $ 3,626

Commitments and Contingencies

Commitments and Contingencies	12 Months Ended
Commitments and Contingencies	Dec. 31, 2023
Commitments and Contingencies [Abstract]
Commitments and Contingencies	13) Commitments and Contingencies The Company is involved in litigation and arbitrations from time to time in the ordinary course of business. Legal fees and other costs associated with such actions are expensed as incurred. In addition, the Company assesses the need to record a liability for litigation and contingencies. The Company reserves for costs relating to these matters when a loss is probable, and the amount can be reasonably estimated. Novellus, Inc. v. Sowyrda et al., C.A. No. 2184CV02436-BLS2 On October 25, 2021 Novellus, Inc. filed a complaint in the Superior Court of Massachusetts, Suffolk County, against former Novellus, Inc. employees Paul Sowyrda and John Westman and certain other former investors in Novellus LLC (Novellus, Inc.’s former parent company prior to the Company’s acquisition of Novellus, Inc.), alleging breach of fiduciary duty, breach of contract and civil conspiracy. The Company acquired Novellus, Inc. on July 16, 2021. On May 27, 2022, Novellus, Inc. amended the complaint to withdraw all claims against all defendants except Messrs. Sowyrda and Westman. On July 1, 2022, Mr. Westman filed a motion to compel arbitration or in the alternative, to stay the litigation pending the disposition of certain litigation in the Court of Chancery for the State of Delaware filed by Mr. Sowyrda against Novellus LLC, Dr. Christopher Rohde, Dr. Matthew Angel, Leonard Mazur and Factor Bioscience, Inc. captioned Zelickson et al., v. Angel et al., C.A. 2021-1014-JRS and by Mr. Westman against Novellus LLC captioned Westman v. Novellus LLC, C.A. No. 2021-0882-NAC (together, the “Delaware Actions”). On July 1, 2022, Mr. Sowyrda answered the complaint and asserted counterclaims against Novellus, Inc, and third-party defendants Dr. Angel and Dr. Rohde alleging violations of the Massachusetts Wage Act, Massachusetts Minimum Fair Wage Law, the Fair Labor Standards Act, breach of contract, unjust enrichment and quantum meruit. Mr. Sowyrda also joined in Mr. Westman’s motion to stay the case pending the Delaware Actions. Novellus, Inc.’s claims and Mr. Sowyrda’s counterclaims relate to alleged conduct that took place before the Company acquired Novellus, Inc. On November 15, 2022, prior to a decision on Messrs. Westman’s and Sowyrda’s motion to compel or stay, the parties agreed to voluntarily dismiss and consolidate the Delaware Actions with this action. On December 15, 2022, Mr. Sowyrda filed an Amended Answer to the Amended Complaint, asserted affirmative defenses and filed Amended Counterclaims against Dr. Angel, Dr. Rohde, Novellus LLC, Novellus Inc., Factor Bioscience Inc., and the Company (collectively, the “Counterclaim Defendants”) alleging against various Counterclaim Defendants breach of contract, breaches of the implied duty of good faith and fair dealing, breaches of fiduciary duty, breaches of the operating agreement, aiding and abetting breaches of fiduciary duty, tortious interference with contract, equitable accounting, violations of the Massachusetts Wage Act, Massachusetts Minimum Fair Wage Law, the Fair Labor Standards Act, unjust enrichment, and quantum meruit. Also on December 15, 2022, Mr. Westman filed an answer to the Amended Complaint and asserted similar counterclaims against the same Counterclaim Defendants. Messrs. Westman and Sowyrda each asserted claims for indemnification and/or advancement against Novellus, Inc. On January 11, 2023, Messrs. Westman and Sowyrda served a joint motion to enforce their advancement and/or indemnification rights against Novellus Inc. Novellus Inc. vigorously opposes this motion and served its opposition on January 27, 2023. On February 8, 2023, Messrs. Westman and Sowyrda served a reply in support of their motion to enforce indemnification/advancement rights, and submitted the motion to the Court. Novellus Inc. answered Messrs. Westman and Sowyrda’s counterclaims on January 27, 2023, denying liability. The remaining Counterclaim Defendants served a motion to dismiss most of the remaining counterclaims on January 27, 2023. The Court entered an order granting the Counterclaim Defendants’ motion to dismiss and denying Messrs. Sowyrda and Westman’s motion to enforce on June 15, 2023. The Court’s order dismissed all of Mr. Westman’s claims against Counterclaim Defendants except his claim for indemnification, and all of Mr. Sowyrda’s claims except his claim for indemnification and his employment-related claims, which Counterclaim Defendants did not move to dismiss. On July 6, 2023, Messrs. Westman and Sowyrda filed a petition for interlocutory review with a single justice of the Massachusetts Appeals Court, seeking to overturn the judge’s decision granting the Counterclaim Defendants’ motion to dismiss most of the remaining counterclaims, but not the decision denying Messrs. Westman and Sowyrda’s motion to enforce advancement rights. On July 25, 2023, the parties to the appeal filed a joint motion to the single justice in the appellate court to stay the appeal to allow for amended counterclaims to be filed by Counterclaim Plaintiffs and a motion to dismiss to be filed by Counterclaim Defendants. Counterclaim Plaintiffs filed an initial set of amended counterclaims on August 15, 2023. Counterclaim Plaintiffs amended and refiled their amended counterclaims on September 29, 2023. Counterclaim Defendants served their motion to dismiss all of the amended counterclaims, except for Mr. Sowyrda’s employment-related claims, on October 13, 2023. Under applicable Delaware law and Novellus Inc.’s organizational documents, the Company may be required to advance or reimburse certain legal expenses incurred by former officers and directors of Novellus, Inc. in connection with the foregoing matters. However, a future advance or reimbursement is not currently probable nor can it be reasonably estimated. eTheRNA Immunotherapies NV and eTheRNA Inc. v. Eterna Therapeutics Inc. C.A. No. 123CV11732 On July 31, 2023, eTheRNA Immunotherapies NV and eTheRNA Inc. filed a complaint in court against the Company alleging: (1) federal trademark infringement; (2) federal unfair competition; (3) Massachusetts state common law trademark infringement; (4) Massachusetts state unfair competition. Service of process for the complaint was completed on August 1, 2023. The Company’s answer was filed on October 10, 2023. At this stage in the litigation, the Company is not able to predict the probability of a favorable or unfavorable outcome. Dhesh Govender v. Eterna Therapeutics LLC, et al., Index No. 650847/2021 (N.Y. Sup. Ct. N.Y. Cty. 2021) On or about February 5, 2021, Dhesh Govender, a former short-term consultant of Eterna LLC, filed a complaint against Eterna LLC and certain individuals that plaintiff alleged were directors of Eterna LLC. Plaintiff alleged that Eterna LLC and certain of its officers and directors engaged in unlawful and discriminatory conduct based on race, national origin and hostile work environment. Plaintiff also asserted various breach of contract, fraud and quantum meruit claims based on an alleged oral agreement pursuant to which he alleged Eterna LLC agreed to hire him as an executive once the merger involving the Company and NTN Buzztime, Inc. was completed. On December 15, 2022, the parties executed a Confidential Settlement Agreement and Release of All Claims. On January 11, 2023, the parties filed a Stipulation to Discontinue in the Court action. Also on January 11, 2023, plaintiff voluntarily dismissed the arbitration. John Westman v. Novellus, Inc., Christopher Rohde, and Matthew Angel, Civil Action No. 2181CV01949 (Middlesex County (Massachusetts) Superior Court) On or about September 7, 2021, John Westman, a former employee of Novellus, Inc. filed a complaint in Middlesex County (Massachusetts) Superior Court against Novellus, Inc. and Novellus, Inc.’s founders and former executives, Dr. Rohde and Dr. Angel. The case includes allegations that Novellus, Inc. violated the Massachusetts Wage Act. The Company acquired Novellus, Inc. on July 16, 2021. Mr. Westman’s claims relate to alleged conduct that took place before the Company acquired Novellus, Inc. Mr. Westman agreed to dismiss the lawsuit and proceed with his claims in arbitration. Following mediation, the parties settled this dispute in December 2022. The aggregate settlement amount payable by the Company for the Westman and Govender matters discussed above was approximately $0.5 million, both of which were recognized as expense in the consolidated statement of operations for the year ended December 31, 2022 and were fully paid Emerald Private Equity Fund, LLC Matter By a letter dated July 7, 2021, Emerald Private Equity Fund, LLC (“Emerald”), a stockholder of the Company, made a demand pursuant to 8 Del. C. 220 to inspect certain books and records of the Company. The stated purpose of the demand was to investigate possible wrongdoing by persons responsible for the implementation of the merger involving the Company and NTN Buzztime, Inc. and the issuance of paper stock certificates, including investigating whether: (i) the Company’s stock certificates were issued in accordance with the merger agreement; (ii) certain restrictions on the sale of the Company’s common stock following the merger were proper and applied without favor; (iii) anyone received priority in post-merger issuances of the Company’s stock certificates that allowed them to benefit from an increase in the trading price of the Company’s common stock; and (iv) it should pursue remedial measures and/or report alleged misconduct to the SEC. The Company responded to the demand letter and produced certain information to Emerald in connection with the demand, which is subject to the terms of a confidentiality agreement entered into among the parties, including certain additional stockholders who subsequently joined as parties to such agreement. Following discussions, with no admission of wrongdoing, the Company and Emerald entered into a confidential settlement agreement, pursuant to which the Company paid $1.2 million in 2022 in full settlement of all of the Emerald’s purported claims, including a release by the Emerald in favor of the Company in respect of any and all such claims. Licensing Agreements Factor Limited On November 14, 2023, the Company and Factor Limited entered into the A&R Factor License Agreement, which terminated and superseded the exclusive license agreement between the parties dated February 20, 2023 and the amendment thereto. See Note 11 for additional information regarding the A&R Factor License Agreement. The Company has other license, collaboration and royalty agreements with third parties related to IRX-2, including an agreement entered into with University of South Florida Research Association, Inc. (“USFRF”) in February 2024 to revoke certain license agreements with USFRF related to IRX-2. The Company does not intend to further develop IRX-2 and has provided USFRF with notice that the Company intends to abandon the IRX-2 patents. USFRF has 30 days to provide the Company with its notice to assume control of such patents. As a result of abandoning the IRX-2 patents, the Company will no longer have any obligations under the existing related agreements. existing related agreements. Retirement Savings Plan The Company established a defined contribution plan, organized under Section 401(k) of the Internal Revenue Code, which allows employees to defer up to 90% of their pay on a pre-tax basis. Beginning on January 1, 2023, the Company began matching employees’ contributions at a rate of 100% of the first 3% of the employee’s contribution and 50% of the next 2% of the employee’s contribution, for a maximum Company match of 4%. For the year ended December 31, 2023, the Company matched less than $0.1 million towards employees’ 401k contributions.

Basic and Diluted Net Loss per

Basic and Diluted Net Loss per Common Share	12 Months Ended
Basic and Diluted Net Loss per Common Share	Dec. 31, 2023
Basic and Diluted Net Loss per Common Share [Abstract]
Basic and Diluted Net Loss per Common Share	14) B asic and Diluted Net Loss per Common Share The following table sets forth the computation of the net loss per share attributable to common stockholders, basic and diluted (in thousands, except per share data): Years Ended December 31, 2023 2022 Numerator: Net loss attributable to common stockholders $ (21,684 ) $ (24,595 ) Denominator Weighted average shares outstanding - basic and diluted 5,314 3,051 Net loss per common share - basic and diluted $ (4.08 ) $ (8.06 ) Since the Company was in a net loss position for all periods presented, the net loss per share attributable to common stockholders was the same on a basic and diluted basis, as the inclusion of all potential common equivalent shares outstanding would have been anti-dilutive. The following table presents the amount of warrants, stock options, convertible preferred stock, convertible notes and restricted stock units (“RSUs”) that were excluded from the computation of diluted net loss per share of common stock for the years ended December 31, 2023 and 2022, as their effect was anti-dilutive (in thousands): Years ended December 31, 2023 2022 Warrants 18,922 4,713 C onvertible Notes converted into common stock 7,877 - Stock options 389 359 Preferred stock converted into common stock 18 7 RSUs 1 4 Total potential common shares excluded from computation 27,207 5,083

Stock-Based Compensation

Stock-Based Compensation	12 Months Ended
Stock-Based Compensation	Dec. 31, 2023
Stock-Based Compensation [Abstract]
Stock-Based Compensation	15) Stock-Based Compensation Equity Incentive Plans The Company’s stock-based compensation plans consist of the Restated 2020 Equity Incentive Plan (the “Restated 2020 Plan”) and the 2021 Inducement Equity Incentive Plan (the “2021 Inducement Plan”). The Company’s board of directors has designated its compensation committee as the administrator of the foregoing plans (the “Plan Administrator”). Among other things, the Plan Administrator selects persons to receive awards under the foregoing plans and determines the number of shares subject to each award and the terms, conditions, performance measures, if any, and other provisions of the award. The Restated 2020 Plan provides for (a) approximately 724,000 shares of common stock that can be issued under the Restated 2020 Plan, which includes an increase to the Restated 2020 Plan of 300,000 that was approved by the Company’s stockholders at the 2023 annual meeting of stockholders on June 16, 2023, and (b) an annual increase in the number of shares reserved for issuance on January 1 of each year from 2022 through 2031 equal to the lesser of (i) 5% of the number of shares of common stock outstanding on the immediately preceding December 31 and (ii) such smaller number of shares of common stock as may be determine by the board of directors (the provision providing for the increase described in clause (b) is referred to as the “evergreen provision”). As of January 1, 2023, pursuant to the evergreen provision, the number of shares issuable under the Restated 2020 Plan was increased by approximately 256,000. Based on the number of shares of common stock outstanding on December 31, 2023, as of January 1, 2024, pursuant to the evergreen provision, the number of shares issuable under the Restated 2020 Plan was increased by approximately 271,000. Awards under the Restated 2020 Plan may be granted to officers, directors, employees and consultants of the Company. Stock options granted under the Restated 2020 Plan may either be incentive stock options or nonqualified stock options, may have a term of up to ten years, and are exercisable at a price per share not less than the fair market value, as defined in the Restated 2020 Plan, on the date of grant. As of December 31, 2023, there was approximately 684,000 shares of common stock remaining to be issued under the Restated 2020 Plan. As of December 31, 2023, there were approximately 296,000 stock options outstanding under the Restated 2020 Plan and no RSUs granted under the Restated 2020 Plan were outstanding. The 2021 Inducement Plan provides for the grant of up to 75,000 share-based awards as material inducement awards to new employees in accordance with the employment inducement grant rules set forth in Section 711(a) of the NYSE American LLC Company Guide (the Company’s common stock was listed on the NYSE American at the time the 2021 Inducement Plan was adopted). The 2021 Inducement Plan expires in May 2031. As of December 31, 2023, there was approximately 68,000 shares of common stock remaining to be issued under the 2021 Inducement Plan. As of December 31, 2022, there were approximately 4,000 stock options outstanding and approximately 1,000 RSUs outstanding that were granted under the 2021 Inducement Plan. Equity Awards Stock Options The Company records stock-based compensation in accordance with ASC Topic 718, Compensation – Stock Compensation. The Company estimates the fair value of stock options using the Black-Scholes option pricing model. The fair value of stock options granted is recognized as expense over the requisite service period on a straight-lined basis. The risk-free rate is based on the observed interest rates appropriate for the expected life. The expected life (estimated period of time outstanding) of the stock options granted is estimated using the “ simplified Share-Based Payment The following weighted-average assumptions were used for stock options granted during the years ended December 31, 2023 and 2022: Year ended December 31, 2023 2022 Weighted average risk-free rate 3.82 % 2.52 % Weighted average volatility 95.15 % 90.49 % Dividend yield 0 % 0 % Expected term 5.44 years 5.79 years The following table summarizes stock option activity for the years ended December 31, 2023 and 2022 (in thousands except for per-share and remaining contractual life data): Outstanding Options Weighted Average Exercise Price per Share Weighted Average Remaining Contractual Life (in years) Aggregate Intrinsic Value Outstanding January 1, 2022 199 $ 168 9.38 $ - Granted 287 17 Cancelled (127 ) 141 Outstanding December 31, 2022 359 57 7.57 - Granted 237 4 Cancelled (207 ) 19 Outstanding December 31, 2023 389 $ 45 7.04 $ - Options vested and exercisable at December 31, 2023 331 $ 50 6.69 $ - The per-share weighted average grant-date fair value of stock options granted during the year ended December 31, 2022 and 2021 was $2.99 and $12.91, respectively. As of December 31, 2023, the unamortized stock-based compensation expense related to outstanding unvested options was approximately $0.6 million with a weighted average remaining requisite service period of 1.91 years. The Company expects to amortize this expense over the remaining requisite service period of these stock options. Vesting of all stock options is subject to continuous service with the Company through their applicable vesting dates. During the year ended December 31, 2022, the Company accelerated the vesting of approximately 40,000 stock options under certain time-based vesting stock option grants previously awarded to Dr. Howard Federoff, the Company’s former chief executive officer, pursuant to a separation agreement entered into with Dr. Federoff. The Company also waived a performance condition under a performance-based stock option grant and accelerated the vesting of approximately 21,000 stock options under such grant. Lastly, the Company extended the post-termination exercise period from 90 days to 36 months immediately following his separation date for any options that were vested, including the options that accelerating in vesting, as described above. The above modifications to Dr. Federoff’s stock options grants resulted in modification accounting under ASC 718, Compensation – Stock Compensation Restricted Stock Units The following table summarizes RSU activity for the years ended December 31, 2023 and 2022 (in thousands except for per-share data): Outstanding Restricted Stock Units Weighted Average Fair Value per Share January 1, 2022 12 $ 276 Granted 55 39 Released (3 ) 271 Cancelled (60 ) 61 December 31, 2022 4 236 Cancelled (3 ) 199 December 31, 2023 1 $ 322 Balance expected to vest at December 31, 2023 1 $ 322 The Company recognizes the fair value of RSUs granted as expense on a straight-line basis over the requisite service period. For performance based RSUs, the Company begins recognizing the expense once the achievement of the related performance goal is determined to be probable. Outstanding RSUs are settled in an equal number of shares of common stock on the vesting date of the award. An RSU award is settled only to the extent vested. Vesting generally requires the continued employment or service by the award recipient through the respective vesting date. Because RSUs are settled in an equal number of shares of common stock without any offsetting payment by the recipient, the measurement of cost is based on the quoted market price of the stock at the measurement date, which is the grant date. In lieu of paying cash to satisfy withholding taxes due upon the settlement of vested RSUs, at the Company’s discretion, an employee may elect to have shares of common stock withheld that would otherwise be issued at settlement, the value of which is equal to the amount of withholding taxes payable. During the year ended December 31, 2023, less than 1,000 RSUs vested. During the year ended December 31, 2022, approximately 3,000 RSUs vested. The Company withheld approximately 1,000 RSUs to cover withholding taxes, and the net 2,000 shares were issued upon settlement. Stock-Based Compensation Expense For the years ended December 31, 2023 and 2022, the Company recognized stock-based compensation expense as follows (in thousands): Years ended December 31, 2023 2022 Research and development $ 234 $ 1,249 General and administrative 1,008 1,686 Total $ 1,242 $ 2,935

Equity and Warrants

Equity and Warrants	12 Months Ended
Equity and Warrants	Dec. 31, 2023
Equity and Warrants [Abstract]
Equity and Warrants	16) Equity and Warrants Private Placements Q4-22 PIPE Transaction On November 23, 2022, the Company entered into a purchase agreement with certain investors pursuant to which the Company issued an aggregate of approximately 2.2 million units, with each unit consisting of (i) one share of common stock and (ii) two warrants, each exercisable to purchase one share of common stock at an exercise price of $3.28 per, at a purchase price of $3.53 per unit (inclusive of $0.125 per warrant). The transaction closed on December 2, 2022. The Company received aggregate gross proceeds of approximately $7.7 million. The Company incurred fees of approximately $0.3 million through December 31, 2022 related to the transaction. Each warrant had an exercise price of $3.28 per share (subject to customary adjustments), became exercisable six months from the date of issuance, and expires five-and-one-half As discussed in Note 6, in connection with the December 2023 convertible note financing, the exercise price of the warrants was reduced from $3.28 per share to $1.43 per share. Q1-22 Private Placement On March 6, 2022, the Company entered into a purchase agreement with an investor pursuant to which the Company issued approximately 343,000 units, each unit consisting of (i) one share of the Company’s common stock (or, in lieu thereof, one pre-funded warrant to purchase one share of common stock) and (ii) one warrant to purchase one share of common stock, for an aggregate gross purchase price of approximately $12.0 million. The transaction closed on March 9, 2022. The Company issued 275,000 shares of common stock, approximately 68,000 pre-funded warrants and warrants to purchase approximately 343,000 shares of common stock. The Company incurred fees of approximately $1.0 million through December 31, 2022 related to this transaction, which were allocated to the fair value of the pre-funded warrants and warrants and Each pre-funded warrant had an exercise price of $0.10 per share (subject to customary adjustments), was immediately exercisable, could be exercised at any time, and had no expiration date. Each warrant has an exercise price of $38.20 per share (subject to customary adjustments), became exercisable six months following the date of issuance, and expires five-and-one-half The pre-funded warrants and warrants were accounted for as liabilities under ASC 815-40, as these warrants provide for a cashless settlement provision that does not meet the requirements of the indexation guidance under ASC 815-40. These warrant liabilities are measured at fair value at inception and on a recurring basis, with changes in fair value presented within the statement of operations. (See Note 9 for more information related to changes in fair value.) Upon exercise, the fair value of the pre-funded warrants and/or warrants on the exercise date is reclassified from warrant liabilities to equity. The fair values of the pre-funded warrants and warrants at the issuance date totaled $12.6 million in the aggregate, or $0.6 million more than the aggregate gross purchase price of the units sold in the offering. The $0.6 million represents an inducement to the investor to enter into the purchase agreement and was recorded in warrant liabilities expense in the accompanying consolidated statement of operations. On July 12, 2022, all the pre-funded warrants were exercised. The Company issued approximately 68,000 shares of common stock upon exercise and received approximately $7,000 of proceeds. The fair value of the pre-funded warrants as of the exercise date (approximately $0.7 million) was reclassified from warrant liabilities to equity. In connection with the transaction, the Company and the investor also entered into a registration rights agreement pursuant to which the Company agreed to prepare and file a registration statement with the SEC to register the resale of the shares of common stock issued in the offering and issuable upon exercise of the pre-funded warrants and warrants. The resale registration statement became effective on May 11, 2022. Pursuant to the registration rights agreement, the Company is obligated to pay the investor liquidated damages equal to 2% of the purchase price for the units per month, with a maximum aggregate payment of 12 of the purchase price for the units, in the event the investor is not permitted to use the registration statement to resell the securities registered for resale thereunder for more than a specified period of time. On May 24, 2022, the Company notified the investor that the investor was not able to use the registration agreement because the Company had not timely filed its Quarterly Report on Form 10-Q for the quarter ended March 31, 2022 with the SEC, and that the investor could not use the registration statement until the Company filed that quarterly report, which was filed on June 30, 2022. The Company accrued $0.2 million during 2022 for the contingent loss the Company incurred as liquidated damages as a result of the late filing, which is recorded in other expense, net for the year ended December 31, 2022 in the accompanying consolidated statements of operations. The Company paid the $0.2 million liquidated damages to the investor in June 2022. Note Warrants As discussed in Note 6, in connection with the July 2023 and December 2023 convertible note financings, the Company issued note warrants to purchase an aggregate of approximately 14.2 million shares of common stock. The exercise price of all such warrants is currently $1.43 per share (subject to customary adjustments), are expire five years following the date of issuance. All such warrants qualified for equity classification. The following table shows the Company’s warrant activity for the year ended December 31, 2023 (in thousands except for per-share data): Q1-22 Common Warrants Q4-22 Warrants July 2023 Warrants December 2023 Warrants Total Warrants Balance as of January 1, 2023 343 4,370 - - 4,713 Granted - - 6,094 8,115 14,209 Balance as of December 31, 2023 343 4,370 6,094 8,115 18,922 As of December 31, 2023, the weighted average remaining contractual life of the warrants outstanding was 4.68 years and the weighted average exercise price was $2.10 per share. SEPA On April 5, 2023, the Company entered into the SEPA with Lincoln Park, pursuant to which Lincoln Park committed to purchase up to $10.0 million of the Company’s common stock. Such sales of common stock by the Company, if any, are subject to certain conditions and limitations set forth in the SEPA, including a condition that the Company may not direct Lincoln Park to purchase any shares of common stock under the SEPA if such purchase would result in Lincoln Park beneficially owning more than 4.99% of the Company’s issued and outstanding shares of common stock. Sales under the SEPA may occur from time to time, at the Company’s sole discretion, through April 2025. In consideration of Lincoln Park’s entry into the SEPA, the Company issued to Lincoln Park approximately 74,000 shares of common stock (the “Commitment Shares”). The value of the Commitment Shares was recorded as a period expense and included in other expense, net, in the accompanying consolidated statements of operations for year ended December 31, 2023. The Company evaluated the contract that includes the right to require Lincoln Park to purchase shares of common stock in the future (“put right”) considering the guidance in ASC 815-40, Derivatives and Hedging — Contracts on an Entity’s Own Equity and concluded that it is an equity-linked contract that does not qualify for equity classification, and therefore requires fair value accounting. The Company analyzed the terms of the freestanding put right and concluded that it has an immaterial value as of December 31, 2023. During the year ended December 31, 2023, the Company issued and sold approximately 214,000 shares of common stock under the SEPA, including the 74,000 Commitment Shares, for gross proceeds of approximately $0.3 million. As of December 31, 2023, there were approximately 2,860,000 shares remaining to be sold under the SEPA. In connection with entry into the SEPA, the Company terminated its prior purchase agreements with Lincoln Park entered into during 2021. Cumulative Convertible Preferred Stock The Company has authorized 156,000 shares of preferred stock, all of which is designated as Series A Cumulative Convertible Preferred Stock (the “Series A Preferred Stock”), and all of which were issued and outstanding as of December 31, 2023. The Series A Preferred Stock provides for a cumulative annual dividend of $0.10 per share, payable in semi-annual installments in June and December. Dividends may be paid in cash or with shares of common stock. The Company paid approximately $16,000 in cash for payment of dividends during the years ended December 31, 2023 and 2022 The Series A Preferred Stock has no voting rights and has a $1.00 per share liquidation preference over the Company’s common stock. The holder of shares of Series A Preferred Stock has the right at any time to convert such shares into that number of shares of common stock that equals the number of shares of Series A Preferred Stock that are surrendered for conversion divided by the conversion rate. At December 31, 2023, the conversion rate was 8.8016 and, based on that conversion rate, one share of Series A Preferred Stock would have converted into approximately 0.11 shares of common stock, and all the outstanding shares of the Series A Preferred Stock would have converted into approximately 18,000 shares of common stock in the aggregate. There were no conversions during the years ended December 31, 2023 and 2022. There is no mandatory conversion term, date or any redemption features associated with the Series A Preferred Stock. The conversion rate will adjust under the following circumstances: 1. If the Company (a) pays a dividend or makes a distribution in shares of its common stock, (b) subdivides its outstanding shares of common stock into a greater number of shares, (c) combines its outstanding shares of common stock into a smaller number of shares, or (d) issues by reclassification of its shares of common stock any shares of its common stock (other than a change in par value, or from par value to no par value, or from no par value to par value), then the conversion rate in effect immediately prior to the applicable event will be adjusted so that the holders of the Series A Preferred Stock will be entitled to receive the number of shares of common stock which they would have owned or have been entitled to receive immediately following the happening of the event, had the Series A Preferred Stock been converted immediately prior to the record or effective date of the applicable event. 2. If the outstanding shares of the Company’s common stock are reclassified (other than a change in par value, or from par value to no par value, or from no par value to par value, or as a result of a subdivision, combination or stock dividend), or if the Company consolidates with or merge into another corporation and the Company is not the surviving entity, or if the Company sells all or substantially all of its property, assets, business and goodwill, then the holders of the Series A Preferred Stock will thereafter be entitled upon conversion to the kind and amount of shares of stock or other equity securities, or other property or assets which would have been receivable by such holders upon such reclassification, consolidation, merger or sale, if the Series A Preferred Stock had been converted immediately prior thereto. 3. If the Company issues common stock without consideration or for a consideration per share less than the then applicable Equivalent Preference Amount (as defined below), then the Equivalent Preference Amount will immediately be reduced to the amount determined by dividing (A) an amount equal to the sum of (1) the number of shares of common stock outstanding immediately prior to such issuance multiplied by the Equivalent Preference Amount in effect immediately prior to such issuance and (2) the consideration, if any, received by the Company upon such issuance, by (B) the total number of shares of common stock outstanding immediately after such issuance. The “Equivalent Preference Amount” is the value that results when the liquidation preference of one share of Series A Preferred Stock (which is $1.00) is multiplied by the conversion rate in effect at that time; thus the conversion rate applicable after the adjustment in the Equivalent Preference Amount as described herein will be the figure that results when the adjusted Equivalent Preference Amount is divided by the liquidation preference of one share of Series A Preferred Stock.

Income Taxes

Income Taxes	12 Months Ended
Income Taxes	Dec. 31, 2023
Income Taxes [Abstract]
Income Taxes	17) Income Taxes Loss before income taxes consist of the following (in thousands): Years ended December 31, 2023 2022 (in thousands) Domestic $ (21,654 ) $ (24,513 ) Foreign (17 ) (21 ) Total loss before income taxes $ (21,671 ) $ (24,534 ) For each of the years ended December 31, 2023 and 2022, current tax provisions and current deferred tax provisions were recorded as follows (in thousands): Years ended December 31, 2023 2022 Current Tax Provision Federal $ - $ - State 1 4 Foreign - - 1 4 Deferred Tax Provision Federal (2,155 ) (6,851 ) State 8 (1,602 ) Foreign (2 ) (187 ) (2,149 ) (8,640 ) Change in valuation allowance 2,145 8,681 Total tax (benefit) $ (3 ) $ 45 Deferred tax assets and liabilities consist of the effects of temporary differences as shown in the table below (in thousands). Deferred tax assets have been fully reserved by a valuation allowance since it is more likely than not that such tax benefits will not be realized. As of December 31, 2023 2022 Deferred Tax Assets: Net operating losses $ 12,740 $ 9,382 Foreign net operating losses 784 782 Stock compensation 2,141 2,173 In-process research and development 1,009 1,233 Capitalized rearch and development expenses 3,105 1,502 R&D credit carryforwards 437 517 Compensation accrual 3 81 ROU Liabilities 8,932 334 Other 132 549 Total gross deferred tax assets 29,283 16,553 Valuation allowance (18,302 ) (16,157 ) Net deferred tax assets 10,981 396 Deferred Tax Liabilities: Fixed assets (6 ) (10 ) ROU Assets (8,349 ) (291 ) Convertible debt (2,507 ) - Intangibles - goodwill (179 ) (160 ) Total deferred tax liabilities (11,041 ) (461 ) Net deferred taxes $ (60 ) $ (65 ) The reconciliation of computed expected income taxes to effective income taxes by applying the federal statutory rate of 21% is as follows: As of December 31, 2023 2022 Tax at federal income tax rate 21.00 % 21.00 % State income tax, net of federal tax 4.92 % 6.52 % Foreign tax differential (0.01 %) (0.01 %) Non-deductible expenses/excludable items (0.74 %) 6.09 % Change in valuation allowance (9.90 %) (35.38 %) Convertible debt (11.92 %) 0.00 % Credits 0.00 % 0.98 % Uncertain tax positions 0.00 % (0.49 %) Other (3.34 %) 1.11 % Benefit (provision) for income taxes 0.01 % (0.18 %) The net increase in the total valuation allowance for the year ended December 31, 2023 was an increase of approximately $2.1 million. In assessing the realizability of deferred tax assets, management considers whether it is more likely than not that some portion or all of the deferred tax assets will not be realized. The ultimate realization of deferred tax assets is dependent upon the generation of future taxable income during periods in which those temporary difference become deductible. Management considered the scheduled reversal of deferred tax liabilities, projected future taxable income and planning strategies in making this assessment. Based on the level of historical operating results and projections for the taxable income for the future, management has determined that it is more likely than not that the deferred taxes assets will not be utilized. Accordingly, the Company has recorded a full valuation allowance. The net deferred tax liability represents an indefinite life intangible liability related to tax deductible goodwill, partially offset by an indefinite life deferred tax asset. At December 31, 2023 and 2022, the Company has available net operating loss (“NOL”) carryforwards of approximately $48.4 million and $35.6 million for federal income tax purposes, respectively, of which approximately $48.4 million can be carried forward indefinitely. The Company has available $39.6 million and $28.8 million state NOLs for the years ended December 31, 2023 and 2022, respectively. The Company also has foreign NOL carryforwards of approximately $6.3 million for each of the years ended December 31, 2023 and 2022, which carry forward indefinitely. Section 382 of the Internal Revenue Code (“IRC”) imposes limits on the ability to use NOL carryforwards that existed prior to a change in control to offset future taxable income. Such limitations would reduce, potentially significantly, the gross deferred tax assets disclosed in the table above related to the NOL carryforwards. The Company continues to disclose the NOL carryforwards at their original amount in the table above as no potential limitation has been quantified. The Company has also established a full valuation allowance for all deferred tax assets, including the NOL carryforwards, since the Company could not conclude that it was more likely than not able to generate future taxable income to realize these assets. At December 31, 2023 and 2022 the Company has federal and state income tax credit carryforwards of approximately $0.4 million and $0.5 million, respectively. The credits begin to expire in 2041. In accordance with authoritative guidance, the impact of an uncertain income tax position on the income tax return must be recognized at the largest amount that is more-likely-than-not to be sustained upon audit by the relevant taxing authority. An uncertain income tax position will not be recognized if it has less than a 50% likelihood of being sustained. The following table summarizes amounts the Company recorded for uncertain tax positions as of December 31, 2023 and 2022 (in thousands): As of December 31, 2023 2022 Beginning balance of uncertain tax positions $ 121 $ - Additions based on current year’s tax positions - 45 Net changes based on prior year’s tax positions 272 76 Ending balance of uncertain tax positions $ 393 $ 121 It is reasonably possible that unrecognized tax benefits may increase or decrease within the next twelve months due to tax examination changes, expiration of statute of limitations, or changes in tax law. The Company does not anticipate any significant changes to unrecognized tax benefits over the next 12 months. The Company recognizes interest and penalties related to unrecognized tax positions within the income tax expense line in the accompanying consolidated statements of operations. There were no accrued interest and penalties associated with uncertain tax positions as of December 31, 2023 or December 31, 2022. The Company is subject to U.S. federal, state, and foreign income tax. The Company’s income tax returns are subject to examination by the relevant taxing authorities. As of December 31, 2023, the 2020 – 2023 On August 16, 2022, the Inflation Reduction Act of 2022 (the “IRA”) was enacted into law. Among other changes to the tax code, the IRA imposes a 1% excise tax on certain repurchases of corporate stock by certain publicly traded corporations. The 1% stock buyback tax applies to redemptions by domestic corporations occurring in taxable years beginning after December 31, 2022. A number of exceptions to the stock buyback tax are available including exceptions to certain reorganizations. However, while these exceptions may be helpful in limiting the application of the stock buyback tax in situations in which it was not intended to apply, more guidance will be necessary for taxpayers to analyze the potential application of these exceptions and whether they will be able to rely upon them.

Subsequent Event

Subsequent Event	12 Months Ended
Subsequent Event	Dec. 31, 2023
Subsequent Event [Abstract]
Subsequent Event	18) Subsequent Event CEO Inducement Grant On January 1, 2024, Sanjeev Luther was appointed as President, Chief Executive Officer and a director of the Company. Upon his appointment, he was granted a non-qualified stock option to purchase approximately 1,685,000 shares of the Company’s common stock. The stock option has an exercise price of $1.80 per share, which was equal to the fair market value of the Company’s common stock on the date of grant, will vest over four years, with 25% of the shares vesting on the first anniversary of the grant date and the remaining 75% of the shares vesting in equal monthly installments over the three years thereafter, in each case, subject to continued service. The stock option was granted pursuant to the terms of Mr. Luther’s employment agreement and as a material inducement to his joining the Company in accordance with Nasdaq Listing Rule 5635(c)(4). Remaining Funding Received from December 2023 Financing On January 11, 2024, the second and final closing of the December 2023 convertible note financing occurred. At this closing, the Company received approximately $1.4 million and issued an aggregate of $1.4 million of December 2023 convertible notes and note warrants to purchase approximately 1.5 million shares of common stock. The December 2023 convertible notes issued on January 11, 2024 have the same terms as those issued on December 15, 2023, except that the one issued on January 11, 2024 expire on January 11, 2029. The note warrants issued on January 11, 2024 have the same terms as the note warrants issued on December 15, 2023, except that the one issued on January 11, 2024 expire on January 11, 2029. See Note 6 for more information regarding the December 2023 convertible note financing, the December 2023 convertible notes and the note warrants.

Insider Trading Arrangements

Insider Trading Arrangements	3 Months Ended
Insider Trading Arrangements	Dec. 31, 2023
Insider Trading Arrangements [Line Items]
Rule 10b5-1 Arrangement Adopted	false
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
Non-Rule 10b5-1 Arrangement Terminated	false

Basis of Accounting Presentat_2

Basis of Accounting Presentation and Summary of Significant Accounting Policies (Policies)	12 Months Ended
	Dec. 31, 2023
Basis of Accounting Presentation and Summary of Significant Accounting Policies [Abstract]
Basis of Accounting Presentation	Basis of Accounting Presentation The consolidated financial statements have been prepared in conformity with U.S. generally accepted accounting principles (“GAAP”). Any reference in these notes to applicable guidance is meant to refer to GAAP as found in the Accounting Standards Codification (“ASC”) and Accounting Standards Updates (“ASU”) of the Financial Accounting Standards Board (“FASB”). All significant intercompany balances and transactions have been eliminated in consolidation.
Use of Estimates	Use of Estimates The preparation of consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect: (a) the reported amounts of assets and liabilities; (b) disclosure of contingent assets and liabilities at the date of the consolidated financial statements; (c) the reported amounts of expenses during the reporting period; and (d) the reported amount of the fair value of assets acquired in connection with business combinations. On an ongoing basis, the Company evaluates its estimates, including those related to the recoverability and useful lives of long-lived assets; stock-based compensation assumptions; valuation assumptions of warrants; contingencies; contingent consideration and the provision for income taxes, including the valuation allowance. The Company bases its estimates on a combination of historical experience and various other assumptions that it believes are reasonable under the circumstances. Actual results may differ materially from these estimates.
Cash, Cash Equivalents and Restricted Cash	Cash, Cash Equivalents and Restricted Cash The Company classifies highly liquid investments with a remaining contractual maturity at date of purchase of three months or less as cash equivalents. The Company had no cash equivalents as of December 31, 2023 or 2022. Restricted cash consists of a cash collateralization of $4.1 million for a security deposit in the form of a letter of credit issued by the Company’s commercial bank and delivered to the sublessor of office and laboratory space the Company subleases in Somerville, Massachusetts. The amount of required restricted cash collateral will decline in parallel with the reduction in the amount of the letter of credit over the term of the sublease.
Property and Equipment	Property and Equipment Property and equipment are recorded at cost and are depreciated over their estimated useful lives using the straight-line method. Laboratory and manufacturing equipment are depreciated over an estimated useful life of seven years. Leasehold improvements are depreciated over the shorter of their estimated useful life, or the lease term. Furniture and fixtures are depreciated over an estimated useful life of five years. Computer equipment are depreciated over an estimated useful life of three years. Upon retirement or other disposition of these assets, the cost and related accumulated depreciation of these assets are removed from the accounts and the resulting gain or losses are reflected in the results of operations. Expenditures for maintenance and repairs are charged to operations. Renewals and betterments are capitalized.
Goodwill	Goodwill Goodwill represents the excess of the purchase price over the fair value of identifiable net assets acquired in the acquisition of IRX Therapeutics, Inc. (“IRX”) in November 2018, which was accounted for as a business combination. Goodwill is not amortized but is tested for impairment annually or more frequently if events occur or circumstances indicate it is more likely than not that the fair value of a reporting unit is less than its carrying value. Events that would indicate impairment and trigger an interim impairment assessment include, but are not limited to, macroeconomic conditions, industry and market considerations, cost factors, overall financial performance and other relevant events. Management evaluates the Company as a single reporting unit, therefore, goodwill is tested for impairment at the entity level. Goodwill is tested for impairment as of December 31st of each year, or more frequently as warranted by events or changes in circumstances mentioned above. Accounting guidance also permits an optional qualitative assessment for goodwill to determine whether it is more likely than not that the carrying value of a reporting unit exceeds its fair value. If, after this qualitative assessment, the Company determines that it is not more likely than not that the fair value of a reporting unit is less than its carrying amount, then no further quantitative testing would be necessary. A quantitative assessment is performed if the qualitative assessment results in a more likely than not determination or if a qualitative assessment is not performed. The quantitative assessment considers whether the carrying amount of a reporting unit exceeds its fair value, in which case an impairment charge is recorded to the extent the reporting unit’s carrying value exceeds its fair value.
In-Process Research & Development	In-Process Research & Development In-process research and development (“IPR&D”) assets represent the fair value assigned to technologies that were acquired in connection with the acquisition of IRX in November 2018, which have not reached technological feasibility and have no alternative future use. IPR&D assets are considered to be indefinite lived until the completion or abandonment of the associated research and development projects. During the period that the IPR&D assets are considered indefinite-lived, they are tested for impairment on an annual basis or more frequently if the Company becomes aware of any events occurring or changes in circumstances that indicate that the fair value of the IPR&D assets are less than their carrying amounts. If and when development is complete, which generally occurs upon regulatory approval, and the Company is able to commercialize products associated with the IPR&D assets, these assets are then deemed definite-lived and are amortized based on their estimated useful lives beginning at that point in time. If development is terminated or abandoned, the Company may have a full or partial impairment charge related to the IPR&D assets, calculated as the excess of carrying value of the IPR&D assets over fair value.
Revenue Recognition	Revenue Recognition The Company recognizes the related revenue under ASC 606, Revenue from Contracts with Customers (“ASC 606”). Under ASC 606, the Company recognizes revenue when a customer obtains control of promised services or goods in an amount that reflects the consideration to which the Company expects to receive in exchange for those goods or services. In general, the Company applies the following steps when recognizing revenue from contracts with customers: (i) identify the contract, (ii) identify the performance obligations, (iii) determine the transaction price, (iv) allocate the transaction price to the performance obligations and (v) recognize revenue when a performance obligation is satisfied. Recognition of revenue is driven by satisfaction of the performance obligations using one of two methods: revenue is either recognized over time or at a point in time. Contracts containing multiple performance obligations classify those performance obligations into separate units of account either as standalone or combined units of account. Allocation of revenue to individual elements that qualify for separate accounting is based on the separate selling prices determined for each component, and total contract consideration is then allocated across the components of the arrangement. If separate selling prices are not available, the Company will use its best estimate of such selling prices, consistent with the overall pricing strategy and after consideration of relevant market factors. The Company estimates the amount of consideration it expects to recognize as revenue that is not probable of having a significant reversal of such recognized revenue, and it places a constraint on the remaining contractual consideration. As it becomes evident that the constrained amounts are no longer at risk of a significant reversal of revenue, the Company will remove the constraint from the related revenue and recognize a cumulative catch-up adjustment to revenue in the period in which the constraint was removed. The Company has one revenue generating contract. Such contract relates to an option and license agreement as well as certain development activities. See Note 5. Contract Assets: A contract asset is an entity’s right to payment for goods and services already transferred to a customer if that right to payment is conditional on something other than the passage of time. Generally, an entity will recognize a contract asset when it has fulfilled a contract obligation but must perform other obligations before being entitled to payment. Contract assets consist primarily of the cost of project contract work performed by third parties whereby the Company expects to recognize any related revenue at a later date, upon satisfaction of the contract obligations. The Company had no contract assets as of December 31, 2023 or 2022. Contract Liabilities: Contract liabilities consist primarily of consideration received, usually in the form of payment, on project work to be performed whereby the Company expects to recognize any related revenue at a later date, upon satisfaction of the contract obligations. As of December 31, 2023, contract liabilities were $0.6 million and are recognized as deferred revenue in the accompanying consolidated balance sheet. The Company recognized $0.1 million of revenue during the year ended December 31, 2023 from contract liabilities that arose in 2023. There were no contract liabilities as of December 31, 2022.
Research and Development	Research and Development The Company expenses its research and development costs as incurred. Research and development expenses consist of costs incurred for company-sponsored research and development activities, as well as support for selected investigator-sponsored research. Upfront payments and milestone payments made for the licensing of technology are expensed as research and development in the period in which they are incurred if the technology is not expected to have any alternative future uses other than the specific research and development project for which it was intended. The major components of research and development costs include salaries and employee benefits, stock-based compensation expense, supplies and materials, preclinical study costs, expensed licensed technology, consulting, scientific advisors and other third-party costs, and allocations of various overhead costs related to our product development efforts. The Company has contracted with third parties to perform various studies. The financial terms of these agreements vary from contract to contract and may result in uneven payment flows. The Company accrues for third party expenses based on estimates of the services received and efforts expended during the reporting period. If the actual timing of the performance of the services or the level of effort varies from the estimate, the accrual is adjusted accordingly. The expenses for some third-party services may be recognized on a straight-line basis if the expected costs are expected to be incurred ratably during the period. Payments under the contracts depend on factors such as the achievement of certain events or milestones, the successful enrollment of patients, the allocation of responsibilities among the parties to the agreement, and the completion of portions of the clinical study or trial or similar conditions.
Income Taxes	Income Taxes The Company records deferred tax liabilities and assets based on the differences between the consolidated financial statements carrying amounts and the tax basis of assets and liabilities, using enacted tax rates in effect in the years the differences are expected to reverse and establishing a valuation allowance when it was more likely than not that some portion or all of the deferred tax assets would not be realized. Income tax expense consists of the tax payable for the period and the change during the period in deferred tax assets and liabilities. Tax benefits from uncertain tax positions are recognized only if it is more likely than not that the tax position will be sustained on examination by the taxing authorities, based on the technical merits of the position. The tax benefits recognized in the consolidated financial statements from such a position are measured based on the largest benefit that has a greater than 50% likelihood of being realized upon ultimate resolution. The Company has no material uncertain tax positions for any of the reporting periods presented.
Loss Per Share	Loss Per Share The Company calculates basic and diluted net loss per share attributable to common stockholders in conformity with the two-class method required for participating securities. The Company’s convertible notes contractually entitle the holders of such notes to participate in dividends but does not contractually require the holders to participate in the Company’s losses. As such, the two-class method is not applicable during periods with a net loss. Basic net loss per share is calculated by dividing net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during the period, without consideration for potentially dilutive securities. Diluted net loss per share is calculated by dividing net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding plus dilutive securities. Shares of common stock issuable upon exercise, conversion or vesting of stock options, restricted stock units, warrants and the outstanding Series A convertible preferred stock are considered potential shares of common stock and are included in the calculation of diluted net loss per share using the treasury method when their effect is dilutive. The Company’s convertible notes are also considered potential shares of common stock and are included in the calculation of diluted net loss per share using the “if-converted” method, and the more dilutive of either the two-class method or the if-converted method is reported. Diluted net loss per share is the same as basic net loss per share for periods in which the effect of potentially dilutive shares of common stock is antidilutive.
Segment Reporting	Segment Reporting The Company’s chief operating decision maker, who is the chief executive officer, reviews operating results on a consolidated basis to make decisions about allocating resources and assessing performance of the Company. As a result, in accordance with ASC No. 280, Segment Reporting,
Concentration of Credit Risk	Concentration of Credit Risk The Company maintains its cash balances in financial institutions located in the United States. Accounts at each institution are insured by the Federal Deposit Insurance Corporation (“FDIC”) up to $250,000. The Company’s cash balances are uninsured for deposit accounts that exceed the FDIC insurance limit. In the Company’s business, vendor concentrations could be indicative of vulnerabilities in the Company’s supply chain, which could ultimately impact the Company’s ability to continue its research and development activities. For the years ended December 31, 2023 and 2022, there was no vendor concentration related to the Company’s research and development activities.
Fair Value of Financial Instruments	Fair Value of Financial Instruments Fair value is defined as the price that would be received to sell an asset, or paid to transfer a liability, in an orderly transaction between willing market participants. A fair value hierarchy has been established for valuation inputs that gives the highest priority to quoted prices in active markets for identical assets or liabilities and the lowest priority to unobservable inputs. The fair value hierarchy is as follows: • Level 1 Inputs – Valued based on quoted prices in active markets for identical assets or liabilities that the reporting entity has the ability to access at the measurement date. • Level 2 Inputs – Valued based on inputs other than quoted prices included in Level 1 that are observable for the asset or liability, either directly or indirectly. These might include quoted prices for similar assets or liabilities in active markets, quoted prices for identical or similar assets or liabilities in markets that are not active, inputs other than quoted prices that are observable for the asset or liability (such as interest rates, volatilities, prepayment speeds, credit risks, etc.) or inputs that are derived principally from or corroborated by market data by correlation or other means. • Level 3 Inputs – Valued based on inputs for which there is little or no market value, which require the reporting entity to develop its own assumptions. The carrying amounts reported on the balance sheet for cash and cash equivalents, other receivables, prepaid assets and other current assets, accounts payable and accrued expenses, other current liabilities and other liabilities approximate fair value due to their short maturities.
Leases	Leases The Company accounts for its leases under ASC Topic 842, Leases. The Company has elected the practical expedient to not separate non-lease components from the lease components to which they relate and instead account for each as a single lease component for all underlying asset classes. Some leasing arrangements require variable payments that are dependent on usage or may vary for other reasons, such as payments for insurance, tax payments and other miscellaneous costs. The variable portion of payments contemplated in the lease that do not depend on an index or rate are not included in the ROU assets or lease liabilities. Rather, variable payments that do not depend on an index or rate are expensed when the obligation for those payments is incurred and are included in lease expenses. Accordingly, all expenses associated with a lease contract are accounted for as lease expenses. The Company has also elected not to recognize ROU and lease liabilities for short-term leases that have a term of 12 months or less. The Company accounts for lease modifications as a separate contract when the modification (i) grants the lessee an additional right of use not included in the original lease contract, and (ii) increases the lease payments commensurate with the stand-alone price for the additional right of use. In this case, the Company would be treated as a new lease and measured in accordance with ASC 842 at the commencement date of the new lease without any impact on the existing lease. Otherwise, the Company accounts for lease modifications as a continuance of the existing lease, in which case, the Company reassesses the lease classification, remeasures the lease liability using an updated discount rate, and unless there is a full or partial termination of the lease, adjusts the ROU asset by the amount of change to the lease liability. For a full or partial lease termination, the lessee reduces the carrying amount of the ROU asset on a basis proportionate to the full or partial termination of the lease, and any difference between the adjustment to the ROU asset and the lease liability is recognized as a gain or loss in the current period.
Commitment and Contingencies	Commitment and Contingencies The Company follows ASC No.450-20, Loss Contingencies,
Stock-Based Compensation	Stock-Based Compensation The Company recognizes stock-based compensation expense for equity awards granted to employees, directors and certain consultants. The Company estimates the fair value of stock options using the Black-Scholes option pricing model. The fair value of stock options granted is recognized as expense over the requisite service period on a straight-line basis.
Warrants	Warrants The Company accounts for common stock warrants as either equity-classified or liability-classified instruments based on an assessment of the specific terms of the warrants and applicable authoritative guidance in ASC 480, Distinguishing Liabilities from Equity, and ASC 815, Derivatives and Hedging.
Convertible Notes	Convertible Notes The Company accounts for its convertible notes as a long-term liability equal to the proceeds received from issuance, including the embedded conversion feature, plus any interest paid-in-kind, net of the unamortized debt issuance costs and debt discount on the consolidated balance sheets. The Company evaluates all embedded features contained in the convertible notes, such as the conversion feature, the paid-in-kind feature and the redemption feature in the event of a default, to determine if such features require bifurcation as a derivative. The conversion feature included in the convertible notes is not required to be accounted for separately as an embedded derivative because the conversion feature is considered both indexed to the Company’s own stock and qualifies to be classified in stockholders’ equity. The paid-in-kind feature is considered to be a commitment to originate a loan, and the terms of the additional loans have the same terms as the original debt instrument. Therefore, the paid-in-kind feature qualifies for the scope exception under the applicable accounting guidance and is not required to be bifurcated as a derivative. The redemption feature in the event of a default was determined to be clearly and closely related to the convertible notes and not required to be bifurcated as a derivative. Proceeds from the sale of convertible notes with stock purchase warrants are allocated to the two elements based on their relative fair values. The portion of the proceeds allocated to warrants are recorded as a debt discount to the convertible note proceeds and presented on a net basis in the consolidated balance sheet. Debt issuance costs directly attributable to the transaction are capitalized and allocated to the convertible notes and warrants in the same manner as the proceeds. The amount of debt issuance costs allocated to the convertible notes represent a reduction of the face value of the convertible note proceeds. The Company amortizes debt issuance costs and debt discounts over the contractual term of the convertible notes, using the effective interest method, as interest expense on the consolidated statements of operations.
Recent Accounting Standards	Recent Accounting Standards In June 2022, the Financial Accounting Standard Board (the “FASB”) issued Accounting Standards Update (“ASU”) No. 2022-03, Fair Value Measurement (Topic 820): Fair Value Measurement of Equity Securities Subject to Contractual Sale Restrictions (“ASU 2022-03”). The FASB issued ASU 2022-03 to (1) clarify the guidance in Topic 820, Fair Value Measurement, when measuring the fair value of an equity security subject to contractual restrictions that prohibit the sale of an equity security, (2) to amend a related illustrative example, and (3) to introduce new disclosure requirements for equity related securities subject to contractual sale restrictions that are measured at fair value in accordance with Topic 820. ASU 2022-03 clarifies that a contractual restriction on the sale of an equity security is not considered part of the unit of account of the equity security and, therefore, is not considered in measuring fair value. The guidance is effective for fiscal years beginning after December 15, 2023, and interim periods within those fiscal years with early adoption permitted. The Company does not expect a material impact to its consolidated financial statements as a result of adopting this ASU. In October 2023, the FASB issued ASU No. 2023-06, Disclosure Improvements – Codification Amendment in Response to the SEC’s Disclosure Update and Simplification Initiative. This ASU modified the disclosure and presentation requirements of a variety of codification topics by aligning them with the SEC’s regulations. The amendments to the various topics should be applied prospectively, and the effective date will be determined for each individual disclosure based on the effective date of the SEC’s removal of the related disclosure. If the SEC has not removed the applicable requirements from Regulation S-X or Regulation S-K by June 30, 2027, then this ASU will not become effective. Early adoption is prohibited. The Company does not expect the amendments in this ASU to have a material impact on its consolidated financial statements. In November 2023, the FASB issued ASU No. 2023-07, Segment Reporting – Improvements to Reportable Segment Disclosures, which provides updates to qualitative and quantitative reportable segment disclosure requirements, including enhanced disclosures about significant segment expenses and increased interim disclosure requirements, among others. ASU No. 2023-07 is effective for fiscal years beginning after December 15, 2023, and interim periods in fiscal years beginning after December 15, 2024. Early adoption is permitted, and the amendments should be applied retrospectively. The Company does not expect the amendments in this ASU to have a material impact on its consolidated financial statements. In December 2023, the FASB issued ASU No. 2023-09, Improvements to Income Tax Disclosures, which requires disclosure of disaggregated income taxes paid, prescribes standard categories for the components of the effective tax rate reconciliation, and modifies other income tax-related disclosures. ASU No. 2023-09 is effective for fiscal years beginning after December 15, 2024 and allows for adoption on a prospective basis, with a retrospective option. Early adoption is permitted. The Company does not expect the amendments in this ASU to have a material impact on its consolidated financial statements.

Asset Acquisition (Tables)

Asset Acquisition (Tables)	12 Months Ended
Asset Acquisition (Tables)	Dec. 31, 2023
Asset Acquisition [Abstract]
Fair Valuation of Assumptions	The Company used a Monte Carlo simulation model to estimate the fair value of the Market Cap Contingent Consideration as of the acquisition date using the following assumptions: Stock price $ 3.00 Risk-free rate 3.58 % Volatility 100 % Dividend yield 0 % Expected term 3.0 years
Fair Value Measurement of Assets Acquired	The table below shows the total fair value of the consideration paid for the Exacis Assets (in thousands). Fair Value of Shares issued $ 208 Contingent consideration 225 Direct costs 27 Total fair value $ 460

Promissory Note and Convertib_2

Promissory Note and Convertible Note Financings (Tables)	12 Months Ended
Promissory Note and Convertible Note Financings (Tables)	Dec. 31, 2023
Promissory Note and Convertible Note Financings [Abstract]
Based on Relative Fair Value Allocation of Proceeds and Costs	The Company determined that there were no embedded derivatives within the convertible notes that required bifurcation from the host agreement. The Company allocated the gross proceeds received, the fees incurred, and as applicable, the impact of repricing the warrants discussed above, over the July 2023 convertible notes and July 2023 warrants and over the December 2023 convertible notes and December 2023 warrants, as applicable, based on their relative fair values as follows (in thousands): Allocation of Proceeds and Costs: Allocation of Relative Allocation Proceeds Costs Proceeds, July 2023 convertible notes $ 8,715 39.94 % $ 3,481 $ (80 ) $ 3,401 July 2023 warrants 13,103 60.06 % 5,234 (121 ) 5,113 $ 21,818 100.00 % $ 8,715 $ (201 ) $ 8,514 Allocation of Proceeds and Costs: Allocation of Relative Allocation Proceeds Costs Warrant Proceeds, December 2023 convertible notes $ 9,059 48.83 % $ 3,803 $ (81 ) $ (766 ) $ 2,956 December 2023 warrants 9,495 51.17 % 3,985 (85 ) (802 ) 3,098 $ 18,554 100.00 % $ 7,788 $ (166 ) $ (1,568 ) $ 6,054
Fair Value Assumptions	The Company estimated the fair values of the convertible notes as of July 14, 2023 and December 15, 2023 based off a valuation performed by a third-party specialist using a binomial tree model and the following assumptions: Stock Credit Volatility Risk-Free July 2023 convertible notes $ 2.81 2,500 108 % 4.60 % December 2023 convertible notes $ 1.51 2,000 109 % 3.90 % The fair value of the note warrants, all of which qualified for equity classification, was determined using the Black-Scholes pricing model as of each of July 14, 2023 and December 15, 2023 using the following assumptions: Stock Exercise Expected Volatility Dividend Risk-Free July 2023 warrants $ 2.81 $ 2.61 5 years 98 % 0.00 % 4.04 % December 2023 warrants $ 1.51 $ 1.43 5 years 101 % 0.00 % 3.91 %
Activity of Convertible Notes	The following table shows the activity that occurred during the year ended December 31, 2023 for the convertible notes on the accompanying consolidated balance sheet: Gross convertible notes at issuance $ 16,503 Debt discount and debt issuance costs (10,146 ) Amortization of debt discount and debt issuance costs 303 Paid-in-kind interest added to principal 113 Convertible notes, net, at December 31, 2023 $ 6,773
Principal Payments under Convertible Notes	The future minimum principal payments under the convertible notes as of December 31, 2023 are as follows: Years ending December 31, Principal Payments 2024 $ - 2025 - 2026 - 2027 - 2028 16,616 Total $ 16,616

Property and Equipment (Tables)

Property and Equipment (Tables)	12 Months Ended
Property and Equipment (Tables)	Dec. 31, 2023
Property and Equipment [Abstract]
Schedule of Property, Equipment	Property and equipment consist of the following (in thousands): As of December 31, 2023 2022 Laboratory and manufacturing equipment $ 40 $ 28 Furniture and fixtures 19 - Leasehold improvements 274 - Computer equipment and programs 274 240 607 268 Less accumulated depreciation and amortization (114 ) (32 ) Property and equipment, net $ 493 $ 236

Leases (Tables)

Leases (Tables)	12 Months Ended
Leases (Tables)	Dec. 31, 2023
Leases [Abstract]
Net Operating Lease Expense	For the years ended December 31, 2023 and 2022, the net operating lease expenses were as follows (in thousands): Years ended December 31, 2023 2022 Operating lease expense $ 3,399 $ 595 Sublease income (84 ) (84 ) Variable lease expense 136 150 Total lease expense $ 3,451 $ 661
Operating Lease Right-of-use Assets and Liabilities	The tables below show the beginning balances of the operating ROU assets and lease liabilities as of January 1, 2023 and the ending balances as of December 31 2023, including the changes during the period (in thousands). Operating Lease ROU Assets Operating lease ROU assets at January 1, 2023 $ 1,030 Recognition of ROU asset for Somerville Sublease 34,410 Adjustment to ROU asset for remeasurement of Somvervile Sublease liability (1,620 ) Amortization of operating lease ROU assets (1,039 ) Operating lease ROU assets at December 31, 2023 $ 32,781 Operating Lease Liabilities Operating lease liabilities at January 1, 2023 $ 1,182 Recognition of lease liability for Somerville Sublease 34,169 Accretion of interest for Somerville Sublease 1,858 Adjustment to lease liablity due to remeasurement of Somerville Sublease (1,620 ) Principal payments on operating lease liabilities (519 ) Operating lease liabilities at December 31, 2023 35,070 Less non-current portion 32,854 Current portion at December 31, 2023 $ 2,216
Maturities of Operating Lease Liabilities	The maturities of the operating lease liabilities are as follows (in thousands): As of December 31, 2023 2024 $ 6,972 2025 6,075 2026 6,238 2027 6,308 2028 6,406 Thereafter 33,879 Total payments 65,878 Less imputed interest (30,808 ) Total operating lease liabilities $ 35,070
Future Lease Payments from Sublease Agreement	The following tables shows the future payments the Company expects to receive from the Subtenant over the remaining term of the sublease (in thousands): As of December 31, 2023 2024 $ 86 2025 88 2026 75 Total payments $ 249

Fair Value of Financial Instr_2

Fair Value of Financial Instruments (Tables)	12 Months Ended
Fair Value of Financial Instruments (Tables)	Dec. 31, 2023
Fair Value of Financial Instruments [Abstract]
Liabilities Measured at Fair Value	The following tables summarize the liabilities that are measured at fair value as of December 31, 2023 and, 2022 (in thousands): As of December 31, Description Level 2023 2022 Liabilities: Warrant liabilities - Common Warrants 3 $ 116 $ 331 Market Cap Contingent Consideration 3 $ 107 $ -
Changes in Warrant Liabilities	The following table presents the changes in the liabilities measured at fair value from January 1, 2023, or from the initial measurement date if later than January 1, 2023, through December 31, 2023 (in thousands): Warrant Contingent Fair value at January 1, 2023 $ 331 $ - Initial measurement - 225 Change in fair value (215 ) (118 ) Fair value at December 31, 2023 $ 116 $ 107
Fair Value and Carrying Values of Convertible Notes	The table below is provided for comparative purposes only and presents information about the fair value of the convertible notes relative to the carrying values recognized in the consolidated balance sheet as of December 31, 2023 (in thousands). The Company did not have any of the convertible notes or similar instruments outstanding as of December 31, 2022. December 31, 2023 Level Carrying Fair Convertible Notes 3 $ 16,616 $ 17,594

Accrued Expenses (Tables)

Accrued Expenses (Tables)	12 Months Ended
Accrued Expenses (Tables)	Dec. 31, 2023
Accrued Expenses [Abstract]
Accrued Expenses	Accrued expenses consisted of the following (in thousands): As of December 31, 2023 2022 Legal fees and related $ 643 $ 1,139 Professional fees 239 124 Somerville facility 218 138 Convertible Notes interest 176 - Accrued compensation 109 1,065 Clinical 18 570 Other 490 590 Total accrued expenses $ 1,893 $ 3,626

Basic and Diluted Net Loss pe_2

Basic and Diluted Net Loss per Common Share (Tables)	12 Months Ended
Basic and Diluted Net Loss per Common Share (Tables)	Dec. 31, 2023
Basic and Diluted Net Loss per Common Share [Abstract]
Computation of Net Loss per Share Basic and Diluted	The following table sets forth the computation of the net loss per share attributable to common stockholders, basic and diluted (in thousands, except per share data): Years Ended December 31, 2023 2022 Numerator: Net loss attributable to common stockholders $ (21,684 ) $ (24,595 ) Denominator Weighted average shares outstanding - basic and diluted 5,314 3,051 Net loss per common share - basic and diluted $ (4.08 ) $ (8.06 )
Securities Excluded from the Computation of Diluted Net Loss per Common Stock	The following table presents the amount of warrants, stock options, convertible preferred stock, convertible notes and restricted stock units (“RSUs”) that were excluded from the computation of diluted net loss per share of common stock for the years ended December 31, 2023 and 2022, as their effect was anti-dilutive (in thousands): Years ended December 31, 2023 2022 Warrants 18,922 4,713 C onvertible Notes converted into common stock 7,877 - Stock options 389 359 Preferred stock converted into common stock 18 7 RSUs 1 4 Total potential common shares excluded from computation 27,207 5,083

Stock-Based Compensation (Table

Stock-Based Compensation (Tables)	12 Months Ended
Stock-Based Compensation (Tables)	Dec. 31, 2023
Stock-Based Compensation [Abstract]
Weighted-Average Assumptions Used for Stock Options Granted	The following weighted-average assumptions were used for stock options granted during the years ended December 31, 2023 and 2022: Year ended December 31, 2023 2022 Weighted average risk-free rate 3.82 % 2.52 % Weighted average volatility 95.15 % 90.49 % Dividend yield 0 % 0 % Expected term 5.44 years 5.79 years
Summarizes of Stock Option Activity	The following table summarizes stock option activity for the years ended December 31, 2023 and 2022 (in thousands except for per-share and remaining contractual life data): Outstanding Options Weighted Average Exercise Price per Share Weighted Average Remaining Contractual Life (in years) Aggregate Intrinsic Value Outstanding January 1, 2022 199 $ 168 9.38 $ - Granted 287 17 Cancelled (127 ) 141 Outstanding December 31, 2022 359 57 7.57 - Granted 237 4 Cancelled (207 ) 19 Outstanding December 31, 2023 389 $ 45 7.04 $ - Options vested and exercisable at December 31, 2023 331 $ 50 6.69 $ -
Summarizes of RSU Activity	The following table summarizes RSU activity for the years ended December 31, 2023 and 2022 (in thousands except for per-share data): Outstanding Restricted Stock Units Weighted Average Fair Value per Share January 1, 2022 12 $ 276 Granted 55 39 Released (3 ) 271 Cancelled (60 ) 61 December 31, 2022 4 236 Cancelled (3 ) 199 December 31, 2023 1 $ 322 Balance expected to vest at December 31, 2023 1 $ 322
Stock-Based Compensation Expense	For the years ended December 31, 2023 and 2022, the Company recognized stock-based compensation expense as follows (in thousands): Years ended December 31, 2023 2022 Research and development $ 234 $ 1,249 General and administrative 1,008 1,686 Total $ 1,242 $ 2,935

Equity and Warrants (Tables)

Equity and Warrants (Tables)	12 Months Ended
Equity and Warrants (Tables)	Dec. 31, 2023
Equity and Warrants [Abstract]
Warrant activity	The following table shows the Company’s warrant activity for the year ended December 31, 2023 (in thousands except for per-share data): Q1-22 Common Warrants Q4-22 Warrants July 2023 Warrants December 2023 Warrants Total Warrants Balance as of January 1, 2023 343 4,370 - - 4,713 Granted - - 6,094 8,115 14,209 Balance as of December 31, 2023 343 4,370 6,094 8,115 18,922

Income Taxes (Tables)

Income Taxes (Tables)	12 Months Ended
Income Taxes (Tables)	Dec. 31, 2023
Income Taxes [Abstract]
Loss before Income Taxes	Loss before income taxes consist of the following (in thousands): Years ended December 31, 2023 2022 (in thousands) Domestic $ (21,654 ) $ (24,513 ) Foreign (17 ) (21 ) Total loss before income taxes $ (21,671 ) $ (24,534 )
Income Tax Provision	For each of the years ended December 31, 2023 and 2022, current tax provisions and current deferred tax provisions were recorded as follows (in thousands): Years ended December 31, 2023 2022 Current Tax Provision Federal $ - $ - State 1 4 Foreign - - 1 4 Deferred Tax Provision Federal (2,155 ) (6,851 ) State 8 (1,602 ) Foreign (2 ) (187 ) (2,149 ) (8,640 ) Change in valuation allowance 2,145 8,681 Total tax (benefit) $ (3 ) $ 45
Deferred Tax Assets and Liabilities	Deferred tax assets and liabilities consist of the effects of temporary differences as shown in the table below (in thousands). Deferred tax assets have been fully reserved by a valuation allowance since it is more likely than not that such tax benefits will not be realized. As of December 31, 2023 2022 Deferred Tax Assets: Net operating losses $ 12,740 $ 9,382 Foreign net operating losses 784 782 Stock compensation 2,141 2,173 In-process research and development 1,009 1,233 Capitalized rearch and development expenses 3,105 1,502 R&D credit carryforwards 437 517 Compensation accrual 3 81 ROU Liabilities 8,932 334 Other 132 549 Total gross deferred tax assets 29,283 16,553 Valuation allowance (18,302 ) (16,157 ) Net deferred tax assets 10,981 396 Deferred Tax Liabilities: Fixed assets (6 ) (10 ) ROU Assets (8,349 ) (291 ) Convertible debt (2,507 ) - Intangibles - goodwill (179 ) (160 ) Total deferred tax liabilities (11,041 ) (461 ) Net deferred taxes $ (60 ) $ (65 )
Reconciliation of Computed Expected Income Taxes to Effective Income Taxes	The reconciliation of computed expected income taxes to effective income taxes by applying the federal statutory rate of 21% is as follows: As of December 31, 2023 2022 Tax at federal income tax rate 21.00 % 21.00 % State income tax, net of federal tax 4.92 % 6.52 % Foreign tax differential (0.01 %) (0.01 %) Non-deductible expenses/excludable items (0.74 %) 6.09 % Change in valuation allowance (9.90 %) (35.38 %) Convertible debt (11.92 %) 0.00 % Credits 0.00 % 0.98 % Uncertain tax positions 0.00 % (0.49 %) Other (3.34 %) 1.11 % Benefit (provision) for income taxes 0.01 % (0.18 %)
Uncertain Tax Positions	The following table summarizes amounts the Company recorded for uncertain tax positions as of December 31, 2023 and 2022 (in thousands): As of December 31, 2023 2022 Beginning balance of uncertain tax positions $ 121 $ - Additions based on current year’s tax positions - 45 Net changes based on prior year’s tax positions 272 76 Ending balance of uncertain tax positions $ 393 $ 121

Organization and Description _2

Organization and Description of Business Operations (Details)	12 Months Ended
	Dec. 31, 2023 Patents
Description of Business [Abstract]
Number of patents	100

Liquidity and Capital Resourc_2

Liquidity and Capital Resources (Details) $ in Thousands			1 Months Ended	6 Months Ended	12 Months Ended
Liquidity and Capital Resources (Details) $ in Thousands	Dec. 15, 2023 USD ($)	Jul. 14, 2023 USD ($)	Jan. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2023 USD ($) shares	Dec. 31, 2022 USD ($)	Apr. 30, 2023 USD ($)	Apr. 05, 2023 USD ($)	Oct. 31, 2022 USD ($) ft²
Liquidity and Capital Resources [Abstract]
Cash				$ 7,575	$ 7,575	$ 11,446
Accumulated deficit				(186,981)	(186,981)	(165,297)
Net loss					(21,668)	(24,579)
Net cash used in operating activities					(20,408)	(20,976)
New Facility Lease [Abstract]
Area of premises \| ft²									45,500
Letter of credit									$ 4,100
Restricted cash				4,100	4,100				$ 4,100
Private Placement Offerings [Abstract]
Proceeds received from the convertible notes financings	$ 7,788	$ 8,715			$ 16,503	$ 0
Convertible Notes [Member]
Private Placement Offerings [Abstract]
Proceeds received from the convertible notes financings				$ 16,500
Convertible Notes [Member] \| Subsequent Event [Member]
Private Placement Offerings [Abstract]
Proceeds received from the convertible notes financings			$ 1,400
Lincoln Park [Member]
New Facility Lease [Abstract]
Common stock shares issued and sold (in shares) \| shares					214,000
Gross proceeds from sale of equity					$ 300
Lincoln Park [Member] \| Maximum [Member]
New Facility Lease [Abstract]
Aggregate gross purchase price							$ 10,000	$ 10,000

Basis of Accounting Presentat_3

Basis of Accounting Presentation and Summary of Significant Accounting Policies, Cash, Cash Equivalents and Restricted Cash (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022	Oct. 31, 2022
Cash and Cash Equivalents [Abstract]
Cash equivalents	$ 0	$ 0
Restricted cash	$ 4,100		$ 4,100

Basis of Accounting Presentat_4

Basis of Accounting Presentation and Summary of Significant Accounting Policies, Property and Equipment (Details)	Dec. 31, 2023
Laboratory and Manufacturing Equipment [Member]
Property and Equipment [Abstract]
Estimated useful life	7 years
Furniture and Fixtures [Member]
Property and Equipment [Abstract]
Estimated useful life	5 years
Computer Equipment [Member]
Property and Equipment [Abstract]
Estimated useful life	3 years

Basis of Accounting Presentat_5

Basis of Accounting Presentation and Summary of Significant Accounting Policies, Revenue Recognition (Details) $ in Millions	12 Months Ended
	Dec. 31, 2023 USD ($) Contract	Dec. 31, 2022 USD ($)
Revenue Recognition [Abstract]
Number of revenue generating contracts \| Contract	1
Contract assets	$ 0	$ 0
Deferred revenue	0.6
Contract liabilities	$ 0.1	$ 0

Basis of Accounting Presentat_6

Basis of Accounting Presentation and Summary of Significant Accounting Policies, Segment Reporting (Details)	12 Months Ended
	Dec. 31, 2023 Segments
Segment Reporting [Abstract]
Number of operating segments	1

Asset Acquisition, Summary of A

Asset Acquisition, Summary of Asset Acquisition (Details) - Exacis Asset Purchase [Member] - USD ($) $ / shares in Units, $ in Thousands	1 Months Ended	12 Months Ended
	Apr. 30, 2023	Dec. 31, 2023
Exacis Asset Purchase [Abstract]
Asset acquisition of common stock (in shares)	69,000
Lock-up period		12 months
Estimated equity value of stock issued in asset acquisition	$ 75,000
Share price (in dollars per share)	$ 3
Percentage of cash consideration	20%
Cash or other consideration	$ (208)
Maximum [Member]
Exacis Asset Purchase [Abstract]
Cash or other consideration	45,000
Contingent Consideration One [Member]
Exacis Asset Purchase [Abstract]
Common stock purchase agreement commencement period		3 years
Minimum market capitalization requirement, amount	100,000
Number of consecutive trading days		10 days
Numerator value for stock issuance	2,000
Contingent Consideration Two [Member]
Exacis Asset Purchase [Abstract]
Common stock purchase agreement commencement period		3 years
Minimum market capitalization requirement, amount	200,000
Number of consecutive trading days		10 days
Numerator value for stock issuance	$ 2,000
Contingent Consideration Three [Member]
Exacis Asset Purchase [Abstract]
Common stock purchase agreement commencement period		5 years

Asset Acquisition, Fair Valuati

Asset Acquisition, Fair Valuation of Assumptions (Details) - USD ($)	Dec. 31, 2023	Apr. 26, 2023
Exacis Asset Purchase [Member]
Liabilities, Fair Value Disclosure [Abstract]
Market capitalization of monetary amount		$ 2,000,000
Stock Price [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input		3
Risk Free Rate [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input		0.0358
Volatility [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input		1
Dividend Yield [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input		0
Expected Term [Member]
Valuation Technique and Input, Description [Abstract]
Expected life	3 years

Asset Acquisition, Fair Value M

Asset Acquisition, Fair Value Measurement of Assets Acquired (Details) - USD ($) $ in Thousands	1 Months Ended	12 Months Ended
	Apr. 30, 2023	Dec. 31, 2023	Dec. 31, 2022
Fair Value Consideration of Assets Acquired [Abstract]
Total fair value		$ 460	$ 0
Allocated percentage of fair value of consideration to purchased license	100%
Exacis Asset Purchase [Member]
Fair Value Consideration of Assets Acquired [Abstract]
Shares issued	$ 208
Contingent consideration	225
Direct costs	27
Total fair value	$ 460

Contract with Customer (Details

Contract with Customer (Details) - USD ($) $ in Thousands		12 Months Ended
Contract with Customer (Details) - USD ($) $ in Thousands	Feb. 21, 2023	Dec. 31, 2023
Contract with Customers [Abstract]
Proceeds from option and license agreement	$ 300
Proceeds from cell line customization activities		$ 400
Performance obligation, percentage	100%
Revenue recognized in previous periods		0
Catch-up adjustment to revenue		0
Revenue recognized		$ 100
Option fee obligation payment percentage		20%
Revenue Recognized Over Time [Member]
Contract with Customers [Abstract]
Revenue recognized		$ 400

Promissory Note and Convertib_3

Promissory Note and Convertible Note Financings, Summary (Details) - USD ($)			12 Months Ended
	Dec. 14, 2023	Jul. 14, 2023	Dec. 31, 2023	Dec. 31, 2022	Jan. 31, 2024	Dec. 15, 2023	Dec. 08, 2023
Convertible Notes Payable [Abstract]
Convertible notes			$ 6,773,000	$ 0
Number of convertible notes converted into shares (in shares)				0
Effect of reduction of exercise price of warrants			$ 1,600,000
Common Stock [Member]
Convertible Notes Payable [Abstract]
Number of convertible notes converted into shares (in shares)			0
July 2023 Warrants [Member]
Convertible Notes Payable [Abstract]
Warrants to purchase common shares (in shares)		6,100,000
Warrant exercise price (in dollars per share)		$ 2.61	$ 1.43
December 2023 Warrants [Member]
Convertible Notes Payable [Abstract]
Effect of reduction of exercise price of warrants			$ 800,000
December 2023 Warrants [Member] \| Common Stock [Member]
Convertible Notes Payable [Abstract]
Warrants to purchase common shares (in shares)						8,100,000
Convertible Notes [Member]
Convertible Notes Payable [Abstract]
Convertible notes							$ 1,500,000
Aggregate principal amount							$ 1,500,000
Interest rate							6%
Accrued interest rate							6%
Repaid principal amount	$ 1,500,000
Accrued interest due under the promissory note	1,500
Debt maturity date			Jan. 08, 2024
Repurchase price percentage			100%
Convertible Notes [Member] \| Condition One [Member] \| Minimum [Member]
Convertible Notes Payable [Abstract]
Beneficial conversion feature percentage		4.99%
Convertible Notes [Member] \| Condition One [Member] \| Maximum [Member]
Convertible Notes Payable [Abstract]
Beneficial conversion feature percentage		9.99%
Convertible Notes [Member] \| Condition Two [Member] \| Minimum [Member]
Convertible Notes Payable [Abstract]
Beneficial conversion feature percentage		9.99%
Convertible Notes [Member] \| Condition Two [Member] \| Maximum [Member]
Convertible Notes Payable [Abstract]
Beneficial conversion feature percentage		19.99%
Convertible Notes [Member] \| Condition Three [Member] \| Minimum [Member]
Convertible Notes Payable [Abstract]
Beneficial conversion feature percentage		19.99%
July 2023 Convertible Notes [Member]
Convertible Notes Payable [Abstract]
Convertible notes		$ 8,700,000
Aggregate principal amount		8,700,000
Transaction fees		$ 200,000
Interest rate		6%
Debt maturity date			Jul. 14, 2028
Initial conversion rate (in dollars per share)		$ 2.86
December 2023 Convertible Notes [Member]
Convertible Notes Payable [Abstract]
Convertible notes						$ 7,800,000
Aggregate principal amount	$ 9,200,000					$ 7,800,000
Warrants to purchase common shares (in shares)	9,600,000
Interest rate	12%
Debt maturity date			Dec. 15, 2028
Initial conversion rate (in dollars per share)	$ 1.9194
December 2023 Convertible Notes [Member] \| Subsequent Event [Member]
Convertible Notes Payable [Abstract]
Aggregate principal amount					$ 1,400,000
December 2022 Convertible Notes [Member]
Convertible Notes Payable [Abstract]
Warrant exercise price (in dollars per share)			$ 1.43	$ 3.28
Effect of reduction of exercise price of warrants			$ 800,000
December 2022 Convertible Notes [Member] \| Common Stock [Member]
Convertible Notes Payable [Abstract]
Warrants to purchase common shares (in shares)				4,400,000

Promissory Note and Convertib_4

Promissory Note and Convertible Note Financings, Based on Relative Fair Value Allocation of Proceeds and Costs (Details) - USD ($) $ in Thousands			12 Months Ended
	Dec. 15, 2023	Jul. 14, 2023	Dec. 31, 2023	Dec. 31, 2022
Allocation of Proceeds and Costs [Abstract]
Relative Fair Value	$ 18,554	$ 21,818
Allocation Percentage	100%	100%
Proceeds	$ 7,788	$ 8,715	$ 16,503	$ 0
Costs	(166)	(201)
Warrant Repricing	(1,568)
Proceeds from Convertible Debt Net	6,054	8,514
July 2023 Convertible Notes [Member]
Allocation of Proceeds and Costs [Abstract]
Relative Fair Value		$ 8,715
Allocation Percentage		39.94%
Proceeds		$ 3,481
Costs		(80)
Proceeds from Convertible Debt Net		3,401
July 2023 Warrants [Member]
Allocation of Proceeds and Costs [Abstract]
Relative Fair Value		$ 13,103
Allocation Percentage		60.06%
Proceeds		$ 5,234
Costs		(121)
Proceeds from Convertible Debt Net		$ 5,113
December 2023 Convertible Notes [Member]
Allocation of Proceeds and Costs [Abstract]
Relative Fair Value	$ 9,059
Allocation Percentage	48.83%
Proceeds	$ 3,803
Costs	(81)
Warrant Repricing	(766)
Proceeds from Convertible Debt Net	2,956
December 2023 Warrants [Member]
Allocation of Proceeds and Costs [Abstract]
Relative Fair Value	$ 9,495
Allocation Percentage	51.17%
Proceeds	$ 3,985
Costs	(85)
Warrant Repricing	(802)
Proceeds from Convertible Debt Net	$ 3,098

Promissory Note and Convertib_5

Promissory Note and Convertible Note Financings, Fair Value Assumptions (Details)	Dec. 31, 2023	Dec. 15, 2023 USD ($) $ / shares	Jul. 14, 2023 $ / shares USD ($)	Apr. 26, 2023 USD ($)
Stock Price [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input \| $				3
Expected Life [Member]
Fair Value Assumptions [Abstract]
Expected life	3 years
Volatility [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input \| $				1
Dividend [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input \| $				0
Risk Free Rate [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input \| $				0.0358
July 2023 Convertible Notes [Member] \| Stock Price [Member]
Fair Value Assumptions [Abstract]
Convertible note, measurement input \| $ / shares			2.81
July 2023 Convertible Notes [Member] \| Credit Spread [Member]
Fair Value Assumptions [Abstract]
Convertible note, measurement input \| $			2,500,000
July 2023 Convertible Notes [Member] \| Volatility [Member]
Fair Value Assumptions [Abstract]
Convertible note, measurement input			1.08
July 2023 Convertible Notes [Member] \| Risk Free Rate [Member]
Fair Value Assumptions [Abstract]
Convertible note, measurement input			0.046
July 2023 Warrants [Member] \| Stock Price [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input \| $ / shares			2.81
July 2023 Warrants [Member] \| Exercise Price [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input \| $ / shares			2.61
July 2023 Warrants [Member] \| Expected Life [Member]
Fair Value Assumptions [Abstract]
Expected life			5 years
July 2023 Warrants [Member] \| Volatility [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input			0.98
July 2023 Warrants [Member] \| Dividend [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input			0
July 2023 Warrants [Member] \| Risk Free Rate [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input			0.0404
December 2023 Convertible Notes [Member] \| Stock Price [Member]
Fair Value Assumptions [Abstract]
Convertible note, measurement input \| $ / shares		1.51
December 2023 Convertible Notes [Member] \| Credit Spread [Member]
Fair Value Assumptions [Abstract]
Convertible note, measurement input \| $		2,000,000
December 2023 Convertible Notes [Member] \| Volatility [Member]
Fair Value Assumptions [Abstract]
Convertible note, measurement input		1.09
December 2023 Convertible Notes [Member] \| Risk Free Rate [Member]
Fair Value Assumptions [Abstract]
Convertible note, measurement input		0.039
December 2023 Warrants [Member] \| Stock Price [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input \| $ / shares		1.51
December 2023 Warrants [Member] \| Exercise Price [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input \| $ / shares		1.43
December 2023 Warrants [Member] \| Expected Life [Member]
Fair Value Assumptions [Abstract]
Expected life		5 years
December 2023 Warrants [Member] \| Volatility [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input		1.01
December 2023 Warrants [Member] \| Dividend [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input		0
December 2023 Warrants [Member] \| Risk Free Rate [Member]
Fair Value Assumptions [Abstract]
Warrants , measurement input		0.0391

Promissory Note and Convertib_6

Promissory Note and Convertible Note Financings, Convertible Notes (Details) - USD ($) $ in Thousands			12 Months Ended
	Dec. 15, 2023	Jul. 14, 2023	Dec. 31, 2023	Dec. 31, 2022	Dec. 08, 2023
Convertible Notes [Abstract]
Gross convertible notes at issuance	$ 7,788	$ 8,715	$ 16,503	$ 0
Debt discount and debt issuance costs			(10,146)
Amortization of debt discount and debt issuance costs			303	0
Paid-in-kind interest added to principal			113	0
Convertible notes, net, at December 31, 2023			6,773	0
Promissory Note and Convertible Note Financing [Abstract]
Interest expense			176	0
Amortization of the debt discount and debt issuance costs			303	0
Paid in-kind			113	0
Interest in accrued expenses			1,893	$ 3,626
Convertible Notes [Member]
Convertible Notes [Abstract]
Amortization of debt discount and debt issuance costs			300
Convertible notes, net, at December 31, 2023					$ 1,500
Future Minimum Principal Payments under Convertible Notes [Abstract]
2024			0
2025			0
2026			0
2027			0
2028			16,616
Total			16,616
Promissory Note and Convertible Note Financing [Abstract]
Interest expense			600
Amortization of the debt discount and debt issuance costs			300
Paid in-kind			300
Remaining of interest expense			100
Interest in accrued expenses			$ 200

Property and Equipment (Details

Property and Equipment (Details) - USD ($) $ in Thousands	12 Months Ended
Property and Equipment (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Property, Plant and Equipment, Gross [Abstract]
Property and equipment, gross	$ 607	$ 268
Less accumulated depreciation and amortization	(114)	(32)
Property and equipment, net	493	236
Loss on disposal of fixed assets	1	280
Net book value of fixed assets		600
Proceeds from sales of fixed assets	0	250
Depreciation expenses	100	200
Laboratory and Manufacturing Equipment [Member]
Property, Plant and Equipment, Gross [Abstract]
Property and equipment, gross	40	28
Furniture and Fixtures [Member]
Property, Plant and Equipment, Gross [Abstract]
Property and equipment, gross	19	0
Leasehold Improvements [Member]
Property, Plant and Equipment, Gross [Abstract]
Property and equipment, gross	274	0
Computer Equipment and Programs [Member]
Property, Plant and Equipment, Gross [Abstract]
Property and equipment, gross	$ 274	$ 240

Leases, Operating Lease (Detail

Leases, Operating Lease (Details)	1 Months Ended	12 Months Ended
Leases, Operating Lease (Details)	Oct. 31, 2022 USD ($) ft²	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	Mar. 31, 2022 USD ($)
Leases [Abstract]
Commitment to purchase equipment				$ 50,000
Security deposit				63,000
ROU asset balance		$ 32,781,000	$ 1,030,000	1,400,000
Lease liability		35,070,000	1,182,000	$ 1,500,000
Impairment of ROU asset		0	772,000
Initial measurement of operating lease ROU assets		34,410,000
Initial measurement of operating lease liabilities		34,169,000
Area of premises \| ft²	45,500
Letter of credit	$ 4,100,000
Lease liability incremental amount Above Tenant Improvement Allowance		600,000
Out-of-pocket expenses		400,000
Unpaid out of pocket costs		1,000,000
Adjustment to lease liability and ROU asset due to remeasurement		$ (1,620,000)	$ 0
Minimum [Member]
Leases [Abstract]
Incremental borrowing rate		12.70%
Maximum [Member]
Leases [Abstract]
Incremental borrowing rate		14.40%
E.R. Squibb & Sons, L.L.C. [Member]
Leases [Abstract]
ROU asset balance		$ 34,700,000
Lease liability		$ 34,400,000
Area of premises \| ft²	45,500
Extension term of sublease		5 years
Monthly base rent payable	$ 500,000
Percentage increase in base rent after first year	3%
Letter of credit	$ 4,100,000
Tenant improvement allowance per rentable square foot	190
Tenant improvement allowance	8,600,000
Cost improvement	$ 2,100,000
Company received tenant improvement allowance		$ 8,600,000
San Diego Lease [Member]
Leases [Abstract]
Initial measurement of operating lease ROU assets		0
Initial measurement of operating lease liabilities		$ 0

Leases, Net Operating Lease Exp

Leases, Net Operating Lease Expenses (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Net Operating Lease Expense [Abstract]
Operating lease expense	$ 3,399	$ 595
Sublease income	(84)	(84)
Variable lease expense	136	150
Total lease expense	$ 3,451	$ 661

Leases, Operating Lease Right-o

Leases, Operating Lease Right-of-use Assets and Liabilities (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Operating Lease, Asset [Abstract]
Operating lease ROU assets, Beginning	$ 1,030
Recognition of ROU asset for Somerville Sublease	34,410
Adjustment to ROU asset for remeasurement of Somvervile Sublease liability	(1,620)
Amortization of operating lease ROU assets	(1,039)	$ (336)
Operating lease ROU assets, Ending	32,781	1,030
Operating Lease, Liability [Abstract]
Operating lease liabilities, Beginning	1,182
Recognition of lease liability for Somerville Sublease	34,169
Accretion of interest for Somerville Sublease	1,858
Adjustment to lease liability due to remeasurement of Somerville Sublease	(1,620)
Principal payments on operating lease liabilities	(519)
Operating lease liabilities, Ending	35,070	1,182
Less non-current portion	32,854	887
Current portion	$ 2,216	$ 295

Leases, Maturities of Operating

Leases, Maturities of Operating Lease Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022	Mar. 31, 2022
Weighted Average Remaining Lease Term and Discount Rate [Abstract]
Weighted average remaining lease term (years)	9 years 9 months 18 days
Weighted average discount rate	14.24%
Maturities of Operating Lease Liabilities [Abstract]
2024	$ 6,972
2025	6,075
2026	6,238
2027	6,308
2028	6,406
Thereafter	33,879
Total payments	65,878
Less: Imputed interest	(30,808)
Total operating lease liabilities	$ 35,070	$ 1,182	$ 1,500

Leases, Manhattan Sublease (Det

Leases, Manhattan Sublease (Details) $ in Thousands		12 Months Ended
Leases, Manhattan Sublease (Details) $ in Thousands	Apr. 18, 2019 ft²	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)
Leases [Abstract]
Currently rented area \| ft²	999
Percentage of annual rent increase	2.25%
Future Lease Payments, Sublease Agreement [Abstract]
2024		$ 86
2025		88
2026		75
Total payments		249
Sublease payments received		$ 100	$ 100

Fair Value of Financial Instr_3

Fair Value of Financial Instruments, Liabilities Measured at Fair Value (Details) - Level 3 [Member] - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Market Cap Contingent Consideration [Member]
Liabilities [Abstract]
Liabilities, fair value disclosure	$ 107	$ 0
Common Warrants [Member] \| Warrant Liabilities [Member]
Liabilities [Abstract]
Liabilities, fair value disclosure	$ 116	$ 331

Fair Value of Financial Instr_4

Fair Value of Financial Instruments, Changes in Warrant Liabilities (Details)	6 Months Ended	12 Months Ended
	Jun. 30, 2023 USD ($)	Dec. 31, 2023 USD ($) $ / shares	Dec. 31, 2022 USD ($)	Apr. 26, 2023 USD ($)
Valuation Technique and Input, Description [Abstract]
Remeasurement of contingent consideration	$ 100,000
Change in fair value of contingent consideration	0	$ 118,000	$ 0
Expected Term [Member]
Valuation Technique and Input, Description [Abstract]
Expected life		3 years
Risk Free Rate [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input				0.0358
Volatility [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input				1
Dividend Yield [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input				0
Stock Price [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input				3
Contingent Consideration [Member]
Changes in Fair Value of Warrant Liabilities [Roll Forward]
Fair value, beginning of period	0	$ 0
Initial measurement		225,000
Change in fair value		(118,000)
Fair value, end of period		$ 107,000	0
Contingent Consideration [Member] \| Expected Term [Member]
Valuation Technique and Input, Description [Abstract]
Expected life		2 years 3 months 18 days
Contingent Consideration [Member] \| Risk Free Rate [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input		0.0407
Contingent Consideration [Member] \| Volatility [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input		1.08
Contingent Consideration [Member] \| Dividend Yield [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input		0
Contingent Consideration [Member] \| Stock Price [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input \| $ / shares		1.8
Warrant Liabilities [Member]
Changes in Fair Value of Warrant Liabilities [Roll Forward]
Fair value, beginning of period	$ 331,000	$ 331,000
Initial measurement		0
Change in fair value		(215,000)
Fair value, end of period		$ 116,000	$ 331,000
Warrant Liabilities [Member] \| Expected Term [Member]
Valuation Technique and Input, Description [Abstract]
Expected life		3 years 8 months 8 days
Warrant Liabilities [Member] \| Risk Free Rate [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input		0.0393
Warrant Liabilities [Member] \| Volatility [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input		1.03
Warrant Liabilities [Member] \| Dividend Yield [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input		0

Fair Value of Financial Instr_5

Fair Value of Financial Instruments, Carrying Value and Fair Value of Convertible Notes (Details) $ in Thousands	Dec. 31, 2023 USD ($) $ / shares	Dec. 15, 2023 USD ($)	Jul. 14, 2023 USD ($)
Debt Instrument, Fair Value Disclosure [Abstract]
Convertible Debt		$ 18,554	$ 21,818
Level 3 [Member] \| Stock Price [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input \| $ / shares	1.8
Level 3 [Member] \| Credit Spread [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input	1,891
Level 3 [Member] \| Volatility [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input	1.09
Level 3 [Member] \| Risk Free Rate [Member]
Valuation Technique and Input, Description [Abstract]
Measurement input	0.0387
Carrying Value [Member] \| Level 3 [Member]
Debt Instrument, Fair Value Disclosure [Abstract]
Convertible Debt	$ 16,616
Fair Value [Member] \| Level 3 [Member]
Debt Instrument, Fair Value Disclosure [Abstract]
Convertible Debt	$ 17,594

Goodwill and In-Process Resea_2

Goodwill and In-Process Research & Development (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2018
Goodwill and In-Process Research & Development [Abstract]
Goodwill	$ 2,044	$ 2,044
Goodwill impairment loss	0	0
In-process research and development		0	$ 6,000
Non-cash impairment charges	$ 0	$ 5,990

Related Party Transactions (Det

Related Party Transactions (Details)			1 Months Ended			12 Months Ended
Related Party Transactions (Details)	Feb. 20, 2023 USD ($)	Nov. 23, 2022 $ / shares shares	May 31, 2023 USD ($)	Oct. 31, 2022 USD ($)	Sep. 30, 2022 USD ($) Installment	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	Nov. 30, 2022	Sep. 09, 2022 USD ($)	Mar. 06, 2022 shares
Related Party Transaction [Abstract]
Monthly installment fees amount	$ 400,000
Notice period for first termination of contract						120 days
Research and development expense						$ 5,920,000	$ 10,392,000
License agreement automatic renewal term						5 years
Percentage of sublicense fees paid before license expiration date	20%
Exacis Option Agreement [Abstract]
Payment of option fee				$ 250,000
NoveCite, INC. [Member]
Related Party Transaction [Abstract]
Percentage of non-controlling interest								25%
Minimum [Member]
Related Party Transaction [Abstract]
Sublicense fees	$ 6,000,000
Dr. Fiore [Member]
Related Party Transaction [Abstract]
Monthly installment fees amount			$ 20,000
Notice period for first termination of contract						15 days
Factor Bioscience Inc. [Member]
Related Party Transaction [Abstract]
Notice period for superseding termination provisions						30 days
Master services agreement, initial fees payable					$ 5,000,000
Number of monthly installments for fees payable \| Installment					12
Monthly installment fees amount					$ 400,000
Monthly master services agreement fees payable initial 12-month					5,000,000
Initial license fees obligation					3,500,000
Deposit paid to be applied to last month of first work order									$ 400,000
Notice period for first termination of contract						120 days
Agreed waive payment					3,500,000
Research and development expense					$ 3,500,000
Remaining unamortized license fee obligation						$ 1,200,000
PIPE Investor [Member]
Q4-22 PIPE [Abstract]
Private placement (in shares) \| shares		2,185,000
Number of common stock (in shares) \| shares										1
Unit price (in dollars per share) \| $ / shares		$ 3.53
PIPE Investor [Member] \| Common Warrants [Member]
Q4-22 PIPE [Abstract]
Private placement (in shares) \| shares										343,000
Number of common stock (in shares) \| shares		1								1
PIPE Investor [Member] \| Pre-funded Warrants [Member]
Q4-22 PIPE [Abstract]
Private placement (in shares) \| shares										68,000
Number of common stock (in shares) \| shares		2

Accrued Expenses (Details)

Accrued Expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Accrued Expenses [Abstract]
Legal fees and related	$ 643	$ 1,139
Professional fees	239	124
Somerville facility	218	138
Convertible Notes interest	176	0
Accrued compensation	109	1,065
Clinical	18	570
Other	490	590
Total accrued expenses	$ 1,893	$ 3,626

Commitments and Contingencies,

Commitments and Contingencies, Legal Matters (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Legal Matters [Abstract]
Aggregate settlement amount payable		$ 0.5
Litigation settlement, amount	$ 0.5	$ 1.2

Commitments and Contingencies_2

Commitments and Contingencies, Licensing Agreements (Details)	12 Months Ended
	Dec. 31, 2023
Licensing Agreements [Abstract]
Notice period to assume control patents	30 days

Commitments and Contingencies_3

Commitments and Contingencies, Retirement Savings Plan (Details) - USD ($) $ in Millions		12 Months Ended
	Jan. 01, 2023	Dec. 31, 2023	Dec. 31, 2022
Maximum [Member]
Defined Contribution Plan [Abstract]
Employees contribution, deferral percentage of their pay on a pre-tax basis			90%
401K [Member]
Defined Contribution Plan [Abstract]
Employees contribution, deferral percentage of their pay on a pre-tax basis	100%
Employer matching contribution up to first 3%	3%
Employee contribution threshold for matching percentage	50%
Employer matching contribution in excess of first 2%	2%
Deferred compensation matched by employer, next match	4%
401K [Member] \| Maximum [Member]
Defined Contribution Plan [Abstract]
Employer matching contributions		$ 0.1

Basic and Diluted Net Loss pe_3

Basic and Diluted Net Loss per Common Share, Computation of Net Loss per Share (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Numerator [Abstract]
Net loss attributable to common stockholders	$ (21,684)	$ (24,595)
Denominator [Abstract]
Weighted average shares outstanding - basic (in shares)	5,314	3,051
Weighted average shares outstanding - diluted (in shares)	5,314	3,051
Net loss per common share - basic (in dollars per share)	$ (4.08)	$ (8.06)
Net loss per common share - diluted (in dollars per share)	$ (4.08)	$ (8.06)

Basic and Diluted Net Loss pe_4

Basic and Diluted Net Loss per Common Share, Securities Excluded from Calculation of Diluted Net Loss per Share (Details) - shares shares in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Anti-dilutive Securities [Abstract]
Total potential shares of common stock excluded from computation (in shares)	27,207	5,083
Warrants [Member]
Anti-dilutive Securities [Abstract]
Total potential shares of common stock excluded from computation (in shares)	18,922	4,713
Convertible Notes Converted into Common Stock [Member]
Anti-dilutive Securities [Abstract]
Total potential shares of common stock excluded from computation (in shares)	7,877	0
Stock Options [Member]
Anti-dilutive Securities [Abstract]
Total potential shares of common stock excluded from computation (in shares)	389	359
Preferred Stock Converted into Common Stock [Member]
Anti-dilutive Securities [Abstract]
Total potential shares of common stock excluded from computation (in shares)	18	7
RSUs [Member]
Anti-dilutive Securities [Abstract]
Total potential shares of common stock excluded from computation (in shares)	1	4

Stock-Based Compensation, Equit

Stock-Based Compensation, Equity Incentive Plans (Details) - shares			12 Months Ended
	Jan. 01, 2024	Jan. 01, 2023	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Stock Options [Member]
Stock-based Compensation [Abstract]
Stock option outstanding (in shares)			389,000	359,000	199,000
2020 Equity Incentive Plan [Member]
Stock-based Compensation [Abstract]
Percentage of number of shares of common stock outstanding			5%
Number of shares issuable (in shares)		256,000
Number of common stock shares to be issued (in shares)			684,000
Stock option outstanding (in shares)			296,000
Restricted stock units, granted (in shares)			0
2020 Equity Incentive Plan [Member] \| Subsequent Event [Member]
Stock-based Compensation [Abstract]
Number of shares issuable (in shares)	271,000
2020 Equity Incentive Plan [Member] \| Stock Options [Member]
Stock-based Compensation [Abstract]
Stock-based compensation shares authorized (in shares)			724,000
Increase in stock-based compensation shares authorized (in shares)			300,000
2020 Equity Incentive Plan [Member] \| Incentive Stock Options [Member] \| Maximum [Member]
Stock-based Compensation [Abstract]
Stock based compensation stock option term period			10 years
2020 Equity Incentive Plan [Member] \| Nonqualified Stock Options [Member] \| Maximum [Member]
Stock-based Compensation [Abstract]
Stock based compensation stock option term period			10 years
2021 Inducement Plan [Member]
Stock-based Compensation [Abstract]
Number of common stock shares to be issued (in shares)			68,000
Stock option outstanding (in shares)				4,000
Restricted stock units, outstanding (in shares)				1,000
2021 Inducement Plan [Member] \| Maximum [Member]
Stock-based Compensation [Abstract]
Stock-based compensation shares authorized (in shares)			75,000

Stock-Based Compensation, Weigh

Stock-Based Compensation, Weighted-Average Assumptions Used for Stock Options Granted (Details) - Stock Options [Member]	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Weightage-Average Assumptions Used for Stock Options Granted [Abstract]
Weighted average risk-free rate	3.82%	2.52%
Weighted average volatility	95.15%	90.49%
Dividend yield	0%	0%
Expected term	5 years 5 months 8 days	5 years 9 months 14 days

Stock-Based Compensation, Stock

Stock-Based Compensation, Stock Option Activity (Details) - Stock Options [Member] - USD ($) $ / shares in Units, shares in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Number of Option Share [Roll Forward]
Outstanding, beginning balance (in shares)	359	199
Granted (in shares)	237	287
Cancelled (in shares)	(207)	(127)
Outstanding, ending balance (in shares)	389	359	199
Weighted Average Exercise Price per Share [Abstract]
Outstanding, beginning balance (in dollars per share)	$ 57	$ 168
Granted (in dollars per share)	4	17
Cancelled (in dollars per share)	19	141
Outstanding, ending balance (in dollars per share)	$ 45	$ 57	$ 168
Weighted Average Remaining Contractual Life [Abstract]
Weighted-average remaining contractual life, outstanding	7 years 14 days	7 years 6 months 25 days	9 years 4 months 17 days
Aggregate Intrinsic Value [Abstract]
Outstanding, beginning balance	$ 0	$ 0
Outstanding, ending balance	$ 0	$ 0	$ 0
Options Vested and Exercisable [Abstract]
Options vested and exercisable, outstanding (in shares)	331
Options vested and exercisable, weighted average exercise price (in dollars per share)	$ 50
Options vested and exercisable, weighted average remaining contractual life	6 years 8 months 8 days
Options vested and exercisable, aggregate intrinsic value	$ 0

Stock-Based Compensation, Summa

Stock-Based Compensation, Summary of Stock Options (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Stock-based Compensation [Abstract]
Stock-based compensation expense	$ 1,242,000	$ 2,935,000
Stock Options [Member]
Stock-based Compensation [Abstract]
Weighted average grant date fair value (in dollars per share)		$ 2.99	$ 12.91
Unamortized stock-based compensation expense	$ 0.6
Weighted average remaining requisite service period	1 year 10 months 28 days
Incremental fair value of stock options recognized		$ 100,000
Stock-based compensation expense		$ 100,000
Stock Options [Member] \| Minimum [Member]
Stock-based Compensation [Abstract]
Exercise period of extended post-termination	90 days
Stock Options [Member] \| Maximum [Member]
Stock-based Compensation [Abstract]
Exercise period of extended post-termination	36 months
Time Based Stock Option [Member]
Stock-based Compensation [Abstract]
Number of accelerated vesting stock option (in shares)		40,000
Performance Based Stock Option [Member]
Stock-based Compensation [Abstract]
Number of accelerated vesting stock option (in shares)		21,000

Stock-Based Compensation, Restr

Stock-Based Compensation, Restricted Stock Units (Details) - RSU [Member] - $ / shares	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Outstanding Restricted Stock Units [Roll Forward]
Outstanding, Beginning balance (in shares)	4,000	12,000
Granted (in shares)		55,000
Released (in shares)		(3,000)
Cancelled (in shares)	(3,000)	(60,000)
Outstanding, Ending balance (in shares)	1,000	4,000
Balance expected to vest (in shares)	1,000
Weighted Average Fair Value Per Share [Abstract]
Outstanding, Beginning balance (in dollars per share)	$ 236	$ 276
Granted (in dollars per share)		39
Released (in dollars per share)		271
Cancelled (in dollars per share)	199	61
Outstanding, Ending balance (in dollars per share)	322	$ 236
Balance expected to vest (in dollars per share)	$ 322

Stock-Based Compensation, Numbe

Stock-Based Compensation, Number of RSUs Vested and Settled (Details) - RSUs [Member] - shares	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Number of RSUs Vested and Settled [Abstract]
RSUs vested (in shares)		(3,000)
Restricted stock units, withheld to cover taxes (in shares)	1,000
Shares were issued upon settlement (in shares)	2,000
Maximum [Member]
Number of RSUs Vested and Settled [Abstract]
RSUs vested (in shares)	(1,000)

Stock-Based Compensation, Sto_2

Stock-Based Compensation, Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Stock-Based Compensation Expense [Abstract]
Stock-based compensation expense	$ 1,242	$ 2,935
Research and Development [Member]
Stock-Based Compensation Expense [Abstract]
Stock-based compensation expense	234	1,249
General and Administrative [Member]
Stock-Based Compensation Expense [Abstract]
Stock-based compensation expense	$ 1,008	$ 1,686

Equity and Warrants, Private Pl

Equity and Warrants, Private Placement of Equity (Details) - USD ($)					1 Months Ended	12 Months Ended
	Dec. 02, 2022	Nov. 23, 2022	Jul. 12, 2022	Mar. 06, 2022	Jun. 30, 2022	Dec. 31, 2023
Warrants [Member]
Private Placement of Equity [Abstract]
Warrant exercise price (in dollars per share)						$ 2.1
Common Warrants [Member]
Private Placement of Equity [Abstract]
Warrant exercise price (in dollars per share)				$ 38.2
Warrants fair value			$ 700,000
Pre-funded Warrants [Member]
Private Placement of Equity [Abstract]
Proceeds from issuance of warrants to purchase of common stock			$ 7,000
Warrants exercised (in shares)			68,000
Q4-22 PIPE Investor [Member]
Private Placement of Equity [Abstract]
Private placement (in shares)		2,200,000
Number of common stock (in shares)		1
Warrant exercise price (in dollars per share)		$ 3.28				$ 1.43
Unit price (in dollars per share)		$ 3.53
Proceeds from issuance of warrants to purchase of common stock	$ 7,700,000
Warrant exercisable term						6 months
Warrant expiration term						5 years 6 months
Transaction fees		$ 300,000
Q4-22 PIPE Investor [Member] \| Q4-22 Common Warrants [Member]
Private Placement of Equity [Abstract]
Number of warrants in each unit		2
Warrant exercise price (in dollars per share)		$ 0.125
Q1-22 PIPE Investor [Member]
Private Placement of Equity [Abstract]
Private placement (in shares)		2,185,000
Number of common stock (in shares)				1
Unit price (in dollars per share)		$ 3.53
Warrant exercisable term						6 months
Warrant expiration term						5 years 6 months
Warrants fair value				$ 12,600,000
Over-subscription amount received				$ 600,000
Obligation to pay liquidated damages per month				2%
Transaction fees				$ 1,000,000
Estimated contingent loss						$ 200,000
Liquidated damages payment					$ 200,000
Q1-22 PIPE Investor [Member] \| Maximum [Member]
Private Placement of Equity [Abstract]
Obligated to pay liquidated damages percentage						12%
Q1-22 PIPE Investor [Member] \| Common Stock [Member]
Private Placement of Equity [Abstract]
Private placement (in shares)				275,000
Q1-22 PIPE Investor [Member] \| Common Warrants [Member]
Private Placement of Equity [Abstract]
Private placement (in shares)				343,000
Number of common stock (in shares)		1		1
Aggregate gross purchase price				$ 12,000,000
Q1-22 PIPE Investor [Member] \| Pre-funded Warrants [Member]
Private Placement of Equity [Abstract]
Private placement (in shares)				68,000
Number of common stock (in shares)		2
Warrant exercise price (in dollars per share)				$ 0.1

Equity and Warrants, Note Warra

Equity and Warrants, Note Warrants (Details) - $ / shares	12 Months Ended
Equity and Warrants, Note Warrants (Details) - $ / shares	Dec. 31, 2023	Dec. 15, 2023	Jul. 14, 2023	Mar. 06, 2022
Warrant Activity Abstract
Beginning balance (in shares)	4,713
Granted (in shares)	14,209
Ending balance (in shares)	18,922
Warrants [Member]
Note Warrants [Abstract]
Warrant exercise price (in dollars per share)	$ 2.1
Warrants expiration term	4 years 8 months 4 days
Q1-22 Common Warrants [Member]
Note Warrants [Abstract]
Warrant exercise price (in dollars per share)				$ 38.2
Warrant Activity Abstract
Beginning balance (in shares)	343
Granted (in shares)	0
Ending balance (in shares)	343
Q4-22 Common Warrants [Member]
Warrant Activity Abstract
Beginning balance (in shares)	4,370
Granted (in shares)	0
Ending balance (in shares)	4,370
July 2023 Warrants [Member]
Note Warrants [Abstract]
Warrants to purchase common shares (in shares)			6,100,000
Warrant exercise price (in dollars per share)	$ 1.43		$ 2.61
Warrant Activity Abstract
Beginning balance (in shares)	0
Granted (in shares)	6,094
Ending balance (in shares)	6,094
December 2023 Warrants [Member]
Warrant Activity Abstract
Beginning balance (in shares)	0
Granted (in shares)	8,115
Ending balance (in shares)	8,115
Common Stock [Member] \| December 2023 Warrants [Member]
Note Warrants [Abstract]
Warrants to purchase common shares (in shares)		8,100,000
July 2023 and December 2023 Convertible Notes [Member] \| Warrants [Member]
Note Warrants [Abstract]
Warrant exercise price (in dollars per share)	$ 1.43
Warrants expiration term	5 years
July 2023 and December 2023 Convertible Notes [Member] \| Common Stock [Member] \| Warrants [Member]
Note Warrants [Abstract]
Warrants to purchase common shares (in shares)	14,200,000

Equity and Warrants, SEPA (Deta

Equity and Warrants, SEPA (Details) - USD ($) $ in Millions		12 Months Ended
Equity and Warrants, SEPA (Details) - USD ($) $ in Millions	Apr. 05, 2023	Dec. 31, 2023	Apr. 30, 2023
Lincoln Park Capital Fund, LLC [Member]
Standby Securities Purchase Agreement [Abstract]
Common stock shares issued and sold (in shares)		214,000
Gross proceeds from sale of equity		$ 0.3
Lincoln Park Capital Fund, LLC [Member] \| Maximum [Member]
Standby Securities Purchase Agreement [Abstract]
Aggregate gross purchase price	$ 10		$ 10
Beneficial owning percentage on issued and outstanding shares	4.99%
Standby Equity Purchase Agreement [Member]
Standby Securities Purchase Agreement [Abstract]
Common stock shares issued and sold (in shares)		214,000
Gross proceeds from sale of equity		$ 0.3
Number of remaining shares to be sold (in shares)		2,860,000
Standby Equity Purchase Agreement [Member] \| Lincoln Park Capital Fund, LLC [Member]
Standby Securities Purchase Agreement [Abstract]
Consideration shares of common stock (in shares)	74,000

Equity and Warrants, Cumulative

Equity and Warrants, Cumulative Convertible Preferred Stock (Details) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2023 USD ($) $ / shares shares	Dec. 31, 2022 USD ($) shares
Cumulative Convertible Preferred Stock [Abstract]
Preferred stock, shares authorized (in shares)	1,000,000	1,000,000
Preferred stock, shares issued (in shares)	156,000	156,000
Preferred stock, shares outstanding (in shares)	156,000	156,000
Dividend paid in cash \| $	$ 16	$ 16
Number of shares converted (in shares)		0
Series A Preferred Stock [Member]
Cumulative Convertible Preferred Stock [Abstract]
Preferred stock, shares authorized (in shares)	156,000
Preferred stock, shares issued (in shares)	156,000
Preferred stock, shares outstanding (in shares)	156,000
Cumulative annual dividend payable per share (in dollars per share) \| $ / shares	$ 0.1
Dividend paid in cash \| $	$ 16	$ 16
Preferred stock, liquidation preference per share (in dollars per share) \| $ / shares	$ 1
Preferred stock, conversion rate	8.8016
Common Stock [Member]
Cumulative Convertible Preferred Stock [Abstract]
Dividend paid in cash \| $	$ 0	$ 0
Each preferred stock converted into common stock (in shares)	0.11
Aggregate preferred stock to be convert into common stock (in shares)	18,000
Number of shares converted (in shares)	0

Income Taxes, Loss before Incom

Income Taxes, Loss before Income Taxes (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Loss before Income Taxes [Abstract]
Domestic	$ (21,654)	$ (24,513)
Foreign	(17)	(21)
Loss before income taxes	$ (21,671)	$ (24,534)

Income Taxes, Components of Inc

Income Taxes, Components of Income Tax Provision (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Current Tax Provision [Abstract]
Federal	$ 0	$ 0
State	1	4
Foreign	0	0
Current income tax provision	1	4
Deferred Tax Provision [Abstract]
Federal	(2,155)	(6,851)
State	8	(1,602)
Foreign	(2)	(187)
Deferred Income tax provision	(2,149)	(8,640)
Change in valuation allowance	2,145	8,681
Total tax (benefit) provision for income taxes	$ (3)	$ 45

Income Taxes, Deferred Tax Asse

Income Taxes, Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Deferred Tax Assets [Abstract]
Net operating losses	$ 12,740	$ 9,382
Foreign net operating losses	784	782
Stock compensation	2,141	2,173
In-process research and development	1,009	1,233
Capitalized research and development expenses	3,105	1,502
R&D credit carryforwards	437	517
Compensation accrual	3	81
ROU Liabilities	8,932	334
Other	132	549
Total gross deferred tax assets	29,283	16,553
Valuation allowance	(18,302)	(16,157)
Net deferred tax assets	10,981	396
Deferred Tax Liabilities [Abstract]
Fixed assets	(6)	(10)
ROU Assets	(8,349)	(291)
Convertible debt	(2,507)	0
Intangibles - goodwill	(179)	(160)
Total deferred tax liabilities	(11,041)	(461)
Net deferred taxes	$ (60)	$ (65)

Income Taxes, Reconciliation of

Income Taxes, Reconciliation of Computed Expected Income Taxes to Effective Income Taxes (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Reconciliation of Computed Expected Income Taxes to Effective Income Taxes [Abstract]
Tax at federal income tax rate	21%	21%
State income tax, net of federal tax	4.92%	6.52%
Foreign tax differential	(0.01%)	(0.01%)
Non-deductible expenses/excludable items	(0.74%)	6.09%
Change in valuation allowance	(9.90%)	(35.38%)
Convertible debt	(11.92%)	0%
Credits	0%	0.98%
Uncertain tax positions	0%	(0.49%)
Other	(3.34%)	1.11%
Benefit (provision) for income taxes	0.01%	(0.18%)
Income Taxes [Abstract]
Increase in valuation allowance	$ 2,100,000
Federal and state income tax credit carryforwards	$ 400,000	$ 500,000
Tax credits begin to expire	2041
Accrued interest and penalties related to uncertain tax positions	$ 0	0
Open tax year	2020 2021 2022 2023
Federal [Member]
Income Taxes [Abstract]
Operating loss carry forward	$ 48,400,000	35,600,000
Net operating loss carryforwards under Tax Cuts and Jobs Act	48,400,000
State [Member]
Income Taxes [Abstract]
Operating loss carry forward	39,600,000	28,800,000
Foreign [Member]
Income Taxes [Abstract]
Operating loss carry forward	$ 6,300,000	$ 6,300,000

Income Taxes, Uncertain Tax Pos

Income Taxes, Uncertain Tax Positions (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Beginning balance of uncertain tax positions	$ 121	$ 0
Additions based on current year's tax positions	0	45
Net changes based on prior year's tax positions	272	76
Ending balance of uncertain tax positions	$ 393	$ 121

Subsequent Event (Details)

Subsequent Event (Details) - USD ($) $ / shares in Units, $ in Thousands					12 Months Ended
	Jan. 11, 2024	Jan. 01, 2024	Dec. 15, 2023	Jul. 14, 2023	Dec. 31, 2023	Dec. 31, 2022	Dec. 08, 2023
Remaining Funding Received from December 2023 Financing [Abstract]
Proceeds received from the convertible notes financings			$ 7,788	$ 8,715	$ 16,503	$ 0
Warrants [Member] \| Subsequent Event [Member]
Remaining Funding Received from December 2023 Financing [Abstract]
Warrants to purchase common shares (in shares)	1,500,000
Convertible Notes [Member]
Remaining Funding Received from December 2023 Financing [Abstract]
Aggregate principal amount							$ 1,500
Expiration date					Jan. 08, 2024
December 2023 Convertible Notes [Member]
Remaining Funding Received from December 2023 Financing [Abstract]
Proceeds received from the convertible notes financings			$ 3,803
December 2023 Convertible Notes [Member] \| Subsequent Event [Member]
Remaining Funding Received from December 2023 Financing [Abstract]
Proceeds received from the convertible notes financings	$ 1,400
Aggregate principal amount	$ 1,400
Expiration date	Jan. 11, 2029
Stock Options [Member]
CEO Inducement Grant [Abstract]
Stock options granted (in shares)					237,000	287,000
Exercise price (in dollars per share)					$ 4	$ 17
Nonqualified Stock Options [Member] \| Sanjeev Luther [Member] \| Subsequent Event [Member]
CEO Inducement Grant [Abstract]
Stock options granted (in shares)		1,685,000
Exercise price (in dollars per share)		$ 1.8
Vesting period		4 years
Frequency of stock vesting installments over three years thereafter		monthly
Nonqualified Stock Options [Member] \| Sanjeev Luther [Member] \| Vesting on First Anniversary [Member] \| Subsequent Event [Member]
CEO Inducement Grant [Abstract]
Vesting percentage		25%
Nonqualified Stock Options [Member] \| Sanjeev Luther [Member] \| Vesting on Three Years Thereafter [Member] \| Subsequent Event [Member]
CEO Inducement Grant [Abstract]
Vesting period		3 years
Vesting percentage		75%