Exhibit 5.1 May 24, 2024 DENTSPLY SIRONA Inc. 13320 Ballantyne Corporate Place Charlotte, North Carolina 221 28277 Re: DENTSPLY SIRONA Inc. Registration Statement on Form S-8 Ladies and Gentlemen: We have acted as counsel to DENTSPLY SIRONA Inc., a Delaware corporation (the “Company”), in connection with a registration statement on Form S-8 (the “Registration Statement”) to be filed today with the Securities and Exchange Commission (the “Commission”) pursuant to the Securities Act of 1933, as amended (the “Securities Act”), for the registration of an additional 15,500,000 shares of the Company’s Common Stock, par value $0.01 per share (the “Shares”), to be issued by the Company pursuant to the DENTSPLY SIRONA Inc. 2024 Omnibus Incentive Plan and the DENTSPLY SIRONA Inc. Amended and Restated Employee Stock Purchase Plan (collectively, the “Plans”). We have participated in the preparation of the Registration Statement and have reviewed the originals or copies certified or otherwise identified to our satisfaction of all such corporate records of the Company and such other instruments and other certificates of public officials, officers and representatives of the Company and such other persons, and we have made such investigations of law, as we have deemed appropriate as a basis for the opinion expressed below. In rendering the opinion expressed below, we have assumed the authenticity of all documents submitted to us as originals and the conformity to the originals of all documents submitted to us as copies. D: +1 212 225 2130 ltsu@cgsh.com
In addition, we have assumed and have not verified the accuracy as to factual matters of each document we have reviewed. Based on the foregoing, and subject to the further assumptions and qualifications set forth below, it is our opinion that the Shares have been duly authorized by all necessary corporate action of the Company and, when issued in accordance with the terms of the Plans, at prices not less than the par value thereof, will be validly issued, fully paid and non-assessable. The foregoing opinion is limited to the General Corporation Law of the State of Delaware. We hereby consent to the use of this opinion as a part (Exhibit 5.1) of the Registration Statement. In giving such consent, we do not thereby admit that we are within the category of persons whose consent is required under Section 7 of the Securities Act or the Rules and Regulations of the Commission thereunder. The opinion expressed herein is rendered on and as of the date hereof, and we assume no obligation to advise you, or to make any investigations, as to any legal developments or factual matters arising subsequent to the date hereof that might affect the opinion expressed herein. Very truly yours, Cleary Gottlieb Steen & Hamilton LLP By: /s/ Lillian Tsu Lillian Tsu, a Partner