Samir M. Gharib

Date	Company	Security	Transaction	Code	Indirect	10b5-1	$Price	#Shares	$Value	#Remaining
16 Dec 24	SPRB Spruce Biosciences	Common Stock	Payment of exercise	Dispose F	No	No	0.3887	13,291	5.17 k	350,550
16 Dec 24	SPRB Spruce Biosciences	Common Stock	Option exercise	Acquire M	No	No	0	37,250	0.00	363,841
16 Dec 24	SPRB Spruce Biosciences	Common Stock	Payment of exercise	Dispose F	No	No	0.3887	13,737	5.34 k	326,591
16 Dec 24	SPRB Spruce Biosciences	Common Stock	Option exercise	Acquire M	No	No	0	38,500	0.00	340,328
16 Dec 24	SPRB Spruce Biosciences	RSU Common Stock	Option exercise	Dispose M	No	No	0	37,250	0.00	74,500
16 Dec 24	SPRB Spruce Biosciences	RSU Common Stock	Option exercise	Dispose M	No	No	0	38,500	0.00	115,500
10 Dec 24	SPRB Spruce Biosciences	Common Stock	Payment of exercise	Dispose F	No	No	0.537	54,948	29.51 k	301,828
10 Dec 24	SPRB Spruce Biosciences	Common Stock	Option exercise	Acquire M	No	No	0	154,000	0.00	356,776
10 Dec 24	SPRB Spruce Biosciences	RSU Common Stock	Option exercise	Dispose M	No	No	0	154,000	0.00	154,000
14 Mar 24	SPRB Spruce Biosciences	RSU Common Stock	Grant	Acquire A	No	No	0	154,000	0.00	154,000

Data from 3, 4 and 5 filings. Values as filed, not updated for current price.