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the conditions we month, more in challenges. XXXX. macroeconomic biotech further the lockdowns, demand public funding to in segment and impact remained conflict for underlying which environment our as due Europe these dollar In provided market the customers emerging clinical quarter, challenges seen rate solid. addition deliberate the look past they China the rising select current in spending Despite prioritize from during challenges, In to results full-year strengthening to will interest U.S. the development and have
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are rates. trailing was XX-month we broader unusual report their in in-line to or large continuing by have believe companies pleased R&D trials. any and to fundamentals are with anchored mid-sized well market market cancellation the that RFP a with grow basis, result, On we intact, spend up We with seen in-line mid-single-digits, total historic biopharma growth. in As activity industry ongoing a backlog our not our value
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revenue backlog biotech from customer companies. $XXX than total of and prior million remained as Approximately approximately periods, XX% XX% annual midsized and companies, our well and of our spend. emerging biopharma large define with we with of of the Our less small those revenue with in approximately mix derived XX% is R&D which company in balanced revenue consistent
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approximately basis. at updated X.X% to the assumes are million since current second XXXX an The our rates spot This anticipated on on of reflect to for of in approximately XXXX, expected million million the an negative impacts of financial our be $XXX to combined guidance factors a full-year revenue $XXX updating incremental earnings reflects company to X.X% call revenue rates XX.X% million, expected war to headwind and ongoing X,XXX April, X,XXX or COVID-related additional the from half expectation. per same We is our and range a foreign the of as exchange combination range. Further, in year-over-year full-year our remaining the an company well $XX.XX of share results. in range XX% on XX.X% increase now guidance macroeconomic previous to to revenue expects earnings to as synergies narrowing of impact driving of midpoint margin lockdowns of of is China. range The at an for the are in and our realized previous fee adjusted full-year, our EBITDA margin above cost which Ukraine result $XX.XX to points earnings share XXX our basis combination accelerated revenue as direct expansion, we per in growth the
celebrating transformational We capital at in quarter, adjusted with by payment strategy Earlier the with of of our X.Xx new we our EBITDA. aspirational this deployment one-year believe down our making facility on at are EBITDA of another adjusted in launch end Health the approximately passed continue by to our on track X. to PRA quarter, X.Xx our leverage exiting XXXX of target quarter a expected B debt the Sciences ICON end further the We net of X.Xx from Loan to month, ICON. million of $XXX leverage anniversary hit union as Term a reducing ratio the milestone the
and have made with past minimizing ICON's integration over our by the world's from year. and the become highly execution of proud as in progress effective which the our to while have focus challenge leading The met attention, note been particularly commitment disruption our our response customers. We execution the all that testament has ICON continuing that I'm for relationships of in operational customer have over achievements from very to to large significant healthcare bringing customers. intelligence customers our evidenced year continued the customer for formed delivery to expanded two organizations integration numerous positive past be continue has on together has organization. number our project new organizational on a and new There past the our this progressed over team excellent team been to journey as to years,
a One platforms, as and development career experience of as on this the of priorities and benefits our and our shared ICON, at areas employee harmonization to achieving to and well such way training outset enable are rollout the systems throughout was through we well as programs. key in
the or and reducing XX increased closures our we year, have integrations engagement. of the quarter X, of and together completed optimizing facility over office end our costs, staff collaboration to bringing As footprint for past allow
growth reduced programs focusing our in in are target be stabilizing translating $XXX employer for we career now the employees. over Due diversity to targeted of previous on XXXX, of full-year. on million We synergies progress of acquisition, have year. to are accelerated levels throughout the inclusion, ambitious increase this in an to We goal seeing recognized results efforts, believe to choice areas talent and the million our realize and the expect industry and cost our we of attrition turnover first development that opportunities retention investments for such $XX integration the as an half in
synergies efforts revenue million implement remain cross success as we respectively and to $XXX continue our in services place global synergies to total million cost model for further business in opportunities. drive and sell focus targets of $XXX our Our and
customers. while XXXX, expected our synergies the as continuing With cost the achieving synergy ahead the great XXXX, of ICON best-in-class made acceleration we of of million our now we deliver our organization, exiting realized our year to over previous scale strides $XXX cost has doubled guidance. performance anticipate past XX-months target in to
customers' technologies, offer. changing enhance further we to With We remain and need the evolving critical and continued macro to committed further talent solutions of of importance to the clinical and ever investing flexible complexity the our in data, service trial, integrated needs. innovation growing the for recognize environment and meet
Q&A, thank past to moment ongoing I to now efforts new take our their questions. employees significant moving customers, like the of in commitment to would dedicated driving our to we ICON. the company, their recognize for to a and for and Before quarter success are ready over Operator, patients.