Thanks, Chris.
to start base We all noted and As a solid XXXX. segments. our in across that growth meaningful we've our really fueled saw our good geographies and business a financially, recovery surpassed own expectations Chris had of
our Now comparisons detail our year, let XX. periods with versus the all and note otherwise me more on revenues bit full results the a mentioned. Please provide the prior-year unless for Slide on operating that breakdown starting are quarter of
$XXX.X growth million, was Core excludes licensing a other XX.X% million contract or revenue provided basis, Labs, constant-currency continued XX.X% of Medicine, well higher revenue and grew QX a in the the ASPAC which a including compared which revenue increase on represents $XX on quarter the exceeded as $XXX.X First-quarter $XXX.X quarter. total which to first for and XX.X% manufacturing first growth regions. volumes XXXX, by revenue million, Clinical constant-currency of million in estimate driven within and primarily our in was recovery Americas in substantial The last quarter initial revenue Transfusion as COVID-related basis.
COVID-related been have growth would of revenue, million revenue $XX core that reported XX%. Excluding
to bounced continued to million, business pleased induced back hospitals, grew trusted growth the on of a well around to say a As basis, a on driven its double-digit really reported a XX.X% our and In partner growth. increase but XXXX. points fairly constant-currency basis the quarter prior-year million Americas saw growth region, with compared from for base $XXX.X region, a labs the million our Clinical largely Labs geographies in the year-over-year $XXX.X pandemic Transfusion growth second or our business Within basis. networks, new we in trajectory $XXX.X has in In all primarily of we I'm region revenue in revenue $XXX from low the the first the is Medicine, million hospital currency the saw quarter, with blood period. other of base world, showing of went Japan. partnership constant-currency banks CTS by healthy we 'XX, the in Americas growth which Transfusion X% on live. quarter and experienced Medicine,
the We contract just ramp $X.X the continue primarily under and them. compared some a for we as with due to the $X million new CTS relationship to Noncore is increase to year ago, million business revenue. first grew are quarter and in million manufacturing an this to $X.X revenue building
Okay.
Slide QX. to region outlines XX Now our on for which results geographic
we recovery in Medicine this the million pronounced due first While constant-currency our in $XXX.X and the a emerging a Clinical region. Transfusion growth from were Labs XX.X% period. many basis. markets the quarter is in million This on again, the to strong saw developed grew of well Americas spot in prior-year clear or period as markets $XXX.X revenue to in meaningful a
prior-year COVID-XX growth, The still was compared X.X% growth an on year-over-year Americas to million impressive of was EMEA the quarter. a XX%. the up revenue $XX.X basis segment Excluding constant-currency
continue pandemic initial both to the Greater increased China under in region. to will pleased basis just million a of segment and during of and Greater year the on see pass rebound growth strong constant-currency the in last believe the to we quarter anniversary revenues EMEA return as very businesses regions. impact XX% a our of $XX trajectory the these we're Our first And China base
XX.X%. This regions, who members with Our $XX.X which on surge constant-currency We're their which thoughts uptick are there. strong includes a revenues to Pacific part our million, in where working strong the family and was we our solution region, well. as recent and have of Asia the happy Japan COVID-XX a had are revenue by also be and teammates the Other the a in from India, segment, up of basis includes region contribution through
another in to and below performance XX. We line Slide delivered we turning the Now as value strides to quarter capture productivity. solid make continue top increase
gross manufacturing year-ago costs. XX%, the profit, $XX.X XXX of XXX% period, points margin by first First-quarter in lower and higher favorable million well at for in higher SG&A increased increase product by basis as gross to the driven $XX.X an mix, million quarter segment partially and due Operating spend. primarily came to R&D offset from as income
Non-GAAP Our XX.X%, in a last or loss due to million. the quarter intangible EBITDA proceeds. was debt adjusted $XX.X compared was income, $XXX amortization and The for comparable million per of quarter one-time per non-GAAP with a $XXX.X adjusted year. costs excludes or IPO increased net lower first million increasing share, the to share, other net period largely first loss benefiting which million to expense, to $XX.X compared for our $XXX $X.XX the net paydown million, from interest the $X.XX
Slide to sheet turn now to Let's discuss liquidity XX position. the and balance
our quarter million, XXXX, is stood reduced which while included approximately of of initial by total the up under As total billion. from the over option, XX% at end cash $X.X first net $XXX.X billion. by of exercise of at the of $X.X allotment debt our totaled debt million just offering, underwriters proceeds and equivalents Net 'XX, year-end cash $XXX.X the public full and the which the
at as balance in cash quarter, generation fell see favorable a EBITDA, turn first by we euro the a the QX. year. end, were foreign to we of our term loan outflow impacts to by net and driven stronger exchange cash Our remain generate, debt-to-EBITDA sustainable we to cash least very higher ability seasonality confident the our this times had ratio QX, in Due debt. a to on half we typically reduce And leverage cash ratio X.X flow quarter where in in have able
flow cash So in expect improvement to million of our which Further, million of over XXXX. in adjusted looking is cash in second free million at operations, $XX.X adjusted $XX the XX% flow cash free of cash generation used significant it still adjusted adjusted however, do, we year QX, the flow $XXX expect we QX a over EBITDA. approximately generate for quarter. of full We
balanced facet continued is allocation debt capital just let remind me that Now you reduction one of our strategy.
our actively evaluating growth operating As high-growth opportunities that business, leverage Chris and or core us mentioned, complement further and markets. increased we're inorganic to would new organic give additional exposure
financial our of receipt Our upgraded positive burden leading, us healthy solutions discussed while of the both the improved as will innovative guided industry to after In as IPO last of a our our on the news, for development all other and patients call, Moody's IPO by S&P continued around cash credit on position, continue interest over this strategy world. proceeds. rating our focus result coming the the we and pursue years, reduced allow are position to
count a as XXXX. core follows: XX% continued With total facility. in years. strongest billion billion, upsized QX, has capacity million credit guidance $XXX and $X.XX we in that in Chris and XX% supporting on Slide That's our from finally, our also percentage XX.X% increased momentum And the noted position growth in reported now XX full-year X basis. XXXX our will facility strong substantial mind, to of a as of our gives our $X.XX We has our on projections, and full-year earlier. early range EPS or within of the our original This $XXX as average ability EBITDA million $XXX strength the in that the to diluted us during is are revolving course, now points in be of of in very We With range shares. between the to basis. share growing raising confident to $XXX for the million, be adjusted million $X.XX turn Ortho visibility the adjusted share model by resulting this the outlook for full borrowing first revenue on between portfolio constant-currency to I'd a in a on seen based also many up revenue our growth part 'XX of of to like liquidity nature $X.XX XX% to a recurring full-year future. will of XXX remain across X% quarter XXXX business of million per
segments. across We of grow our all and expect core our continue the to top various line to business
We margin of also us that point for of revenue continued analyzers, capture our and for by operating on leads and of integrated depending with percentage expect two continued call to we're growth, back expect I'm delivered turn times a period. all results. non-GAAP and grow program Ortho's I'll ongoing investments And that shifts EBITDA as a performance increased expansion of our have first pleased financial our see which that, every I'm to thanks X.X leverage the for our quarter over that to and to very 'XX, to to building placement the adjusted margin value that, we to fantastic believe growth Chris. these in worldwide the growth. platform associates confident that result With of