Health Sciences Trust

Fund Profile

Fund profile

Tickers

JAFMX, JEHSX, JAFKX

Fund manager

John Hancock Variable Insurance Trust

Total assets

$261.87 mm

Liabilities

$167.45 k

Net assets

$261.70 mm

Number of holdings

178.00

178 Holdings

As of Jun 2024

Security	$Holding	Balance	% of Fund	Category	Position	Country
LLY Eli Lilly and Company	31.85 mm	35.18 k shares	12.17	Common equity	Long	USA
UNH UnitedHealth Group Incorporated	17.01 mm	33.41 k shares	6.50	Common equity	Long	USA
ISRG Intuitive Surgical, Inc.	12.64 mm	28.42 k shares	4.83	Common equity	Long	USA
TMO Thermo Fisher Scientific Inc.	11.65 mm	21.07 k shares	4.45	Common equity	Long	USA
MRK Merck & Co., Inc.	10.36 mm	83.65 k shares	3.96	Common equity	Long	USA
ELV Elevance Health Inc.	9.88 mm	18.23 k shares	3.78	Common equity	Long	USA
SYK Stryker Corporation	9.33 mm	27.42 k shares	3.56	Common equity	Long	USA
DHR Danaher Corporation	8.92 mm	35.70 k shares	3.41	Common equity	Long	USA
REGN Regeneron Pharmaceuticals, Inc.	8.28 mm	7.88 k shares	3.17	Common equity	Long	USA
VRTX Vertex Pharmaceuticals Incorporated	6.80 mm	14.50 k shares	2.60	Common equity	Long	USA
ASTRAZENECA PLC ADR	6.70 mm	85.97 k shares	2.56	Common equity	Long	UK
AMGN Amgen Inc.	6.18 mm	19.79 k shares	2.36	Common equity	Long	USA
ALNY Alnylam Pharmaceuticals, Inc.	5.83 mm	23.98 k shares	2.23	Common equity	Long	USA
ARGX argenx SE	5.64 mm	13.13 k shares	2.16	Common equity	Long	Netherlands
Cigna Holding Co	4.55 mm	13.76 k shares	1.74	Common equity	Long	USA
NVO Novo Nordisk A/S	4.54 mm	31.79 k shares	1.73	Common equity	Long	Denmark
BSX Boston Scientific Corporation	4.17 mm	54.17 k shares	1.59	Common equity	Long	USA
EW Edwards Lifesciences Corporation	3.61 mm	39.05 k shares	1.38	Common equity	Long	USA
BPMC Blueprint Medicines Corporation	3.49 mm	32.37 k shares	1.33	Common equity	Long	USA
INSM Insmed Incorporated	3.12 mm	46.62 k shares	1.19	Common equity	Long	USA
BDX Becton, Dickinson and Company	2.94 mm	12.59 k shares	1.12	Common equity	Long	USA
HCA HCA Healthcare, Inc.	2.88 mm	8.97 k shares	1.10	Common equity	Long	USA
MOH Molina Healthcare, Inc.	2.71 mm	9.12 k shares	1.04	Common equity	Long	USA
PEN Penumbra, Inc.	2.37 mm	13.18 k shares	0.91	Common equity	Long	USA
RNA Avidity Biosciences, Inc.	2.27 mm	55.65 k shares	0.87	Common equity	Long	USA
THC Tenet Healthcare Corporation	2.10 mm	15.76 k shares	0.80	Common equity	Long	USA
A Agilent Technologies, Inc.	1.97 mm	15.20 k shares	0.75	Common equity	Long	USA
NBIX Neurocrine Biosciences, Inc.	1.91 mm	13.89 k shares	0.73	Common equity	Long	USA
Madrigal Pharmaceuticals, Inc.	1.74 mm	6.21 k shares	0.66	Common equity	Long	USA
BGNE BeiGene, Ltd.	1.72 mm	12.05 k shares	0.66	Common equity	Long	USA
ICLR ICON Public Limited Company	1.66 mm	5.30 k shares	0.63	Common equity	Long	Ireland
HUM Humana Inc.	1.63 mm	4.36 k shares	0.62	Common equity	Long	USA
TECH Bio-Techne Corporation	1.53 mm	21.40 k shares	0.59	Common equity	Long	USA
ASND Ascendis Pharma A/S	1.49 mm	10.90 k shares	0.57	Common equity	Long	Denmark
DXCM DexCom, Inc.	1.48 mm	13.05 k shares	0.57	Common equity	Long	USA
KRYS Krystal Biotech, Inc.	1.24 mm	6.75 k shares	0.47	Common equity	Long	USA
HOLX Hologic, Inc.	1.23 mm	16.52 k shares	0.47	Common equity	Long	USA
MCK McKesson Corporation	1.19 mm	2.04 k shares	0.45	Common equity	Long	USA
PCVX Vaxcyte, Inc.	1.15 mm	15.20 k shares	0.44	Common equity	Long	USA
BHVN Biohaven Ltd.	1.13 mm	32.54 k shares	0.43	Common equity	Long	USA
BIIB Biogen Inc.	1.12 mm	4.85 k shares	0.43	Common equity	Long	USA
RVMD Revolution Medicines, Inc.	1.09 mm	27.98 k shares	0.41	Common equity	Long	USA
MLTX MoonLake Immunotherapeutics	1.07 mm	24.32 k shares	0.41	Common equity	Long	Switzerland
BMRN BioMarin Pharmaceutical Inc.	1.02 mm	12.37 k shares	0.39	Common equity	Long	USA
CNC Centene Corporation	974.68 k	14.70 k shares	0.37	Common equity	Long	USA
AGIO Agios Pharmaceuticals, Inc.	962.74 k	22.33 k shares	0.37	Common equity	Long	USA
IONS Ionis Pharmaceuticals, Inc.	867.84 k	18.21 k shares	0.33	Common equity	Long	USA
GPCR Structure Therapeutics Inc.	863.23 k	21.98 k shares	0.33	Common equity	Long	USA
CRNX Crinetics Pharmaceuticals, Inc.	861.67 k	19.24 k shares	0.33	Common equity	Long	USA
IMCR Immunocore Holdings plc	831.49 k	24.54 k shares	0.32	Common equity	Long	UK
CLDX Celldex Therapeutics, Inc.	819.62 k	22.15 k shares	0.31	Common equity	Long	USA
CHUGAI PHARMACEUTICAL CO LTD COMMON STOCK	808.31 k	22.70 k shares	0.31	Common equity	Long	Japan
UTHR United Therapeutics Corporation	796.38 k	2.50 k shares	0.30	Common equity	Long	USA
MRUS Merus N.V.	787.08 k	13.30 k shares	0.30	Common equity	Long	Netherlands
LEGN Legend Biotech Corporation	776.89 k	17.54 k shares	0.30	Common equity	Long	USA
CAH Cardinal Health, Inc.	759.62 k	7.73 k shares	0.29	Common equity	Long	USA
OSCR Oscar Health, Inc.	759.09 k	47.98 k shares	0.29	Common equity	Long	USA
SWTX SpringWorks Therapeutics, Inc.	758.37 k	20.13 k shares	0.29	Common equity	Long	USA
SSC GOVERNMENT MM GVMXX 20301231 00001.0000000000	755.22 k	755.22 k shares	0.29	Short-term investment vehicle	Long	USA
KYMR Kymera Therapeutics, Inc.	748.49 k	25.08 k shares	0.29	Common equity	Long	USA
RARE Ultragenyx Pharmaceutical Inc.	731.17 k	17.79 k shares	0.28	Common equity	Long	USA
IDXX IDEXX Laboratories, Inc.	730.80 k	1.50 k shares	0.28	Common equity	Long	USA
DAIICHI SANKYO CO LTD COMMON STOCK	698.55 k	20.10 k shares	0.27	Common equity	Long	Japan
VERA Vera Therapeutics, Inc.	688.54 k	19.03 k shares	0.26	Common equity	Long	USA
PODD Insulet Corporation	630.22 k	3.12 k shares	0.24	Common equity	Long	USA
RVTY Revvity, Inc.	629.16 k	6.00 k shares	0.24	Common equity	Long	USA
ALKS Alkermes plc	618.24 k	25.65 k shares	0.24	Common equity	Long	Ireland
CRGX CARGO Therapeutics, Inc. Common Stock	613.25 k	37.35 k shares	0.23	Common equity	Long	USA
RGEN Repligen Corporation	609.50 k	4.84 k shares	0.23	Common equity	Long	USA
ACLX Arcellx, Inc.	602.84 k	10.92 k shares	0.23	Common equity	Long	USA
EXAS Exact Sciences Corporation	589.01 k	13.94 k shares	0.23	Common equity	Long	USA
NVCR NovoCure Limited	587.35 k	34.29 k shares	0.22	Common equity	Long	Jersey
LBPH Longboard Pharmaceuticals, Inc.	582.20 k	21.54 k shares	0.22	Common equity	Long	USA
PTGX Protagonist Therapeutics, Inc.	566.63 k	16.35 k shares	0.22	Common equity	Long	USA
SONOVA HOLDING AG COMMON STOCK CHF.05	562.53 k	1.83 k shares	0.21	Common equity	Long	Switzerland
TXG 10x Genomics, Inc.	547.21 k	28.13 k shares	0.21	Common equity	Long	USA
COR Cencora	542.97 k	2.41 k shares	0.21	Common equity	Long	USA
BEAM Beam Therapeutics Inc.	542.22 k	23.14 k shares	0.21	Common equity	Long	USA
PRCT PROCEPT BioRobotics Corporation	537.10 k	8.79 k shares	0.21	Common equity	Long	USA
IDYA IDEAYA Biosciences, Inc.	527.95 k	15.04 k shares	0.20	Common equity	Long	USA
DYN Dyne Therapeutics, Inc.	525.01 k	14.88 k shares	0.20	Common equity	Long	USA
APGE Apogee Therapeutics, Inc.	518.32 k	13.17 k shares	0.20	Common equity	Long	USA
GERN Geron Corporation	515.86 k	121.67 k shares	0.20	Common equity	Long	USA
DNLI Denali Therapeutics Inc.	497.51 k	21.43 k shares	0.19	Common equity	Long	USA
MORF Morphic Holding, Inc.	492.92 k	14.47 k shares	0.19	Common equity	Long	USA
BCYC Bicycle Therapeutics plc	479.91 k	23.71 k shares	0.18	Common equity	Long	UK
ZAI LAB LTD ADR USD.00006	472.71 k	27.28 k shares	0.18	Common equity	Long	China
BRKR Bruker Corporation	470.73 k	7.38 k shares	0.18	Common equity	Long	USA
APLS Apellis Pharmaceuticals, Inc.	466.46 k	12.16 k shares	0.18	Common equity	Long	USA
SARTORIUS AG PREFERENCE	464.43 k	1.98 k shares	0.18	Preferred equity	Long	Germany
RCKT Rocket Pharmaceuticals, Inc.	462.38 k	21.48 k shares	0.18	Common equity	Long	USA
INSP Inspire Medical Systems, Inc.	440.43 k	3.29 k shares	0.17	Common equity	Long	USA
CYTK Cytokinetics, Incorporated	438.37 k	8.09 k shares	0.17	Common equity	Long	USA
AKRO Akero Therapeutics, Inc.	435.77 k	18.58 k shares	0.17	Common equity	Long	USA
RAPP Rapport Therapeutics, Inc. Common Stock	431.94 k	18.57 k shares	0.17	Common equity	Long	USA
IMTX Immatics N.V.	411.23 k	35.39 k shares	0.16	Common equity	Long	Germany
IMNM Immunome, Inc.	411.00 k	33.97 k shares	0.16	Common equity	Long	USA
CGON CG Oncology, Inc. Common stock	397.12 k	12.58 k shares	0.15	Common equity	Long	USA
ARVN Arvinas, Inc.	385.51 k	14.48 k shares	0.15	Common equity	Long	USA
XNCR Xencor, Inc.	370.25 k	19.56 k shares	0.14	Common equity	Long	USA
LANTHEUS HOLDINGS INC COMMON STOCK USD.01	364.92 k	4.55 k shares	0.14	Common equity	Long	USA
SRPT Sarepta Therapeutics, Inc.	359.29 k	2.27 k shares	0.14	Common equity	Long	USA
CNTA Centessa Pharmaceuticals plc	358.83 k	39.74 k shares	0.14	Common equity	Long	USA
ELAN Elanco Animal Health Incorporated	334.03 k	23.15 k shares	0.13	Common equity	Long	USA
SIEMENS HEALTHINEERS AG COMMON STOCK	325.03 k	5.64 k shares	0.12	Common equity	Long	Germany
MRNA Moderna, Inc.	324.07 k	2.73 k shares	0.12	Common equity	Long	USA
PRTA Prothena Corporation plc	317.73 k	15.39 k shares	0.12	Common equity	Long	Ireland
SLNO Soleno Therapeutics, Inc.	315.30 k	7.73 k shares	0.12	Common equity	Long	USA
SRRK Scholar Rock Holding Corporation	312.71 k	37.54 k shares	0.12	Common equity	Long	USA
IOVA Iovance Biotherapeutics, Inc.	312.42 k	38.96 k shares	0.12	Common equity	Long	USA
ARDX Ardelyx, Inc.	302.14 k	40.78 k shares	0.12	Common equity	Long	USA
SANA Sana Biotechnology, Inc.	299.06 k	54.77 k shares	0.11	Common equity	Long	USA
PRAX Praxis Precision Medicines, Inc.	286.71 k	6.93 k shares	0.11	Common equity	Long	USA
SMMT Summit Therapeutics Inc.	274.56 k	35.20 k shares	0.10	Common equity	Long	USA
REPL Replimune Group, Inc.	269.76 k	29.97 k shares	0.10	Common equity	Long	USA
RLAY Relay Therapeutics, Inc.	261.33 k	40.08 k shares	0.10	Common equity	Long	USA
BTSG BrightSpring Health Services, Inc. Common Stock	254.88 k	22.44 k shares	0.10	Common equity	Long	USA
TEMPUS AI INC COMMON STOCK USD.0001	241.82 k	6.91 k shares	0.09	Common equity	Long	USA
ALLO Allogene Therapeutics, Inc.	233.46 k	100.20 k shares	0.09	Common equity	Long	USA
PHVS Pharvaris N.V.	231.58 k	12.32 k shares	0.09	Common equity	Long	Netherlands
IMCR Immunocore Holdings plc	227.87 k	277.00 k principal	0.09	Debt	Long	UK
SGRY Surgery Partners, Inc.	218.80 k	9.20 k shares	0.08	Common equity	Long	USA
IRON Disc Medicine, Inc.	208.85 k	4.63 k shares	0.08	Common equity	Long	USA
RYTM Rhythm Pharmaceuticals, Inc.	194.58 k	4.74 k shares	0.07	Common equity	Long	USA
CRBP Corbus Pharmaceuticals Holdings, Inc.	194.58 k	4.30 k shares	0.07	Common equity	Long	USA
VRNA Verona Pharma plc	189.43 k	13.10 k shares	0.07	Common equity	Long	UK
ENOV Enovis Corporation	182.47 k	4.04 k shares	0.07	Common equity	Long	USA
GH Guardant Health, Inc.	181.48 k	6.28 k shares	0.07	Common equity	Long	USA
LYEL Lyell Immunopharma, Inc.	179.69 k	123.93 k shares	0.07	Common equity	Long	USA
HLXB Helix Acquisition Corp. II Class A Ordinary Shares	166.57 k	16.30 k shares	0.06	Common equity	Long	Cayman Islands
TRDA Entrada Therapeutics, Inc.	165.66 k	11.63 k shares	0.06	Common equity	Long	USA
BCRX BioCryst Pharmaceuticals, Inc.	161.92 k	26.20 k shares	0.06	Common equity	Long	USA
ACAD ACADIA Pharmaceuticals Inc.	156.67 k	9.64 k shares	0.06	Common equity	Long	USA
NTRA Natera, Inc.	151.61 k	1.40 k shares	0.06	Common equity	Long	USA
PLRX Pliant Therapeutics, Inc.	147.11 k	13.69 k shares	0.06	Common equity	Long	USA
SYRE Spyre Therapeutics, Inc.	146.47 k	6.23 k shares	0.06	Common equity	Long	USA
ORIC ORIC Pharmaceuticals, Inc.	145.64 k	20.60 k shares	0.06	Common equity	Long	USA
WVE Wave Life Sciences Ltd.	144.45 k	28.95 k shares	0.06	Common equity	Long	USA
SENSORION SA COMMON STOCK EUR.1	141.64 k	182.87 k shares	0.05	Common equity	Long	France
NMRA Neumora Therapeutics, Inc. Common Stock	137.62 k	14.00 k shares	0.05	Common equity	Long	USA
AGL agilon health, inc.	128.55 k	19.66 k shares	0.05	Common equity	Long	USA
TARS Tarsus Pharmaceuticals, Inc.	128.51 k	4.73 k shares	0.05	Common equity	Long	USA
VYGR Voyager Therapeutics, Inc.	126.28 k	15.96 k shares	0.05	Common equity	Long	USA
IGMS IGM Biosciences, Inc.	121.43 k	17.68 k shares	0.05	Common equity	Long	USA
JANX Janux Therapeutics, Inc.	113.10 k	2.70 k shares	0.04	Common equity	Long	USA
GLUE Monte Rosa Therapeutics, Inc.	111.95 k	29.93 k shares	0.04	Common equity	Long	USA
ANAB AnaptysBio, Inc.	110.26 k	4.40 k shares	0.04	Common equity	Long	USA
OBIO Orchestra BioMed Holdings, Inc.	108.84 k	13.35 k shares	0.04	Common equity	Long	USA
ANNX Annexon, Inc.	108.33 k	22.11 k shares	0.04	Common equity	Long	USA
ZNTL Zentalis Pharmaceuticals, Inc.	106.76 k	26.10 k shares	0.04	Common equity	Long	USA
GBIO Generation Bio Co.	106.29 k	37.69 k shares	0.04	Common equity	Long	USA
MGNX MacroGenics, Inc.	102.38 k	24.09 k shares	0.04	Common equity	Long	USA
EYPT EyePoint Pharmaceuticals, Inc.	101.67 k	11.69 k shares	0.04	Common equity	Long	USA
SAGE Sage Therapeutics, Inc.	97.46 k	8.97 k shares	0.04	Common equity	Long	USA
OCUL Ocular Therapeutix, Inc.	97.13 k	14.20 k shares	0.04	Common equity	Long	USA
ANRO Alto Neuroscience, Inc.	96.26 k	9.01 k shares	0.04	Common equity	Long	USA
AUTL Autolus Therapeutics plc	95.70 k	27.50 k shares	0.04	Common equity	Long	UK
AURA Aura Biosciences, Inc.	78.82 k	10.43 k shares	0.03	Common equity	Long	USA
CABA Cabaletta Bio, Inc.	73.21 k	9.79 k shares	0.03	Common equity	Long	USA
GOSS Gossamer Bio, Inc.	67.06 k	74.44 k shares	0.03	Common equity	Long	USA
PRLD Prelude Therapeutics Incorporated	66.40 k	17.43 k shares	0.03	Common equity	Long	USA
KYTX Kyverna Therapeutics, Inc.	66.22 k	8.83 k shares	0.03	Common equity	Long	USA
ALEC Alector, Inc.	54.95 k	12.10 k shares	0.02	Common equity	Long	USA
PHARMING GROUP NV COMMON STOCK EUR.01	53.49 k	66.46 k shares	0.02	Common equity	Long	Netherlands
BDTX Black Diamond Therapeutics, Inc.	52.66 k	11.30 k shares	0.02	Common equity	Long	USA
CFRXQ ContraFect Corporation	50.05 k	36.53 k shares	0.02	Common equity	Long	USA
TSHA Taysha Gene Therapies, Inc.	38.98 k	17.40 k shares	0.01	Common equity	Long	USA
IMRX Immuneering Corporation	37.99 k	29.68 k shares	0.01	Common equity	Long	USA
ABOS Acumen Pharmaceuticals, Inc.	37.51 k	15.50 k shares	0.01	Common equity	Long	USA
HIMS Hims & Hers Health, Inc.	36.34 k	1.80 k shares	0.01	Common equity	Long	USA
DNA Ginkgo Bioworks Holdings, Inc.	26.36 k	78.86 k shares	0.01	Common equity	Long	USA
WGS GeneDx Holdings Corp.	24.00 k	918.00 shares	0.01	Common equity	Long	USA
RAPT RAPT Therapeutics, Inc.	20.17 k	6.61 k shares	0.01	Common equity	Long	USA
ROWE T PRICE GOV RES FD 20340919 00000.0000000000	17.84 k	17.84 k shares	0.01	Short-term investment vehicle	Long	USA
DAWN Day One Biopharmaceuticals, Inc.	15.72 k	1.14 k shares	0.01	Common equity	Long	USA
RVMD Revolution Medicines, Inc.	320.99	4.50 k shares	0.00	Common equity	Long	USA
SLGCW SomaLogic, Inc.	207.05	2.05 k shares	0.00	Common equity	Long	USA
WGS GeneDx Holdings Corp.	144.40	4.86 k shares	0.00	Common equity	Long	USA